{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:52:13Z","timestamp":1791341533148,"version":"4.3.1"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI21\/00470"],"award-info":[{"award-number":["PI21\/00470"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.canlet.2026.218837","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:08:43Z","timestamp":1789085323000},"page":"218837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Connexin-mediated regulation of nuclear activity in cancer: Direct and indirect mechanisms"],"prefix":"10.1016","volume":"660","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-3923","authenticated-orcid":false,"given":"T\u00e2nia","family":"Martins-Marques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3157-1028","authenticated-orcid":false,"given":"Aldo","family":"Di Vito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-8447","authenticated-orcid":false,"given":"Henrique","family":"Gir\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0763-2695","authenticated-orcid":false,"given":"Trond","family":"Aasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218837_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002576","article-title":"Gap junctions","volume":"1","author":"Goodenough","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.canlet.2026.218837_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/biology13050298","article-title":"Connexin gap junction channels and hemichannels: insights from high-resolution structures","volume":"13","author":"Jagielnicki","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.canlet.2026.218837_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbamem.2017.05.008","article-title":"The connexin 43 C-terminus: a tail of many tales","volume":"1860","author":"Leithe","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.canlet.2026.218837_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/15419060802014222","article-title":"Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes","volume":"15","author":"Iacobas","year":"2008","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.canlet.2026.218837_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physiolgenomics.00229.2003","article-title":"Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart","volume":"20","author":"Iacobas","year":"2005","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.canlet.2026.218837_bib68","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.230258","article-title":"Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells","volume":"13","author":"Martins-Marques","year":"2023","journal-title":"Open Biol."},{"key":"10.1016\/j.canlet.2026.218837_bib88","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1523\/JNEUROSCI.21-19-07534.2001","article-title":"Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice","volume":"21","author":"Oguro","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.canlet.2026.218837_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1996.0001q.x","article-title":"Connections with connexins: the molecular basis of direct intercellular signaling","volume":"238","author":"Bruzzone","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.canlet.2026.218837_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.795401","article-title":"The cGAS\/STING pathway: a novel target for cancer therapy","volume":"12","author":"Gan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218837_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/ars.2008.2146","article-title":"Oxidative-Dependent integration of signal transduction with intercellular gap junctional communication in the control of gene expression","volume":"11","author":"Upham","year":"2009","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.canlet.2026.218837_bib11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/bies.201500195","article-title":"Polyamine signal through gap junctions: a key regulator of proliferation and gap-junction organization in mammalian tissues?","volume":"38","author":"Hamon","year":"2016","journal-title":"Bioessays"},{"key":"10.1016\/j.canlet.2026.218837_bib12","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1091\/mbc.e12-10-0729","article-title":"An intercellular polyamine transfer via gap junctions regulates proliferation and response to stress in epithelial cells","volume":"24","author":"Desforges","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.canlet.2026.218837_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrd.2015.1","article-title":"Gasotransmitters in cancer: from pathophysiology to experimental therapy","volume":"15","author":"Szabo","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2026.218837_bib19","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.3390\/cells11172701","article-title":"Inhibition of gap junctional intercellular communication upregulates pluripotency gene expression in endogenous pluripotent muse cells","volume":"11","author":"Hatabi","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2026.218837_bib20","doi-asserted-by":"crossref","first-page":"24377","DOI":"10.1074\/jbc.M212554200","article-title":"New Collective Author, gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters","volume":"278","author":"Stains","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2026.218837_bib24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature18268","article-title":"Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer","volume":"533","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218837_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082335","article-title":"Intercellular redistribution of cAMP underlies selective suppression of cancer cell growth by Connexin 26","volume":"8","author":"Chandrasekhar","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218837_bib22","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cellsig.2016.04.014","article-title":"Communication of cAMP by connexin43 gap junctions regulates osteoblast signaling and gene expression","volume":"28","author":"Gupta","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.canlet.2026.218837_bib23","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1242\/jcs.081695","article-title":"A functional channel is necessary for growth suppression by Cx37","volume":"124","author":"Good","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2026.218837_bib26","doi-asserted-by":"crossref","first-page":"15566","DOI":"10.18632\/oncotarget.3904","article-title":"Gap junctions modulate glioma invasion by direct transfer of microRNA","volume":"6","author":"Hong","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2026.218837_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01899","article-title":"Connexin 43 hemichannel activity promoted by pro-inflammatory cytokines and high glucose alters endothelial cell function","volume":"9","author":"S\u00e1ez","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218837_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12964-023-01245-7","article-title":"Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury","volume":"21","author":"Roger","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.canlet.2026.218837_bib39","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/j.yexcr.2013.10.002","article-title":"Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: role of \u03b2-catenin\/connexin43 association","volume":"319","author":"Talhouk","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.canlet.2026.218837_bib40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/cancers11030339","article-title":"Connexin 43 loss triggers cell cycle entry and invasion in non-neoplastic breast epithelium: a role for noncanonical wnt signaling","volume":"11","author":"Fostok","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.canlet.2026.218837_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2025.2589645","article-title":"Nuclear translocation of Cx43 promotes to CRC progression and associates with \u03b2-catenin accumulation","volume":"26","author":"Wang","year":"2025","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2026.218837_bib45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/mp.54.5.293","article-title":"Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV)","volume":"54","author":"Gupta","year":"2001","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.canlet.2026.218837_bib46","doi-asserted-by":"crossref","first-page":"36943","DOI":"10.1074\/jbc.M403952200","article-title":"CCN3 (NOV) interacts with Connexin43 in C6 glioma cells: possible mechanism OF connexin-mediated growth suppression","volume":"279","author":"Fu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2026.218837_bib52","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.3892\/ijo.2017.3985","article-title":"Downregulated connexin 32 promotes EMT through the Wnt\/\u03b2-catenin pathway by targeting Snail expression in hepatocellular carcinoma","volume":"50","author":"Yang","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2026.218837_bib53","article-title":"Connexin restrains EMT by dual-domain mechanisms to preserve epithelial identity","author":"Ma","year":"2025","journal-title":"Res Sq"},{"key":"10.1016\/j.canlet.2026.218837_bib54","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ags3.12552","article-title":"Cytoplasmic localization of connexin 26 suppresses transition of \u03b2\u2010catenin into the nucleus in intestinal\u2010 and mix\u2010type gastric cancer","volume":"6","author":"Nakazawa","year":"2022","journal-title":"Ann. Gastroenterol. Surg."},{"key":"10.1016\/j.canlet.2026.218837_bib36","doi-asserted-by":"crossref","first-page":"49819","DOI":"10.18632\/oncotarget.10454","article-title":"Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes","volume":"7","author":"Gonz\u00e1lez-S\u00e1nchez","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2026.218837_bib37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.stemcr.2017.06.007","article-title":"A short Region of Connexin43 reduces human glioma stem cell migration, invasion, and survival through Src, PTEN, and FAK","volume":"9","author":"Jara\u00edz-Rodr\u00edguez","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.canlet.2026.218837_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10735-026-10786-3","article-title":"Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src\/PTEN\/FAK axis","volume":"57","author":"Chi","year":"2026","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.canlet.2026.218837_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116303","article-title":"Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis","volume":"44","author":"Mulkearns-Hubert","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218837_bib51","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201685","article-title":"Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest","volume":"6","author":"Acharya","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.canlet.2026.218837_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/srep15365","article-title":"Interaction of Cx43 with Hsc70 regulates G1\/S transition through CDK inhibitor p27","volume":"5","author":"Hino","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218837_bib50","first-page":"1623","article-title":"A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2)","volume":"63","author":"Zhang","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218837_bib42","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1091\/mbc.e06-12-1064","article-title":"Cx43 mediates TGF-\u03b2 signaling through competitive smads binding to microtubules","volume":"18","author":"Dai","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.canlet.2026.218837_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.slast.2024.100190","article-title":"Connexin 43 controls metastatic behavior in triple negative breast cancer through TGF\u03b21-Smad3-intergin \u03b1V signaling axis based on optical image diagnosis","volume":"29","author":"Fu","year":"2024","journal-title":"SLAS Technol"},{"key":"10.1016\/j.canlet.2026.218837_bib44","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41419-025-07514-2","article-title":"Cytoplasmic connexin43-microtubule interactions promote glioblastoma stem-like cell maintenance and tumorigenicity","volume":"16","author":"Smyth","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218837_bib55","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1186\/s12967-025-06983-5","article-title":"CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability","volume":"23","author":"He","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218837_bib56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1098-2744(199608)16:4<203::AID-MC4>3.0.CO;2-G","article-title":"Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells","volume":"16","author":"de Feijter","year":"1996","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2026.218837_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11030320","article-title":"Insight into the role and regulation of gap junction genes in lung cancer and identification of nuclear Cx43 as a putative biomarker of poor prognosis","volume":"11","author":"Aasen","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.canlet.2026.218837_bib77","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/cam4.730","article-title":"Expression of a gap junction protein, connexin43, in a large panel of human gliomas: new insights","volume":"5","author":"Crespin","year":"2016","journal-title":"Cancer Med."},{"key":"10.1016\/j.canlet.2026.218837_bib58","article-title":"Levonorgestrel inhibits human endometrial cell proliferation through the upregulation of gap junctional intercellular communication via the nuclear translocation of Ser 255 phosphorylated Cx43","volume":"2015","author":"Zhao","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.canlet.2026.218837_bib59","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1073\/pnas.1013124108","article-title":"N\u03b5-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart","volume":"108","author":"Colussi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218837_bib61","doi-asserted-by":"crossref","first-page":"R248","DOI":"10.1152\/ajpregu.00268.2018","article-title":"Wnt signaling regulates cytosolic translocation of connexin 43","volume":"317","author":"Hou","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.canlet.2026.218837_bib62","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s10495-012-0800-8","article-title":"The anti-mitotic drug griseofulvin induces apoptosis of human germ cell tumor cells through a connexin 43-dependent molecular mechanism","volume":"18","author":"Mauro","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.canlet.2026.218837_bib67","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1074\/mcp.M115.050211","article-title":"Proteomic analysis of connexin 43 reveals novel interactors related to osteoarthritis","volume":"14","author":"Gago-Fuentes","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.canlet.2026.218837_bib75","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1038\/s41467-025-60971-3","article-title":"Cx43 enhances response to BRAF\/MEK inhibitors by reducing DNA repair capacity","volume":"16","author":"Varela-V\u00e1zquez","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218837_bib64","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.celrep.2013.10.009","article-title":"Autoregulation of connexin43 gap junction formation by internally translated isoforms","volume":"5","author":"Smyth","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218837_bib65","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1038\/s41467-018-06368-x","article-title":"Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo","volume":"9","author":"Kotini","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218837_bib66","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3390\/biom10030473","article-title":"An alternatively translated connexin 43 isoform, GJA1-11k, localizes to the nucleus and can inhibit cell cycle progression","volume":"10","author":"Epifantseva","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2026.218837_bib78","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12964-025-02151-w","article-title":"Connexin 46 in the nucleus of cancer cells: a possible role as transcription modulator","volume":"23","author":"Fern\u00e1ndez-Olivares","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.canlet.2026.218837_bib70","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/1759-7714.13435","article-title":"Cx43 and AKAP95 regulate G1\/S conversion by competitively binding to cyclin E1\/E2 in lung cancer cells","volume":"11","author":"Chen","year":"2020","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.canlet.2026.218837_bib71","article-title":"Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218837_bib72","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/mc.23781","article-title":"AKAP95 regulates ubiquitination and degradation of cyclin Ds\/Es, influencing the G1\/S transition of lung cancer cells","volume":"63","author":"Deng","year":"2024","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2026.218837_bib80","article-title":"Connexin 26 functions as a direct transcriptional regulator during the cochlea development","volume":"13","author":"Liu","year":"2026","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2026.218837_bib81","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41467-018-02938-1","article-title":"Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase","volume":"9","author":"Thiagarajan","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218837_bib82","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1158\/1535-7163.MCT-21-0783","article-title":"Targeting NANOG and FAK via Cx26-derived cell-penetrating peptides in triple-negative breast cancer","volume":"23","author":"Mulkearns-Hubert","year":"2024","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2026.218837_bib4","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/2091248a0","article-title":"Intercellular communication and the control of tissue growth: lack of communication between cancer cells","volume":"209","author":"Loewenstein","year":"1966","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218837_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrc.2016.105","article-title":"Gap junctions and cancer: communicating for 50 years","volume":"16","author":"Aasen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2026.218837_bib6","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3390\/biom10121654","article-title":"Connexins in cancer: Jekyll or Hyde?","volume":"10","author":"Mulkearns-Hubert","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2026.218837_bib7","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.tcb.2019.07.001","article-title":"Biological functions of Connexin43 beyond intercellular communication","volume":"29","author":"Martins-Marques","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2026.218837_bib14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.lfs.2010.09.013","article-title":"Calcium wave signaling in cancer cells","volume":"87","author":"Parkash","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2026.218837_bib15","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00029.2011","article-title":"Intercellular Ca2+ waves: mechanisms and function","volume":"92","author":"Leybaert","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2026.218837_bib16","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/cdd.2011.176","article-title":"Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis","volume":"19","author":"Decrock","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2026.218837_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax8933","article-title":"Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation","volume":"14","author":"Lorusso","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218837_bib27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1113\/jphysiol.2005.090985","article-title":"Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions","volume":"568","author":"Valiunas","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.canlet.2026.218837_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/srep19884","article-title":"Gap junction mediated miRNA intercellular transfer and gene regulation: a novel mechanism for intercellular genetic communication","volume":"6","author":"Zong","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218837_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00237","article-title":"Possible role of hemichannels in cancer","volume":"5","author":"Schalper","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.canlet.2026.218837_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2025.120013","article-title":"Are connexin hemichannels playing any role in cancer?","volume":"1872","author":"Tittarelli","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.canlet.2026.218837_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041043","article-title":"The potential for connexin hemichannels to drive breast cancer progression through regulation of the inflammatory response","volume":"19","author":"Rhett","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218837_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114377","article-title":"Antibody-activation of connexin hemichannels in bone osteocytes with ATP release suppresses breast cancer and osteosarcoma malignancy","volume":"43","author":"Riquelme","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218837_bib35","doi-asserted-by":"crossref","first-page":"19190","DOI":"10.1074\/jbc.M609653200","article-title":"Differential potency of dominant negative Connexin43 mutants in oculodentodigital dysplasia","volume":"282","author":"Gong","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2026.218837_bib47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1478-811X-12-31","article-title":"Internal translation of the connexin 43 transcript","volume":"12","author":"Salat-Canela","year":"2014","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.canlet.2026.218837_bib57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00441-002-0645-5","article-title":"Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells","volume":"311","author":"Leykauf","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.canlet.2026.218837_bib60","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/mc.20393","article-title":"Aberrant expression and localization of connexin43 and connexin 30 in a rat glioma cell line","volume":"47","author":"Mennecier","year":"2008","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2026.218837_bib63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1021152709313","article-title":"The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth","volume":"242","author":"Dang","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.canlet.2026.218837_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2025.103090","article-title":"Connexin 43 as a novel Ca2+ transport pathway in the nuclear envelope of human induced pluripotent stem cell derived cardiomyocytes","volume":"132","author":"Toth","year":"2025","journal-title":"Cell Calcium"},{"key":"10.1016\/j.canlet.2026.218837_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182495","article-title":"Distinctive actions of connexin 46 and connexin 50 in anterior pituitary folliculostellate cells","volume":"12","author":"Vitale","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218837_bib74","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/15419060902783833","article-title":"Identification of binding partners for the cytoplasmic loop of Connexin43: a novel interaction with \u03b2-Tubulin","volume":"15","author":"Kang","year":"2009","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.canlet.2026.218837_bib79","article-title":"Internal translation of truncated protein isoforms throughout the connexin gene family","volume":"13","author":"Mu\u00f1oz","year":"2026","journal-title":"Genes Dis."},{"key":"10.1016\/j.canlet.2026.218837_bib83","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/biology13070468","article-title":"Protector role of Cx30.2 in pancreatic \u03b2-Cell against glucotoxicity-induced apoptosis","volume":"13","author":"Ortega-Cuellar","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.canlet.2026.218837_bib84","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/cancers13010058","article-title":"Connexins and cAMP cross-talk in cancer progression and metastasis","volume":"13","author":"Chen","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.canlet.2026.218837_bib85","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/cas.16101","article-title":"Gap junction beta-4 accelerates cell cycle progression and metastasis through MET-AKT activation in pancreatic cancer","volume":"115","author":"Muramatsu","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2026.218837_bib86","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1038\/s41388-019-0741-6","article-title":"Connexins in cancer: bridging the gap to the clinic","volume":"38","author":"Aasen","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218837_bib87","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/cancers16020423","article-title":"Mapping the anti-cancer activity of \u03b1-Connexin carboxyl-terminal (aCT1) peptide in resistant HER2+ breast cancer","volume":"16","author":"Baker","year":"2024","journal-title":"Cancers (Basel)"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:20:24Z","timestamp":1791339624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526006014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":88,"alternative-id":["S0304383526006014"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218837","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connexin-mediated regulation of nuclear activity in cancer: Direct and indirect mechanisms","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218837","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218837"}}