{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:58:56Z","timestamp":1792519136550,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M753766"],"award-info":[{"award-number":["2024M753766"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503845"],"award-info":[{"award-number":["82503845"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.canlet.2026.218614","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:07:38Z","timestamp":1779984458000},"page":"218614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Hypoxia drives ANGPTL4 expression in tumor-associated macrophages and promotes intrahepatic cholangiocarcinoma intrahepatic metastasis"],"prefix":"10.1016","volume":"656","author":[{"given":"Zhu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3995-2895","authenticated-orcid":false,"given":"Hongpeng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3551-7426","authenticated-orcid":false,"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3230-9968","authenticated-orcid":false,"given":"Xingyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongling","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0483-3757","authenticated-orcid":false,"given":"Taijun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunle","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-6499","authenticated-orcid":false,"given":"Guolin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.canlet.2026.218614_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.canlet.2026.218614_bib2","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/hep.31598","article-title":"Liver metastases of intrahepatic cholangiocarcinoma: implications for an updated staging system","volume":"73","author":"Lamarca","year":"2021","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.canlet.2026.218614_bib3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1001\/jamasurg.2022.1298","article-title":"Comparison of hepatic arterial infusion pump chemotherapy vs resection for patients with multifocal intrahepatic cholangiocarcinoma","volume":"157","author":"Franssen","year":"2022","journal-title":"JAMA Surg."},{"key":"10.1016\/j.canlet.2026.218614_bib4","doi-asserted-by":"crossref","first-page":"v280","DOI":"10.1093\/annonc\/mdz247.058","article-title":"731P - Liver metastases (LM) from intrahepatic cholangiocarcinoma (iCCA): outcomes from the european Network for the study of cholangiocarcinoma (ENS-CCA) registry and implications on current American Joint Committee on Cancer (AJCC) staging","volume":"30","author":"Lamarca","year":"2019","journal-title":"Ann. Oncol."},{"issue":"7","key":"10.1016\/j.canlet.2026.218614_bib5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/bjs.10676","article-title":"Early versus late recurrence of intrahepatic cholangiocarcinoma after resection with curative intent","volume":"105","author":"Zhang","year":"2018","journal-title":"Br. J. Surg."},{"issue":"5","key":"10.1016\/j.canlet.2026.218614_bib6","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jhep.2020.05.039","article-title":"Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma","volume":"73","author":"Zhang","year":"2020","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.canlet.2026.218614_bib7","article-title":"Single-Cell and spatial transcriptomics delineate the microstructure and immune landscape of intrahepatic cholangiocarcinoma in the leading-edge area","volume":"12","author":"Zuyin","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12943-022-01645-2","article-title":"The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies","volume":"21","author":"Bai","year":"2022","journal-title":"Mol. Cancer"},{"issue":"24","key":"10.1016\/j.canlet.2026.218614_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211332","article-title":"Reprogramming hypoxic tumor-associated macrophages by nanoglycoclusters for boosted cancer immunotherapy","volume":"35","author":"Zhao","year":"2023","journal-title":"Adv Mater"},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41392-025-02325-5","article-title":"Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct Target Ther"},{"issue":"7779","key":"10.1016\/j.canlet.2026.218614_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.canlet.2026.218614_bib12","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/cac2.12311","article-title":"Crosstalk between IL-15R\u03b1(+) tumor-associated macrophages and breast cancer cells reduces CD8(+) T cell recruitment","volume":"42","author":"Zhang","year":"2022","journal-title":"Cancer Commun."},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/HEP.0000000000001138","article-title":"The co-location of MARCO+ tumor-associated macrophages and CTSE+ tumor cells determined the poor prognosis in intrahepatic cholangiocarcinoma","volume":"82","author":"Fan","year":"2025","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.canlet.2026.218614_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.canlet.2026.218614_bib15","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.canlet.2026.218614_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1511","article-title":"RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1","volume":"13","author":"Qiu","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"12","key":"10.1016\/j.canlet.2026.218614_bib17","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/bjs.8953","article-title":"Treatment of recurrent intrahepatic cholangiocarcinoma","volume":"99","author":"Sulpice","year":"2012","journal-title":"Br. J. Surg."},{"issue":"6282","key":"10.1016\/j.canlet.2026.218614_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aaf4405","article-title":"Hypoxic control of metastasis","volume":"352","author":"Rankin","year":"2016","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.canlet.2026.218614_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncb1691","article-title":"Direct regulation of TWIST by HIF-1alpha promotes metastasis","volume":"10","author":"Yang","year":"2008","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.canlet.2026.218614_bib20","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1158\/0008-5472.CAN-11-1433","article-title":"Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer","volume":"73","author":"Spivak-Kroizman","year":"2013","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13046-023-02865-0","article-title":"TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages","volume":"42","author":"Huang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12943-019-0976-4","article-title":"Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis","volume":"18","author":"Wei","year":"2019","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2026.218614_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001946","article-title":"Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3","volume":"9","author":"Zhou","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13046-021-02235-8","article-title":"Macrophages-aPKC(\u0269)-CCL5 feedback loop modulates the progression and chemoresistance in cholangiocarcinoma","volume":"41","author":"Yang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.canlet.2026.218614_bib25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/cncr.34552","article-title":"The clinicopathological significance and relapse predictive role of tumor microenvironment of intrahepatic cholangiocarcinoma after radical surgery","volume":"129","author":"Zheng","year":"2023","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2026.218614_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/MOH.0000000000000580","article-title":"ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis","volume":"27","author":"Fern\u00e1ndez-Hernando","year":"2020","journal-title":"Curr. Opin. Hematol."},{"issue":"16","key":"10.1016\/j.canlet.2026.218614_bib27","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.7150\/thno.44744","article-title":"Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis","volume":"10","author":"Shen","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13046-025-03458-9","article-title":"Adipocytes-induced ANGPTL4\/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer","volume":"44","author":"Yin","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218614_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217731","article-title":"COL1A1-positive endothelial cells promote gastric cancer progression via the ANGPTL4-SDC4 axis driven by endothelial-to-mesenchymal transition","volume":"623","author":"Liu","year":"2025","journal-title":"Cancer Lett."},{"issue":"12","key":"10.1016\/j.canlet.2026.218614_bib30","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1093\/brain\/awy274","article-title":"Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy","volume":"141","author":"Chakraborty","year":"2018","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.canlet.2026.218614_bib31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1158\/0008-5472.CAN-19-1532","article-title":"HIF2-Induced long noncoding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis","volume":"80","author":"Niu","year":"2020","journal-title":"Cancer Res."},{"issue":"22","key":"10.1016\/j.canlet.2026.218614_bib32","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1158\/0008-5472.CAN-11-1262","article-title":"ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression","volume":"71","author":"Kim","year":"2011","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.canlet.2026.218614_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1161\/hh0202.103647","article-title":"C\/EBP-beta mediates iNOS induction by hypoxia in rat pulmonary microvascular smooth muscle cells","volume":"90","author":"Teng","year":"2002","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.canlet.2026.218614_bib34","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1182\/blood-2011-01-328716","article-title":"ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters","volume":"118","author":"Huang","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.canlet.2026.218614_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3396","article-title":"Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome","volume":"20","author":"Clement","year":"2014","journal-title":"Nat Med"},{"issue":"34","key":"10.1016\/j.canlet.2026.218614_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202500872","article-title":"De Novo Design of Integrin \u03b15\u03b21 Modulating Proteins to Enhance Biomaterial Properties","volume":"37","author":"Wang","year":"2025","journal-title":"Adv Mater"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:24:50Z","timestamp":1783437890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526003770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"alternative-id":["S0304383526003770"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218614","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia drives ANGPTL4 expression in tumor-associated macrophages and promotes intrahepatic cholangiocarcinoma intrahepatic metastasis","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218614"}}