{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:38:37Z","timestamp":1792759117329,"version":"4.5.0"},"reference-count":267,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.canlet.2026.218665","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:27:49Z","timestamp":1781076469000},"page":"218665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Targeting colorectal cancer stem-like cells: Overcoming therapeutic resistance and reprogramming the immunosuppressive niche"],"prefix":"10.1016","volume":"656","author":[{"given":"Mahasin","family":"Hamid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia M.A.","family":"Siddig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaa","family":"Suliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwaar","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-9519","authenticated-orcid":false,"given":"Mohammad A.I.","family":"Al-Hatamleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15122763","article-title":"Colorectal cancer stem cells and targeted agents","volume":"15","author":"Zhao","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.canlet.2026.218665_bib2","doi-asserted-by":"crossref","DOI":"10.1177\/1533033819892261","article-title":"Targeting colorectal cancer stem cells as an effective treatment for colorectal cancer","volume":"19","author":"Ma","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.canlet.2026.218665_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.968089","article-title":"The immune phenotypes and different immune escape mechanisms in colorectal cancer","volume":"13","author":"Mao","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40164-024-00474-x","article-title":"Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs","volume":"13","author":"Zhao","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib5","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1158\/2326-6066.CIR-22-0644","article-title":"\u03b2-Catenin drives butyrophilin-like molecule loss and \u03b3\u03b4 T-cell exclusion in Colon cancer","volume":"11","author":"Suzuki","year":"2023","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.canlet.2026.218665_bib6","article-title":"Colorectal cancer stem cells crosstalk in tumor immune microenvironment and targeted therapeutic strategies","volume":"16","author":"Duan","year":"2025","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib7","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.7150\/thno.110379","article-title":"Colorectal cancer stem cells develop NK cell resistance via homotypic cell-in-cell structures suppressed by Stathmin1","volume":"15","author":"Lin","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.canlet.2026.218665_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1057181","article-title":"Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: mechanisms and clinical implications","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218665_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1760555","article-title":"Expression profiling of inhibitory immune checkpoints in colorectal cancer stem cells and their association with tumor immunity and immunotherapy biomarkers","volume":"17","author":"Hussein","year":"2026","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218665_bib10","article-title":"Constructing a cancer stem cell related prognostic model for predicting immune landscape and drug sensitivity in colorectal cancer","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.canlet.2026.218665_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1114621","article-title":"Current understanding of cancer stem cells: immune evasion and targeted immunotherapy in gastrointestinal malignancies","volume":"13","author":"An","year":"2023","journal-title":"Front. Oncol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib12","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1200\/JCO-24-02081","article-title":"Chimeric antigen Receptor-T cells in colorectal cancer: pioneering new avenues in solid tumor immunotherapy","volume":"43","author":"Ouladan","year":"2025","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11030310","article-title":"Recent advances in cancer stem cell-targeted immunotherapy","volume":"11","author":"Badrinath","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"24","key":"10.1016\/j.canlet.2026.218665_bib14","doi-asserted-by":"crossref","first-page":"10158","DOI":"10.1073\/pnas.0703478104","article-title":"Phenotypic characterization of human colorectal cancer stem cells","volume":"104","author":"Dalerba","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.canlet.2026.218665_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16111995","article-title":"Current and future trends of colorectal cancer treatment: exploring advances in immunotherapy","volume":"16","author":"Nikolouzakis","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"14","key":"10.1016\/j.canlet.2026.218665_bib16","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.7150\/ijbs.64077","article-title":"Immunotherapy in colorectal cancer: current achievements and future perspective","volume":"17","author":"Fan","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10620-024-08774-2","article-title":"Emerging frontiers in colorectal cancer therapy: from targeted molecules to immunomodulatory breakthroughs and cell-based approaches","volume":"70","author":"Fatemi","year":"2025","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.canlet.2026.218665_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/dvdy.70042","article-title":"Therapeutic potential of stem cells in colorectal cancer management: current trends and future prospects","author":"Desai","year":"2025","journal-title":"Dev. Dyn."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib19","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1159\/000488743","article-title":"Lgr5+CD44+EpCAM+ strictly defines cancer stem cells in human colorectal cancer","volume":"46","author":"Leng","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"11","key":"10.1016\/j.canlet.2026.218665_bib20","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s41416-018-0118-6","article-title":"Targeting LGR5 in colorectal cancer: therapeutic gold or too plastic?","volume":"118","author":"Morgan","year":"2018","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/jclinpath-2017-204739","article-title":"Cancer stem cells in colorectal cancer: a review","volume":"71","author":"Munro","year":"2018","journal-title":"J. Clin. Pathol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib22","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/jcmm.14882","article-title":"Kr\u00fcppel-like factor 4 regulates stemness and mesenchymal properties of colorectal cancer stem cells through the TGF-\u03b21\/Smad\/snail pathway","volume":"24","author":"Leng","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib23","first-page":"174","article-title":"Co-expression of stem cell markers CD133 and CD44 as predictors of metastatic potential of colorectal carcinoma","volume":"41","author":"Kostovski","year":"2025","journal-title":"Turk J Surg"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41392-025-02290-z","article-title":"Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3\/c-MYC axis","volume":"10","author":"Lepore Signorile","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12964-020-00627-5","article-title":"Drug resistance and cancer stem cells","volume":"19","author":"Li","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.canlet.2026.218665_bib26","doi-asserted-by":"crossref","DOI":"10.1177\/10732748241274196","article-title":"The role of tumor stem cells in colorectal cancer drug resistance","volume":"31","author":"Zhong","year":"2024","journal-title":"Cancer Control"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41392-025-02360-2","article-title":"Cancer stem cells: landscape, challenges and emerging therapeutic innovations","volume":"10","author":"Lee","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"6","key":"10.1016\/j.canlet.2026.218665_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15061897","article-title":"DNA repair and therapeutic strategies in cancer stem cells","volume":"15","author":"Gillespie","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13073-025-01488-8","article-title":"DNA repair and the contribution to chemotherapy resistance","volume":"17","author":"Nesic","year":"2025","journal-title":"Genome Med."},{"issue":"11","key":"10.1016\/j.canlet.2026.218665_bib30","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41568-023-00612-3","article-title":"Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters","volume":"23","author":"Sajid","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2026.218665_bib31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/978-981-13-7647-4_12","article-title":"ABC transporter-mediated multidrug-resistant cancer","volume":"1141","author":"Amawi","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12032-025-02611-w","article-title":"Pharmacogenomics influence on MDR1-associated cancer resistance and innovative drug delivery approaches: advancing precision oncology","volume":"42","author":"Radhakrishnan","year":"2025","journal-title":"Med. Oncol."},{"issue":"6","key":"10.1016\/j.canlet.2026.218665_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114270","article-title":"Dark force rising: reawakening and targeting of fetal-like stem cells in colorectal cancer","volume":"43","author":"Fey","year":"2024","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrclinonc.2015.61","article-title":"Targeting notch, hedgehog, and Wnt pathways in cancer stem cells: clinical update","volume":"12","author":"Takebe","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12032-022-01905-7","article-title":"Targeting crosstalk of signaling pathways in cancer stem cells: a promising approach for development of novel anti-cancer therapeutics","volume":"40","author":"Bhal","year":"2023","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41568-024-00760-0","article-title":"Stemness in solid malignancies: coping with immune attack","volume":"25","author":"Agudo","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12943-023-01748-4","article-title":"Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment","volume":"22","author":"Wu","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2026.218665_bib38","article-title":"Schwann cells promote the migration and invasion of colorectal cancer cells via the activated NF-\u03baB\/IL-8 axis in the tumor microenvironment","volume":"12","author":"Chen","year":"2022","journal-title":"Front. Oncol."},{"issue":"26","key":"10.1016\/j.canlet.2026.218665_bib39","doi-asserted-by":"crossref","first-page":"E5990","DOI":"10.1073\/pnas.1801348115","article-title":"Hypoxic tumor microenvironment activates GLI2 via HIF-1\u03b1 and TGF-\u03b22 to promote chemoresistance in colorectal cancer","volume":"115","author":"Tang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"38","key":"10.1016\/j.canlet.2026.218665_bib40","doi-asserted-by":"crossref","first-page":"26038","DOI":"10.1074\/jbc.M114.564120","article-title":"Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of twist and the transforming growth factor \u03b2 (TGF-\u03b2)-Snail signaling axis","volume":"289","author":"Chanmee","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.canlet.2026.218665_bib41","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41388-018-0480-0","article-title":"Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer","volume":"38","author":"Nakano","year":"2019","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib42","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1007\/s12015-025-10956-y","article-title":"Metabolic plasticity and cancer stem cell metabolism: exploring the Glycolysis-OXPHOS switch as a mechanism for resistance and tumorigenesis","volume":"21","author":"Keoh","year":"2025","journal-title":"Stem Cell Rev. Rep."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41420-025-02670-y","article-title":"Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions","volume":"11","author":"Qiu","year":"2025","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167993","article-title":"Hypoxia facilitates stemness of colon cancer cells via histone lactylation","volume":"1871","author":"Zhang","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/stem.1837","article-title":"Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging","volume":"33","author":"Tirinato","year":"2015","journal-title":"Stem Cell."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13046-018-0784-5","article-title":"Emerging role of lipid metabolism alterations in cancer stem cells","volume":"37","author":"Yi","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib47","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41568-021-00375-9","article-title":"Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment","volume":"21","author":"Kerk","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib48","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-025-07498-z","article-title":"Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis","volume":"16","author":"Deng","year":"2025","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0309700","article-title":"Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch","volume":"19","author":"Aisu","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218665_bib50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41523-018-0071-9","article-title":"Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation","volume":"4","author":"Valcz","year":"2018","journal-title":"NPJ Breast Cancer"},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib51","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s12015-023-10593-3","article-title":"Cancer stem cells and the tumor microenvironment in tumor drug resistance","volume":"19","author":"Gao","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib52","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s10020-025-01112-w","article-title":"Cancer-secreted exosomal miR-1246 promotes colorectal cancer liver metastasis by activating hepatic stellate cells","volume":"31","author":"Liu","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.canlet.2026.218665_bib53","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3389\/fimmu.2020.00604","article-title":"The biogenesis, biology, and clinical significance of exosomal PD-L1 in cancer","volume":"11","author":"Tang","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib54","first-page":"CRC40","article-title":"Exosome-derived miRNAs regulate macrophage-colorectal cancer cell cross-talk during aggressive tumor development","volume":"12","author":"Wadhonkar","year":"2023"},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib55","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008722","article-title":"CCR5 and CCL5 in metastatic colorectal cancer","volume":"12","author":"Schlechter","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17101674","article-title":"The CXCL1-CXCR2 axis as a component of therapy resistance, a source of side effects in cancer treatment, and a therapeutic target","volume":"17","author":"Korbecki","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib57","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s00262-021-03081-5","article-title":"TGF-\u03b2 orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer","volume":"71","author":"Gneo","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib58","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1111\/cas.14940","article-title":"Role of tumor-associated macrophages at the invasive front in human colorectal cancer progression","volume":"112","author":"Inagaki","year":"2021","journal-title":"Cancer Sci."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib59","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1158\/2159-8290.CD-23-1300","article-title":"Spatially segregated macrophage populations predict distinct outcomes in Colon cancer","volume":"14","author":"Matusiak","year":"2024","journal-title":"Cancer Discov."},{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib60","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1172\/JCI123360","article-title":"An osteopontin\/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion","volume":"128","author":"Klement","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.canlet.2026.218665_bib61","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41588-020-0636-z","article-title":"Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer","volume":"52","author":"Lee","year":"2020","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib62","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12957-021-02195-5","article-title":"A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma","volume":"19","author":"Wang","year":"2021","journal-title":"World J. Surg. Oncol."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib63","first-page":"403","article-title":"Role of macrophages in progression of colorectal cancer: a contrast with the traditional paradigm","volume":"15","author":"Konstantinov","year":"2022","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib65","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jhep.2016.08.012","article-title":"Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages","volume":"66","author":"Raggi","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.canlet.2026.218665_bib66","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.canlet.2019.06.005","article-title":"Macrophage-expressed CD51 promotes cancer stem cell properties via the TGF-\u03b21\/smad2\/3 axis in pancreatic cancer","volume":"459","author":"Zhang","year":"2019","journal-title":"Cancer Lett."},{"issue":"9","key":"10.1016\/j.canlet.2026.218665_bib64","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1158\/1078-0432.CCR-18-3684","article-title":"Loss of SMAD4 promotes colorectal cancer progression by recruiting tumor-associated neutrophils via the CXCL1\/8-CXCR2 axis","volume":"25","author":"Ogawa","year":"2019","journal-title":"Clin. Cancer Res."},{"issue":"7851","key":"10.1016\/j.canlet.2026.218665_bib67","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-020-03045-2","article-title":"Metabolic support of tumour-infiltrating regulatory T cells by lactic acid","volume":"591","author":"Watson","year":"2021","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib68","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.ccell.2024.08.020","article-title":"Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation","volume":"42","author":"Gao","year":"2024","journal-title":"Cancer Cell"},{"issue":"7934","key":"10.1016\/j.canlet.2026.218665_bib69","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41586-022-05272-1","article-title":"LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity","volume":"611","author":"Krishnamurty","year":"2022","journal-title":"Nature"},{"issue":"30","key":"10.1016\/j.canlet.2026.218665_bib70","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1073\/pnas.1106645108","article-title":"Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem\/initiating cells","volume":"108","author":"Jinushi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib71","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.canlet.2014.05.008","article-title":"Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"352","author":"Fan","year":"2014","journal-title":"Cancer Lett."},{"issue":"11","key":"10.1016\/j.canlet.2026.218665_bib72","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ncb3041","article-title":"A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages","volume":"16","author":"Lu","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218665_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15080","article-title":"Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth","volume":"8","author":"Shi","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.canlet.2026.218665_bib74","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2014.08.039","article-title":"Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells","volume":"147","author":"Wan","year":"2014","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib75","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s40425-019-0666-1","article-title":"Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments","volume":"7","author":"Raghavan","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib76","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12307-009-0030-y","article-title":"The NF-\u03baB\/AKT-dependent induction of wnt signaling in Colon cancer cells by macrophages and IL-1\u03b2","volume":"2","author":"Kaler","year":"2009","journal-title":"Cancer Microenviron."},{"issue":"7655","key":"10.1016\/j.canlet.2026.218665_bib77","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature22396","article-title":"PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity","volume":"545","author":"Gordon","year":"2017","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.canlet.2026.218665_bib78","article-title":"Colorectal cancer-derived small extracellular vesicles promote tumor immune evasion by upregulating PD-L1 expression in tumor-associated macrophages","volume":"9","author":"Yin","year":"2022","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib79","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ccell.2022.02.013","article-title":"Immune phenotypic linkage between colorectal cancer and liver metastasis","volume":"40","author":"Liu","year":"2022","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib80","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1158\/2159-8290.CD-21-0316","article-title":"Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level","volume":"12","author":"Wu","year":"2022","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib81","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41591-020-1131-x","article-title":"Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination","volume":"27","author":"Yu","year":"2021","journal-title":"Nat. Med."},{"issue":"18","key":"10.1016\/j.canlet.2026.218665_bib82","article-title":"Granulocytic myeloid-derived suppressor cells promote the stemness of colorectal cancer cells through exosomal S100A9","volume":"6","author":"Wang","year":"2019","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib83","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1158\/2326-6066.CIR-22-0462","article-title":"High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis","volume":"11","author":"Cortese","year":"2023","journal-title":"Cancer Immunol. Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib84","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/s41467-025-56714-z","article-title":"WNT11 promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis","volume":"16","author":"Jiang","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011176","article-title":"Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer","volume":"20","author":"Ji","year":"2024","journal-title":"PLoS Genet."},{"key":"10.1016\/j.canlet.2026.218665_bib86","article-title":"Characterizing macrophage diversity in colorectal malignancies through single-cell genomics","volume":"16","author":"Zhao","year":"2025","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib87","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1158\/0008-5472.CAN-13-2169","article-title":"Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells","volume":"74","author":"Yamashina","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218665_bib88","article-title":"The role of innate immune cells in the colorectal cancer tumor microenvironment and advances in anti-tumor therapy research","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/cells12081139","article-title":"TGF\u03b2 and the tumor microenvironment in colorectal cancer","volume":"12","author":"Waldner","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib90","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12672-024-01117-7","article-title":"The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer","volume":"15","author":"Chuang","year":"2024","journal-title":"Discov. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib91","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41392-021-00670-9","article-title":"Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib92","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.4251\/wjgo.v16.i5.1690","article-title":"Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies","volume":"16","author":"Nie","year":"2024","journal-title":"World J. Gastrointest. Oncol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib93","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41423-023-01004-1","article-title":"New insights into the functions of MDSCs in autoimmune pathogenesis","volume":"20","author":"Rui","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.canlet.2026.218665_bib94","series-title":"Immunotherapy of Cancer: an Innovative Treatment Comes of Age","first-page":"323","article-title":"MDSC: myeloid-derived suppressor cells","author":"Shibata","year":"2016"},{"key":"10.1016\/j.canlet.2026.218665_bib95","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3389\/fimmu.2020.01526","article-title":"Myeloid-derived suppressor cells in colorectal cancer","volume":"11","author":"Sieminska","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib96","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/vaccines3030703","article-title":"The role of indoleamine 2, 3-Dioxygenase in immune suppression and autoimmunity","volume":"3","author":"Mbongue","year":"2015","journal-title":"Vaccines (Basel)"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib97","doi-asserted-by":"crossref","first-page":"497","DOI":"10.37349\/etat.2022.00097","article-title":"Myeloid-derived suppressor cells in colorectal cancer: prognostic biomarkers and therapeutic targets","volume":"3","author":"Al-Mterin","year":"2022","journal-title":"Explor Target Antitumor Ther."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib98","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202350635","article-title":"Prostaglandin E2 impacts multiple stages of the natural killer cell antitumor immune response","volume":"54","author":"Patterson","year":"2024","journal-title":"Eur. J. Immunol."},{"issue":"8004","key":"10.1016\/j.canlet.2026.218665_bib99","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41586-024-07135-3","article-title":"SOX17 enables immune evasion of early colorectal adenomas and cancers","volume":"627","author":"Goto","year":"2024","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib100","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ccell.2019.02.008","article-title":"KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer","volume":"35","author":"Liao","year":"2019","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib101","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41568-021-00366-w","article-title":"Cancer stem cell\u2013immune cell crosstalk in tumour progression","volume":"21","author":"Bayik","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib102","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.celrep.2015.06.024","article-title":"CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function","volume":"12","author":"Chun","year":"2015","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib103","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.canlet.2026.218665_bib104","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"issue":"7804","key":"10.1016\/j.canlet.2026.218665_bib105","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-020-2166-3","article-title":"Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche","volume":"580","author":"Roulis","year":"2020","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib106","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41568-019-0168-y","article-title":"YAP and TAZ: a signalling hub of the tumour microenvironment","volume":"19","author":"Zanconato","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib107","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ccell.2021.03.004","article-title":"Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver","volume":"39","author":"Bertocchi","year":"2021","journal-title":"Cancer Cell"},{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib108","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.46094","article-title":"Liver metastases and immune checkpoint inhibitor efficacy in patients with refractory metastatic colorectal cancer: a secondary analysis of a randomized clinical trial","volume":"6","author":"Chen","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"9","key":"10.1016\/j.canlet.2026.218665_bib109","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1136\/gutjnl-2022-327909","article-title":"Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade","volume":"72","author":"Conche","year":"2023","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib110","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1080\/08820139.2025.2529970","article-title":"Regulatory T cells in Colon cancer: implications for pathogenesis, prognosis and emerging therapeutic strategies","volume":"54","author":"Anad Muhammad","year":"2025","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.canlet.2026.218665_bib111","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1479-5876-4-52","article-title":"In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer","volume":"4","author":"Loddenkemper","year":"2006","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030695","article-title":"Accumulation of CCR4+ CTLA-4hi FOXP3+CD25hi regulatory T cells in Colon adenocarcinomas correlate to reduced activation of conventional T cells","volume":"7","author":"Svensson","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib113","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1158\/0008-5472.CAN-11-2493","article-title":"Tumor-derived chemokine CCL5 enhances TGF-\u03b2-mediated killing of CD8(+) T cells in Colon cancer by T-regulatory cells","volume":"72","author":"Chang","year":"2012","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib114","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/bjc.2014.572","article-title":"The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer","volume":"112","author":"Ward","year":"2015","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s40425-019-0701-2","article-title":"Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1\/CEBPB\/NF-\u03baB signaling","volume":"7","author":"Wang","year":"2019","journal-title":"J. ImmunoTher. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib116","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1186\/s12967-024-05518-8","article-title":"Targeting tumor-infiltrating CCR8+ regulatory T cells induces antitumor immunity through functional restoration of CD4+ tconvs and CD8+ T cells in colorectal cancer","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"issue":"18","key":"10.1016\/j.canlet.2026.218665_bib117","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1158\/0008-5472.CAN-18-1119","article-title":"Targeting CCR8 induces protective antitumor immunity and enhances vaccine-induced responses in Colon cancer","volume":"78","author":"Villarreal","year":"2018","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12071888","article-title":"Relevance of regulatory T cells during colorectal cancer development","volume":"12","author":"Olgu\u00edn","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.canlet.2026.218665_bib119","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41568-025-00832-9","article-title":"Regulatory T cells in the tumour microenvironment","volume":"25","author":"Imianowski","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12032-023-02289-y","article-title":"Evaluation of regulatory T-cells in cancer immunotherapy: therapeutic relevance of immune checkpoint inhibition","volume":"41","author":"Singh","year":"2024","journal-title":"Med. Oncol."},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib121","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1188243","article-title":"The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy","volume":"5","author":"Roselli","year":"2016","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib122","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1038\/s41467-020-18731-y","article-title":"HIF-2\u03b1 is indispensable for regulatory T cell function","volume":"11","author":"Hsu","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib123","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.canlet.2026.218665_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2025.149220","article-title":"Identification of lactylation-associated fibroblast subclusters predicting prognosis and cancer immunotherapy response in Colon cancer","volume":"940","author":"Liang","year":"2025","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib125","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1038\/s41467-025-62628-7","article-title":"Regulatory T cell therapy promotes TGF-\u03b2 and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2","volume":"16","author":"Cheng","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib126","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12943-020-01234-1","article-title":"Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib127","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/s41467-020-15404-8","article-title":"TGF\u03b2 suppresses CD8(+) T cell expression of CXCR3 and tumor trafficking","volume":"11","author":"Gunderson","year":"2020","journal-title":"Nat. Commun."},{"issue":"25","key":"10.1016\/j.canlet.2026.218665_bib128","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.1016\/j.cell.2023.11.004","article-title":"An oncogenic phenoscape of colonic stem cell polarization","volume":"186","author":"Qin","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib129","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1189\/jlb.0910506","article-title":"Foxp3+IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer","volume":"89","author":"Yang","year":"2011","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-3083.2011.02539.x","article-title":"Colorectal cancer\u2013derived Foxp3+IL-17+ T cells suppress tumour-specific CD8+ T cells","volume":"74","author":"Ma","year":"2011","journal-title":"Scand. J. Immunol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib131","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s12094-021-02734-2","article-title":"Cancer-associated fibroblasts in colorectal cancer","volume":"24","author":"Kamali Zonouzi","year":"2022","journal-title":"Clin. Transl. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib132","doi-asserted-by":"crossref","DOI":"10.3390\/genes15020209","article-title":"The impact of cancer-associated fibroblasts on the biology and progression of colorectal carcinomas","volume":"15","author":"Henrich","year":"2024","journal-title":"Genes (Basel)"},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib133","doi-asserted-by":"crossref","first-page":"4674","DOI":"10.1002\/ptr.7934","article-title":"Chelerythrine chloride inhibits the progression of colorectal cancer by targeting cancer-associated fibroblasts through intervention with WNT10B\/\u03b2-catenin and TGF\u03b22\/Smad2\/3 axis","volume":"37","author":"Liang","year":"2023","journal-title":"Phytother Res."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.111956","article-title":"Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype","volume":"391","author":"Liu","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"21","key":"10.1016\/j.canlet.2026.218665_bib135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111366","article-title":"An emerging role for calcium signaling in cancer-associated fibroblasts","volume":"22","author":"Sadras","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.canlet.2026.218665_bib136","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2217\/epi-2019-0110","article-title":"miRNAs derived from cancer-associated fibroblasts in colorectal cancer","volume":"11","author":"Savardashtaki","year":"2019","journal-title":"Epigenomics"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib137","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.3390\/cancers7040876","article-title":"Direct interaction between carcinoma cells and cancer associated fibroblasts for the regulation of cancer invasion","volume":"7","author":"Yamaguchi","year":"2015","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib138","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s12935-021-02252-9","article-title":"Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer","volume":"21","author":"Zheng","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.canlet.2026.218665_bib139","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/3781091","article-title":"Cancer-associated fibroblast risk model for prediction of colorectal carcinoma prognosis and therapeutic responses","volume":"2023","author":"Wang","year":"2023","journal-title":"Mediat. Inflamm."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib140","doi-asserted-by":"crossref","DOI":"10.32604\/biocell.2023.030541","article-title":"Cancer-associated fibroblasts of colorectal cancer: translational prospects in liquid biopsy and targeted therapy","volume":"47","author":"Salleh","year":"2023","journal-title":"Biocell"},{"key":"10.1016\/j.canlet.2026.218665_bib141","doi-asserted-by":"crossref","unstructured":"Chen, Y.-f., X. Wu, and F. Gao, Genome-wide analysis indicating cancer associated fibroblast (CAF) impacts on colorectal cancer (CRC) prognosis via immunosuppression. J. Clin. Oncol.. 39(15_suppl): p. 3543-3543. DOI: 10.1200\/JCO.2021.39.15_suppl.3543..","DOI":"10.1200\/JCO.2021.39.15_suppl.3543"},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib142","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/kjm2.12736","article-title":"Paeoniflorin inhibits colorectal cancer cell stemness through the miR-3194-5p\/catenin beta-interacting protein 1 axis","volume":"39","author":"Su","year":"2023","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.canlet.2026.218665_bib143","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.690816","article-title":"Expression patterns of microenvironmental factors and Tenascin-C at the invasive front of stage II and III colorectal cancer: novel tumor prognostic markers","volume":"11","author":"Hashimoto","year":"2021","journal-title":"Front. Oncol."},{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib144","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/mc.23615","article-title":"Integrated analysis of single cell and bulk RNA sequencing identifies CTHRC1(+) INHBA(+) CAF as drivers of colorectal cancer progression","volume":"62","author":"Hu","year":"2023","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2026.218665_bib145","doi-asserted-by":"crossref","DOI":"10.1177\/10732748251381441","article-title":"Cancer stem cells decide the fate of cancer immunotherapy by remodeling tumor microenvironment","volume":"32","author":"Chakraborty","year":"2025","journal-title":"Cancer Control"},{"issue":"6","key":"10.1016\/j.canlet.2026.218665_bib146","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDra2300353","article-title":"Immunotherapy in colorectal cancer - finding the achilles' heel","volume":"3","author":"Park","year":"2024","journal-title":"NEJM Evid."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib147","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41467-024-45960-2","article-title":"Clinical and biomarker results from a phase II trial of combined cabozantinib and durvalumab in patients with chemotherapy-refractory colorectal cancer (CRC): CAMILLA CRC cohort","volume":"15","author":"Saeed","year":"2024","journal-title":"Nat. Commun."},{"issue":"10517","key":"10.1016\/j.canlet.2026.218665_bib148","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/S0140-6736(25)02025-2","article-title":"Zanzalintinib plus atezolizumab versus regorafenib in refractory colorectal cancer (STELLAR-303): a randomised, open-label, phase 3 trial","volume":"406","author":"Hecht","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2026.218665_bib149","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.569017","article-title":"Molecular immunotherapy: promising approach to treat metastatic colorectal cancer by targeting resistant cancer cells or cancer stem cells","volume":"10","author":"Forster","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218665_bib150","article-title":"Targeting colorectal cancer stem cells as an effective treatment for colorectal","volume":"19","author":"Ma","year":"2020","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.canlet.2026.218665_bib151","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/jnci\/djn123","article-title":"Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy","volume":"100","author":"Li","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib152","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/2326-6066.CIR-17-0518","article-title":"The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer","volume":"6","author":"Miyamoto","year":"2018","journal-title":"Cancer Immunol. Res."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib153","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1158\/1535-7163.MCT-17-1086","article-title":"Development of MGD007, a gpA33 x CD3-Bispecific DART protein for T-Cell immunotherapy of metastatic colorectal cancer","volume":"17","author":"Moore","year":"2018","journal-title":"Mol. Cancer Therapeut."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib154","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30525-3","article-title":"Cancer stem cells as targets for DC-based immunotherapy of colorectal cancer","volume":"8","author":"Szary\u0144ska","year":"2018","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib155","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1245\/s10434-008-0074-0","article-title":"CD133+CD44+ population efficiently enriches Colon cancer initiating cells","volume":"15","author":"Haraguchi","year":"2008","journal-title":"Ann. Surg Oncol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib156","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094621","article-title":"Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells","volume":"9","author":"Sahlberg","year":"2014","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.canlet.2026.218665_bib157","doi-asserted-by":"crossref","first-page":"10158","DOI":"10.1073\/pnas.0703478104","article-title":"Phenotypic characterization of human colorectal cancer stem cells","volume":"104","author":"Dalerba","year":"2007","journal-title":"J. Proceed. Natl. Acad. Sci."},{"issue":"21","key":"10.1016\/j.canlet.2026.218665_bib158","first-page":"6751","article-title":"CD44 is of functional importance for colorectal","volume":"14","author":"Du","year":"2008","journal-title":"Cancer Stem Cells"},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib159","first-page":"2927","article-title":"CD133+ CD44+ population efficiently enriches colon cancer initiating cells","volume":"15","author":"Haraguchi","year":"2008"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib160","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s11307-019-01467-7","article-title":"Radiotheranostic targeting cancer stem cells in human colorectal cancer xenografts","volume":"22","author":"She","year":"2020","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.canlet.2026.218665_bib161","volume":"9","author":"Lei","year":"2021"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib162","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1089\/hum.2018.229","article-title":"Preclinical evaluation of chimeric antigen receptor-modified T cells specific to epithelial cell adhesion molecule for treating colorectal cancer","volume":"30","author":"Zhang","year":"2019","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.canlet.2026.218665_bib163","article-title":"Disrupting \u03b2-Catenin\/BCL9 interaction with a peptide prodrug boosts immunotherapy in colorectal cancer","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110492","article-title":"Tumor-derived Jagged1 promotes cancer progression through immune evasion","volume":"38","author":"Meng","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib165","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12964-019-0459-7","article-title":"Hedgehog\/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications","volume":"17","author":"Grund-Gr\u00f6schke","year":"2019","journal-title":"Cell Commun. Signal."},{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib166","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1158\/1078-0432.CCR-09-2846","article-title":"Targeting Hedgehog--a cancer stem cell pathway","volume":"16","author":"Merchant","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib167","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s13277-015-3198-4","article-title":"Biomarkers and signaling pathways of colorectal cancer stem cells","volume":"36","author":"Abetov","year":"2015","journal-title":"Tumour Biol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib168","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrclinonc.2015.61","article-title":"Targeting notch, hedgehog, and Wnt pathways in cancer stem cells: clinical update","volume":"12","author":"Takebe","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib169","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/cancers7030851","article-title":"Hedgehog signaling in the maintenance of cancer stem cells","volume":"7","author":"Cochrane","year":"2015","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib170","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1158\/1078-0432.CCR-12-1800","article-title":"A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer","volume":"19","author":"Berlin","year":"2013","journal-title":"Clin. Cancer Res."},{"issue":"20","key":"10.1016\/j.canlet.2026.218665_bib171","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1002\/anie.200906967","article-title":"Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives","volume":"49","author":"Heretsch","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"issue":"11","key":"10.1016\/j.canlet.2026.218665_bib172","first-page":"6339","article-title":"Cyclopamine decreased the expression of sonic hedgehog and its downstream genes in colon cancer stem cells","volume":"34","author":"Batsaikhan","year":"2014","journal-title":"Anticancer Res."},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib173","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.canlet.2026.218665_bib174","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41580-023-00591-1","article-title":"Cellular and molecular mechanisms of hedgehog signalling","volume":"24","author":"Zhang","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib175","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41392-023-01559-5","article-title":"Hedgehog signaling in tissue homeostasis, cancers and targeted therapies","volume":"8","author":"Jing","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"6\u20137","key":"10.1016\/j.canlet.2026.218665_bib176","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/emmm.200900039","article-title":"Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion","volume":"1","author":"Varnat","year":"2009","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib177","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2174\/1573394718666220822175032","article-title":"Inhibition of the sonic hedgehog pathway using small molecule inhibitors: targeting Colon cancer stem cells","volume":"19","author":"Omar","year":"2023","journal-title":"Curr. Cancer Ther. Rev."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib178","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pharmthera.2013.02.003","article-title":"Notch inhibitors for cancer treatment","volume":"139","author":"Espinoza","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib179","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.3892\/etm.2017.4282","article-title":"Smoothened antagonist GDC-0449 (vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines","volume":"13","author":"Wu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.canlet.2026.218665_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2013.09.005","article-title":"Targeting notch signaling pathway in cancer: clinical development advances and challenges","volume":"141","author":"Takebe","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2026.218665_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical notch signaling pathway: unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218665_bib182","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.24872","article-title":"The role of notch receptors in transcriptional regulation","volume":"230","author":"Wang","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2026.218665_bib183","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.115.305350","article-title":"Endocardial notch signaling in cardiac development and disease","volume":"118","author":"Lux\u00e1n","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.canlet.2026.218665_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2017.04.001","article-title":"The canonical notch signaling pathway: structural and biochemical insights into shape, sugar, and force","volume":"41","author":"Kovall","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2026.218665_bib185","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-07-1393","article-title":"Delta-like 4\/notch signaling and its therapeutic implications","volume":"13","author":"Yan","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218665_bib186","doi-asserted-by":"crossref","DOI":"10.1242\/dev.154807","article-title":"Redundancy and cooperation in notch intercellular signaling","volume":"145","author":"Luna-Escalante","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.canlet.2026.218665_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2017.12.008","article-title":"Notch after cleavage","volume":"51","author":"Bray","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib188","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib189","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41573-020-00091-3","article-title":"Targeting notch in oncology: the path forward","volume":"20","author":"Majumder","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2026.218665_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2023.102244","article-title":"Mechanical regulation of the notch signaling pathway","volume":"85","author":"Suarez Rodriguez","year":"2023","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218665_bib191","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac601","article-title":"Notch-dependent and -independent functions of transcription factor RBPJ","volume":"50","author":"Friedrich","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib192","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.str.2013.12.007","article-title":"Keeping notch target genes off: a CSL corepressor caught in the act","volume":"22","author":"Borggrefe","year":"2014","journal-title":"Structure"},{"key":"10.1016\/j.canlet.2026.218665_bib193","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.10208","article-title":"HES and HERP families: multiple effectors of the notch signaling pathway","volume":"194","author":"Iso","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2026.218665_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.tips.2023.09.011","article-title":"New tricks for an old pathway: emerging Notch-based biotechnologies and therapeutics","volume":"44","author":"Medina","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.canlet.2026.218665_bib195","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.29800","article-title":"The notch pathway in colorectal cancer","volume":"138","author":"Vinson","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218665_bib196","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2009.04.005","article-title":"Endocytic regulation of notch signaling","volume":"19","author":"Fortini","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.canlet.2026.218665_bib197","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-14-862","article-title":"Epithelial notch signaling is a limiting step for pancreatic carcinogenesis","volume":"14","author":"Thomas","year":"2014","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib198","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-2187-7-11","article-title":"Signaling in Colon cancer stem cells","volume":"7","author":"Roy","year":"2012","journal-title":"J. Mol. Signal."},{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib199","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/carcin\/bgp236","article-title":"Role of notch signaling in colorectal cancer","volume":"30","author":"Qiao","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2026.218665_bib200","volume":"11","author":"Qiu","year":"2021"},{"key":"10.1016\/j.canlet.2026.218665_bib201","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110451","article-title":"Notch-mediated lactate metabolism regulates MDSC development through the Hes1\/MCT2\/c-Jun axis","volume":"38","author":"Zhao","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218665_bib202","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2016.08.019","article-title":"The blockage of notch signalling promoted the generation of polymorphonuclear myeloid-derived suppressor cells with lower immunosuppression","volume":"68","author":"Wang","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218665_bib203","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1231416","article-title":"Notch receptor\/ligand diversity: contribution to colorectal cancer stem cell heterogeneity","volume":"11","author":"Brisset","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2026.218665_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2019.08.003","article-title":"Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis","volume":"36","author":"Jackstadt","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218665_bib205","doi-asserted-by":"crossref","DOI":"10.3233\/CBM-150533","article-title":"Immunohistochemical expression of Notch1, Jagged1, NF-\u03baB and MMP-9 in colorectal cancer patients and the relationship to clinicopathological parameters","volume":"15","author":"Zheng","year":"2015","journal-title":"Cancer Biomarkers"},{"key":"10.1016\/j.canlet.2026.218665_bib206","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.953405","article-title":"LncRNA profiles from notch signaling: implications for clinical management and tumor microenvironment of colorectal cancer","volume":"13","author":"Dang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218665_bib207","article-title":"Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer","volume":"9","author":"Wang","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2026.218665_bib208","doi-asserted-by":"crossref","DOI":"10.1158\/2326-6066.CIR-20-0428","article-title":"Notch-regulated dendritic cells restrain inflammation-associated colorectal carcinogenesis","volume":"9","author":"Wang","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.canlet.2026.218665_bib209","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400797","article-title":"Notch-targeted therapeutic in colorectal cancer by Notch1 attenuation via tumor microenvironment-responsive Cascade DNA delivery","volume":"13","author":"Lu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib210","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1158\/2326-6066.CIR-20-0428","article-title":"Notch-regulated dendritic cells restrain inflammation-associated colorectal carcinogenesis","volume":"9","author":"Wang","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.canlet.2026.218665_bib211","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191515","article-title":"AKT-Dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer","volume":"217","author":"Varga","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2026.218665_bib212","doi-asserted-by":"crossref","DOI":"10.1002\/1878-0261.13296","article-title":"NICD3 regulates the expression of MUC5AC and MUC2 by recruiting SMARCA4 and is involved in the differentiation of mucinous colorectal adenocarcinoma","volume":"16","author":"Yan","year":"2022","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib213","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12916-021-02031-3","article-title":"Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy","volume":"19","author":"Long","year":"2021","journal-title":"BMC Med."},{"issue":"24","key":"10.1016\/j.canlet.2026.218665_bib214","doi-asserted-by":"crossref","first-page":"eadf5464","DOI":"10.1126\/sciadv.adf5464","article-title":"Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer","volume":"9","author":"Wang","year":"2023","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib215","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.bjc.6605368","article-title":"Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer","volume":"101","author":"Jubb","year":"2009","journal-title":"Br. J. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib216","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/15384047.2015.1016662","article-title":"Hes1: a key role in stemness, metastasis and multidrug resistance","volume":"16","author":"Liu","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2026.218665_bib217","article-title":"Hes1 in malignant tumors: from molecular mechanism to therapeutic potential","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib218","article-title":"Loss of HES1 expression is associated with extracellular matrix remodeling and tumor immune suppression in KRAS mutant colon adenocarcinomas","volume":"13","author":"Wang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218665_bib219","article-title":"PSEN1 is associated with colon cancer development via potential influences on PD-L1 nuclear translocation and tumor-immune interactions","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.canlet.2026.218665_bib220","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.20151095","article-title":"An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth","volume":"213","author":"Atapattu","year":"2016","journal-title":"J. Exp. Med."},{"issue":"13","key":"10.1016\/j.canlet.2026.218665_bib221","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/jnci\/djm056","article-title":"Targeting vessel abnormalization in cancer","volume":"99","author":"Garber","year":"2007","journal-title":"J. Natl. Cancer Inst."},{"issue":"23","key":"10.1016\/j.canlet.2026.218665_bib222","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1158\/0008-5472.CAN-07-0969","article-title":"Delta-like 4 notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib223","first-page":"3853","article-title":"Inhibition of notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation","volume":"30","author":"Grudzien","year":"2010","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib224","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2019.08.137","article-title":"Clinical and biochemical relevance of monounsaturated fatty acid metabolism targeting strategy for cancer stem cell elimination in Colon cancer","volume":"519","author":"Choi","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib225","first-page":"106","article-title":"Targeting a lipid desaturation enzyme","volume":"10","author":"Yu","year":"2021","journal-title":"SCD1, Selectively Eliminates Colon Cancer Stem Cells through the Suppression of Wnt and NOTCH Signaling"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib226","first-page":"963","article-title":"Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells","volume":"11","author":"Ponnurangam","year":"2012"},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib227","first-page":"60","article-title":"Wnt signaling in cancer stem cell biology","volume":"8","author":"De Sousa e Melo","year":"2016"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib228","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.canlet.2026.218665_bib229","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1080\/15384047.2019.1599660","article-title":"Colon cancer stem cells: potential target for the treatment of colorectal cancer","volume":"20","author":"Gupta","year":"2019","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2026.218665_bib230","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/978-1-4614-0899-4_13","article-title":"Notch signaling in cancer stem cells","author":"Wang","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib231","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1158\/0008-5472.CAN-15-1519","article-title":"A small-molecule antagonist of the \u03b2-Catenin\/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis","volume":"76","author":"Fang","year":"2016","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib232","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12586","article-title":"TNIK inhibition abrogates colorectal cancer stemness","volume":"7","author":"Masuda","year":"2016","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.canlet.2026.218665_bib233","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110180","article-title":"A novel aminothiazole KY-05009 with potential to inhibit Traf2- and nck-interacting kinase (TNIK) attenuates TGF-\u03b21-Mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib234","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41416-020-01162-3","article-title":"Pharmacological blockage of transforming growth factor-\u03b2 signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846","volume":"124","author":"Sugano","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib235","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-025-02557-7","article-title":"Cancer stem cell-driven drug resistance in colorectal carcinoma: molecular aspects and therapeutic potentials","volume":"25","author":"Zhou","year":"2026","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.canlet.2026.218665_bib236","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","article-title":"Clinical and therapeutic relevance of cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib237","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12943-024-01992-2","article-title":"tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application","volume":"23","author":"Zhou","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib238","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12935-026-04177-7","article-title":"Advances in immunotherapy for colorectal cancer: overcoming resistance in mismatch repair-proficient tumors","volume":"26","author":"Keivany","year":"2026","journal-title":"Cancer Cell Int."},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib239","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13040951","article-title":"Artificial intelligence advancements in oncology: a review of current trends and future directions","volume":"13","author":"Huhulea","year":"2025","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib240","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.ccell.2021.04.002","article-title":"Artificial intelligence for clinical oncology","volume":"39","author":"Kann","year":"2021","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib241","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41392-022-00994-0","article-title":"Artificial intelligence in cancer target identification and drug discovery","volume":"7","author":"You","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib242","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00335-025-10141-z","article-title":"Elucidation of novel diagnostic biomarkers and therapeutic targets in colorectal carcinoma: an integrative approach leveraging multi-omics, computational biology, and single-cell sequencing technologies","volume":"36","author":"Li","year":"2025","journal-title":"Mamm. Genome"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib243","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-75438-6","article-title":"Integrating machine learning and bioinformatics approaches for identifying novel diagnostic gene biomarkers in colorectal cancer","volume":"14","author":"Vaziri-Moghadam","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib244","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s12672-025-02435-0","article-title":"Integrating machine learning and genetic evidence to uncover novel gene biomarkers for colorectal cancer diagnosis","volume":"16","author":"Zhou","year":"2025","journal-title":"Discov. Oncol."},{"issue":"22","key":"10.1016\/j.canlet.2026.218665_bib245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262211045","article-title":"Biomarker identification via spatial transcriptomics profiling of colorectal cancer and colorectal cancer with liver metastasis stem cells","volume":"26","author":"Lee","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib246","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41419-024-06598-6","article-title":"Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer","volume":"15","author":"Xiao","year":"2024","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.canlet.2026.218665_bib247","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41591-022-02134-1","article-title":"Multistain deep learning for prediction of prognosis and therapy response in colorectal cancer","volume":"29","author":"Foersch","year":"2023","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib248","article-title":"AI based natural inhibitor targeting RPS20 for colorectal cancer treatment using integrated computational approaches","volume":"15","author":"Ali","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218665_bib249","article-title":"Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: a systematic literature review","volume":"3\u20134","author":"Echle","year":"2021","journal-title":"ImmunoInformatics"},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib250","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41698-025-01094-2","article-title":"Deepath-MSI: a clinic-ready deep learning model for microsatellite instability detection in colorectal cancer using whole-slide imaging","volume":"9","author":"Feng","year":"2025","journal-title":"npj Precis. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib251","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41698-024-00592-z","article-title":"Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology","volume":"8","author":"Gustav","year":"2024","journal-title":"npj Precis. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib252","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12911-025-03134-0","article-title":"Exploring doctors' perspectives on precision medicine and AI in colorectal cancer: opportunities and challenges for the doctor-patient relationship","volume":"25","author":"Ancillotti","year":"2025","journal-title":"BMC Med. Inf. Decis. Making"},{"key":"10.1016\/j.canlet.2026.218665_bib253","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2024.102842","article-title":"Artificial intelligence for high content imaging in drug discovery","volume":"87","author":"Carreras-Puigvert","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib254","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40364-025-00758-2","article-title":"Integrating artificial intelligence in drug discovery and early drug development: a transformative approach","volume":"13","author":"Ocana","year":"2025","journal-title":"Biomark. Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218665_bib255","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s12672-025-02411-8","article-title":"The immunosuppressive role of VSIG4 in colorectal cancer and its interaction with the tumor microenvironment","volume":"16","author":"Zhang","year":"2025","journal-title":"Discov. Oncol."},{"issue":"11","key":"10.1016\/j.canlet.2026.218665_bib256","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1016\/j.ymthe.2023.09.021","article-title":"Arming CAR-T cells with cytokines and more: innovations in the fourth-generation CAR-T development","volume":"31","author":"Tang","year":"2023","journal-title":"Mol. Ther."},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib257","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1158\/2159-8290.CD-23-1199","article-title":"Artificial intelligence in oncology: current landscape, challenges, and future directions","volume":"14","author":"Lotter","year":"2024","journal-title":"Cancer Discov."},{"issue":"3","key":"10.1016\/j.canlet.2026.218665_bib258","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/gutjnl-2023-330243","article-title":"Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis","volume":"73","author":"Li","year":"2024","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib259","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/cas.16117","article-title":"Cell cycle heterogeneity and plasticity of colorectal cancer stem cells","volume":"115","author":"Higa","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2026.218665_bib260","article-title":"Targeting CSC-immune cell crosstalk to overcome chemoresistance and enhance immunotherapy efficacy","volume":"16","author":"Yu","year":"2025","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218665_bib261","doi-asserted-by":"crossref","first-page":"e580","DOI":"10.1093\/oncolo\/oyae013","article-title":"The efficacy of immune checkpoint inhibitors in microsatellite stable colorectal cancer: a systematic review","volume":"29","author":"Guven","year":"2024","journal-title":"Oncologist"},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib262","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1007\/s12029-023-00945-0","article-title":"Cancer stem cells in colorectal cancer: implications for targeted immunotherapies","volume":"54","author":"Jalil","year":"2023","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.canlet.2026.218665_bib263","article-title":"Mechanisms on chemotherapy resistance of colorectal cancer stem cells and research progress of reverse transformation: a mini-review","volume":"9","author":"Chen","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"7","key":"10.1016\/j.canlet.2026.218665_bib264","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.trecan.2024.05.001","article-title":"Advancements in combining targeted therapy and immunotherapy for colorectal cancer","volume":"10","author":"Singh","year":"2024","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2026.218665_bib265","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1200\/EDBK_237987","article-title":"Reprogramming the tumor microenvironment to improve immunotherapy: emerging strategies and combination therapies","volume":"39","author":"Datta","year":"2019","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"10.1016\/j.canlet.2026.218665_bib266","article-title":"Novel strategies to overcome tumor immunotherapy resistance using CAR NK cells","volume":"16","author":"Guo","year":"2025","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218665_bib267","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaf440","article-title":"Deep learning-driven multi-omics analysis: enhancing cancer diagnostics and therapeutics","volume":"26","author":"Zhang","year":"2025","journal-title":"Briefings Bioinf."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526004283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526004283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:21:34Z","timestamp":1785874894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526004283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":267,"alternative-id":["S0304383526004283"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218665","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting colorectal cancer stem-like cells: Overcoming therapeutic resistance and reprogramming the immunosuppressive niche","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218665","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218665"}}