{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:26:22Z","timestamp":1791923182946,"version":"4.3.4"},"reference-count":235,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA267893-01A1"],"award-info":[{"award-number":["R01 CA267893-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019535","name":"Texas Tech University Health Sciences Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019535","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021079","name":"Lizanell and Colbert Coldwell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021079","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.canlet.2026.218845","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:41:54Z","timestamp":1789800114000},"page":"218845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Endometriosis from initiation to innovation: Immune microenvironments, clonal lesion biology, and the emerging therapeutic pipeline"],"prefix":"10.1016","volume":"660","author":[{"given":"Bindu","family":"Santhamma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-7528","authenticated-orcid":false,"given":"Jessica","family":"Chacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Deemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-9961","authenticated-orcid":false,"given":"Dorota","family":"Stary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayla A.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadevi","family":"Subramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Lakshmanaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus J.","family":"Nickisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surinder K.","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-9560","authenticated-orcid":false,"given":"Hareesh B.","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3390\/ijms27020908","article-title":"Endometriosis as a systemic and complex disease: toward phenotype-based classification and personalized therapy","volume":"27","author":"Simancas-Racines","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/AOG.0000000000006181","article-title":"ACOG clinical practice guideline no. 11","volume":"147","year":"2026","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.canlet.2026.218845_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpobgyn.2026.102706","article-title":"Endometriosis in adolescents: a state-of-the-art review","volume":"105","author":"Smith","year":"2026","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogc.2025.103188","article-title":"The financial toxicity of endometriosis: unseen costs and policy gaps","volume":"48","author":"Abousifein","year":"2026","journal-title":"J. Obstet. Gynaecol. Can."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib221","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.contraception.2020.02.004","article-title":"Multicenter, open-label trial to assess the safety and tolerability of drospirenone 4.0 mg over 13 cycles in adolescent females, with a 6-cycle comparative arm with desogestrel 0.075 mg","volume":"101","author":"Apter","year":"2020","journal-title":"Contraception"},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib222","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.contraception.2015.07.014","article-title":"Drospirenone-only oral contraceptive: results from a multicenter noncomparative trial of efficacy, safety and tolerability","volume":"92","author":"Archer","year":"2015","journal-title":"Contraception"},{"issue":"22","key":"10.1016\/j.canlet.2026.218845_bib223","article-title":"Dienogest may reduce estradiol- and inflammatory cytokine-induced cell viability and proliferation and inhibit the pathogenesis of endometriosis: a mouse model","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.canlet.2026.218845_bib224","first-page":"501","article-title":"The association between progestins, nuclear receptors and inflammatory pathways in endometriosis: a systematic review","volume":"33","author":"Grandi","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.canlet.2026.218845_bib225","article-title":"A prospective study examining the effect of dienogest on endometrioma size and symptom severity","author":"Kizilkaya","year":"2022","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib226","first-page":"245","article-title":"Modification of endometrioma size during hormone therapy containing dienogest: a retrospective study","volume":"21","author":"Xholli","year":"2020","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"issue":"8","key":"10.1016\/j.canlet.2026.218845_bib227","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/1471-0528.16157","article-title":"A core outcome set for future endometriosis research: an international consensus development study","volume":"127","author":"Duffy","year":"2020","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib228","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/aogs.14694","article-title":"Developing a set of patient-centered outcomes for routine use in endometriosis care","volume":"103","author":"Nicolas-Boluda","year":"2024","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"11","key":"10.1016\/j.canlet.2026.218845_bib229","first-page":"2079","article-title":"Liver safety parameters of ulipristal acetate for the treatment of uterine fibroids: a review of the clinical trial data","volume":"33","author":"Donnez","year":"2018","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib230","first-page":"337","article-title":"Ulipristal acetate: insights into the mechanisms implicated in the hepatic toxicity","volume":"16","author":"Dinis-Oliveira","year":"2021","journal-title":"Curr. Drug Saf."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib231","first-page":"791","article-title":"Use of ulipristal acetate and risk of liver disease: a nationwide cohort study","volume":"10","author":"Yoon","year":"2021","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib232","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/13625187.2018.1550576","article-title":"Hormonal contraception in women with endometriosis: a systematic review","volume":"24","author":"Grandi","year":"2019","journal-title":"Eur. J. Contracept. Reprod. Health Care"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib233","article-title":"Dysmenorrhea pattern in adolescence informing adult endometriosis risk","volume":"7","author":"Dai","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib234","first-page":"3030","article-title":"Peritoneal fluid biomarkers in patients with endometriosis: Glycodelin, PP14 and midkine concentrations are increased","volume":"9","author":"Nirgianakis","year":"2020","journal-title":"J. Clin. Med."},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib235","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1158\/1535-7163.MCT-25-0130","article-title":"The discovery and characterization of HBS-101, a novel inhibitor of midkine, as a therapeutic agent for the treatment of triple-negative breast cancer","volume":"24","author":"Mahajan","year":"2025","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2026.218845_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1727183","article-title":"Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies","volume":"16","author":"Shifon","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s40168-025-02243-2","article-title":"Microbiota insights in endometriosis","volume":"13","author":"Parpex","year":"2025","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66706-8","article-title":"Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas","volume":"16","author":"Qi","year":"2025","journal-title":"Nat. Commun."},{"issue":"29","key":"10.1016\/j.canlet.2026.218845_bib8","article-title":"Integrative single-cell analysis reveals iron overload-induced senescence and metabolic reprogramming in ovarian endometriosis-associated infertility","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"10","key":"10.1016\/j.canlet.2026.218845_bib9","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1111\/aogs.70022","article-title":"Educational and occupational outcomes during early adulthood following surgically verified endometriosis at a young age: a register-based study","volume":"104","author":"Rasp","year":"2025","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib10","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/biolre\/ioaf164","article-title":"Endometriosis: new insights and opportunities for relief of symptoms","volume":"113","author":"Saunders","year":"2025","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.2025.2975","article-title":"Endometriosis: a review","volume":"334","author":"As-Sanie","year":"2025","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/humrep\/deae269","article-title":"Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study","volume":"40","author":"Tucker","year":"2025","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12958-025-01483-z","article-title":"Global prevalence of adenomyosis and endometriosis: a systematic review and meta-analysis","volume":"23","author":"Wang","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"14","key":"10.1016\/j.canlet.2026.218845_bib14","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.3390\/jcm14145091","article-title":"Non-hormonal strategies in endometriosis: targets with future clinical potential","volume":"14","author":"Ramos-Nino","year":"2025","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/1471-0528.17973","article-title":"Time to diagnose endometriosis: current status, challenges and regional characteristics-a systematic literature review","volume":"132","author":"De Corte","year":"2025","journal-title":"BJOG"},{"issue":"13","key":"10.1016\/j.canlet.2026.218845_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/JCI188787","article-title":"Endometriosis and ovulatory menstruation: beyond the Sampson principle","volume":"135","author":"Bulun","year":"2025","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoae045","article-title":"Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates","volume":"2024","author":"Vigan\u00f2","year":"2024","journal-title":"Hum. Reprod. Open"},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.104345","article-title":"Potential anatomical determinants of retrograde menstruation: a comprehensive narrative review","volume":"49","author":"Vercellini","year":"2024","journal-title":"Reprod. Biomed. Online"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2023.103696","article-title":"How do women get endometriosis?","volume":"48","author":"Guo","year":"2024","journal-title":"Reprod. Biomed. Online"},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib20","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/cjp2.317","article-title":"KRAS mutations and endometriosis burden of disease","volume":"9","author":"Orr","year":"2023","journal-title":"J. Pathol. Clin. Res."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib21","first-page":"151","article-title":"Retrograde menstruation in healthy women and in patients with endometriosis","volume":"64","author":"Halme","year":"1984","journal-title":"Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.canlet.2026.218845_bib22","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/humrep\/deae086","article-title":"M\u00fcllerian anomalies and endometriosis as potential explanatory models for the retrograde menstruation\/implantation and the embryonic remnants\/celomic metaplasia pathogenic theories: a systematic review and meta-analysis","volume":"39","author":"Vercellini","year":"2024","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/stmcls\/sxaf016","article-title":"Stem cells and female reproduction: endometrial physiology, disease and therapy","volume":"43","author":"Cevik","year":"2025","journal-title":"Stem Cell."},{"issue":"10","key":"10.1016\/j.canlet.2026.218845_bib24","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/biomedicines13102435","article-title":"Unlocking the secrets of the endometrium: stem cells, niches and modern methodologies","volume":"13","author":"Huang","year":"2025","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib25","doi-asserted-by":"crossref","first-page":"864","DOI":"10.7150\/ijbs.89795","article-title":"Endometrial stem cells: orchestrating dynamic regeneration of endometrium and their implications in diverse endometrial disorders","volume":"20","author":"Hong","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.canlet.2026.218845_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejogrb.2023.07.017","article-title":"Sox-2 positive cells identified in lymph nodes from endometriosis patients may play a role in the disease pathogenesis","volume":"288","author":"Velho","year":"2023","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12958-023-01099-1","article-title":"Is neonatal uterine bleeding responsible for early-onset endometriosis?","volume":"21","author":"Ogawa","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3390\/biom14050549","article-title":"Is neonatal uterine bleeding involved in early-onset endometriosis?","volume":"14","author":"Habiba","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2026.218845_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2025.1675051","article-title":"Etiologies of endometriosis and model systems: is there a risk of a tunnel vision?","volume":"12","author":"Manavalan","year":"2025","journal-title":"Front. Med."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib30","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/humrep\/deaf057","article-title":"Prevalence of endometriosis in Mayer-Rokitansky-K\u00fcster-Hauser syndrome variants: a systematic review and meta-analysis","volume":"40","author":"Vercellini","year":"2025","journal-title":"Hum. Reprod."},{"issue":"24","key":"10.1016\/j.canlet.2026.218845_bib31","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.3390\/jcm13247602","article-title":"Thoracic endometriosis syndrome: a comprehensive review and multidisciplinary approach to management","volume":"13","author":"Nezhat","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.canlet.2026.218845_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1505399","article-title":"A bird-eye view of diaphragmatic endometriosis: current practices and future perspectives","volume":"11","author":"Naem","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.canlet.2026.218845_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejogrb.2024.01.020","article-title":"Diaphragm endometriosis: random localization or extended form of pelvis endometriosis. A large comparative analysis of 202 cases","volume":"294","author":"Piriyev","year":"2024","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.canlet.2026.218845_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15539","article-title":"Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism","volume":"8","author":"Sapkota","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib35","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1210\/endrev\/bnad020","article-title":"Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics","volume":"44","author":"Marquardt","year":"2023","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12588","article-title":"Progesterone resistance in endometriosis: a pathophysiological perspective and potential treatment alternatives","volume":"23","author":"Tang","year":"2024","journal-title":"Reprod. Med. Biol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib37","first-page":"182","article-title":"Transcriptomic changes in eutopic endometrium and ectopic lesions during endometriosis progression in a mouse model","volume":"5","author":"Li","year":"2024","journal-title":"F S Sci"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib38","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s42003-024-06713-5","article-title":"Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level","volume":"7","author":"Sarsenova","year":"2024","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-76125-2","article-title":"Endometriosis specific vaginal microbiota links to urine and serum N-glycome","volume":"14","author":"MacSharry","year":"2024","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib45","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/1471-0528.17979","article-title":"Oral, vaginal, and stool microbial signatures in patients with endometriosis as potential diagnostic non-invasive biomarkers: a prospective cohort study","volume":"132","author":"Hicks","year":"2025","journal-title":"BJOG"},{"issue":"8","key":"10.1016\/j.canlet.2026.218845_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.70202","article-title":"Gut microbiota-derived acetate ameliorates endometriosis via JAK1\/STAT3-Mediated M1 macrophage polarisation","volume":"18","author":"Xu","year":"2025","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.canlet.2026.218845_bib41","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.freeradbiomed.2025.07.019","article-title":"Gut microbiota derived butyrate enhances ferroptosis sensitivity in endometriosis through FFAR2\/PPAR-\u03b3\/PINK1\/Parkin mediated mitophagy","volume":"238","author":"Gou","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2026.218845_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1730739","article-title":"Gut microbiota as a key regulator in endometriosis: mechanisms, therapeutic opportunities, and future perspectives","volume":"15","author":"Liu","year":"2026","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.canlet.2026.218845_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1631522","article-title":"Leveraging the role of the microbiome in endometriosis: novel non-invasive and therapeutic approaches","volume":"16","author":"Kalopedis","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218845_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1434582","article-title":"The causality between gut microbiota and endometriosis: a bidirectional Mendelian randomization study","volume":"11","author":"Yang","year":"2024","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib46","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/CEJ.0000000000000965","article-title":"Endometriosis and cancer risk","volume":"34","author":"Bogani","year":"2025","journal-title":"Eur. J. Cancer Prev."},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib47","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.3390\/jcm14092975","article-title":"New evidence about malignant transformation of Endometriosis-A systematic review","volume":"14","author":"Ioannidou","year":"2025","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib48","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/biomedicines12061209","article-title":"Atypical endometriosis: a comprehensive systematic review of pathological patterns and diagnostic challenges","volume":"12","author":"Capozzi","year":"2024","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/GCO.0000000000001043","article-title":"Atypical endometriosis and the progression to endometriosis-associated ovarian cancer: an updated review","volume":"37","author":"Voigt","year":"2025","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"182","key":"10.1016\/j.canlet.2026.218845_bib50","doi-asserted-by":"crossref","first-page":"467","DOI":"10.24976\/Discov.Med.202436182.44","article-title":"Rare but still there: a scoping review on endometriosis-associated ovarian cancer","volume":"36","author":"Livori","year":"2024","journal-title":"Discov. Med."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib51","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/s43032-024-01489-9","article-title":"Histologic subtypes in endometriosis-associated ovarian cancer and ovarian cancer arising in endometriosis: a systematic review and meta-analysis","volume":"31","author":"Chiaffarino","year":"2024","journal-title":"Reprod. Sci."},{"issue":"14","key":"10.1016\/j.canlet.2026.218845_bib52","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.3390\/ijms25147624","article-title":"Pathogenesis of endometriosis and endometriosis-associated cancers","volume":"25","author":"Adilbayeva","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218845_bib53","article-title":"Research progress in endometriosis-associated ovarian cancer","author":"Tang","year":"2024","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib55","doi-asserted-by":"crossref","DOI":"10.1080\/09513590.2024.2409911","article-title":"Factors in malignant transformation of ovarian endometriosis: a narrative review","volume":"40","author":"Giannini","year":"2024","journal-title":"Gynecol. Endocrinol."},{"issue":"11","key":"10.1016\/j.canlet.2026.218845_bib54","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.3390\/cancers16112160","article-title":"The \"Road\" to malignant transformation from endometriosis to endometriosis-associated ovarian cancers (EAOCs): an mTOR-Centred review","volume":"16","author":"Hablase","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib59","doi-asserted-by":"crossref","first-page":"18824","DOI":"10.3390\/ijms140918824","article-title":"ARID1A mutations and PI3K\/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas","volume":"14","author":"Samartzis","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218845_bib60","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-2407-14-120","article-title":"A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A\/BAF250a is associated with AKT phosphorylation","volume":"14","author":"Wiegand","year":"2014","journal-title":"BMC Cancer"},{"issue":"8","key":"10.1016\/j.canlet.2026.218845_bib56","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041315","article-title":"Ovarian clear cell carcinoma: an endometriosis-associated cancer with therapeutic challenges","volume":"15","author":"Huang","year":"2025","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib57","first-page":"704","article-title":"Genetic links between endometriosis and endometriosis-associated ovarian Cancer-A narrative review (Endometriosis-Associated cancer)","volume":"14","author":"Pejovic","year":"2024","journal-title":"Life (Basel)"},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib58","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/ijms26051995","article-title":"Establishment of a novel in vitro and in vivo model to understand molecular carcinogenesis of endometriosis-related ovarian neoplasms","volume":"26","author":"Sohel","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218845_bib61","article-title":"Bioengineering approaches for the endometrial research and application","volume":"26","author":"Dai","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.canlet.2026.218845_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1495338","article-title":"Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends","volume":"12","author":"Agustina-Hern\u00e1ndez","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218845_bib62","first-page":"554","article-title":"Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk","volume":"4","author":"Gnecco","year":"2023","journal-title":"Med (N Y)"},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib63","first-page":"1287","article-title":"Matrix scaffolds for endometrium-derived organoid models","volume":"13","author":"De Vriendt","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2026.218845_bib64","first-page":"386","article-title":"Recent advances in defined hydrogels in organoid research","volume":"28","author":"Gan","year":"2023","journal-title":"Bioact. Mater."},{"issue":"11","key":"10.1016\/j.canlet.2026.218845_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303838","article-title":"Hybrid endometrial-derived hydrogels: human organoid culture models and in vivo perspectives","volume":"13","author":"G\u00f3mez-\u00c1lvarez","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.canlet.2026.218845_bib66","article-title":"Bovine and human endometrium-derived hydrogels support organoid culture and recapitulate endometrial extracellular matrix composition","volume":"293","author":"Jamaluddin","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.canlet.2026.218845_bib67","first-page":"1","article-title":"An endometrial biomimetic extracellular matrix for enhanced endometrial regeneration using hyaluronic acid hydrogel containing recombinant proteins","volume":"35","author":"Wei","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.canlet.2026.218845_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1551791","article-title":"Defining optimal electrospun membranes to enhance biological activities of human endometrial MSCs","volume":"13","author":"An","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"10","key":"10.1016\/j.canlet.2026.218845_bib70","article-title":"Cell electrospinning: a review of materials and methodologies for biofabrication","volume":"7","author":"Maurmann","year":"2023","journal-title":"Adv Biol (Weinh)"},{"key":"10.1016\/j.canlet.2026.218845_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123641","article-title":"Electrospinning technologies for the delivery of biopharmaceuticals: current status and future trends","volume":"651","author":"Lian","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib69","article-title":"Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration","volume":"4","author":"Chen","year":"2024","journal-title":"Exploration (Beijing)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib72","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s43032-025-02032-0","article-title":"Human endometriosis scaffold can enhance cell seeding and engraftment: an in vitro and in vivo study","volume":"33","author":"Azimzadeh","year":"2026","journal-title":"Reprod. Sci."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib73","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.052436","article-title":"Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis","volume":"19","author":"Rahmana","year":"2026","journal-title":"Dis. Model. Mech."},{"issue":"10","key":"10.1016\/j.canlet.2026.218845_bib74","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/cells14100742","article-title":"Endometriosis cell spheroids undergo mesothelial clearance in a similar manner to ovarian cancer cell spheroids","volume":"14","author":"Kloeckner","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2026.218845_bib76","article-title":"Peritoneal immune microenvironment of endometriosis: role and therapeutic perspectives","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"issue":"19","key":"10.1016\/j.canlet.2026.218845_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910792","article-title":"The role of peritoneal macrophages in endometriosis","volume":"22","author":"Ram\u00edrez-Pavez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib78","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41588-022-01254-1","article-title":"Single-cell transcriptomic analysis of endometriosis","volume":"55","author":"Fonseca","year":"2023","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib79","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13578-021-00637-x","article-title":"Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity","volume":"11","author":"Ma","year":"2021","journal-title":"Cell Biosci."},{"issue":"8","key":"10.1016\/j.canlet.2026.218845_bib80","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/s41556-022-00961-5","article-title":"Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues","volume":"24","author":"Tan","year":"2022","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib81","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70216","article-title":"Single-cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis-associated mesothelial cells and ectopic stromal cells may influence progesterone resistance","volume":"15","author":"Hou","year":"2025","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib82","article-title":"Single-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions","volume":"5","author":"Liu","year":"2025","journal-title":"Cell Genom."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166602","article-title":"The heterogeneity of fibrosis and angiogenesis in endometriosis revealed by single-cell RNA-sequencing","volume":"1869","author":"Zhu","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib90","first-page":"395","article-title":"A seed or soil problem in early endometriosis: stromal cell origin drives cellular invasion and coupling over mesothelial cell origin","volume":"5","author":"Go","year":"2024","journal-title":"F S Sci"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib84","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoaf003","article-title":"FAP+ activated fibroblasts are detectable in the microenvironment of endometriosis and correlate with stroma composition and infiltrating CD8+ and CD68+ cells","volume":"2025","author":"Kellers","year":"2025","journal-title":"Hum. Reprod. Open"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70227","article-title":"Human endometriotic lesion-derived small extracellular vesicles impair macrophage function in the peritoneal microenvironment","volume":"15","author":"Wang","year":"2026","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.canlet.2026.218845_bib86","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.2147\/JIR.S421389","article-title":"Plasma and peritoneal fluid annexin A2 levels in patients with endometriosis","volume":"16","author":"Zygarowicz","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib107","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/molehr\/gay049","article-title":"Macrophages alternatively activated by endometriosis-exosomes contribute to the development of lesions in mice","volume":"25","author":"Sun","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.canlet.2026.218845_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111573","article-title":"Exosomes from ectopic endometrial stromal cells promote M2 macrophage polarization by delivering miR-146a-5p","volume":"128","author":"Ji","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2026.218845_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123383","article-title":"Uterine-derived exosomes induce the M2 polarization of macrophages via miR-210-3p\/ATP5D to promote endometriosis progression","volume":"363","author":"Chen","year":"2025","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib110","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/humrep\/det003","article-title":"Suppression of annexin A2 by prostaglandin E2 impairs phagocytic ability of peritoneal macrophages in women with endometriosis","volume":"28","author":"Wu","year":"2013","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib87","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoae034","article-title":"Endometriosis: from iron and macrophages to exosomes. Is the sky clearing?","volume":"2024","author":"Donnez","year":"2024","journal-title":"Hum. Reprod. Open"},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib88","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/AOG.0000000000005587","article-title":"Pathophysiology and clinical implications of ovarian endometriomas","volume":"143","author":"Nezhat","year":"2024","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.canlet.2026.218845_bib89","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2022.12.105","article-title":"Iron overload modulates follicular microenvironment via ROS\/HIF-1\u03b1\/FSHR signaling","volume":"196","author":"Wu","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib91","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/jc.2002-020666","article-title":"Tumor necrosis factor-\u03b1-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-\u03baB activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression","volume":"88","author":"Sakamoto","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib92","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00281-025-01058-5","article-title":"Immunopathological insights into endometriosis: from research advances to future treatments","volume":"47","author":"Dai","year":"2025","journal-title":"Semin. Immunopathol."},{"issue":"13","key":"10.1016\/j.canlet.2026.218845_bib97","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202501493R","article-title":"MRGPRX2 mediates mast cell-induced endometriosis pain through the sensitization of sensory neurons via histamine\/HRH1\/TRPV1 signaling pathway","volume":"39","author":"Mao","year":"2025","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib98","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/ijms27010212","article-title":"The histamine-associated inflammatory landscape of endometriosis: molecular profiling of HDC, HRH1-HRH4, and cytokines across lesion subtypes","volume":"27","author":"Velho","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/mmr.2024.13422","article-title":"Prospects for potential therapy targeting immune-associated factors in endometriosis (Review)","volume":"31","author":"Zhang","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.canlet.2026.218845_bib106","article-title":"Immunotherapy: a promising novel endometriosis therapy","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"issue":"38","key":"10.1016\/j.canlet.2026.218845_bib93","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2405474121","article-title":"Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche","volume":"121","author":"Henlon","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218845_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1657605","article-title":"Dysfunction of natural killer cells promotes immune escape and disease progression in endometriosis","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib95","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.186133","article-title":"Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development","volume":"10","author":"Wilson","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.canlet.2026.218845_bib96","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.2147\/IJWH.S504327","article-title":"Neutrophil extracellular traps and endometriosis: insights from a case-control study","volume":"17","author":"Xu","year":"2025","journal-title":"Int.J. Womens Health"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2025.101019","article-title":"Increased circulating T helper 17 (TH17) cells and endometrial tissue IL-17-producing cells in patients with endometriosis compared with non-endometriotic subjects","volume":"25","author":"Delbandi","year":"2025","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.canlet.2026.218845_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1582762","article-title":"IL-24 producing regulatory T and B lymphocytes in endometriosis","volume":"16","author":"Kedzierska","year":"2025","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib101","first-page":"335","article-title":"Tertiary lymphoid structures in endometriosis","volume":"5","author":"Zutautas","year":"2024","journal-title":"F S Sci"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib102","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fertnstert.2023.02.025","article-title":"Peritoneal autoantibody profiling identifies p53 as an autoantibody target in endometriosis","volume":"120","author":"Harden","year":"2023","journal-title":"Fertil. Steril."},{"issue":"772","key":"10.1016\/j.canlet.2026.218845_bib103","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adk8230","article-title":"Nociceptor-to-macrophage communication through CGRP\/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice","volume":"16","author":"Fattori","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218845_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1621178","article-title":"Neuroinflammation is responsible for pain in endometriosis - targeting the JAK-STAT pathway and mast cell activation","volume":"16","author":"Golinska","year":"2025","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.canlet.2026.218845_bib111","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/1471-0528.17719","article-title":"Patient experiences of endometriosis diagnosis: a mixed methods approach","volume":"131","author":"Requadt","year":"2024","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib112","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12958-023-01181-8","article-title":"An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review","volume":"22","author":"Brulport","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218845_bib113","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1097\/MS9.0000000000002261","article-title":"Potential for and challenges of menstrual blood as a non-invasive diagnostic specimen: current status and future directions","volume":"86","author":"Zaheer","year":"2024","journal-title":"Ann Med Surg (Lond)"},{"key":"10.1016\/j.canlet.2026.218845_bib114","first-page":"652","volume":"vol. 8","author":"Wang","year":"2025"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib115","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fertnstert.2023.12.017","article-title":"Noninvasive diagnostic imaging for endometriosis part 2: a systematic review of recent developments in magnetic resonance imaging, nuclear medicine and computed tomography","volume":"121","author":"Avery","year":"2024","journal-title":"Fertil. Steril."},{"issue":"22","key":"10.1016\/j.canlet.2026.218845_bib116","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.3390\/diagnostics15222856","article-title":"The diagnostic accuracy of magnetic resonance imaging versus transvaginal ultrasound in deep infiltrating endometriosis and their impact on surgical decision-making: a systematic review","volume":"15","author":"O'Leary","year":"2025","journal-title":"Diagnostics (Basel)"},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib117","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/GCO.0000000000000983","article-title":"Medical management of endometriosis","volume":"36","author":"Alonso","year":"2024","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib118","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.fertnstert.2024.07.033","article-title":"Recurrence after surgery for endometrioma: a systematic review and meta-analyses","volume":"122","author":"Veth","year":"2024","journal-title":"Fertil. Steril."},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib119","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.3390\/biomedicines13092294","article-title":"Tolerability and shared decision-making in the hormonal management of endometriosis-associated pain","volume":"13","author":"Pinto da Costa Viana","year":"2025","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib120","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1097\/AOG.0000000000005923","article-title":"Pharmacologic interventions for endometriosis-related pain: a systematic review and meta-analysis","volume":"146","author":"Kou","year":"2025","journal-title":"Obstet. Gynecol."},{"issue":"23","key":"10.1016\/j.canlet.2026.218845_bib121","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/healthcare12232435","article-title":"The effect of endometriosis on in vitro fertilization outcomes: a systematic review and meta-analysis","volume":"12","author":"Mappa","year":"2024","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.canlet.2026.218845_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpobgyn.2024.102496","article-title":"Impact of surgery for endometriosis on the outcomes of in vitro fertilization","volume":"95","author":"Ferrero","year":"2024","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2025.105178","article-title":"IVF\/ICSI or surgery as first approach for the treatment of infertility associated with ovarian and deep infiltrating endometriosis? A systematic review and meta-analysis","volume":"52","author":"Riemma","year":"2026","journal-title":"Reprod. Biomed. Online"},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib124","first-page":"1985","article-title":"Relationship between endometriosis and mental health: a systematic review and meta-analysis","volume":"21","author":"Li","year":"2025","journal-title":"Arch. Med. Sci."},{"issue":"11","key":"10.1016\/j.canlet.2026.218845_bib125","article-title":"Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management","volume":"4","author":"Yang","year":"2023","journal-title":"Cell Rep. Med."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib126","doi-asserted-by":"crossref","first-page":"263","DOI":"10.52054\/FVVO.2025.153","article-title":"Race and ethnicity reporting in endometriosis literature: a systematic review","volume":"17","author":"Raffone","year":"2025","journal-title":"Facts Views Vis Obgyn"},{"issue":"16","key":"10.1016\/j.canlet.2026.218845_bib127","article-title":"Investigating racial disparities in drug prescriptions for patients with endometriosis","volume":"12","author":"Kashyap","year":"2023","journal-title":"J. Comp. Eff. Res."},{"issue":"9447","key":"10.1016\/j.canlet.2026.218845_bib128","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109298","article-title":"An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry","volume":"27","author":"Xu","year":"2024","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s44294-024-00052-w","article-title":"Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence","volume":"3","author":"Nezhat","year":"2025","journal-title":"NPJ Womens Health"},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib131","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0300186","article-title":"FEMaLe: the use of machine learning for early diagnosis of endometriosis based on patient self-reported data-study protocol of a multicenter trial","volume":"19","author":"Balogh","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218845_bib132","article-title":"Expanding the genetic landscape of endometriosis: integrative -omics analyses uncover key pathways from a multi-ancestry study of over 900,000 women","author":"Guare","year":"2024","journal-title":"medRxiv [preprint]"},{"key":"10.1016\/j.canlet.2026.218845_bib133","article-title":"New potential pharmacological options for endometriosis treatment","volume":"176","author":"Garc\u00eda-Izquierdo","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib134","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41571-020-0339-5","article-title":"Exploiting the folate receptor \u03b1 in oncology","volume":"17","author":"Scaranti","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib135","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/1933719113497292","article-title":"Elagolix treatment for endometriosis-associated pain: results from a phase 2, randomized, double-blind, placebo-controlled study","volume":"21","author":"Diamond","year":"2014","journal-title":"Reprod. Sci."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib136","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fertnstert.2020.07.055","article-title":"Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose-response manner: a randomized, double-blind, placebo-controlled study","volume":"115","author":"Osuga","year":"2021","journal-title":"Fertil. Steril."},{"issue":"10343","key":"10.1016\/j.canlet.2026.218845_bib137","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/S0140-6736(22)00622-5","article-title":"Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind studies (SPIRIT 1 and 2)","volume":"399","author":"Giudice","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib138","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/AOG.0000000000002675","article-title":"Long-term outcomes of elagolix in women with endometriosis: results from two extension studies","volume":"132","author":"Surrey","year":"2018","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib139","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0029-7844(97)00620-0","article-title":"Leuprolide acetate depot and hormonal add-back in endometriosis: a 12-month study","volume":"91","author":"Hornstein","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.canlet.2026.218845_bib140","article-title":"The oral GnRH antagonists, a new class of drugs in gynecology: from pharmacokinetics to possible clinical applications","author":"Barretta","year":"2024","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib141","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0002-9378(98)70316-3","article-title":"Preliminary report on the treatment of endometriosis with low-dose mifepristone (RU 486)","volume":"178","author":"Kettel","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib142","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/humrep\/deaa017","article-title":"Role of interleukin-1\u03b2 in nerve growth factor expression, neurogenesis and deep dyspareunia in endometriosis","volume":"35","author":"Peng","year":"2020","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib143","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1210\/jc.2004-1946","article-title":"Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation","volume":"90","author":"Yagyu","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.canlet.2026.218845_bib144","article-title":"Current developments in endometriosis-associated pain","volume":"5","author":"Coxon","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib145","first-page":"671","article-title":"Potency of oral gonadotropin-releasing hormone antagonist as endometriosis-associated pain novel treatments: an updated meta-analysis of randomized controlled trials","volume":"23","author":"Tjahyadi","year":"2025","journal-title":"Int J Reprod Biomed"},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib146","article-title":"Efficacy of elagolix and relugolix for the treatment of pelvic pain in patients with endometriosis: a systematic review","volume":"17","author":"Quishpe","year":"2025","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib147","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00404-022-06862-0","article-title":"Efficacy and safety of oral gonadotropin-releasing hormone antagonists in moderate-to-severe endometriosis-associated pain: a systematic review and network meta-analysis","volume":"308","author":"Xin","year":"2023","journal-title":"Arch. Gynecol. Obstet."},{"issue":"12","key":"10.1016\/j.canlet.2026.218845_bib148","first-page":"3325","article-title":"Oral gonadotropin-releasing hormone antagonists for endometriosis-associated pain: a systematic review and meta-analysis","volume":"29","author":"Yan","year":"2022","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.canlet.2026.218845_bib149","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2147\/IJWH.S442357","article-title":"Oral GnRH antagonists in combination with estradiol and norethindrone acetate for pain relief associated with endometriosis: a review of evidence of a novel class of hormonal agents","volume":"16","author":"Othman","year":"2024","journal-title":"Int.J. Womens Health"},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib150","doi-asserted-by":"crossref","first-page":"299","DOI":"10.14740\/jocmr6236","article-title":"Oral gonadotropin-releasing hormone antagonists in the treatment of endometriosis: advances in research","volume":"17","author":"Wang","year":"2025","journal-title":"J. Clin. Med. Res."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib152","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/humrep\/dead263","article-title":"Two-year efficacy and safety of relugolix combination therapy in women with endometriosis-associated pain: SPIRIT open-label extension study","volume":"39","author":"Becker","year":"2024","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib153","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.fertnstert.2024.06.009","article-title":"Impact of relugolix combination therapy on functioning and quality of life in women with endometriosis-associated pain","volume":"122","author":"As-Sanie","year":"2024","journal-title":"Fertil. Steril."},{"issue":"7","key":"10.1016\/j.canlet.2026.218845_bib155","first-page":"761","article-title":"Relugolix\/estradiol\/norethisterone acetate: a review in endometriosis-associated pain","volume":"84","author":"Blair","year":"2024","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib151","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/humrep\/deae076","article-title":"Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, phase 3 study (EDELWEISS 3)","volume":"39","author":"Donnez","year":"2024","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib154","first-page":"465","article-title":"Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain compared with leuprorelin in Japanese women: a phase 3, randomized, double-blind, noninferiority study","volume":"117","author":"Harada","year":"2022","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib156","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13063-025-08750-9","article-title":"Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY study): study protocol for a multicenter randomized controlled study","volume":"26","author":"Taniguchi","year":"2025","journal-title":"Trials"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib157","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53467-w","article-title":"EC313-a tissue selective SPRM reduces the growth and proliferation of uterine fibroids in a human uterine fibroid tissue xenograft model","volume":"9","author":"Nair","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218845_bib158","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1201547","article-title":"Next step in the development of mesoprogestins: the preclinical profile of EC313","volume":"14","author":"B\u0142aszczak-\u015awi\u0105tkiewicz","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib159","first-page":"189","article-title":"Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial","volume":"5","author":"Taylor","year":"2024","journal-title":"F S Rep"},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.23736\/S2724-606X.24.05631-8","article-title":"An update on epigenetic mechanisms in endometriosis","volume":"77","author":"Le","year":"2025","journal-title":"Minerva Obstet Gynecol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib161","first-page":"305","article-title":"Non-hormonal therapy for endometriosis based on angiogenesis, oxidative stress and inflammation","volume":"18","author":"Sanamiri","year":"2024","journal-title":"Int. J. Fertil. Steril."},{"key":"10.1016\/j.canlet.2026.218845_bib162","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.2147\/IJWH.S467041","article-title":"Pilot study of IL-1 antagonist anakinra for treatment of endometriosis","volume":"16","author":"Sullender","year":"2024","journal-title":"Int.J. Womens Health"},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib163","first-page":"261","article-title":"Safety and pharmacology of AMY109, a long-acting anti-interleukin-8 antibody, for endometriosis: a double-blind, randomized phase 1 trial","volume":"6","author":"Wang","year":"2025","journal-title":"F S Rep"},{"issue":"684","key":"10.1016\/j.canlet.2026.218845_bib164","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq5858","article-title":"A long-acting anti-IL-8 antibody improves inflammation and fibrosis in endometriosis","volume":"15","author":"Nishimoto-Kakiuchi","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218845_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108435","article-title":"Prolactin and pain of endometriosis","volume":"247","author":"Lee","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib166","doi-asserted-by":"crossref","DOI":"10.1177\/03331024241313378","article-title":"Prolactin-induced sensitization of trigeminal nociceptors promotes migraine comorbidity in endometriosis","volume":"45","author":"Lee","year":"2025","journal-title":"Cephalalgia"},{"key":"10.1016\/j.canlet.2026.218845_bib167","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1716062","article-title":"An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target","volume":"16","author":"Gunther","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"20","key":"10.1016\/j.canlet.2026.218845_bib168","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2501229122","article-title":"A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain","volume":"122","author":"Stratton","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218845_bib169","first-page":"423","article-title":"Nanotechnology strategies for endometrium health: are we on the right track?","volume":"54","author":"Herrara","year":"2025","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib170","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s40824-023-00442-2","article-title":"Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal\/endocrine synergistic endometriosis therapy","volume":"27","author":"Tian","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.canlet.2026.218845_bib171","article-title":"Comprehensive overview of antibody drug-related clinical studies in gynecology: insights from clinicalTrials.gov","volume":"12","author":"Zhou","year":"2025","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib172","first-page":"94","article-title":"Comments on \u201cSafety and pharmacology of AMY109, a long-acting anti-interleukin-8 antibody, for endometriosis: a double-blind, randomized phase 1 trial\u201d","volume":"7","author":"Dokania","year":"2026","journal-title":"F S Rep"},{"key":"10.1016\/j.canlet.2026.218845_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123716","article-title":"Emerging frontiers in microRNA technology: innovations driving precision medicine","volume":"326","author":"Guo","year":"2026","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib174","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00253-025-13620-0","article-title":"MiRNA-based drugs: challenges and delivery strategies","volume":"109","author":"Wang","year":"2025","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib175","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-025-03391-x","article-title":"MicroRNA in cancer therapy: breakthroughs and challenges in early clinical applications","volume":"44","author":"Di Martino","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"22","key":"10.1016\/j.canlet.2026.218845_bib176","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216325","article-title":"CRISPR\/Cas9-Mediated genome editing in cancer therapy","volume":"24","author":"Ding","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib177","article-title":"CRISPR\/CAS9-based gene editing in cancer therapy: a systematic review and meta-analysis on current status and future directions","volume":"105","author":"Rehman","year":"2026","journal-title":"Medicine (Baltim.)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib178","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12951-025-03898-7","article-title":"Nanotechnology for reproductive healthcare: a comprehensive review","volume":"24","author":"Koduru","year":"2026","journal-title":"J. Nanobiotechnol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109388","article-title":"Identifying therapeutic candidates for endometriosis through a transcriptomics-based drug repositioning approach","volume":"27","author":"Oskotsky","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.canlet.2026.218845_bib180","article-title":"A transcriptomics-based computational drug repositioning pipeline identifies simvastatin and primaquine as novel therapeutics for endometriosis pain","author":"Oskotsky","year":"2025","journal-title":"bioRxiv [Preprint]"},{"key":"10.1016\/j.canlet.2026.218845_bib181","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.biopha.2017.03.092","article-title":"A peek into the drug development scenario of endometriosis - a systematic review","volume":"90","author":"Goenka","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib182","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1177\/1933719118785767","article-title":"Drug development in endometriosis and adenomyosis: it takes more than just good science","volume":"25","author":"Groothuis","year":"2018","journal-title":"Reprod. Sci."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib183","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/humupd\/dmy020","article-title":"Is it time for a paradigm shift in drug research and development in endometriosis\/adenomyosis?","volume":"24","author":"Guo","year":"2018","journal-title":"Hum. Reprod. Update"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib184","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ajog.2019.02.033","article-title":"Assessing research gaps and unmet needs in endometriosis","volume":"221","author":"As-Sanie","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib185","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1056\/NEJMoa1700089","article-title":"Treatment of endometriosis-associated pain with elagolix, an oral GnRH antagonist","volume":"377","author":"Taylor","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib186","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1016\/j.fertnstert.2019.04.031","article-title":"Impact of elagolix on work loss due to endometriosis-associated pain: results from two randomized phase III trials","volume":"112","author":"Pokrzywinski","year":"2019","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib187","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/AOG.0000000000003917","article-title":"Health-related quality of life improvements in patients with endometriosis-associated pain treated with elagolix","volume":"136","author":"Taylor","year":"2020","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218845_bib188","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.fertnstert.2020.02.114","article-title":"Treatment of endometriosis-associated pain with linzagolix, an oral gonadotropin-releasing hormone-antagonist: a randomized clinical trial","volume":"114","author":"Donnez","year":"2020","journal-title":"Fertil. Steril."},{"issue":"9","key":"10.1016\/j.canlet.2026.218845_bib189","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/13543784.2021.1957830","article-title":"Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine fibroids","volume":"30","author":"Dababou","year":"2021","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.canlet.2026.218845_bib190","series-title":"Linzagolix \u2013 New Perspectives in the Pharmacotherapeutic Management of Uterine Fibroids and Endometriosis","author":"Paszkowski","year":"2025"},{"key":"10.1016\/j.canlet.2026.218845_bib191","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jconrel.2024.10.036","article-title":"The long road of drug development for endometriosis \u2013 pains, gains, and hopes","volume":"376","author":"Liao","year":"2024","journal-title":"J. Contr. Release"},{"issue":"10","key":"10.1016\/j.canlet.2026.218845_bib195","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1097\/JS9.0000000000002854","article-title":"Global landscape of clinical trials for endometriosis: dynamic trends and future directions","volume":"111","author":"He","year":"2025","journal-title":"Int. J. Surg."},{"issue":"12","key":"10.1016\/j.canlet.2026.218845_bib192","first-page":"806","article-title":"From mice to primates: assessing hormone-based endometriosis models for preclinical and therapeutic insights","volume":"50","author":"Tamadon","year":"2025","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"11","key":"10.1016\/j.canlet.2026.218845_bib194","first-page":"3201","article-title":"Role of molecular biomarkers in endometriosis-related symptoms and disease: state of the art","volume":"13","author":"Koutalia","year":"2024","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib193","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3390\/ijms26041770","article-title":"Unveiling the mechanisms of pain in endometriosis: comprehensive analysis of inflammatory sensitization and therapeutic potential","volume":"26","author":"Chen","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib196","first-page":"801","article-title":"Assessing the true prevalence of endometriosis","volume":"30","author":"Harder","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.canlet.2026.218845_bib197","article-title":"Comorbidity analysis and clustering of endometriosis patients across a multicenter electronic health record network","volume":"27","author":"Khan","year":"2025","journal-title":"J. Med. Internet Res."},{"key":"10.1016\/j.canlet.2026.218845_bib198","article-title":"Validation of administrative health data for the identification of surgically confirmed endometriosis phenotypes","author":"Kiser","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib199","first-page":"487","article-title":"Assessing the utility of artificial intelligence in endometriosis","volume":"30","author":"Dungate","year":"2024","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib200","article-title":"Symptom tracking in endometriosis using digital technologies","volume":"47","author":"Edgley","year":"2023","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.canlet.2026.218845_bib201","article-title":"A digital program for daily life management with endometriosis: pilot cohort study on symptoms and quality of life among participants","volume":"27","author":"Breton","year":"2025","journal-title":"J. Med. Internet Res."},{"key":"10.1016\/j.canlet.2026.218845_bib202","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoag006","article-title":"Telehealth cognitive behavioural therapy improves health-related quality of life and pain in endometriosis: the healing Pelvic Pain Intervention (HaPPI) randomized controlled trial","author":"Evans","year":"2026","journal-title":"Hum. Reprod. Open"},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib203","first-page":"e161","article-title":"Research priorities of endometriosis patients and supporters in Aotearoa New Zealand","volume":"64","author":"Ellis","year":"2024","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"10.1016\/j.canlet.2026.218845_bib204","article-title":"Patient-centered priorities in endometriosis and chronic pelvic pain: a mixed-methods and thematic analysis of intake narratives","author":"Freger","year":"2025","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib205","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41588-026-02582-2","article-title":"Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations","volume":"58","author":"Koller","year":"2026","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.canlet.2026.218845_bib206","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","article-title":"Rethinking mechanisms, diagnosis and management of endometriosis","volume":"15","author":"Chapron","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"13","key":"10.1016\/j.canlet.2026.218845_bib207","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10085","key":"10.1016\/j.canlet.2026.218845_bib208","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/S0140-6736(17)31344-2","article-title":"Top ten endometriosis research priorities in the UK and Ireland","volume":"389","author":"Horne","year":"2017","journal-title":"Lancet"},{"issue":"10352","key":"10.1016\/j.canlet.2026.218845_bib209","first-page":"685","article-title":"Pathophysiology, diagnosis, and management of endometriosis","volume":"400","author":"Horne","year":"2022","journal-title":"Lancet"},{"issue":"10276","key":"10.1016\/j.canlet.2026.218845_bib210","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.canlet.2026.218845_bib211","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: etiology, pathobiology, and therapeutic prospects","volume":"184","author":"Saunders","year":"2021","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib212","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum. Reprod. Open"},{"issue":"6","key":"10.1016\/j.canlet.2026.218845_bib213","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humupd\/dmq009","article-title":"Peripheral biomarkers of endometriosis: a systematic review","volume":"16","author":"May","year":"2010","journal-title":"Hum. Reprod. Update"},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib214","article-title":"Blood biomarkers for the non-invasive diagnosis of endometriosis","volume":"5","author":"Nisenblat","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.canlet.2026.218845_bib215","doi-asserted-by":"crossref","first-page":"354.e1","DOI":"10.1016\/j.ajog.2018.12.039","article-title":"Clinical diagnosis of endometriosis: a call to action","volume":"220","author":"Agarwal","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"25","key":"10.1016\/j.canlet.2026.218845_bib216","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Clinical practice. Endometriosis","volume":"362","author":"Giudice","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.canlet.2026.218845_bib217","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218845_bib218","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/humupd\/dmaa045","article-title":"Endometriosis and cancer: a systematic review and meta-analysis","volume":"27","author":"Kvaskoff","year":"2021","journal-title":"Hum. Reprod. Update"},{"issue":"19","key":"10.1016\/j.canlet.2026.218845_bib219","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1614814","article-title":"Cancer-associated mutations in endometriosis without cancer","volume":"376","author":"Anglesio","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.canlet.2026.218845_bib220","first-page":"214","article-title":"Endometriosis typology and ovarian cancer risk","volume":"332","author":"Barnard","year":"2024","journal-title":"JAMA"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:19:47Z","timestamp":1791339587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526006099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":235,"alternative-id":["S0304383526006099"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218845","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endometriosis from initiation to innovation: Immune microenvironments, clonal lesion biology, and the emerging therapeutic pipeline","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218845","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218845"}}