{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:06:40Z","timestamp":1789110400311,"version":"build-2803163510"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017501","name":"Science-Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","award":["2024DBXM003"],"award-info":[{"award-number":["2024DBXM003"]}],"id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["823QN366"],"award-info":[{"award-number":["823QN366"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273094"],"award-info":[{"award-number":["82273094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.canlet.2026.218774","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:03:53Z","timestamp":1785884633000},"page":"218774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tumor-derived CDHR2-enriched extracellular vesicles engage ANPEP on liver sinusoidal endothelial cells to facilitate transendothelial migration in PDAC"],"prefix":"10.1016","volume":"659","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuilin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songsong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5934-5879","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-8547","authenticated-orcid":false,"given":"Ming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218774_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2025.116099","article-title":"G. Dutch pancreatic cancer, 10-year survival after resection of pancreatic ductal adenocarcinoma with pathological re-examination of a nationwide cohort","volume":"231","author":"Verkolf","year":"2025","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218774_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41392-025-02562-8","article-title":"Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis","volume":"11","author":"Yu","year":"2026","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218774_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41698-025-01202-2","article-title":"Deciphering the liver's role in pancreatic cancer metastasis: pathways and therapeutic approaches","volume":"9","author":"Inzunza","year":"2025","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.canlet.2026.218774_bib4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41392-024-01955-5","article-title":"Multi-stage mechanisms of tumor metastasis and therapeutic strategies","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218774_bib5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41575-018-0020-y","article-title":"Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity","volume":"15","author":"Shetty","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2026.218774_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/molecules31081339","article-title":"Diagnostic potential of exosomes in colorectal cancer: current advances and future perspectives","volume":"31","author":"Suska","year":"2026","journal-title":"Molecules"},{"key":"10.1016\/j.canlet.2026.218774_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030456","article-title":"The roles of exosomes in metastasis of sarcoma: from biomarkers to therapeutic targets","volume":"13","author":"Tan","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2026.218774_bib8","doi-asserted-by":"crossref","first-page":"864","DOI":"10.7150\/jca.27663","article-title":"Cadherin related family member 2 acts as A tumor suppressor by inactivating AKT in human hepatocellular carcinoma","volume":"10","author":"Xia","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.canlet.2026.218774_bib9","article-title":"Proteomic and serological markers for diagnosing cardia gastric cancer and precursor lesions in a Chinese population","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218774_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116895","article-title":"Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization","volume":"45","author":"Bejarano","year":"2026","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218774_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114487","article-title":"Microfluidic-based exosome isolation and highly sensitive aptamer exosome membrane protein detection for lung cancer diagnosis","volume":"214","author":"Zhao","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.canlet.2026.218774_bib12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3343\/alm.2024.0492","article-title":"Pancreatic cancer detection and differentiation from chronic pancreatitis: potential biomarkers identified through a high-throughput multiplex proteomic assay and machine learning-based analysis","volume":"45","author":"Kim","year":"2025","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.canlet.2026.218774_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218774_bib14","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ncb3169","article-title":"Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver","volume":"17","author":"Costa-Silva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218774_bib15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1349-7006.2010.01826.x","article-title":"Aminopeptidase N (CD13) as a target for cancer chemotherapy","volume":"102","author":"Wickstrom","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2026.218774_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2026.102843","article-title":"Targeted extracellular vesicle-photoimmunotherapy remodels stromal-immune microenvironment to boost chemo-immunotherapy in preclinical models","author":"Qu","year":"2026","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.canlet.2026.218774_bib17","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526005380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526005380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:31:19Z","timestamp":1789108279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526005380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":17,"alternative-id":["S0304383526005380"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218774","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor-derived CDHR2-enriched extracellular vesicles engage ANPEP on liver sinusoidal endothelial cells to facilitate transendothelial migration in PDAC","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218774","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218774"}}