{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:03:46Z","timestamp":1784563426120,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2208085MH241"],"award-info":[{"award-number":["2208085MH241"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["82573851"],"award-info":[{"award-number":["82573851"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0940101"],"award-info":[{"award-number":["XDB0940101"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2023ZD0507500"],"award-info":[{"award-number":["2023ZD0507500"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.canlet.2026.218569","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:22:01Z","timestamp":1778743321000},"page":"218569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["ZDHHC5-mediated BRAF palmitoylation activates the MAPK pathway and drives cholangiocarcinoma progression"],"prefix":"10.1016","volume":"653","author":[{"given":"Chunxi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiezong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3535-6467","authenticated-orcid":false,"given":"Lianxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9765-649X","authenticated-orcid":false,"given":"Qingsong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218569_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41572-021-00300-2","article-title":"Cholangiocarcinoma","volume":"7","author":"Brindley","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.canlet.2026.218569_bib2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2026.218569_bib3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41571-023-00770-1","article-title":"Cholangiocarcinoma - novel biological insights and therapeutic strategies","volume":"20","author":"Ilyas","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canlet.2026.218569_bib4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S2468-1253(24)00095-5","article-title":"Durvalumab or placebo plus gemcitabine and cisplatin in participants with advanced biliary tract cancer (TOPAZ-1): updated overall survival from a randomised phase 3 study","volume":"9","author":"Oh","year":"2024","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2026.218569_bib5","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1002\/ijc.33013","article-title":"Efficacy and safety of pembrolizumab for the treatment of advanced biliary cancer: results from the KEYNOTE-158 and KEYNOTE-028 studies","volume":"147","author":"Piha-Paul","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218569_bib6","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaoncol.2020.0930","article-title":"A phase 2 multi-institutional study of Nivolumab for patients with advanced refractory biliary tract cancer","volume":"6","author":"Kim","year":"2020","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.canlet.2026.218569_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41698-021-00206-y","article-title":"Genomic context of NTRK1\/2\/3 fusion-positive tumours from a large real-world population","volume":"5","author":"Westphalen","year":"2021","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.canlet.2026.218569_bib8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMoa1714448","article-title":"Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children","volume":"378","author":"Drilon","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2026.218569_bib9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.21037\/jgo.2019.03.10","article-title":"Frequency and prognostic significance of isocitrate dehydrogenase 1 mutations in cholangiocarcinoma: a systematic literature review","volume":"10","author":"Boscoe","year":"2019","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.canlet.2026.218569_bib10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S1470-2045(20)30157-1","article-title":"Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study","volume":"21","author":"Abou-Alfa","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2026.218569_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10555-016-9645-x","article-title":"HER2\/HER3 pathway in biliary tract malignancies; systematic review and meta-analysis: a potential therapeutic target?","volume":"36","author":"Galdy","year":"2017","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.canlet.2026.218569_bib12","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/hep.26890","article-title":"Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma","volume":"59","author":"Arai","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2026.218569_bib13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S1470-2045(20)30109-1","article-title":"Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study","volume":"21","author":"Abou-Alfa","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2026.218569_bib14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S2468-1253(21)00196-5","article-title":"Infigratinib (BGJ398) in previously treated patients with advanced or metastatic cholangiocarcinoma with FGFR2 fusions or rearrangements: mature results from a multicentre, open-label, single-arm, phase 2 study","volume":"6","author":"Javle","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2026.218569_bib15","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.molcel.2021.03.015","article-title":"Discovering the landscape of protein modifications","volume":"81","author":"Keenan","year":"2021","journal-title":"Mol Cell"},{"key":"10.1016\/j.canlet.2026.218569_bib16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nsmb.1842","article-title":"Post-translational modifications in signal integration","volume":"17","author":"Deribe","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.canlet.2026.218569_bib17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41580-024-00700-8","article-title":"Mechanisms and functions of protein S-acylation","volume":"25","author":"F","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218569_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrm2084","article-title":"Palmitoylation: policing protein stability and traffic","volume":"8","author":"Linder","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218569_bib19","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846666","article-title":"Protein palmitoylation and cancer","volume":"19","author":"Ko","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.canlet.2026.218569_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.13308","article-title":"Protein palmitoylation in cancer: molecular functions and therapeutic potential","volume":"17","author":"Zhou","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.canlet.2026.218569_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.molcel.2016.04.003","article-title":"Inhibition of DHHC20-Mediated EGFR palmitoylation creates a dependence on EGFR signaling","volume":"62","author":"Runkle","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/j.canlet.2026.218569_bib22","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1182\/blood-2009-03-213876","article-title":"Palmitoylation of oncogenic NRAS is essential for leukemogenesis","volume":"115","author":"Cuiffo","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2026.218569_bib23","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/sj.bjc.6603818","article-title":"Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups","volume":"96","author":"Mansilla","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218569_bib24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41551-019-0375-6","article-title":"Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours","volume":"3","author":"Yao","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.canlet.2026.218569_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41422-018-0124-5","article-title":"Palmitoylation stabilizes PD-L1 to promote breast tumor growth","volume":"29","author":"Yang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2026.218569_bib26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4174\/astr.2019.96.4.153","article-title":"Genetic features associated with 18F-FDG uptake in intrahepatic cholangiocarcinoma","volume":"96","author":"Ahn","year":"2019","journal-title":"Annals of surgical treatment and research"},{"key":"10.1016\/j.canlet.2026.218569_bib27","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.jcmgh.2022.02.014","article-title":"Single-cell transcriptomic architecture unraveling the complexity of tumor heterogeneity in distal cholangiocarcinoma","volume":"13","author":"Li","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2026.218569_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ccell.2021.12.006","article-title":"Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma","volume":"40","author":"Dong","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218569_bib29","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/jcp.24779","article-title":"The differential palmitoylation states of N\u2010Ras and h-ras determine their distinct Golgi subcompartment localizations","volume":"230","author":"Lynch","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2026.218569_bib30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1042\/BST20160303","article-title":"Targeting the Ras palmitoylation\/depalmitoylation cycle in cancer","volume":"45","author":"Lin","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.canlet.2026.218569_bib31","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1038\/s41467-020-18565-8","article-title":"CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis","volume":"11","author":"Hao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218569_bib32","first-page":"639","volume":"vol. 21","author":"Ren","year":"2008"},{"key":"10.1016\/j.canlet.2026.218569_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41420-023-01359-4","article-title":"Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models","volume":"9","author":"Wang","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.canlet.2026.218569_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101172","article-title":"Mitogen-activated protein kinases (MAPKs) and cholangiocarcinoma: the missing link","volume":"8","author":"Chen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2026.218569_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2017.06.009","article-title":"RAS proteins and their regulators in human disease","volume":"170","author":"Simanshu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218569_bib36","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41467-021-21422-x","article-title":"KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation","volume":"12","author":"Tran","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218569_bib37","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature08314","article-title":"A dimerization-dependent mechanism drives RAF catalytic activation","volume":"461","author":"Rajakulendran","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218569_bib38","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2026.218569_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrm3255","article-title":"Regulating the regulator: post-translational modification of RAS","volume":"13","author":"Ahearn","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218569_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/cr.1998.9","article-title":"The RAF family: an expanding network of post-translational controls and protein-protein interactions","volume":"8","author":"Yuryev","year":"1998","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2026.218569_bib41","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrd2221","article-title":"Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets","volume":"6","author":"Konstantinopoulos","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2026.218569_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.659861","article-title":"Palmitoylation as a key regulator of Ras Localization and function","volume":"8","author":"Busquets-Hernandez","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.canlet.2026.218569_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5582\/bst.2016.01220","article-title":"Regulation of Ras signaling and function by plasma membrane microdomains","volume":"11","author":"Goldfinger","year":"2017","journal-title":"Biosci Trends"},{"key":"10.1016\/j.canlet.2026.218569_bib44","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1182\/blood.2020005720","article-title":"NRAS palmitoylation and oncogenic fitness","volume":"135","author":"Castilla","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2026.218569_bib45","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/leu.2015.293","article-title":"Palmitoylacyltransferase Zdhhc9 inactivation mitigates leukemogenic potential of oncogenic Nras","volume":"30","author":"Liu","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2026.218569_bib46","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1152\/physrev.00032.2014","article-title":"The physiology of protein S-acylation","volume":"95","author":"Chamberlain","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2026.218569_bib47","article-title":"Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218569_bib48","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41568-024-00666-x","article-title":"Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets","volume":"24","author":"Tate","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2026.218569_bib49","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1158\/0008-5472.CAN-17-1139","article-title":"EZH2 palmitoylation mediated by ZDHHC5 in p53-Mutant glioma drives malignant development and progression","volume":"77","author":"Chen","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218569_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2025.100793","article-title":"Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease","author":"Liu","year":"2025","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.canlet.2026.218569_bib51","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.cmet.2024.04.018","article-title":"Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis","volume":"36","author":"Peng","year":"2024","journal-title":"Cell Metab."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:53:34Z","timestamp":1783126414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526003320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":51,"alternative-id":["S0304383526003320"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218569","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ZDHHC5-mediated BRAF palmitoylation activates the MAPK pathway and drives cholangiocarcinoma progression","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218569"}}