{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:45:33Z","timestamp":1785725133599,"version":"3.56.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019920","name":"R\u00e9seau Soci\u00e9t\u00e9s d'Acc\u00e9l\u00e9ration du Transfert de Technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.canlet.2026.218723","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:09:41Z","timestamp":1783627781000},"page":"218723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Methionine restriction plus vitamin B12 antagonism overcomes methionine independence for cancer therapy"],"prefix":"10.1016","volume":"657","author":[{"given":"Valentin","family":"Lacombe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Aurri\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e9lie","family":"Mellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Khiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Giachetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-8415","authenticated-orcid":false,"given":"Flavien","family":"Bessaguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6871-2345","authenticated-orcid":false,"given":"Sarah","family":"Bellal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Reynier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Genevi\u00e8ve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Urbanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2736-3349","authenticated-orcid":false,"given":"Guy","family":"Lenaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218723_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccell.2019.12.011","article-title":"Emerging roles for branched-chain amino acid metabolism in cancer","volume":"37","author":"Sivanand","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218723_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0305-7372(03)00118-X","article-title":"Methionine dependency and cancer treatment","volume":"29","author":"Cellarier","year":"2003","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.canlet.2026.218723_bib3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ctrv.2012.01.004","article-title":"A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension","volume":"38","author":"Cavuoto","year":"2012","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.canlet.2026.218723_bib4","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.3390\/nu14102058","article-title":"Diagnostic and therapeutic perspectives associated to cobalamin-dependent metabolism and transcobalamins' synthesis in solid cancers","volume":"14","author":"Lacombe","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.canlet.2026.218723_bib5","first-page":"2249","article-title":"Targeting the methionine addiction of cancer","volume":"12","author":"Sedillo","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0003-9861(59)90225-5","article-title":"Quantitative nutritional studies with water-soluble, chemically defined diets. VIII. The forced feeding of diets each lacking in one essential amino acid","volume":"81","author":"Sugimura","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2026.218723_bib7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0006-291X(83)91218-4","article-title":"The metabolic defect of methionine dependence occurs frequently in human tumor cell lines","volume":"117","author":"Mecham","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib8","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3390\/biom10040568","article-title":"Methionine dependence of cancer","volume":"10","author":"Kaiser","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2026.218723_bib9","first-page":"634","article-title":"Effect of nutritional and enzymatic methionine deprivation upon human normal and malignant cells in tissue culture","volume":"40","author":"Kreis","year":"1980","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40170-025-00405-2","article-title":"The role of B12 deficiency and methionine synthase in methionine-dependent cancer cells","volume":"13","author":"Husseiny","year":"2025","journal-title":"Cancer Metabol."},{"key":"10.1016\/j.canlet.2026.218723_bib11","series-title":"Methionine Dependence of Cancer and Aging [Internet]","first-page":"13","article-title":"Altered methionine metabolism in cancer cells","author":"Hoffman","year":"2019"},{"key":"10.1016\/j.canlet.2026.218723_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bcp.2018.05.003","article-title":"Exploiting methionine restriction for cancer treatment","volume":"154","author":"Chaturvedi","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2026.218723_bib13","first-page":"5235","article-title":"Phase II trial of the association of a methionine-free diet with cystemustine therapy in melanoma and glioma","volume":"29","author":"Thivat","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41586-019-1437-3","article-title":"Dietary methionine influences therapy in mouse cancer models and alters human metabolism","volume":"572","author":"Gao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218723_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000313700","article-title":"Dietary methionine restriction with FOLFOX regimen as first line therapy of metastatic colorectal cancer: a feasibility study","volume":"78","author":"Durando","year":"2010","journal-title":"Oncology"},{"key":"10.1016\/j.canlet.2026.218723_bib16","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/1097-0142(19951001)76:7<1275::AID-CNCR2820760727>3.0.CO;2-Z","article-title":"Effect of methionine-deprived total parenteral nutrition on tumor protein turnover in rats","volume":"76","author":"Yoshida","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3748\/wjg.v7.i5.698","article-title":"Influence of L-methionine-deprived total parenteral nutrition with 5-fluorouracil on gastric cancer and host metabolism","volume":"7","author":"Xiao","year":"2001","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.canlet.2026.218723_bib18","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0024-3205(96)00672-8","article-title":"Methionine deprivation and methionine analogs inhibit cell proliferation and growth of human xenografted gliomas","volume":"60","author":"Poirson-Bichat","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2026.218723_bib19","series-title":"Methionine Dependence of Cancer and Aging [Internet]","first-page":"231","article-title":"Pilot phase I clinical trial of methioninase on high-stage cancer patients: rapid depletion of circulating methionine","author":"Hoffman","year":"2019"},{"key":"10.1016\/j.canlet.2026.218723_bib20","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.21873\/anticanres.14629","article-title":"Oral recombinant methioninase sensitizes a bladder cancer orthotopic xenograft mouse model to low-dose cisplatinum and prevents metastasis","volume":"40","author":"Sun","year":"2020","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib21","article-title":"The potential of methioninase for cancer treatment","volume":"1879","author":"Abo","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.canlet.2026.218723_bib22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1207\/s15327914nc5402_6","article-title":"Methionine restriction inhibits colon carcinogenesis","volume":"54","author":"Komninou","year":"2006","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/01635589709514624","article-title":"Effect of long\u2010term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice","volume":"29","author":"Kokkinakis","year":"1997","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12885-016-2367-1","article-title":"Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice","volume":"16","author":"Hens","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib25","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1207\/S15327914NC422_2","article-title":"Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction","volume":"42","author":"Epner","year":"2002","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib26","first-page":"3937","article-title":"Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients","volume":"16","author":"Tan","year":"1996","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib27","first-page":"3857","article-title":"Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients","volume":"17","author":"Tan","year":"1997","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MPA.0000000000001709","article-title":"Triple-methyl blockade with recombinant methioninase, cycloleucine, and azacitidine arrests a pancreatic cancer patient-derived orthotopic xenograft model","volume":"50","author":"Sugisawa","year":"2021","journal-title":"Pancreas"},{"key":"10.1016\/j.canlet.2026.218723_bib29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00280-021-04261-x","article-title":"Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model","volume":"88","author":"Sugisawa","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.canlet.2026.218723_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.149418","article-title":"Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: a potential curable approach to a clinically-incurable disease","volume":"695","author":"Kubota","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/01635581.2024.2340784","article-title":"A phase I trial of a methionine restricted diet with concurrent radiation therapy","volume":"76","author":"Mattes","year":"2024","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2020.07.034","article-title":"Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model","volume":"492","author":"Yamamoto","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218723_bib33","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1038\/s41467-023-40518-0","article-title":"Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade","volume":"14","author":"Xue","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib34","first-page":"2479","article-title":"Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture","volume":"53","author":"Guo","year":"1993","journal-title":"Cancer Res. American Association for Cancer Research"},{"key":"10.1016\/j.canlet.2026.218723_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.21873\/invivo.13432","article-title":"[11C] Methionine-PET imaging as a cancer biomarker for methionine addiction and sensitivity to Methioninerestriction- based combination chemotherapy","volume":"38","author":"Kubota","year":"2024","journal-title":"In Vivo"},{"key":"10.1016\/j.canlet.2026.218723_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40170-016-0148-6","article-title":"Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells","volume":"4","author":"Borrego","year":"2016","journal-title":"Cancer Metabol."},{"key":"10.1016\/j.canlet.2026.218723_bib37","series-title":"Methionine Dependence of Cancer and Aging [Internet]","first-page":"37","article-title":"Isolation and characterization of methionine-independent clones from methionine-dependent cancer cells","author":"Borrego","year":"2019"},{"key":"10.1016\/j.canlet.2026.218723_bib38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s43018-019-0020-z","article-title":"Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer","volume":"1","author":"Stewart","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jcp.22220","article-title":"High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death","volume":"225","author":"Habibi","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2026.218723_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107997","article-title":"O-glycosylation is essential for cell surface expression of the transcobalamin receptor CD320","volume":"300","author":"Du","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2026.218723_bib41","first-page":"415","article-title":"Induction of caspase-dependent and -independent apoptosis in response to methionine restriction","volume":"22","author":"Lu","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2026.218723_bib42","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1134\/S0006297923070076","article-title":"Targeting methionine addiction of cancer cells with methioninase","volume":"88","author":"Pokrovsky","year":"2023","journal-title":"Biochemistry (Mosc)."},{"key":"10.1016\/j.canlet.2026.218723_bib43","article-title":"Vitamin B12 deficiency","volume":"3","author":"Green","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.canlet.2026.218723_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075312","article-title":"4-Ethylphenyl-Cobalamin impairs tissue uptake of vitamin B12 and causes vitamin B12 deficiency in mice","volume":"8","author":"Mutti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218723_bib45","first-page":"861","article-title":"Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet","volume":"7","author":"Breillout","year":"1987","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib46","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1073\/pnas.79.14.4248","article-title":"Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells","volume":"79","author":"Coalson","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218723_bib47","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3390\/nu16070997","article-title":"Rescue of methionine dependence by cobalamin in a human colorectal cancer cell line","volume":"16","author":"Garg","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.canlet.2026.218723_bib48","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.21873\/anticanres.14958","article-title":"Lowering and stabilizing PSA levels in advanced-prostate cancer patients with oral methioninase","volume":"41","author":"Han","year":"2021","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4161\/cbt.11.7.14948","article-title":"Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies","volume":"11","author":"Bertino","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2026.218723_bib50","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1158\/1078-0432.CCR-14-2792","article-title":"Methionine deprivation induces a targetable vulnerability in triple-negative breast cancer cells by enhancing TRAIL Receptor-2 expression","volume":"21","author":"Strekalova","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0304-3835(01)00852-7","article-title":"Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway","volume":"179","author":"Lu","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218723_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005158","article-title":"Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis","volume":"11","author":"Tang","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.canlet.2026.218723_bib53","first-page":"4685","article-title":"Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis","volume":"62","author":"Machover","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218723_bib54","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1124\/jpet.119.256537","article-title":"Effects in cancer cells of the recombinant l-Methionine gamma-lyase from brevibacterium aurantiacum. Encapsulation in human erythrocytes for sustained l-Methionine elimination","volume":"369","author":"Machover","year":"2019","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.canlet.2026.218723_bib55","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.bbrc.2020.09.108","article-title":"Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells","volume":"533","author":"Yamamoto","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib56","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","article-title":"Cancer epigenetics: from mechanism to therapy","volume":"150","author":"Dawson","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218723_bib57","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S1357-2725(03)00098-0","article-title":"Expression of spermidine\/spermine N1-acetyltransferase in HeLa cells is regulated by amino acid sufficiency","volume":"35","author":"Aubel","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218723_bib58","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1073\/pnas.58.4.1527","article-title":"The effects of methionine deprivation on ribosome synthesis in HeLa cells","volume":"58","author":"Vaughan","year":"1967","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218723_bib59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/bjc.1980.210","article-title":"Effect of methionine deprivation on methylation and synthesis of macromolecules","volume":"42","author":"Tisdale","year":"1980","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218723_bib60","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.nut.2009.10.006","article-title":"Methionine-deficient diet induces post-transcriptional downregulation of cystathionine \u03b2-synthase","volume":"26","author":"Tang","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.canlet.2026.218723_bib61","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.ccell.2023.05.005","article-title":"Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity","volume":"41","author":"Fang","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218723_bib62","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1038\/s41467-023-38316-9","article-title":"Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells","volume":"14","author":"Pandit","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib63","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/gutjnl-2022-326928","article-title":"Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts","volume":"72","author":"Li","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2026.218723_bib64","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","article-title":"Cancer SLC43A2 alters T cell methionine metabolism and histone methylation","volume":"585","author":"Bian","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218723_bib65","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/s41467-021-21804-1","article-title":"Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma","volume":"12","author":"Hung","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib66","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1158\/1535-7163.MCT-05-0141","article-title":"Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma","volume":"4","author":"Kokkinakis","year":"2005","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2026.218723_bib67","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3390\/jcm9020474","article-title":"Strength of the association of elevated vitamin B12 and solid cancers: an adjusted case-control study","volume":"9","author":"Urbanski","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.canlet.2026.218723_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92945-y","article-title":"Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer","volume":"11","author":"Lacombe","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218723_bib69","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.5114\/aoms\/140974","article-title":"Evolution of plasma vitamin B12 in patients with solid cancers during curative versus supportive care","volume":"17","author":"Lacombe","year":"2021","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.canlet.2026.218723_bib70","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1474-9726.2005.00152.x","article-title":"Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance","volume":"4","author":"Miller","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.canlet.2026.218723_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101940","article-title":"Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21","volume":"41","author":"Ren","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.canlet.2026.218723_bib72","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1039\/C9FO02819F","article-title":"Dietary methionine restriction improves the impairment of cardiac function in middle-aged obese mice","volume":"11","author":"Han","year":"2020","journal-title":"Food Funct. The Royal Society of Chemistry"},{"key":"10.1016\/j.canlet.2026.218723_bib73","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1038\/s41467-023-43550-2","article-title":"Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in drosophila","volume":"14","author":"Kosakamoto","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib74","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/jn\/119.11.1716","article-title":"Whole rat embryos require methionine for neural tube closure when cultured on cow serum","volume":"119","author":"Coelho","year":"1989","journal-title":"J. Nutr."},{"key":"10.1016\/j.canlet.2026.218723_bib75","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads1532","article-title":"Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner","volume":"11","author":"Hern\u00e1ndez-Arciga","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2026.218723_bib76","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/oby.21806","article-title":"Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype. Obesity (silver spring)","volume":"25","author":"Forney","year":"2017","journal-title":"Silver Spring, Md"},{"key":"10.1016\/j.canlet.2026.218723_bib77","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v25.i4.20","article-title":"Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents","volume":"25","author":"Gupta","year":"2008","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.canlet.2026.218723_bib78","series-title":"Methionine Dependence of Cancer and Aging [Internet]","first-page":"49","article-title":"Tumor-specific S\/G2-Phase cell cycle arrest of cancer cells by methionine restriction","author":"Hoffman","year":"2019"},{"key":"10.1016\/j.canlet.2026.218723_bib79","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.4161\/cc.22767","article-title":"Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells","volume":"11","author":"Booher","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2026.218723_bib80","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbrc.2022.12.062","article-title":"Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer","volume":"643","author":"Miyake","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.21873\/cgp.20246","article-title":"Combination methionine-methylation-axis blockade: a novel approach to target the methionine addiction of cancer","volume":"18","author":"Higuchi","year":"2021","journal-title":"Cancer Genomics Proteomics"},{"key":"10.1016\/j.canlet.2026.218723_bib82","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","article-title":"Next-generation characterization of the cancer cell line encyclopedia","volume":"569","author":"Ghandi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218723_bib83","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2019.12.023","article-title":"Quantitative proteomics of the cancer cell line encyclopedia","volume":"180","author":"Nusinow","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218723_bib84","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s42255-022-00730-6","article-title":"Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness","volume":"5","author":"Cheng","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.canlet.2026.218723_bib85","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41467-024-55769-8","article-title":"Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance","volume":"16","author":"Hong","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218723_bib86","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1073\/pnas.77.12.7306","article-title":"Reversible growth arrest in simian virus 40-transformed human fibroblasts","volume":"77","author":"Hoffman","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218723_bib87","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00109-024-02472-2","article-title":"The caspase-inhibitor emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells","volume":"102","author":"Nassauer","year":"2024","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.canlet.2026.218723_bib88","doi-asserted-by":"crossref","first-page":"W488","DOI":"10.1093\/nar\/gkaa216","article-title":"SynergyFinder 2.0: visual analytics of multi-drug combination synergies","volume":"48","author":"Ianevski","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2026.218723_bib89","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/anie.201209651","article-title":"Access to organometallic arylcobaltcorrins through radical synthesis: 4\u2010ethylphenylcobalamin, a potential \u201cAntivitamin B12 .\u201d","volume":"52","author":"Ruetz","year":"2013","journal-title":"Angew. Chem. Int. Ed."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526004878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526004878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:18:56Z","timestamp":1785723536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526004878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":89,"alternative-id":["S0304383526004878"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218723","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methionine restriction plus vitamin B12 antagonism overcomes methionine independence for cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218723","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218723"}}