{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:54:39Z","timestamp":1785894879711,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["2024CICCPMHR032"],"award-info":[{"award-number":["2024CICCPMHR032"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272651"],"award-info":[{"award-number":["82272651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573311"],"award-info":[{"award-number":["82573311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.canlet.2026.218680","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:28:35Z","timestamp":1781537315000},"page":"218680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["KRT18 promotes the high-grade meningioma proliferation by interacting with LDHA to activate glycolysis and the PI3K\/AKT signaling pathway"],"prefix":"10.1016","volume":"656","author":[{"given":"Huaning","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhumei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-5515","authenticated-orcid":false,"given":"Yongping","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218680_bib1","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015\u20132019","volume":"24","author":"Ostrom","year":"2022","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2019.07.001","article-title":"Incidence, mortality and outcome of meningiomas: a population-based study from Germany","volume":"62","author":"Holleczek","year":"2019","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.canlet.2026.218680_bib3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2017.168","article-title":"Advances in meningioma genetics: novel therapeutic opportunities","volume":"14","author":"Preusser","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.canlet.2026.218680_bib5","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/neuonc\/noab150","article-title":"EANO guideline on the diagnosis and management of meningiomas","volume":"23","author":"Goldbrunner","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib6","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1158\/1078-0432.CCR-19-2109","article-title":"Everolimus and octreotide for patients with recurrent meningioma: results from the phase II CEVOREM trial","volume":"26","author":"Graillon","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218680_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-021-03850-3","article-title":"A clinically applicable integrative molecular classification of meningiomas","volume":"597","author":"Nassiri","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218680_bib8","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/neuonc\/noab168","article-title":"Rethinking immunotherapy in meningiomas","volume":"23","author":"Terabe","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib9","article-title":"A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma","volume":"4","author":"Kumthekar","year":"2022","journal-title":"Neurooncol Adv"},{"issue":"Pt1","key":"10.1016\/j.canlet.2026.218680_bib10","article-title":"Keratin: a potential driver of tumor metastasis","volume":"307","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.canlet.2026.218680_bib11","article-title":"Ectopic expression of a truncated isoform of hair keratin 81 in breast cancer alters biophysical characteristics to promote metastatic propensity","volume":"11","author":"Kang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2026.218680_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2019.09.001","article-title":"Epithelial keratins: biology and implications as diagnostic markers for liquid biopsies","volume":"72","author":"Werner","year":"2020","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.canlet.2026.218680_bib13","first-page":"464","article-title":"Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs","volume":"2","author":"Waseem","year":"1990","journal-title":"New Biol"},{"key":"10.1016\/j.canlet.2026.218680_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s10020-021-00274-7","article-title":"Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors","volume":"27","author":"Menz","year":"2021","journal-title":"Mol Med"},{"key":"10.1016\/j.canlet.2026.218680_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1445978","article-title":"The relationship between keratin 18 and epithelial-derived tumors: as a diagnostic marker, prognostic marker, and its role in tumorigenesis","volume":"14","author":"Yan","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5414\/NP301277","article-title":"Poorly differentiated SMARCB1\/INI1-negative chordomas","volume":"40","author":"Zhao","year":"2021","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.canlet.2026.218680_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000511447","article-title":"The role of keratin-8 and keratin-18 polymorphisms and protein levels in the occurrence and progression of vocal leukoplakia","volume":"83","author":"Yang","year":"2021","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.canlet.2026.218680_bib18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/10668969211056013","article-title":"Clinical characteristics, pathology and outcome of 237 patients with synovial sarcoma: Single center experience","volume":"30","author":"Cheng","year":"2022","journal-title":"Int. J. Surg. Pathol."},{"key":"10.1016\/j.canlet.2026.218680_bib19","article-title":"KRT18 modulates alternative splicing of genes involved in proliferation and apoptosis processes in both gastric cancer cells and clinical samples","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.canlet.2026.218680_bib20","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1021\/acscentsci.4c00163","article-title":"O-GlcNAcylation facilitates the interaction between keratin 18 and isocitrate dehydrogenases and potentially influencing cholangiocarcinoma progression","volume":"10","author":"Meng","year":"2024","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.canlet.2026.218680_bib21","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41417-022-00474-1","article-title":"RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2\/k18\/14-3-3 ternary complex formulation to promote BRAF\/MEK\/ERK signal inhibited cell proliferation in hepatocellular carcinoma","volume":"29","author":"Yang","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.canlet.2026.218680_bib22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1053\/hupa.2002.124912","article-title":"Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases","volume":"33","author":"Miettinen","year":"2002","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.canlet.2026.218680_bib23","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-25-4534","article-title":"Mitochondrial-localized keratin 17 promotes chemoresistance in basal-like pancreatic cancer","author":"Pan","year":"2026","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218680_bib24","article-title":"Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination","volume":"6","author":"Dong","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218680_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.842356","article-title":"Fbw7 inhibits the progression of activated B-Cell like diffuse large B-Cell lymphoma by targeting the positive feedback loop of the LDHA\/lactate\/miR-223 axis","volume":"12","author":"Yao","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib26","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1007\/s11010-023-04920-y","article-title":"Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling","volume":"479","author":"Cong","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.canlet.2026.218680_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-026-08808-9","article-title":"RILPL2 suppresses metabolic reprogramming and progression of cervical cancer by attenuating LDHA protein stability and inhibiting H3K18 lactylation","author":"Shi","year":"2026","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218680_bib28","article-title":"CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44\/c-MYC\/LDHA axis","volume":"15","author":"Cheng","year":"2023","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218680_bib29","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1016\/S1470-2045(16)30321-7","article-title":"EANO guidelines for the diagnosis and treatment of meningiomas","volume":"17","author":"Goldbrunner","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib30","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/neuonc\/noae037","article-title":"3D volume growth rate evaluation in the EORTCBTG-1320 clinical trial for recurrent WHO grade 2 and 3 meningiomas","volume":"26","author":"Tabouret","year":"2024","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib31","article-title":"Analysis of the expression and role of keratin 17 in human tumors","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.canlet.2026.218680_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40478-025-02206-6","article-title":"Novel insights into meningioma brain invasion with spatial transcriptomic profiling","volume":"14","author":"Maier","year":"2026","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.canlet.2026.218680_bib33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/1440-1681.13401","article-title":"Keratin 18 induces proliferation, migration, and invasion in gastric cancer via the MAPK signalling pathway","volume":"48","author":"Wang","year":"2021","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.canlet.2026.218680_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11060-025-05082-1","article-title":"The hormonal nexus in PIK3CA-mutated meningiomas: implications for targeted therapy and clinical trial design","volume":"174","author":"Abikenari","year":"2025","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218680_bib35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/07357907.2020.1773844","article-title":"In vitro effect of dovitinib (TKI258), a multi-target angiokinase inhibitor on aggressive meningioma cells","volume":"38","author":"Das","year":"2020","journal-title":"Cancer Invest."},{"key":"10.1016\/j.canlet.2026.218680_bib36","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41419-018-1030-y","article-title":"Keratin 80 promotes migration and invasion of colorectal carcinoma by interacting with PRKDC via activating the AKT pathway","volume":"9","author":"Li","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218680_bib37","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1233009","article-title":"Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO","volume":"339","author":"Clark","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.canlet.2026.218680_bib38","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.semcancer.2022.11.007","article-title":"Role of LDH in tumor glycolysis: regulation of LDHA by small molecules for cancer therapeutics","volume":"87","author":"Sharma","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2026.218680_bib39","first-page":"319","article-title":"Ueber den stoffwechsel der tumoren","volume":"152","author":"Warburg","year":"1924","journal-title":"Biochem. Z."},{"key":"10.1016\/j.canlet.2026.218680_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.abb2683","article-title":"Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity","volume":"371","author":"Xu","year":"2021","journal-title":"Science."},{"key":"10.1016\/j.canlet.2026.218680_bib41","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.immuni.2021.04.008","article-title":"Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses","volume":"54","author":"Xu","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2026.218680_bib42","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201219RR","article-title":"LDHA deficiency inhibits trophoblast proliferation via the PI3K\/AKT\/FOXO1\/CyclinD1 signaling pathway in unexplained recurrent spontaneous abortion","volume":"37","author":"Zhu","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.canlet.2026.218680_bib43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/ars.2009.2817","article-title":"Intermediate filament carbonylation during acute acrolein toxicity in A549 lung cells: functional consequences, chaperone redistribution, and protection by bisulfite","volume":"12","author":"Burcham","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.canlet.2026.218680_bib44","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3109\/03630269.2013.790828","article-title":"Elevated serum levels of cell death circulating biomarkers, M30 and M65, in patients with \u03b2-thalassemia major","volume":"37","author":"Esmaeil","year":"2013","journal-title":"Hemoglobin"},{"key":"10.1016\/j.canlet.2026.218680_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.603472","article-title":"Honokiol inhibits melanoma growth by targeting keratin 18 in vitro and in vivo","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2026.218680_bib46","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1038\/s41416-023-02210-4","article-title":"Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics","volume":"128","author":"Takano","year":"2023","journal-title":"Br. J. Cancer"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526004441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526004441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:42:57Z","timestamp":1785894177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526004441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S0304383526004441"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218680","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KRT18 promotes the high-grade meningioma proliferation by interacting with LDHA to activate glycolysis and the PI3K\/AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218680"}}