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Investig."},{"key":"10.1016\/j.canlet.2026.218588_bib111","first-page":"2835","article-title":"p53 pathway and circadian clock interplay in tumor suppression","volume":"42","author":"Hou","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218588_bib112","article-title":"Circadian regulation of p53 in cancer: implications for genomic stability and metastasis","volume":"41","author":"Liu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218588_bib113","first-page":"2435","article-title":"Temporal dynamics of p53 and DNA repair in circadian-regulated cellular processes","volume":"22","author":"Wang","year":"2023","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2026.218588_bib114","article-title":"Circadian control of p53 in DNA repair and cell cycle regulation","volume":"12","author":"Zhang","year":"2024","journal-title":"Front. Cell Dev. 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Cell Sci."},{"key":"10.1016\/j.canlet.2026.218588_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110332","article-title":"A signature of circadian rhythm genes in driving anaplastic thyroid carcinoma malignant progression","volume":"95","author":"Xu","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.canlet.2026.218588_bib158","article-title":"Transcriptome profiling revealed multiple circadian rhythm-related genes associated with common gynecological cancers","volume":"15","author":"Peng","year":"2025","journal-title":"Front. 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