{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:08:02Z","timestamp":1784297282298,"version":"3.55.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["HT9425-25-1-0098"],"award-info":[{"award-number":["HT9425-25-1-0098"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007899","name":"University of Arizona","doi-asserted-by":"publisher","award":["P30 CA 23074"],"award-info":[{"award-number":["P30 CA 23074"]}],"id":[{"id":"10.13039\/100007899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA 23074"],"award-info":[{"award-number":["P30 CA 23074"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.canlet.2026.218611","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T15:36:46Z","timestamp":1779464206000},"page":"218611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Kinase-independent signaling by PIM1 promotes drug resistance by increasing mitophagy and reducing oxidative stress"],"prefix":"10.1016","volume":"654","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-5283","authenticated-orcid":false,"given":"Hope","family":"Liou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailender S.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-3941","authenticated-orcid":false,"given":"Caitlyn E.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Kinkade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4116-1348","authenticated-orcid":false,"given":"Madeline R.","family":"Ressel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Cress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-737X","authenticated-orcid":false,"given":"Paul R.","family":"Langlais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh B.","family":"Sutar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-882X","authenticated-orcid":false,"given":"Abhijit A.","family":"Date","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6410-9011","authenticated-orcid":false,"given":"Noel A.","family":"Warfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom8010007","article-title":"PIM kinases and their relevance to the PI3K\/AKT\/mTOR pathway in the regulation of ovarian cancer","volume":"8","author":"Aziz","year":"2018","journal-title":"Biomolecules"},{"issue":"23","key":"10.1016\/j.canlet.2026.218611_bib2","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1158\/0008-5472.CAN-21-1023","article-title":"Inhibition of PIM kinases in DLBCL targets MYC transcriptional program and augments the efficacy of Anti-CD20 antibodies","volume":"81","author":"Szyd\u0142owski","year":"2021","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.canlet.2026.218611_bib3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2217\/fon.13.229","article-title":"PIM kinases: an overview in tumors and recent advances in pancreatic cancer","volume":"10","author":"Xu","year":"2014","journal-title":"Future Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218611_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/jcp.2005.027672","article-title":"Overexpression of Pim-1 during progression of prostatic adenocarcinoma","volume":"59","author":"Cibull","year":"2006","journal-title":"J. Clin. Pathol."},{"issue":"11","key":"10.1016\/j.canlet.2026.218611_bib5","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/nm.4198","article-title":"PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer","volume":"22","author":"Bras\u00f3-Maristany","year":"2016","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.canlet.2026.218611_bib6","doi-asserted-by":"crossref","DOI":"10.1593\/neo.13172","article-title":"Functional role and therapeutic potential of the Pim-1 kinase in Colon carcinoma","volume":"15","author":"Weirauch","year":"2013","journal-title":"Neoplasia"},{"key":"10.1016\/j.canlet.2026.218611_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116016","article-title":"Targeting PIM kinases in cancer therapy: an update on pharmacological small-molecule inhibitors","volume":"264","author":"Chen","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"30","key":"10.1016\/j.canlet.2026.218611_bib8","doi-asserted-by":"crossref","first-page":"20635","DOI":"10.1074\/jbc.M709479200","article-title":"The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells","volume":"283","author":"Zemskova","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2026.218611_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2025.110794","article-title":"PIM kinase inhibition counters resistance to radiotherapy and chemotherapy in human prostate cancer","volume":"206","author":"Rajkumar-Calkins","year":"2025","journal-title":"Radiother. Oncol."},{"issue":"14","key":"10.1016\/j.canlet.2026.218611_bib10","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/onc.2011.371","article-title":"Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells","volume":"31","author":"Wang","year":"2012","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.canlet.2026.218611_bib11","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1158\/1535-7163.MCT-18-0374","article-title":"Mechanisms behind resistance to PI3K inhibitor treatment induced by the PIM kinase","volume":"17","author":"Song","year":"2018","journal-title":"Mol. Cancer Therapeut."},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/1535-7163.MCT-20-0535","article-title":"Targeting PIM kinases to overcome therapeutic resistance in cancer","volume":"20","author":"Toth","year":"2021","journal-title":"Mol. Cancer Therapeut."},{"issue":"28","key":"10.1016\/j.canlet.2026.218611_bib13","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1038\/onc.2009.124","article-title":"Pim-1 plays a pivotal role in hypoxia-induced chemoresistance","volume":"28","author":"Chen","year":"2009","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.canlet.2026.218611_bib14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.clml.2023.05.002","article-title":"Phase 1\/2 study of the Pan-PIM Kinase inhibitor INCB053914 alone or in combination with standard-of-care agents in patients with advanced hematologic malignancies","volume":"23","author":"Patel","year":"2023","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"issue":"11","key":"10.1016\/j.canlet.2026.218611_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41416-018-0082-1","article-title":"Phase I studies of AZD1208, a proviral integration moloney virus kinase inhibitor in solid and haematological cancers","volume":"118","author":"Cortes","year":"2018","journal-title":"Br. J. Cancer"},{"issue":"12","key":"10.1016\/j.canlet.2026.218611_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41375-019-0482-0","article-title":"The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and\/or refractory multiple myeloma","volume":"33","author":"Raab","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2026.218611_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12943-015-0477-z","article-title":"Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in Non-Hodgkin lymphomas","volume":"14","author":"Kreuz","year":"2015","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.canlet.2026.218611_bib18","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.18632\/oncotarget.1951","article-title":"Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms","volume":"5","author":"Huang","year":"2014","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.canlet.2026.218611_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199108","article-title":"Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies","volume":"13","author":"Koblish","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.canlet.2026.218611_bib20","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1111\/cas.15068","article-title":"Reactive oxygen species in cancer: current findings and future directions","volume":"112","author":"Nakamura","year":"2021","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/antiox7010013","article-title":"Reactive oxygen species and mitochondrial dynamics: the yin and yang of mitochondrial dysfunction and cancer progression","volume":"7","author":"Je\u017eek","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.canlet.2026.218611_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"issue":"4","key":"10.1016\/j.canlet.2026.218611_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.canlet.2026.218611_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.tem.2010.12.003","article-title":"mTOR couples cellular nutrient sensing to organismal metabolic homeostasis","volume":"22","author":"Howell","year":"2011","journal-title":"Trends Endocrinol Metab TEM"},{"issue":"5","key":"10.1016\/j.canlet.2026.218611_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/cells8050493","article-title":"Mitophagy in cancer: a tale of adaptation","volume":"8","author":"Vara-Perez","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13046-022-02293-6","article-title":"Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response","volume":"41","author":"Ashrafizadeh","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib27","first-page":"39.e11","article-title":"Autophagy proteins in prostate cancer: relation with anaerobic metabolism and Gleason score1","volume":"32","author":"Giatromanolaki","year":"2014","journal-title":"Urol. Oncol. Semin. Orig. Investig."},{"key":"10.1016\/j.canlet.2026.218611_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.toxrep.2019.03.002","article-title":"HMGB1 protein as a novel target for cancer","volume":"6","author":"Tripathi","year":"2019","journal-title":"Toxicol. Rep."},{"issue":"5","key":"10.1016\/j.canlet.2026.218611_bib29","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.200911078","article-title":"Endogenous HMGB1 regulates autophagy","volume":"190","author":"Tang","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218611_bib30","doi-asserted-by":"crossref","DOI":"10.1177\/1758835920970850","article-title":"Biological functions and theranostic potential of HMGB family members in human cancers","volume":"12","author":"Niu","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.canlet.2026.218611_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101858","article-title":"Reactive oxygen species induce Cys106-mediated anti-parallel HMGB1 dimerization that protects against DNA damage","volume":"40","author":"Kwak","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.canlet.2026.218611_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2147\/OTT.S185876","article-title":"The progression of HMGB1-induced autophagy in cancer biology","volume":"12","author":"Xu","year":"2019","journal-title":"OncoTargets Ther."},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13046-022-02291-8","article-title":"Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization","volume":"41","author":"Li","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.canlet.2026.218611_bib34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/mc.20544","article-title":"HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic","volume":"48","author":"Lange","year":"2009","journal-title":"Mol. Carcinog."},{"issue":"8","key":"10.1016\/j.canlet.2026.218611_bib35","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.4161\/auto.6.8.13651","article-title":"HMGB1: a novel Beclin 1-binding protein active in autophagy","volume":"6","author":"Kang","year":"2010","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.canlet.2026.218611_bib36","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1007\/s13277-015-3617-6","article-title":"Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis","volume":"36","author":"Zhang","year":"2015","journal-title":"Tumor Biol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218611_bib37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3892\/or.2022.8412","article-title":"HMGB1 promotes the development of castration-resistant prostate cancer by regulating androgen receptor activation","volume":"48","author":"Chen","year":"2022","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.canlet.2026.218611_bib38","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.chembiol.2023.10.023","article-title":"PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer","volume":"31","author":"Torres-Ayuso","year":"2024","journal-title":"Cell Chem. Biol."},{"issue":"10","key":"10.1016\/j.canlet.2026.218611_bib39","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1074\/mcp.RA117.000011","article-title":"Characterization of the CLASP2 protein interaction network identifies SOGA1 as a microtubule-associated protein","volume":"16","author":"Kruse","year":"2017","journal-title":"Mol. Cell. Proteomics MCP"},{"issue":"7","key":"10.1016\/j.canlet.2026.218611_bib40","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1074\/mcp.RA119.001450","article-title":"Insulin induces microtubule stabilization and regulates the microtubule plus-end tracking protein network in adipocytes","volume":"18","author":"Parker","year":"2019","journal-title":"Mol. Cell. Proteomics MCP"},{"issue":"10","key":"10.1016\/j.canlet.2026.218611_bib41","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib42","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nmeth.1541","article-title":"SAINT: probabilistic scoring of affinity purification - mass spectrometry data","volume":"8","author":"Choi","year":"2011","journal-title":"Nat. Methods"},{"issue":"W1","key":"10.1016\/j.canlet.2026.218611_bib43","doi-asserted-by":"crossref","first-page":"W404","DOI":"10.1093\/nar\/gkad350","article-title":"PAE viewer: a webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks","volume":"51","author":"Elfmann","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.canlet.2026.218611_bib44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"Sowa","year":"2009","journal-title":"Cell"},{"issue":"7948","key":"10.1016\/j.canlet.2026.218611_bib45","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-022-05682-1","article-title":"Aberrant phase separation and nucleolar dysfunction in rare genetic diseases","volume":"614","author":"Mensah","year":"2023","journal-title":"Nature"},{"issue":"39","key":"10.1016\/j.canlet.2026.218611_bib46","doi-asserted-by":"crossref","first-page":"16817","DOI":"10.1073\/pnas.0904414106","article-title":"Chromatin protein HMGB2 regulates articular cartilage surface maintenance via \u03b2-catenin pathway","volume":"106","author":"Taniguchi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"12","key":"10.1016\/j.canlet.2026.218611_bib47","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1038\/s41388-020-1168-9","article-title":"PIM kinases alter mitochondrial dynamics and chemosensitivity in lung cancer","volume":"39","author":"Chauhan","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218611_bib48","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1038\/s41467-023-41132-w","article-title":"Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation","volume":"14","author":"Jin","year":"2023","journal-title":"Nat. Commun."},{"issue":"6220","key":"10.1016\/j.canlet.2026.218611_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"issue":"7873","key":"10.1016\/j.canlet.2026.218611_bib50","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.canlet.2026.218611_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/or.2023.8653","article-title":"Starvation insult induces the translocation of high mobility group box 1 to cytosolic compartments in glioma","volume":"50","author":"Cui","year":"2023","journal-title":"Oncol. Rep."},{"issue":"38","key":"10.1016\/j.canlet.2026.218611_bib52","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/onc.2010.261","article-title":"HMGB1 release and redox regulates autophagy and apoptosis in cancer cells","volume":"29","author":"Tang","year":"2010","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.canlet.2026.218611_bib53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"10.1016\/j.canlet.2026.218611_bib54","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s41419-018-0866-5","article-title":"Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells","volume":"9","author":"Cristofani","year":"2018","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.canlet.2026.218611_bib55","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/sj.cdd.4401950","article-title":"Mechanisms of cytochrome c release from mitochondria","volume":"13","author":"Garrido","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2026.218611_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217496","article-title":"REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM activity","volume":"613","author":"Carew","year":"2025","journal-title":"Cancer Lett."},{"issue":"7","key":"10.1016\/j.canlet.2026.218611_bib57","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1158\/1535-7163.MCT-15-1018","article-title":"PIM kinase inhibitors kill hypoxic tumor cells by reducing Nrf2 signaling and increasing reactive oxygen species","volume":"15","author":"Warfel","year":"2016","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2026.218611_bib58","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.2147\/OTT.S239243","article-title":"Inhibition of HMGB1 overcomes resistance to radiation and chemotherapy in nasopharyngeal carcinoma","volume":"13","author":"Zhu","year":"2020","journal-title":"OncoTargets Ther."},{"issue":"6","key":"10.1016\/j.canlet.2026.218611_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0327144","article-title":"HMGB1-BoxA gene therapy in reversing cisplatin resistance in non-small cell lung cancer","volume":"20","author":"Puthdee","year":"2025","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib60","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1038\/s41598-025-87773-3","article-title":"The role of box A of HMGB1 in producing \u03b3H2AX associated DNA breaks in lung cancer","volume":"15","author":"Settayanon","year":"2025","journal-title":"Sci. Rep."},{"issue":"39","key":"10.1016\/j.canlet.2026.218611_bib61","doi-asserted-by":"crossref","first-page":"37832","DOI":"10.1074\/jbc.M301546200","article-title":"Inhibition of mitochondrial respiration","volume":"278","author":"Pelicano","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.canlet.2026.218611_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.547","article-title":"Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL\/p53-mediated amplification mechanisms","volume":"5","author":"Shi","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218611_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110904","article-title":"Role of HMGB1 and its associated signaling pathways in human malignancies","volume":"112","author":"Idoudi","year":"2023","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.canlet.2026.218611_bib64","first-page":"455","article-title":"Inflammation in prostate cancer progression and therapeutic targeting","volume":"4","author":"Stark","year":"2015","journal-title":"Transl. Androl. Urol."},{"issue":"9","key":"10.1016\/j.canlet.2026.218611_bib65","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.3390\/molecules28093698","article-title":"PROTACs in the management of prostate cancer","volume":"28","author":"Yedla","year":"2023","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.canlet.2026.218611_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-022-00966-4","article-title":"Targeted protein degradation: mechanisms, strategies and application","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"11","key":"10.1016\/j.canlet.2026.218611_bib67","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41589-020-0620-z","article-title":"Prospecting for molecular glues","volume":"16","author":"den Besten","year":"2020","journal-title":"Nat. Chem. Biol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:05:19Z","timestamp":1783004719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526003745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":67,"alternative-id":["S0304383526003745"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218611","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinase-independent signaling by PIM1 promotes drug resistance by increasing mitophagy and reducing oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218611"}}