{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:34Z","timestamp":1791945934509,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","award":["SL2023A03J00413"],"award-info":[{"award-number":["SL2023A03J00413"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-Sen University","doi-asserted-by":"publisher","award":["2023WW502"],"award-info":[{"award-number":["2023WW502"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2025A0505020039"],"award-info":[{"award-number":["2025A0505020039"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.canlet.2026.218550","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:49:44Z","timestamp":1777520984000},"page":"218550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Excessive lymph node dissection compromises efficacy of postsurgical immunotherapy for gastric cancer:A multicenter retrospective study"],"prefix":"10.1016","volume":"651","author":[{"given":"Jianming","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofeng","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongpu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.canlet.2026.218550_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.canlet.2026.218550_bib2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.annonc.2022.07.004","article-title":"Gastric cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up","volume":"33","author":"Lordick","year":"2022","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218550_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.6004\/jnccn.2022.0008","article-title":"Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Ajani","year":"2022","journal-title":"J. Natl Compr Cancer Netw. JNCCN"},{"issue":"1","key":"10.1016\/j.canlet.2026.218550_bib4","first-page":"1","article-title":"Japanese gastric cancer treatment guidelines 2021","volume":"26","year":"2023","journal-title":"Gastric Cancer Off. J. Int. Gastric Cancer Assoc. Jpn Gastric Cancer Assoc.."},{"issue":"28","key":"10.1016\/j.canlet.2026.218550_bib5","doi-asserted-by":"crossref","first-page":"7114","DOI":"10.1200\/JCO.2005.14.621","article-title":"Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer: data from a large US-Population database","volume":"23","author":"Smith","year":"2005","journal-title":"J. Clin. Oncol."},{"issue":"9\u201310","key":"10.1016\/j.canlet.2026.218550_bib6","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/sj.bjc.6690243","article-title":"Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical co-operative group","volume":"79","author":"Cuschieri","year":"1999","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.canlet.2026.218550_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/SLA.0000000000001814","article-title":"Randomized controlled trial to evaluate splenectomy in total gastrectomy for proximal gastric carcinoma","volume":"265","author":"Sano","year":"2017","journal-title":"Ann. Surg."},{"issue":"12","key":"10.1016\/j.canlet.2026.218550_bib8","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1007\/s00262-022-03223-3","article-title":"Tumor-derived IL-8 facilitates lymph node metastasis of gastric cancer via PD-1 up-regulation in CD8+T cells","volume":"71","author":"Li","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"issue":"6","key":"10.1016\/j.canlet.2026.218550_bib9","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2023.02.021","article-title":"Dynamic CD8(+) T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes","volume":"186","author":"Rahim","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.canlet.2026.218550_bib10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/JS9.0000000000000774","article-title":"Impact of lymphadenectomy extent on immunotherapy efficacy in postresectional recurred non-small cell lung cancer: a multi-institutional retrospective cohort study","volume":"110","author":"Deng","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.canlet.2026.218550_bib11","article-title":"Excessive dissection of non-metastatic tumor-draining lymph nodes impairs immunotherapy efficacy in recurrent biliary tract cancer","volume":"29","author":"Long","year":"2025","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.canlet.2026.218550_bib12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S2468-1253(24)00156-0","volume":"9","author":"Kang","year":"2024","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218550_bib13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S1470-2045(23)00541-7","article-title":"Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomised phase 3 study","volume":"25","author":"Shitara","year":"2024","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218550_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJMoa2503701","article-title":"Perioperative durvalumab in gastric and gastroesophageal junction cancer","volume":"393","author":"Janjigian","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.canlet.2026.218550_bib15","first-page":"93","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"10.1016\/j.canlet.2026.218550_bib16","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1097\/JS9.0000000000001626","article-title":"Finding the minimum number of retrieved lymph nodes and negative lymph nodes in gastric cancer surgery: a real-world study","volume":"110","author":"Liu","year":"2024","journal-title":"Int. J. Surg."},{"issue":"11","key":"10.1016\/j.canlet.2026.218550_bib17","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s00262-021-02934-3","article-title":"Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used","volume":"70","author":"Fear","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"issue":"23","key":"10.1016\/j.canlet.2026.218550_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124507","article-title":"Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy","volume":"3","author":"Fransen","year":"2018","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.canlet.2026.218550_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJMe2507207","article-title":"New perioperative strategy in gastric cancer","volume":"393","author":"Shitara","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.canlet.2026.218550_bib20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.5306\/wjco.v7.i2.174","article-title":"Clinical utilities and biological characteristics of melanoma sentinel lymph nodes","volume":"7","author":"Han","year":"2016","journal-title":"World J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218550_bib21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s12262-016-1531-9","article-title":"What is a false negative sentinel node biopsy: definition, reasons and ways to minimize it?","volume":"78","author":"Kataria","year":"2016","journal-title":"Indian J. Surg."},{"issue":"1","key":"10.1016\/j.canlet.2026.218550_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ags3.12231","article-title":"Is sentinel node mapping useful for esophageal cancer surgery?","volume":"3","author":"Ozawa","year":"2019","journal-title":"Ann. Gastroenterol. Surg."},{"issue":"Suppl 9","key":"10.1016\/j.canlet.2026.218550_bib23","doi-asserted-by":"crossref","first-page":"S744","DOI":"10.21037\/jtd.2016.09.70","article-title":"Clinical use of near-infrared fluorescence imaging with indocyanine green in thoracic surgery: a literature review","volume":"8","author":"Chiu","year":"2016","journal-title":"J. Thorac. Dis."},{"issue":"4","key":"10.1016\/j.canlet.2026.218550_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10151-018-1773-6","article-title":"Feasibility of fluorescence lymph node imaging in colon cancer: FLICC","volume":"22","author":"Chand","year":"2018","journal-title":"Tech. Coloproctol."},{"issue":"52","key":"10.1016\/j.canlet.2026.218550_bib25","doi-asserted-by":"crossref","first-page":"35490","DOI":"10.1021\/acsnano.4c12915","article-title":"Spatiotemporal mapping of lymphatic metastases in gastric cancer using tumor-trackable and enzyme-activatable near-infrared fluorescent nanoprobes","volume":"18","author":"Yu","year":"2024","journal-title":"ACS Nano"},{"issue":"38","key":"10.1016\/j.canlet.2026.218550_bib26","article-title":"Data-driven design of triple-targeted protein nanoprobes for multiplexed imaging of cancer lymphatic metastasis","volume":"36","author":"Shen","year":"2024","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.canlet.2026.218550_bib27","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1109\/TMI.2024.3510836","article-title":"Prediction of lymph node metastasis in colorectal cancer using intraoperative fluorescence multi-modal imaging","volume":"44","author":"Zhu","year":"2025","journal-title":"IEEE Trans. Med. Imag."},{"issue":"10","key":"10.1016\/j.canlet.2026.218550_bib28","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.annonc.2022.07.004","article-title":"Gastric cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up","volume":"33","author":"Lordick","year":"2022","journal-title":"Ann. Oncol."},{"issue":"10294","key":"10.1016\/j.canlet.2026.218550_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0140-6736(21)00797-2","article-title":"First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial","volume":"398","author":"Janjigian","year":"2021","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.canlet.2026.218550_bib30","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jamaoncol.2020.3370","article-title":"Efficacy and safety of pembrolizumab or pembrolizumab plus chemotherapy vs chemotherapy alone for patients with first-line, advanced gastric cancer: the KEYNOTE-062 phase 3 randomized clinical trial","volume":"6","author":"Shitara","year":"2020","journal-title":"JAMA Oncol."},{"issue":"10302","key":"10.1016\/j.canlet.2026.218550_bib31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(21)01234-4","article-title":"Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study","volume":"398","author":"Sun","year":"2021","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.canlet.2026.218550_bib32","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.annonc.2022.05.519","article-title":"Pembrolizumab in microsatellite instability high or mismatch repair deficient cancers: updated analysis from the phase II KEYNOTE-158 study","volume":"33","author":"Maio","year":"2022","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218550_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2020.100036","article-title":"Predictive role of microsatellite instability for PD-1 blockade in patients with advanced gastric cancer: a meta-analysis of randomized clinical trials","volume":"6","author":"Pietrantonio","year":"2021","journal-title":"ESMO Open"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:25:07Z","timestamp":1783103107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526003137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":33,"alternative-id":["S0304383526003137"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218550","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excessive lymph node dissection compromises efficacy of postsurgical immunotherapy for gastric cancer:A multicenter retrospective study","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218550"}}