{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:32:59Z","timestamp":1792895579535,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["YESS20220023"],"award-info":[{"award-number":["YESS20220023"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82422054"],"award-info":[{"award-number":["82422054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473338"],"award-info":[{"award-number":["82473338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172764"],"award-info":[{"award-number":["82172764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272663"],"award-info":[{"award-number":["82272663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["24JCQNJC00490"],"award-info":[{"award-number":["24JCQNJC00490"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["25JCJQJC00240"],"award-info":[{"award-number":["25JCJQJC00240"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Tianjin Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["QN20230211"],"award-info":[{"award-number":["QN20230211"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019539","name":"Science Fund for Distinguished Young Scholars of Tianjin Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.canlet.2026.218590","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:26:25Z","timestamp":1778945185000},"page":"218590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Single-cell analysis reveals IL1B+ macrophages promote lung metastasis in adenoid cystic carcinoma"],"prefix":"10.1016","volume":"653","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4177-9528","authenticated-orcid":false,"given":"Mengyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218590_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2022.105945","article-title":"Current opinions on diagnosis and treatment of adenoid cystic carcinoma","volume":"130","author":"Fang","year":"2022","journal-title":"Oral Oncol."},{"key":"10.1016\/j.canlet.2026.218590_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12041463","article-title":"Recent advances, systemic therapy, and molecular targets in adenoid cystic carcinoma of the head and neck","volume":"12","author":"Dewenter","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.canlet.2026.218590_bib3","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/cam4.5065","article-title":"Prognosis of adenoid cystic carcinoma in head and neck region treated with different regimens-A single-centre study","volume":"12","author":"Cheng","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.canlet.2026.218590_bib4","article-title":"Salivary adenoid cystic carcinoma-derived \u03b12,6-sialylated extracellular vesicles increase vascular permeability by triggering ER-stress in endothelial cells and promote lung metastasis","volume":"611","author":"Dong","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218590_bib5","article-title":"Adenoid cystic carcinoma: a review of clinical features, treatment targets and advances in improving the immune response to monoclonal antibody therapy","volume":"1875","author":"Nightingale","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.canlet.2026.218590_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11864-022-01043-2","article-title":"Systemic and targeted therapies in adenoid cystic carcinoma","volume":"24","author":"Kacew","year":"2023","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.canlet.2026.218590_bib7","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1186\/s12885-025-14884-5","article-title":"Real-world treatment patterns and survival outcomes in metastatic head and neck adenoid cystic carcinoma","volume":"25","author":"B\u00f6lek","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2026.218590_bib8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jhep.2023.10.006","article-title":"Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma","volume":"80","author":"Zhang","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.canlet.2026.218590_bib9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-020-2774-y","article-title":"Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis","volume":"586","author":"Tavora","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218590_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217731","article-title":"COL1A1-positive endothelial cells promote gastric cancer progression via the ANGPTL4-SDC4 axis driven by endothelial-to-mesenchymal transition","volume":"623","author":"Liu","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218590_bib11","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1158\/0008-5472.CAN-23-3508","article-title":"Extracellular vesicles containing circMYBL1 induce CD44 in adenoid cystic carcinoma cells and pulmonary endothelial cells to promote lung metastasis","volume":"84","author":"Fu","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218590_bib12","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ccell.2023.02.005","article-title":"Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment","volume":"41","author":"Klement","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218590_bib13","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1038\/s41467-025-60421-0","article-title":"A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer","volume":"16","author":"Zuljan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218590_bib14","article-title":"Heterogeneous immune landscapes and macrophage dynamics in primary and lung metastatic adenoid cystic carcinoma of the head and neck","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218590_bib15","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1158\/1078-0432.CCR-19-3758","article-title":"The immune microenvironment and neoantigen landscape of aggressive salivary Gland carcinomas differ by subtype","volume":"26","author":"Linxweiler","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218590_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218037","article-title":"Oncoprotein SND1-enriched exosomes facilitate melanoma lung metastasis by regulating CD47-SIRP\u03b1-mediated macrophage reprogramming","volume":"634","author":"Chen","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218590_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217933","article-title":"SMARCA1-NPFF axis inhibits colorectal cancer metastasis by blocking epithelial-mesenchymal transition and macrophage-dependent immune reprogramming","volume":"631","author":"Wang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218590_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218102","article-title":"Biomechanical networks of the pre-metastatic niche: decoding biophysical determinants of tumor metastatic organotropism","volume":"635","author":"Guo","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218590_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218590_bib20","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1158\/2159-8290.CD-15-0012","article-title":"Real-Time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage-derived VEGFA","volume":"5","author":"Harney","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218590_bib21","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1084\/jem.20160392","article-title":"S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3\/IL-1\u03b2","volume":"214","author":"Weichand","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2026.218590_bib22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41392-025-02325-5","article-title":"Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218590_bib23","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1073\/pnas.97.2.734","article-title":"IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1","volume":"97","author":"Vidal-Vanaclocha","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218590_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217972","article-title":"The epigenetic landscape of tumor-associated macrophages: orchestrating immune evasion in the tumor microenvironment","volume":"632","author":"Liu","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218590_bib25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218590_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.canlet.2026.218590_bib27","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/s41591-023-02371-y","article-title":"Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance","volume":"29","author":"Chu","year":"2023","journal-title":"Nature medicine"},{"key":"10.1016\/j.canlet.2026.218590_bib28","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ccell.2021.09.005","article-title":"Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment","volume":"39","author":"Kfoury","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218590_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2019.12.001","article-title":"An integrated gene expression landscape profiling approach to identify lung tumor Endothelial cell heterogeneity and angiogenic candidates","volume":"37","author":"Goveia","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218590_bib30","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s43018-023-00716-7","article-title":"Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency","volume":"5","author":"Jakab","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2026.218590_bib31","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","article-title":"Lineage tracking reveals dynamic relationships of T cells in colorectal cancer","volume":"564","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218590_bib32","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.canlet.2026.218590_bib33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s12276-023-00957-7","article-title":"Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway","volume":"55","author":"Zhou","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.canlet.2026.218590_bib34","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(19)32591-7","article-title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study","volume":"394","author":"Burtness","year":"2019","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.canlet.2026.218590_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1056\/NEJMoa2415434","article-title":"Neoadjuvant and adjuvant pembrolizumab in locally advanced head and neck cancer","volume":"393","author":"Uppaluri","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2026.218590_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.35901","article-title":"Survival outcomes of pulmonary metastasis-directed local therapy in adenoid cystic carcinoma","volume":"131","author":"Hoff","year":"2025","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2026.218590_bib37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1158\/1078-0432.CCR-19-1868","article-title":"Macrophage-Derived CXCL9 and CXCL10 are required for Antitumor immune responses following immune checkpoint blockade","volume":"26","author":"House","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218590_bib38","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1126\/science.ade2292","article-title":"CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers","volume":"381","author":"Bill","year":"2023","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.canlet.2026.218590_bib39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/CIRCRESAHA.115.304718","article-title":"Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability","volume":"115","author":"Rocha","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.canlet.2026.218590_bib40","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/eji.201847623","article-title":"The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis","volume":"48","author":"Rijvers","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.canlet.2026.218590_bib41","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1182\/blood.2022016424","article-title":"The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis","volume":"140","author":"Kondreddy","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2026.218590_bib42","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41388-023-02647-0","article-title":"The platelet pannexin 1-IL-1\u03b2 axis orchestrates pancreatic ductal adenocarcinoma invasion and metastasis","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218590_bib43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-023-06685-2","article-title":"IL-1\u03b2(+) macrophages fuel pathogenic inflammation in pancreatic cancer","volume":"623","author":"Caronni","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218590_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneumeth.2014.03.002","article-title":"Interleukin-1\u03b2 induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model","volume":"228","author":"Labus","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.canlet.2026.218590_bib45","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1038\/s41590-024-01960-4","article-title":"The complexity of immune evasion mechanisms throughout the metastatic cascade","volume":"25","author":"Haynes","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.canlet.2026.218590_bib46","article-title":"Reversing VTN deficiency inhibits the progression of pancreatic cancer and enhances sensitivity to anti-PD1 immunotherapy","volume":"16","author":"Zhao","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218590_bib47","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1038\/s41467-021-25322-y","article-title":"Integrin-\u03b1(V)-mediated activation of TGF-\u03b2 regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade","volume":"12","author":"Malenica","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218590_bib48","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1038\/s41467-024-52577-y","article-title":"Tumor draining lymph nodes connected to cold triple-negative breast cancers are characterized by Th2-associated microenvironment","volume":"15","author":"Guo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218590_bib49","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1038\/s41467-020-20059-6","article-title":"Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma","volume":"11","author":"Zhou","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218590_bib50","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1158\/0008-5472.CAN-19-2288","article-title":"Breast cancer cell-derived soluble CD44 promotes tumor progression by triggering macrophage IL1\u03b2 production","volume":"80","author":"Jang","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218590_bib51","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1038\/s41467-019-12807-0","article-title":"Microenvironmental IL1\u03b2 promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling","volume":"10","author":"Eyre","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218590_bib52","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1002\/hep.32062","article-title":"IL-1\u03b2-Induced elevation of solute carrier family 7 member 11 promotes hepatocellular carcinoma metastasis through Up-regulating programmed death ligand 1 and colony-stimulating factor 1","volume":"74","author":"He","year":"2021","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.canlet.2026.218590_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtocrr.2020.100001","article-title":"The role of interleukin 1\u03b2 in the pathogenesis of lung cancer","volume":"1","author":"Garon","year":"2020","journal-title":"JTO clinical and research reports"},{"key":"10.1016\/j.canlet.2026.218590_bib54","first-page":"6714","article-title":"The CD24\/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells","volume":"60","author":"Friederichs","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218590_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12071791","article-title":"Interleukin-1\u03b2 and cancer","volume":"12","author":"R\u00e9b\u00e9","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2026.218590_bib56","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41416-024-02795-4","article-title":"Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review of the last decade","volume":"131","author":"Zhou","year":"2024","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218590_bib57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41392-025-02137-7","article-title":"Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial","volume":"10","author":"Shen","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218590_bib58","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S1470-2045(24)00203-1","article-title":"Neoadjuvant camrelizumab plus apatinib for locally advanced microsatellite instability-high or mismatch repair-deficient colorectal cancer (NEOCAP): a single-arm, open-label, phase 2 study","volume":"25","author":"Yu","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2026.218590_bib59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.canlet.2016.05.005","article-title":"Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis","volume":"378","author":"Sasaki","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218590_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217347","article-title":"MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1\/anti-TGF-\u03b2 in squamous cell carcinomas with enhanced CD8 T cell memory-driven response","volume":"608","author":"Lind","year":"2025","journal-title":"Cancer Lett."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:57:07Z","timestamp":1783115827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526003538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":60,"alternative-id":["S0304383526003538"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218590","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell analysis reveals IL1B+ macrophages promote lung metastasis in adenoid cystic carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218590","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218590"}}