{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:48:06Z","timestamp":1790225286655,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M744016"],"award-info":[{"award-number":["2023M744016"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM201911010"],"award-info":[{"award-number":["SZSM201911010"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.canlet.2026.218625","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:26:35Z","timestamp":1780118795000},"page":"218625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Exosomal circFXR1 drives immune evasion and tumor progression through dual regulation of PD-L1 and mTOR signaling in gastric cancer"],"prefix":"10.1016","volume":"655","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9014-4793","authenticated-orcid":false,"given":"Hongwu","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-8274","authenticated-orcid":false,"given":"Ian M.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5215-8195","authenticated-orcid":false,"given":"Yuntao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuncan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-4096","authenticated-orcid":false,"given":"Changhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.canlet.2026.218625_bib1","first-page":"229","article-title":"Global cancer statistics 2022: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","article-title":"Gastric cancer treatment: recent progress and future perspectives","volume":"16","author":"Guan","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"7","key":"10.1016\/j.canlet.2026.218625_bib3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.trecan.2024.03.008","article-title":"Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development","volume":"10","author":"Yasuda","year":"2024","journal-title":"Trends Cancer"},{"issue":"6","key":"10.1016\/j.canlet.2026.218625_bib4","doi-asserted-by":"crossref","first-page":"9331","DOI":"10.3390\/ijms15069331","article-title":"A view of pre-mrna splicing from rnase r resistant rnas","volume":"15","author":"Suzuki","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.canlet.2026.218625_bib5","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkl151","article-title":"Characterization of rnase r-digested cellular rna source that consists of lariat and circular rnas from pre-mrna splicing","volume":"34","author":"Suzuki","year":"2006","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.canlet.2026.218625_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1261\/rna.035667.112","article-title":"Circular rnas are abundant, conserved, and associated with alu repeats","volume":"19","author":"Jeck","year":"2013","journal-title":"Rna"},{"issue":"6","key":"10.1016\/j.canlet.2026.218625_bib7","article-title":"Circular rna is expressed across the eukaryotic tree of life","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"issue":"7441","key":"10.1016\/j.canlet.2026.218625_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular rnas are a large class of animal rnas with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218625_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217473","article-title":"Circmfn2\/mir-361-3p\/elk1 feedback loop promotes glutaminolysis and the progression of hepatocellular carcinoma","volume":"614","author":"Hao","year":"2025","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.canlet.2026.218625_bib10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1158\/0008-5472.CAN-22-1923","article-title":"Circpdia4 induces gastric cancer progression by promoting erk1\/2 activation and enhancing biogenesis of oncogenic circrnas","volume":"83","author":"Shen","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218625_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216508","article-title":"A novel axis of circkif4a-mir-637-stat3 promotes brain metastasis in triple-negative breast cancer","volume":"581","author":"Wu","year":"2024","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s13046-022-02518-8","article-title":"Circlrfn5 inhibits the progression of glioblastoma via prrx2\/gch1 mediated ferroptosis","volume":"41","author":"Jiang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.canlet.2026.218625_bib13","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00018-019-03345-5","article-title":"Circrna: a rising star in gastric cancer","volume":"77","author":"Li","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12943-019-1081-4","article-title":"Circlmtk2 acts as a sponge of mir-150-5p and promotes proliferation and metastasis in gastric cancer","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12943-019-1015-1","article-title":"Circdlst promotes the tumorigenesis and metastasis of gastric cancer by sponging mir-502-5p and activating the nras\/mek1\/erk1\/2 signaling","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.canlet.2026.218625_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.coi.2011.12.009","article-title":"Targeting the pd-1\/b7-h1(pd-l1) pathway to activate anti-tumor immunity","volume":"24","author":"Topalian","year":"2012","journal-title":"Curr. Opin. Immunol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218625_bib17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nm730","article-title":"Tumor-associated b7-h1 promotes t-cell apoptosis: a potential mechanism of immune evasion","volume":"8","author":"Dong","year":"2002","journal-title":"Nat Med"},{"issue":"10294","key":"10.1016\/j.canlet.2026.218625_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0140-6736(21)00797-2","article-title":"First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (checkmate 649): a randomised, open-label, phase 3 trial","volume":"398","author":"Janjigian","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.canlet.2026.218625_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.0013","article-title":"Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical keynote-059 trial","volume":"4","author":"Fuchs","year":"2018","journal-title":"JAMA Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218625_bib20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1165\/rcmb.2004-0129OC","article-title":"Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells","volume":"33","author":"Kim","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"10","key":"10.1016\/j.canlet.2026.218625_bib21","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1111\/cas.14174","article-title":"Interleukin-17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma","volume":"110","author":"Aotsuka","year":"2019","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/path.5280","article-title":"Mapk pathway activity plays a key role in pd-l1 expression of lung adenocarcinoma cells","volume":"249","author":"Stutvoet","year":"2019","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010162","article-title":"Siglec11 promotes m2 macrophage polarization through akt-mtor signaling and facilitates the progression of gastric cancer","volume":"13","author":"Yin","year":"2025","journal-title":"J. Immunother. Cancer"},{"issue":"23","key":"10.1016\/j.canlet.2026.218625_bib24","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1158\/0008-5472.CAN-23-1012","article-title":"Neurotransmitter receptor htr2b regulates lipid metabolism to inhibit ferroptosis in gastric cancer","volume":"83","author":"Tu","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218625_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216643","article-title":"Hipk3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer","volume":"584","author":"Wu","year":"2024","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13045-019-0804-8","article-title":"Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment","volume":"12","author":"Yang","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2026.218625_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-9-9","article-title":"Human saliva, plasma and breast milk exosomes contain rna: uptake by macrophages","volume":"9","author":"L\u00e4sser","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218625_bib28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1479-5876-10-5","article-title":"Identification and proteomic profiling of exosomes in human cerebrospinal fluid","volume":"10","author":"Street","year":"2012","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12943-019-1041-z","article-title":"Exosomal circrnas: biogenesis, effect and application in human diseases","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.canlet.2026.218625_bib30","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.7150\/thno.41580","article-title":"Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.canlet.2026.218625_bib31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1034\/j.1600-0854.2002.30502.x","article-title":"The biogenesis and functions of exosomes","volume":"3","author":"Stoorvogel","year":"2002","journal-title":"Traffic"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cdd.2014.130","article-title":"Exosomes as divine messengers: are they the hermes of modern molecular oncology?","volume":"22","author":"Braicu","year":"2015","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00011-008-8210-7","article-title":"Highlights of a new type of intercellular communication: microvesicle-based information transfer","volume":"58","author":"Pap","year":"2009","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.canlet.2026.218625_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217758","article-title":"Exosomal biglycan promotes gastric cancer progression via m2 polarization and cxcl10-mediated jak\/stat1 activation","volume":"626","author":"Li","year":"2025","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13046-017-0528-y","article-title":"Exosomal transfer of tumor-associated macrophage-derived mir-21 confers cisplatin resistance in gastric cancer cells","volume":"36","author":"Zheng","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218625_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.canlet.2019.11.038","article-title":"Circular rna circ-rangap1 regulates vegfa expression by targeting mir-877-3p to facilitate gastric cancer invasion and metastasis","volume":"471","author":"Lu","year":"2020","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13046-025-03288-9","article-title":"Gc-derived exosomal circman1a2 promotes cancer progression and suppresses t-cell antitumour immunity by inhibiting fbxw11-mediated sfpq degradation","volume":"44","author":"Shen","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.canlet.2026.218625_bib38","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nri3902","article-title":"Immunological hallmarks of stromal cells in the tumour microenvironment","volume":"15","author":"Turley","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218625_bib39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc2618","article-title":"Microenvironmental regulation of metastasis","volume":"9","author":"Joyce","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2026.218625_bib40","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ccr.2012.02.017","article-title":"Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance","volume":"21","author":"Nakasone","year":"2012","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.canlet.2026.218625_bib41","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1158\/2159-8290.CD-23-1263","article-title":"Cd8-targeted il2 unleashes tumor-specific immunity in human cancer tissue by reviving the dysfunctional t-cell pool","volume":"14","author":"Kaptein","year":"2024","journal-title":"Cancer Discov."},{"issue":"3","key":"10.1016\/j.canlet.2026.218625_bib42","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2024.5616","article-title":"Exosome as a crucial communicator between tumor microenvironment and gastric cancer","volume":"64","author":"Wang","year":"2024","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-019-0967-5","article-title":"The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy","volume":"18","author":"Huang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12943-024-01966-4","article-title":"Exosome circatp8a1 induces macrophage m2 polarization by regulating the mir-1-3p\/stat6 axis to promote gastric cancer progression","volume":"23","author":"Deng","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib45","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-021-01448-x","article-title":"Cancer cell-derived exosomal circusp7 induces cd8(+) t cell dysfunction and anti-pd1 resistance by regulating the mir-934\/shp2 axis in nsclc","volume":"20","author":"Chen","year":"2021","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2026.218625_bib46","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ymthe.2022.01.022","article-title":"Exosome-derived circtrps1 promotes malignant phenotype and cd8+ t cell exhaustion in bladder cancer microenvironments","volume":"30","author":"Yang","year":"2022","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12943-023-01759-1","article-title":"Exosome-derived circccar1 promotes cd8 + t-cell dysfunction and anti-pd1 resistance in hepatocellular carcinoma","volume":"22","author":"Hu","year":"2023","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12943-021-01485-6","article-title":"Ewsr1-induced circneil3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing igf2bp3","volume":"21","author":"Pan","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12943-023-01824-9","article-title":"Extracellular vesicle-circehd2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts","volume":"22","author":"He","year":"2023","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib50","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12943-022-01608-7","article-title":"Circezh2\/mir-133b\/igf2bp2 aggravates colorectal cancer progression via enhancing the stability of m(6)a-modified creb1 mrna","volume":"21","author":"Yao","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12943-022-01521-z","article-title":"Mettl14-mediated m(6)a modification of circorc5 suppresses gastric cancer progression by regulating mir-30c-2-3p\/akt1s1 axis","volume":"21","author":"Fan","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib52","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12943-022-01567-z","article-title":"Hypoxia-induced circwsb1 promotes breast cancer progression through destabilizing p53 by interacting with usp10","volume":"21","author":"Yang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib53","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ncrna.2023.12.002","article-title":"Role of circular rnas and gut microbiome in gastrointestinal cancers and therapeutic targets","volume":"9","author":"Abdullah","year":"2024","journal-title":"Noncoding RNA Res"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13046-020-01648-1","article-title":"Circular rna circ-cpa4\/let-7 mirna\/pd-l1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (nsclc)","volume":"39","author":"Hong","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib55","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jcmm.17643","article-title":"Circ_0000052\/mir-382-3p axis induces pd-l1 expression and regulates cell proliferation and immune evasion in head and neck squamous cell carcinoma","volume":"27","author":"Zhang","year":"2023","journal-title":"J. Cell Mol. Med."},{"issue":"9","key":"10.1016\/j.canlet.2026.218625_bib56","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/cbin.12049","article-title":"Circular rna hsa_circ_0005239 contributes to hepatocellular carcinoma cell migration, invasion, and angiogenesis by targeting the mir-34a-5p\/pd-l1 axis","volume":"47","author":"He","year":"2023","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib57","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12943-023-01883-y","article-title":"Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the mir-375\/prkdc axis and pd-l1 phosphorylation","volume":"22","author":"Miao","year":"2023","journal-title":"Mol. Cancer"},{"issue":"23","key":"10.1016\/j.canlet.2026.218625_bib58","article-title":"Smc4 promotes prostate cancer cell proliferation and metastasis via the rheb\/mtor pathway","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"4","key":"10.1016\/j.canlet.2026.218625_bib59","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41418-024-01426-y","article-title":"Usp19 potentiates autophagic cell death via inhibiting mtor pathway through deubiquitinating nek9 in pancreatic cancer","volume":"32","author":"Wang","year":"2025","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.7150\/thno.117590","article-title":"Targeting the arl4c\/rap1\/pi3k-akt-mtor signaling loop promotes arl4c ubiquitination and reverses oxaliplatin resistance in colorectal cancer","volume":"16","author":"Wang","year":"2026","journal-title":"Theranostics"},{"issue":"32","key":"10.1016\/j.canlet.2026.218625_bib61","article-title":"Loss of atoh1 in pit cell drives stemness and progression of gastric adenocarcinoma by activating akt\/mtor signaling through gas1","volume":"10","author":"Zhong","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13045-022-01305-4","article-title":"Emerging role of exosomes in cancer progression and tumor microenvironment remodeling","volume":"15","author":"Paskeh","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218625_bib63","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12943-020-01222-5","article-title":"Cancer cell-derived exosomal circuhrf1 induces natural killer cell exhaustion and may cause resistance to anti-pd1 therapy in hepatocellular carcinoma","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526003885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:20:24Z","timestamp":1783128024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526003885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":63,"alternative-id":["S0304383526003885"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218625","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomal circFXR1 drives immune evasion and tumor progression through dual regulation of PD-L1 and mTOR signaling in gastric cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218625"}}