{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:39:48Z","timestamp":1792823988215,"version":"4.5.0"},"reference-count":196,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016321","name":"Lanzhou University First Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.canlet.2026.218906","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:45:57Z","timestamp":1792230357000},"page":"218906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Central neuroendocrine governance as a unifying framework for host\u2013tumor interaction: From afferent sensing to therapeutic modulation"],"prefix":"10.1016","volume":"661","author":[{"given":"Yi-Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-2405","authenticated-orcid":false,"given":"Wei-Lin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/cac2.12316","article-title":"The theory of tumor ecosystem","volume":"42","author":"Chen","year":"2022","journal-title":"Cancer Commun (Lond)"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib2","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1038\/s41467-024-48971-1","article-title":"Area postrema neurons mediate interleukin-6 function in cancer cachexia","volume":"15","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.canlet.2026.218906_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41422-024-00946-z","article-title":"Multiple cancer cell types release LIF and Gal3 to hijack neural signals","volume":"34","author":"Xu","year":"2024","journal-title":"Cell Res."},{"issue":"8103","key":"10.1016\/j.canlet.2026.218906_bib4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41586-025-10028-8","article-title":"Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis","volume":"650","author":"Wei","year":"2026","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.canlet.2026.218906_bib5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2025.11.019","article-title":"Aberrant hypothalamic neuronal activity blunts glucocorticoid diurnal rhythms in murine breast cancer","volume":"114","author":"Gomez","year":"2026","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1158\/2159-8290.CD-24-0718","article-title":"Sympathetic neurons promote small cell lung cancer through the \u03b22-Adrenergic receptor","volume":"15","author":"Fnu","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218906_bib7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbi.2024.10.012","article-title":"Social isolation promotes tumor immune evasion via \u03b22-adrenergic receptor","volume":"123","author":"Zhao","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nm1447","article-title":"Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma","volume":"12","author":"Thaker","year":"2006","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12943-025-02396-6","article-title":"Hijacking homeostasis: the brain-body neural circuitry in tumor pathogenesis and emerging therapeutic frontiers","volume":"24","author":"Wang","year":"2025","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tins.2023.01.003","article-title":"How cancer hijacks the body's homeostasis through the neuroendocrine system","volume":"46","author":"Slominski","year":"2023","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tins.2020.09.011","article-title":"Neural circuits of interoception","volume":"44","author":"Berntson","year":"2021","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tins.2020.10.007","article-title":"The emerging science of interoception: Sensing, integrating, interpreting, and regulating signals within the self","volume":"44","author":"Chen","year":"2021","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib13","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300265RR","article-title":"Tumor-derived semaphorin 3D promoting cancer cachexia via regulating hypothalamic pro-opiomelanocortin neurons","volume":"37","author":"Zhang","year":"2023","journal-title":"Faseb j"},{"key":"10.1016\/j.canlet.2026.218906_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2025.101216","article-title":"How the diffuse neuroendocrine system shapes health, homeostasis, and cancer","volume":"79","author":"Salzet","year":"2025","journal-title":"Front. Neuroendocrinol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib15","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41591-020-0945-x","article-title":"Antibody-mediated inhibition of GDF15\u2013GFRAL activity reverses cancer cachexia in mice","volume":"26","author":"Suriben","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2026.218906_bib16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fnins.2015.00390","article-title":"New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains","volume":"9","author":"Miyata","year":"2015","journal-title":"Front. Neurosci."},{"issue":"17\u201320","key":"10.1016\/j.canlet.2026.218906_bib17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1101\/gad.352276.124","article-title":"The area postrema: a critical mediator of brain-body interactions","volume":"38","author":"van de Lisdonk","year":"2024","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nn.4463","article-title":"Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ","volume":"20","author":"Matsuda","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/j.2040-4603.2015.tb00605.x","article-title":"Hypothalamus as an endocrine organ","volume":"5","author":"Clarke","year":"2015","journal-title":"Compr. Physiol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib20","first-page":"46","article-title":"Cytokines stimulate the CRH but not the vasopressin neuronal system: evidence for a median eminence site of interleukin-6 action","volume":"56","author":"Spinedi","year":"1992","journal-title":"Neuroendocrinology"},{"issue":"12","key":"10.1016\/j.canlet.2026.218906_bib21","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20111020","article-title":"Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis","volume":"208","author":"Braun","year":"2011","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s12264-024-01335-7","article-title":"Neuronal regulation of feeding and energy metabolism: a focus on the hypothalamus and brainstem","volume":"41","author":"Chen","year":"2025","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.canlet.2026.218906_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2024.112179","article-title":"Npy transcription is regulated by noncanonical STAT3 signaling in hypothalamic neurons: implication with lipotoxicity and obesity","volume":"586","author":"He","year":"2024","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib24","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1210\/en.2002-221099","article-title":"Differential role of melanocortin receptor subtypes in cachexia","volume":"144","author":"Marks","year":"2003","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004774","article-title":"Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice","volume":"4","author":"Weyermann","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13268","article-title":"Hypothalamic corticotrophin releasing hormone neurons in stress-induced psychopathology: revaluation of synaptic contributions","volume":"35","author":"Stanton","year":"2023","journal-title":"J. Neuroendocrinol."},{"issue":"11","key":"10.1016\/j.canlet.2026.218906_bib27","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s40618-024-02411-5","article-title":"Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins","volume":"47","author":"Lee","year":"2024","journal-title":"J. Endocrinol. Investig."},{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib28","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.bbi.2011.04.005","article-title":"Acute amygdaloid response to systemic inflammation","volume":"25","author":"Engler","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.canlet.2026.218906_bib29","article-title":"Neuroimmunology of behavioral comorbidities associated with cancer and cancer treatments","volume":"9","author":"Dos Santos","year":"2018","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.canlet.2026.218906_bib30","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1007\/s12035-024-03992-1","article-title":"Keratinocyte-derived cytokine in the hippocampus disrupts extinction of conditioned fear memory in tumor-bearing mice","volume":"61","author":"Ikeda","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib31","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0531-5565(99)00047-9","article-title":"Glucocorticoids, stress, and their adverse neurological effects: relevance to aging","volume":"34","author":"Sapolsky","year":"1999","journal-title":"Exp. Gerontol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12689","article-title":"From sensory circumventricular organs to cerebral cortex: neural pathways controlling thirst and hunger","volume":"31","author":"McKinley","year":"2019","journal-title":"J. Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1017\/S1092852918001621","article-title":"Emotional distress, brain functioning, and biobehavioral processes in cancer patients: a neuroimaging review and future directions","volume":"25","author":"Reis","year":"2020","journal-title":"CNS Spectr."},{"issue":"6564","key":"10.1016\/j.canlet.2026.218906_bib34","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.abf8403","article-title":"Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis","volume":"374","author":"Pernigoni","year":"2021","journal-title":"Science"},{"issue":"1\u20132","key":"10.1016\/j.canlet.2026.218906_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib36","article-title":"The association between the neuroendocrine system and the tumor immune microenvironment: emerging directions for cancer immunotherapy","volume":"1878","author":"Li","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"11","key":"10.1016\/j.canlet.2026.218906_bib37","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.tins.2021.08.008","article-title":"Cancer as a homeostatic challenge: the role of the hypothalamus","volume":"44","author":"Francis","year":"2021","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12929-023-00903-9","article-title":"Chronic stress in solid tumor development: from mechanisms to interventions","volume":"30","author":"Yan","year":"2023","journal-title":"J. Biomed. Sci."},{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib39","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S2213-8587(15)00008-X","article-title":"Effect of cancer treatment on hypothalamic-pituitary function","volume":"3","author":"Crowne","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib40","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/JOE-15-0133","article-title":"The molecular basis of the non-thyroidal illness syndrome","volume":"225","author":"de Vries","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.canlet.2026.218906_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.semcancer.2025.07.003","article-title":"The role of deiodinases on metabolic alteration in cancer","volume":"114","author":"Miro","year":"2025","journal-title":"Semin. Cancer Biol."},{"issue":"15","key":"10.1016\/j.canlet.2026.218906_bib42","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.7150\/ijbs.76924","article-title":"Hepatic FGF21: its emerging role in inter-organ crosstalk and cancers","volume":"18","author":"Sui","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10565-025-10098-4","article-title":"Lipolysis gone rogue: the HSL connection in feeding cancer","volume":"41","author":"Hemadri","year":"2025","journal-title":"Cell Biol. Toxicol."},{"issue":"6039","key":"10.1016\/j.canlet.2026.218906_bib44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1198973","article-title":"Adipose triglyceride lipase contributes to cancer-associated cachexia","volume":"333","author":"Das","year":"2011","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib45","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"issue":"7480","key":"10.1016\/j.canlet.2026.218906_bib46","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"issue":"49","key":"10.1016\/j.canlet.2026.218906_bib47","doi-asserted-by":"crossref","first-page":"18586","DOI":"10.1074\/jbc.RA119.010950","article-title":"Gut microbial \u03b2-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens","volume":"294","author":"Ervin","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib48","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000452364","article-title":"Changes in intestinal motility and gut microbiota composition in a rat stress model","volume":"95","author":"Murakami","year":"2017","journal-title":"Digestion"},{"key":"10.1016\/j.canlet.2026.218906_bib49","doi-asserted-by":"crossref","DOI":"10.1046\/j.1440-1681.2001.03490.x","article-title":"Circumventricular organs: gateways to the brain role of circumventricular organs in pro\u2010inflammatory cytokine\u2010induced activation of the Hypothalamic\u2013 pituitary\u2013adrenal axis","volume":"28","author":"Buller","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib50","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/HYPERTENSIONAHA.113.01404","article-title":"Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines","volume":"62","author":"Wei","year":"2013","journal-title":"Hypertension"},{"issue":"7982","key":"10.1016\/j.canlet.2026.218906_bib51","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41586-023-06568-6","article-title":"The \u03b21-adrenergic receptor links sympathetic nerves to T cell exhaustion","volume":"622","author":"Globig","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109883","article-title":"\u03b22-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME","volume":"37","author":"Mohammadpour","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218906_bib53","first-page":"216","article-title":"Dynamic interplay of neuroendocrine signaling and immuno-surveillance in tumor niche remodeling","author":"Xu","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"7675","key":"10.1016\/j.canlet.2026.218906_bib172","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.canlet.2026.218906_bib173","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ccell.2026.01.014","article-title":"Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia","volume":"44","author":"Shi","year":"2026","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib174","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/s41467-021-22361-3","article-title":"Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia","volume":"12","author":"Olson","year":"2021","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.canlet.2026.218906_bib175","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1073\/pnas.1512603113","article-title":"Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer","volume":"113","author":"Saloman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6610","key":"10.1016\/j.canlet.2026.218906_bib176","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1126\/science.abj2674","article-title":"Pituitary hormone \u03b1-MSH promotes tumor-induced myelopoiesis and immunosuppression","volume":"377","author":"Xu","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib177","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1038\/s41467-018-05283-5","article-title":"Modulation of anti-tumor immunity by the brain's reward system","volume":"9","author":"Ben-Shaanan","year":"2018","journal-title":"Nat. Commun."},{"issue":"28","key":"10.1016\/j.canlet.2026.218906_bib178","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103505118","article-title":"VLM catecholaminergic neurons control tumor growth by regulating CD8(+) T cells","volume":"118","author":"Zhang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6361","key":"10.1016\/j.canlet.2026.218906_bib54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.aah5072","article-title":"Adrenergic nerves activate an angio-metabolic switch in prostate cancer","volume":"358","author":"Zahalka","year":"2017","journal-title":"Science"},{"issue":"250","key":"10.1016\/j.canlet.2026.218906_bib179","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009569","article-title":"Denervation suppresses gastric tumorigenesis","volume":"6","author":"Zhao","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"10","key":"10.1016\/j.canlet.2026.218906_bib163","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00432-025-06338-z","article-title":"Evaluation of the gut microbiome and sex hormones in postmenopausal women with newly diagnosed hormone receptor-positive breast cancer versus healthy women: a prospective case-control study","volume":"151","author":"Kwa","year":"2025","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"7935","key":"10.1016\/j.canlet.2026.218906_bib65","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","article-title":"Nociceptor neurons affect cancer immunosurveillance","volume":"611","author":"Balood","year":"2022","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib95","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2015.04.012","article-title":"Neuronal activity promotes glioma growth through Neuroligin-3 secretion","volume":"161","author":"Venkatesh","year":"2015","journal-title":"Cell"},{"issue":"7673","key":"10.1016\/j.canlet.2026.218906_bib96","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature24014","article-title":"Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma","volume":"549","author":"Venkatesh","year":"2017","journal-title":"Nature"},{"issue":"6921","key":"10.1016\/j.canlet.2026.218906_bib55","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.canlet.2026.218906_bib56","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1038\/s41388-020-1272-x","article-title":"Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis","volume":"39","author":"Goto","year":"2020","journal-title":"Oncogene"},{"issue":"20","key":"10.1016\/j.canlet.2026.218906_bib57","doi-asserted-by":"crossref","first-page":"9994","DOI":"10.3390\/ijms26209994","article-title":"Chronic stress and autoimmunity: the role of HPA axis and cortisol dysregulation","volume":"26","author":"Nunez","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218906_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2021.105641","article-title":"The neuroendocrinology of stress: glucocorticoid signaling mechanisms","volume":"137","author":"Herman","year":"2022","journal-title":"Psychoneuroendocrinology"},{"issue":"22","key":"10.1016\/j.canlet.2026.218906_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70366","article-title":"Hypothalamic-pituitary-adrenal axis dysfunction in people with cancer: a systematic review","volume":"13","author":"Kanter","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.canlet.2026.218906_bib60","article-title":"Stress and cancer: the mechanisms of immune dysregulation and management","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib61","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41568-025-00831-w","article-title":"Neuro-immune cross-talk in cancer","volume":"25","author":"Amit","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib62","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/eji.201646395","article-title":"Sympathetic neural signaling via the \u03b22-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8(+) T-cell effector function","volume":"46","author":"Estrada","year":"2016","journal-title":"Eur. J. Immunol."},{"issue":"11","key":"10.1016\/j.canlet.2026.218906_bib63","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1158\/2326-6066.CIR-18-0833","article-title":"Blockade of \u03b2-Adrenergic receptors improves CD8 + T-cell priming and cancer vaccine efficacy","volume":"7","author":"Daher","year":"2019","journal-title":"Cancer Immunol. Res."},{"issue":"50","key":"10.1016\/j.canlet.2026.218906_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj4226","article-title":"Targeting metabotropic glutamate receptor 4 for cancer immunotherapy","volume":"7","author":"Wan","year":"2021","journal-title":"Sci. Adv."},{"issue":"33","key":"10.1016\/j.canlet.2026.218906_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adx9221","article-title":"Prdm12 governs an epigenetic checkpoint linking neuroimmune cross-talk to CD8(+) T cell exhaustion-suppressed antitumor immunity","volume":"11","author":"Liu","year":"2025","journal-title":"Sci. Adv."},{"issue":"14","key":"10.1016\/j.canlet.2026.218906_bib67","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1016\/j.cell.2025.04.032","article-title":"Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis","volume":"188","author":"Li","year":"2025","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib68","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/eji.201243005","article-title":"Beta2-adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA-dependent manner","volume":"43","author":"Guereschi","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.canlet.2026.218906_bib69","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2019.06.004","article-title":"Catecholamines contribute to the neovascularization of lung cancer via tumor-associated macrophages","volume":"81","author":"Xia","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib70","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13046-023-02696-z","article-title":"Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM\/CXCL1 signaling","volume":"42","author":"Zheng","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib71","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1158\/2326-6066.CIR-20-0445","article-title":"Chronic adrenergic stress contributes to metabolic dysfunction and an exhausted phenotype in T cells in the tumor microenvironment","volume":"9","author":"Qiao","year":"2021","journal-title":"Cancer Immunol. Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib72","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12964-025-02266-0","article-title":"The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2\/IL-2R signaling axis","volume":"23","author":"Albarracin Melo","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib73","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41574-025-01102-2","article-title":"Steroid hormones as modulators of anti-tumoural immunity","volume":"21","author":"Schwarzlmueller","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218906_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2026.117367","article-title":"Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cell dysfunction in human cancer","volume":"45","author":"Ward","year":"2026","journal-title":"Cell Rep."},{"issue":"52","key":"10.1016\/j.canlet.2026.218906_bib75","doi-asserted-by":"crossref","first-page":"19896","DOI":"10.1074\/jbc.RA119.010379","article-title":"Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells","volume":"294","author":"Maeda","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.canlet.2026.218906_bib76","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/jnci\/92.12.994","article-title":"Diurnal cortisol rhythm as a predictor of breast cancer survival","volume":"92","author":"Sephton","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"Suppl","key":"10.1016\/j.canlet.2026.218906_bib77","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/j.bbi.2012.07.019","article-title":"Diurnal cortisol rhythm as a predictor of lung cancer survival","volume":"30","author":"Sephton","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.canlet.2026.218906_bib78","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbi.2016.02.025","article-title":"Stress impairs the efficacy of immune stimulation by CpG-C: potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period","volume":"56","author":"Levi","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.canlet.2026.218906_bib79","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/ncomms2413","article-title":"Src activation by \u03b2-adrenoreceptors is a key switch for tumour metastasis","volume":"4","author":"Armaiz-Pena","year":"2013","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib80","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1158\/1078-0432.CCR-05-1698","article-title":"Stress hormone-mediated invasion of ovarian cancer cells","volume":"12","author":"Sood","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.canlet.2026.218906_bib81","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41419-019-2030-2","article-title":"Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib82","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00432-015-2044-9","article-title":"Norepinephrine induced epithelial-mesenchymal transition in HT-29 and A549 cells in vitro","volume":"142","author":"Zhang","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib83","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.jhep.2014.02.025","article-title":"Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling","volume":"60","author":"Li","year":"2014","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib84","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s10549-011-1348-y","article-title":"\u03b2-Adrenergic receptors (\u03b2-AR) regulate VEGF and IL-6 production by divergent pathways in high \u03b2-AR-expressing breast cancer cell lines","volume":"130","author":"Madden","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"issue":"21","key":"10.1016\/j.canlet.2026.218906_bib85","doi-asserted-by":"crossref","first-page":"10357","DOI":"10.1158\/0008-5472.CAN-06-2496","article-title":"Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells","volume":"66","author":"Yang","year":"2006","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib86","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2024.2366451","article-title":"Role of transforming growth factor-\u03b21 pathway in angiogenesis induced by chronic stress in colorectal cancer","volume":"25","author":"Zhang","year":"2024","journal-title":"Cancer Biol. Ther."},{"issue":"5","key":"10.1016\/j.canlet.2026.218906_bib87","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1530\/ERC-14-0236","article-title":"Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk","volume":"21","author":"Chen","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib88","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.7150\/ijbs.79583","article-title":"Chronic stress promotes colorectal cancer progression by enhancing glycolysis through \u03b22-AR\/CREB1 signal pathway","volume":"19","author":"Guan","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"39","key":"10.1016\/j.canlet.2026.218906_bib197","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adv5673","article-title":"Glioblastoma exploits ATP from leading-edge astrocytes to fuel its infiltrative growth revealed by spatially resolved chimeric analysis","volume":"11","author":"Yang","year":"2025","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib90","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73051-1","article-title":"A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress","volume":"14","author":"Katz","year":"2024","journal-title":"Sci. Rep."},{"issue":"8075","key":"10.1016\/j.canlet.2026.218906_bib91","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41586-025-09176-8","article-title":"Nerve-to-cancer transfer of mitochondria during cancer metastasis","volume":"644","author":"Hoover","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib92","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1158\/2159-8290.CD-24-0287","article-title":"Neuro-mesenchymal interaction mediated by a \u03b22-Adrenergic nerve growth factor feedforward loop promotes colorectal cancer progression","volume":"15","author":"Kobayashi","year":"2025","journal-title":"Cancer Discov."},{"issue":"12","key":"10.1016\/j.canlet.2026.218906_bib93","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1016\/j.ajpath.2014.08.009","article-title":"ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer","volume":"184","author":"Pundavela","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"7795","key":"10.1016\/j.canlet.2026.218906_bib94","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-020-1996-3","article-title":"Loss of p53 drives neuron reprogramming in head and neck cancer","volume":"578","author":"Amit","year":"2020","journal-title":"Nature"},{"issue":"7775","key":"10.1016\/j.canlet.2026.218906_bib97","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-019-1576-6","article-title":"Synaptic proximity enables NMDAR signalling to promote brain metastasis","volume":"573","author":"Zeng","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218906_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbf.70147","article-title":"Nerve adaptations in the tumor microenvironment","volume":"43","author":"Swamy","year":"2025","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.canlet.2026.218906_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202506813","article-title":"Cancer neuroscience: decoding neural circuitry in tumor evolution for targeted therapy","volume":"12","author":"Yuan","year":"2025","journal-title":"Adv. Sci."},{"issue":"23","key":"10.1016\/j.canlet.2026.218906_bib100","doi-asserted-by":"crossref","DOI":"10.3390\/cells13231999","article-title":"Therapeutic exploitation of neuroendocrine transdifferentiation drivers in prostate cancer","volume":"13","author":"Maylin","year":"2024","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib101","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1158\/2159-8290.CD-25-0974","article-title":"Serotonin modulates lineage plasticity in neuroendocrine prostate cancer via epigenetic reprogramming","volume":"16","author":"Ji","year":"2026","journal-title":"Cancer Discov."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib102","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/10253890.2020.1859475","article-title":"Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture","volume":"23","author":"Herman","year":"2020","journal-title":"Stress"},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib103","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/S0100-879X2012007500041","article-title":"Neural regulation of the stress response: glucocorticoid feedback mechanisms","volume":"45","author":"Herman","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.canlet.2026.218906_bib104","series-title":"Handbook of Life Stress, Cognition and Health","first-page":"629","article-title":"Allostasis: a new paradigm to explain arousal pathology","author":"Sterling","year":"1988"},{"issue":"18","key":"10.1016\/j.canlet.2026.218906_bib105","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/archinte.1993.00410180039004","article-title":"Stress and the individual. Mechanisms leading to disease","volume":"153","author":"McEwen","year":"1993","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib106","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/advan.00107.2015","article-title":"A physiologist's view of homeostasis","volume":"39","author":"Modell","year":"2015","journal-title":"Adv. Physiol. Educ."},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib107","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0006-8993(02)03581-3","article-title":"Further evidence for the central effect of dexamethasone at the hypothalamic level in the negative feedback mechanism","volume":"958","author":"Feldman","year":"2002","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.canlet.2026.218906_bib108","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0006-8993(94)91862-7","article-title":"Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus","volume":"640","author":"Makino","year":"1994","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib109","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1460-9568.2004.03568.x","article-title":"Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus","volume":"20","author":"Verkuyl","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib110","first-page":"45","article-title":"Thyroid hormones in conditions of chronic malnutrition. A study with special reference to cancer cachexia","volume":"201","author":"Persson","year":"1985","journal-title":"Ann. Surg."},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib111","first-page":"2495","article-title":"Hypogonadism in male patients with metastatic cancer prior to chemotherapy","volume":"42","author":"Chlebowski","year":"1982","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib112","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0306-4530(96)00009-1","article-title":"Elevated basal cortisol levels and attenuated ACTH and cortisol responses to a behavioral challenge in women with metastatic breast cancer","volume":"21","author":"van der Pompe","year":"1996","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib113","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00964585","article-title":"Tumor host relations. II. Influence of tumor extent and tumor site on plasma cortisol of patients with malignant diseases","volume":"93","author":"Schaur","year":"1979","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.canlet.2026.218906_bib114","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.1998.tb09546.x","article-title":"Stress, adaptation, and disease. Allostasis and allostatic load","volume":"840","author":"McEwen","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.canlet.2026.218906_bib115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yhbeh.2016.12.008","article-title":"Repeated restraint stress lowers the threshold for response to third ventricle CRF administration","volume":"89","author":"Harris","year":"2017","journal-title":"Horm. Behav."},{"issue":"5","key":"10.1016\/j.canlet.2026.218906_bib116","first-page":"246","article-title":"Dissociation between plasma adrenocorticotropin and serum cortisol level during the early postoperative period after gastrectomy","volume":"53","author":"Cho","year":"2000","journal-title":"Horm. Res."},{"key":"10.1016\/j.canlet.2026.218906_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2022.105804","article-title":"Diurnal dynamic range as index of dysregulation of system dynamics. A cortisol examplar using data from the study of Midlife in the United States","volume":"142","author":"Karlamangla","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.canlet.2026.218906_bib118","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.psyneuen.2015.01.010","article-title":"Diurnal cortisol and survival in epithelial ovarian cancer","volume":"53","author":"Schrepf","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.canlet.2026.218906_bib119","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbi.2024.10.005","article-title":"Deleterious effects of social isolation on neuroendocrine-immune status, and cancer progression in rats","volume":"123","author":"Trachtenberg","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib120","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt","year":"2014","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.canlet.2026.218906_bib121","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.3324\/haematol.2022.280907","article-title":"\u03b2 adrenergic signaling regulates hematopoietic stem and progenitor cell commitment and therapy sensitivity in multiple myeloma","volume":"107","author":"Nair","year":"2022","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib122","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/ijc.33552","article-title":"Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through \u03b2-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades","volume":"149","author":"Cao","year":"2021","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.canlet.2026.218906_bib123","first-page":"5286","article-title":"Chronic stress promotes tumor immune evasion via the suppression of MHC-I expression and the upregulation of PD-L1","volume":"12","author":"Chen","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218906_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112568","article-title":"Chronic stress influences the macrophage M1-M2 polarization balance through \u03b2-adrenergic signaling in hepatoma mice","volume":"138","author":"Yang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/path.4988","article-title":"Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre-metastatic niche through activating \u03b2-adrenergic signaling","volume":"244","author":"Chen","year":"2018","journal-title":"J. Pathol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib126","article-title":"Chronic stress-induced and tumor derived SP1(+) exosomes polarizing IL-1\u03b2(+) neutrophils to increase lung metastasis of breast cancer","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2026.218906_bib127","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-026-10222-2","article-title":"A glucocorticoid-FAS axis controls immune evasion during metastatic seeding","volume":"653","author":"Cassandras","year":"2026","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167581","article-title":"Depression decreases immunity and PD-L1 inhibitor efficacy via the hypothalamic-pituitary-adrenal (HPA) axis in triple-negative breast cancer","volume":"1871","author":"Yu","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"9","key":"10.1016\/j.canlet.2026.218906_bib129","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","article-title":"Stress\u2013glucocorticoid\u2013TSC22D3 axis compromises therapy-induced antitumor immunity","volume":"25","author":"Yang","year":"2019","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib130","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1158\/1078-0432.CCR-15-1275","article-title":"Adrenergic stimulation of DUSP1 impairs chemotherapy response in ovarian cancer","volume":"22","author":"Kang","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218906_bib131","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1362675","article-title":"Harnessing adrenergic blockade in stress-promoted TNBC in vitro and solid tumor in vivo: disrupting HIF-1\u03b1 and GSK-3\u03b2\/\u03b2-catenin driven resistance to doxorubicin","volume":"15","author":"Attia","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.canlet.2026.218906_bib180","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.breast.2017.06.016","article-title":"A longitudinal study of diurnal cortisol patterns and associated factors in breast cancer patients from the transition stage of the end of active cancer treatment to post-treatment survivorship","volume":"36","author":"Hsiao","year":"2017","journal-title":"Breast"},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib134","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/WNP.0000000000000210","article-title":"Prognostic value of heart rate variability in patients with cancer","volume":"32","author":"Guo","year":"2015","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.canlet.2026.218906_bib170","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1103979","article-title":"Cancer-related fatigue classification based on heart rate variability signals from wearables","volume":"10","author":"Shih","year":"2023","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib181","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/cncr.32506","article-title":"High neutrophil-to-lymphocyte ratio (NLR) is associated with treatment failure and death in patients who have melanoma treated with PD-1 inhibitor monotherapy","volume":"126","author":"Bartlett","year":"2020","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib182","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000842","article-title":"Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition","volume":"8","author":"Laino","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"22","key":"10.1016\/j.canlet.2026.218906_bib183","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14225518","article-title":"Profiling the adrenergic system in breast cancer and the development of metastasis","volume":"14","author":"Sousa","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.canlet.2026.218906_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2026.107947","article-title":"Higher plasma catecholamine concentrations in oral cancer patients and association with clinical and psychological characteristics","volume":"191","author":"Bastos","year":"2026","journal-title":"Psychoneuroendocrinology"},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib185","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1007\/s00262-023-03453-z","article-title":"Cytokine profiling identifies circulating IL-6 and IL-15 as prognostic stratifiers in patients with non-small cell lung cancer receiving anti-PD-1\/PD-L1 blockade therapy","volume":"72","author":"Inoue","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"2","key":"10.1016\/j.canlet.2026.218906_bib141","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001223","article-title":"Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation","volume":"8","author":"Cassetta","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib142","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s13046-025-03574-6","article-title":"Circulating CD137+Treg cells and LOX-1+PMN-MDSCs as biomarkers of immunotherapy resistance in (R\/M) HNSCC patients","volume":"44","author":"Asquino","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1200\/JCO.2002.20.1.42","article-title":"Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study","volume":"20","author":"Goodwin","year":"2002","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib149","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10549-023-07241-2","article-title":"Effect of metformin and lifestyle intervention on adipokines and hormones in breast cancer survivors: a pooled analysis from two randomized controlled trials","volume":"205","author":"Johansson","year":"2024","journal-title":"Breast Cancer Res. Treat."},{"issue":"19","key":"10.1016\/j.canlet.2026.218906_bib132","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.70094","article-title":"Prognostic value of patient-reported depression in women with hormone-responsive early breast cancer in TEXT and SOFT","volume":"131","author":"Ribi","year":"2025","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib133","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18865-7","article-title":"Increased sympathetic modulation in breast cancer survivors determined by measurement of heart rate variability","volume":"12","author":"Majerova","year":"2022","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jso.20329","article-title":"Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer","volume":"91","author":"Walsh","year":"2005","journal-title":"J. Surg. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib136","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41598-024-84890-3","article-title":"Pretreatment neutrophil-to-lymphocyte ratio is associated with immunotherapy efficacy in patients with advanced cancer: a systematic review and meta-analysis","volume":"15","author":"Su","year":"2025","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib137","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.4110\/in.2020.20.e27","article-title":"Baseline serum Interleukin-6 levels predict the response of patients with advanced non-small cell lung cancer to PD-1\/PD-L1 inhibitors","volume":"20","author":"Kang","year":"2020","journal-title":"Immune Netw."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib138","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10238-025-01587-1","article-title":"Predictive value of serum cytokines in patients with non-small-cell lung cancer receiving anti-PD-1 blockade therapy: a meta-analysis","volume":"25","author":"Liu","year":"2025","journal-title":"Clin. Exp. Med."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib139","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/172460081002500302","article-title":"Significance of serum tumor necrosis factor-alpha and its combination with HER-2 codon 655 polymorphism in the diagnosis and prognosis of breast cancer","volume":"25","author":"Papadopoulou","year":"2010","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.canlet.2026.218906_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/curroncol32060344","article-title":"Prognostic relevance of inflammatory cytokines Il-6 and TNF-Alpha in patients with breast cancer: a systematic review and meta-analysis","volume":"32","author":"De La Cruz-Vargas","year":"2025","journal-title":"Curr. Oncol."},{"issue":"4","key":"10.1016\/j.canlet.2026.218906_bib143","doi-asserted-by":"crossref","first-page":"279","DOI":"10.5468\/ogs.2016.59.4.279","article-title":"Association of plasma adiponectin and leptin levels with the development and progression of ovarian cancer","volume":"59","author":"Jin","year":"2016","journal-title":"Obstet Gynecol Sci"},{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib144","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1158\/1055-9965.EPI-12-1444","article-title":"Adipocytokines, inflammation, and breast cancer risk in postmenopausal women: a prospective study","volume":"22","author":"Gross","year":"2013","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"18","key":"10.1016\/j.canlet.2026.218906_bib146","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1158\/0008-5472.CAN-20-1281","article-title":"Circulating insulin-like growth Factor-I concentrations and risk of 30 cancers: prospective analyses in UK biobank","volume":"80","author":"Knuppel","year":"2020","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.canlet.2026.218906_bib147","doi-asserted-by":"crossref","first-page":"172","DOI":"10.21037\/atm.2020.02.02","article-title":"Myeloid derived suppressor cells are reduced and T regulatory cells stabilised in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega 3","volume":"8","author":"Isherwood","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"9","key":"10.1016\/j.canlet.2026.218906_bib148","doi-asserted-by":"crossref","first-page":"9286","DOI":"10.3390\/cimb46090549","article-title":"Role of nutrients regulating Myeloid derived suppressor cells in cancer: a scoping review","volume":"46","author":"P\u00e9rez-Pel\u00e1ez","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"issue":"15","key":"10.1016\/j.canlet.2026.218906_bib150","doi-asserted-by":"crossref","DOI":"10.3390\/nu15153453","article-title":"WISER survivor trial: combined effect of exercise and weight loss interventions on adiponectin and Leptin levels in breast cancer survivors with overweight or obesity","volume":"15","author":"Lin","year":"2023","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib151","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.4049\/jimmunol.1501677","article-title":"Propranolol Attenuates surgical stress-induced elevation of the regulatory T cell response in patients undergoing radical mastectomy","volume":"196","author":"Zhou","year":"2016","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17081357","article-title":"The impact of beta blockers on survival in cancer patients: a systematic review and meta-analysis","volume":"17","author":"Sharma","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.canlet.2026.218906_bib153","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11523-025-01184-y","article-title":"The efficacy and safety of beta-blockers and immune checkpoint inhibitors in patients with cancer: a systematic review and meta-analysis","volume":"20","author":"Tokunaga","year":"2025","journal-title":"Targeted Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib154","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1158\/1078-0432.CCR-20-2381","article-title":"Phase I clinical trial of combination propranolol and pembrolizumab in locally advanced and metastatic melanoma: safety, tolerability, and preliminary evidence of antitumor activity","volume":"27","author":"Gandhi","year":"2021","journal-title":"Clin. Cancer Res."},{"issue":"10496","key":"10.1016\/j.canlet.2026.218906_bib155","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/S0140-6736(25)01040-2","article-title":"Relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): an open-label, randomised, controlled, phase 3 trial","volume":"405","author":"Olawaiye","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2026.218906_bib156","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ygyno.2024.05.031","article-title":"Association of allostatic load with overall survival in epithelial ovarian cancer","volume":"186","author":"Borho","year":"2024","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib157","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10549-025-07626-5","article-title":"A randomized phase II trial of nab-paclitaxel with or without mifepristone for advanced triple-negative breast cancer","volume":"211","author":"Chen","year":"2025","journal-title":"Breast Cancer Res. Treat."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib158","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ygyno.2009.10.071","article-title":"A phase II evaluation of mifepristone in the treatment of recurrent or persistent epithelial ovarian, fallopian or primary peritoneal cancer: a gynecologic oncology group study","volume":"116","author":"Rocereto","year":"2010","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib159","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1016\/S1470-2045(21)00639-2","article-title":"Toxicity and efficacy of chronomodulated chemotherapy: a systematic review","volume":"23","author":"Printezi","year":"2022","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib160","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/NCC.0000000000000804","article-title":"The effects of cognitive-behavioral stress management for breast cancer patients: a systematic review and meta-analysis of randomized controlled trials","volume":"43","author":"Tang","year":"2020","journal-title":"Cancer Nurs."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib161","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/1099800418789777","article-title":"A large randomized trial: effects of mindfulness-based stress reduction (MBSR) for Breast Cancer (BC) survivors on salivary cortisol and IL-6","volume":"21","author":"Lengacher","year":"2019","journal-title":"Biol. Res. Nurs."},{"issue":"15","key":"10.1016\/j.canlet.2026.218906_bib162","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1158\/0008-5472.CAN-20-4090","article-title":"Gut microbiota\u2013derived short-chain fatty acids promote prostate cancer growth via IGF1 signaling","volume":"81","author":"Matsushita","year":"2021","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib164","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1186\/s12885-025-14788-4","article-title":"Impacts of omega-3 fatty acids intervention on immune functions and clinical outcomes in surgical gastric cancer patients: a systematic review and trial sequential meta-analysis","volume":"25","author":"Yue","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2026.218906_bib165","article-title":"Effects of omega-3 supplementation on gastrointestinal cancers and treatment-related complications: an umbrella review of meta-analyses","volume":"13","author":"Abbasi","year":"2025","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"10.1016\/j.canlet.2026.218906_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2024.112466","article-title":"Does the ratio of eicosapentaenoic acid to docosahexaenoic acid matter in cancer treatment? A systematic review of their effects on cachexia-related inflammation","volume":"124","author":"Szlendak","year":"2024","journal-title":"Nutrition"},{"issue":"8","key":"10.1016\/j.canlet.2026.218906_bib186","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1158\/1078-0432.CCR-19-2641","article-title":"Preoperative \u03b2-Blockade with propranolol reduces biomarkers of metastasis in breast cancer: a phase II randomized trial","volume":"26","author":"Hiller","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"10538","key":"10.1016\/j.canlet.2026.218906_bib187","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(26)00462-9","article-title":"Overall survival with relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): a phase 3 randomised controlled trial","volume":"407","author":"Lorusso","year":"2026","journal-title":"Lancet"},{"issue":"24","key":"10.1016\/j.canlet.2026.218906_bib188","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1056\/NEJMoa2409515","article-title":"Ponsegromab for the treatment of cancer Cachexia","volume":"391","author":"Groarke","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.canlet.2026.218906_bib189","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1158\/1078-0432.CCR-23-1631","article-title":"A phase Ib first-in-patient study assessing the safety, tolerability, pharmacokinetics, and pharmacodynamics of ponsegromab in participants with cancer and Cachexia","volume":"30","author":"Crawford","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"6529","key":"10.1016\/j.canlet.2026.218906_bib190","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.abf3363","article-title":"Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients","volume":"371","author":"Davar","year":"2021","journal-title":"Science"},{"issue":"6529","key":"10.1016\/j.canlet.2026.218906_bib191","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1126\/science.abb5920","article-title":"Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients","volume":"371","author":"Baruch","year":"2021","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.canlet.2026.218906_bib192","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1200\/JCO.2006.06.1440","volume":"24","author":"Giacchetti","year":"2006","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.canlet.2026.218906_bib193","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/PSY.0b013e318186fb27","article-title":"Stress management intervention reduces serum cortisol and increases relaxation during treatment for nonmetastatic breast cancer","volume":"70","author":"Phillips","year":"2008","journal-title":"Psychosom. Med."},{"issue":"24","key":"10.1016\/j.canlet.2026.218906_bib194","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1056\/NEJMoa011871","article-title":"The effect of group psychosocial support on survival in metastatic breast cancer","volume":"345","author":"Goodwin","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.canlet.2026.218906_bib195","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1200\/JCO.2017.75.7526","article-title":"Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or Obese survivors of breast cancer: a randomized controlled trial","volume":"36","author":"Dieli-Conwright","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib196","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa2502760","article-title":"Structured exercise after adjuvant chemotherapy for Colon cancer","volume":"393","author":"Courneya","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib167","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1186\/s12885-025-13956-w","article-title":"Vagal nerve activity and cancer prognosis: a systematic review and meta-analysis","volume":"25","author":"Huang","year":"2025","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2026.218906_bib168","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s40425-019-0674-1","article-title":"Characterization of a whole blood assay for quantifying myeloid-derived suppressor cells","volume":"7","author":"Apodaca","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"7","key":"10.1016\/j.canlet.2026.218906_bib169","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1158\/1078-0432.CCR-18-1449","article-title":"The first-week proliferative response of peripheral blood PD-1(+)CD8(+) T cells predicts the response to Anti-PD-1 therapy in solid tumors","volume":"25","author":"Kim","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218906_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejon.2024.102587","article-title":"Use of a wearable device to compare subjective and objective fatigue in lung cancer patients and cancer-free controls","volume":"70","author":"Chou","year":"2024","journal-title":"Eur. J. Oncol. Nurs."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:25:50Z","timestamp":1792823150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526006701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":196,"alternative-id":["S0304383526006701"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218906","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central neuroendocrine governance as a unifying framework for host\u2013tumor interaction: From afferent sensing to therapeutic modulation","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218906"}}