{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:30:47Z","timestamp":1793327447709,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.canlet.2026.218913","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:16:32Z","timestamp":1792772192000},"page":"218913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Early WEE1 inhibition prevents senescence-like epigenetic reprogramming of pioneer TMZ-resistant cells and synergizes with temozolomide in MYC-high glioblastoma"],"prefix":"10.1016","volume":"662","author":[{"given":"Yilin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-6329","authenticated-orcid":false,"given":"Yongzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-8871","authenticated-orcid":false,"given":"Ruichao","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218913_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218185","article-title":"Chinese glioma cooperative group, updated clinical practice guidelines for the management of adult diffuse gliomas","volume":"640","author":"Jiang","year":"2026","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218913_bib2","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.20892\/j.issn.2095-3941.2022.0469","article-title":"Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011-2017): a multicenter retrospective study from CGGA","volume":"19","author":"Zhang","year":"2022","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.canlet.2026.218913_bib3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.canlet.2020.10.050","article-title":"Clinical practice guidelines for the management of adult diffuse gliomas","volume":"499","author":"Jiang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218913_bib4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2026.218913_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2026.218415","article-title":"Glioma cooperative, the CGCG response assessment criteria for spinal cord gliomas","volume":"646","author":"Wang","year":"2026","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218913_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4161\/cc.9.1.10363","article-title":"Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles","volume":"9","author":"Quiros","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2026.218913_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adh4181","article-title":"Identifying predictors of glioma evolution from longitudinal sequencing","volume":"15","author":"Mu","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218913_bib8","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2026.218913_bib9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.20892\/j.issn.2095-3941.2020.0179","article-title":"Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma","volume":"18","author":"Chai","year":"2021","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.canlet.2026.218913_bib10","first-page":"363","article-title":"Comprehensive understanding of glioblastoma molecular phenotypes: classification, characteristics, and transition","volume":"21","author":"Xu","year":"2024","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.canlet.2026.218913_bib11","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1038\/s41467-020-17717-0","article-title":"MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas","volume":"11","author":"Oldrini","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218913_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.devcel.2021.12.007","article-title":"Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy","volume":"57","author":"Xie","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2026.218913_bib13","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1158\/0008-5472.CAN-21-0752","article-title":"Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence","volume":"81","author":"Fletcher-Sananikone","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218913_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055665","article-title":"Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage","volume":"8","author":"Knizhnik","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218913_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41467-023-36124-9","article-title":"Cellular senescence in malignant cells promotes tumor progression in mouse and patient glioblastoma","volume":"14","author":"Salam","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218913_bib16","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/neuonc\/noaf107","article-title":"Therapy-induced senescent glioblastoma cells sustain a procancer immune microenvironment by activating DDX58-mediated STAT1 signaling","volume":"27","author":"Wang","year":"2025","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218913_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adu3956","article-title":"Ara-C suppresses H3 K27-altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity","volume":"11","author":"Pang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2026.218913_bib18","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1158\/2159-8290.CD-16-0217","article-title":"BRD4 connects enhancer remodeling to senescence immune surveillance","volume":"6","author":"Tasdemir","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218913_bib19","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.molcel.2019.01.021","article-title":"Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence","volume":"73","author":"Sen","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2026.218913_bib20","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/s41388-024-02956-y","article-title":"METTL3 promotes cellular senescence of colorectal cancer via modulation of CDKN2B transcription and mRNA stability","volume":"43","author":"Chen","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218913_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/neuonc\/noag232","article-title":"H3K27me3 loss and METTL3-m6A converge to upregulate SOX11\/SMARCA4 and drive H3K27-altered spinal cord glioma stemness and proliferation","author":"Yan","year":"2026","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218913_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.canlet.2021.04.020","article-title":"METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-\u03baB to promote the malignant progression of IDH-Wildtype glioma","volume":"511","author":"Chang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218913_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13045-021-01124-z","article-title":"YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m(6)A modification to activate NF-\u03baB and promote the malignant progression of glioma","volume":"14","author":"Chai","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2026.218913_bib24","doi-asserted-by":"crossref","first-page":"9169","DOI":"10.1073\/pnas.1403565111","article-title":"DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin","volume":"111","author":"Ayrapetov","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2026.218913_bib25","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1083\/jcb.201611135","article-title":"Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair","volume":"216","author":"Gong","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218913_bib26","article-title":"Targeting WTAP\/ROR1\/WNT5A-Mediated crosstalk between glioma stem cells and macrophages to normalize tumor vasculature and enhance chemotherapy","volume":"13","author":"Chen","year":"2026","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2026.218913_bib27","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1158\/0008-5472.CAN-15-2402","article-title":"A three-dimensional organoid culture system derived from human glioblastomas recapitulates the hypoxic gradients and cancer stem cell heterogeneity of tumors found in vivo","volume":"76","author":"Hubert","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218913_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218913_bib29","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1038\/s41467-020-17467-z","article-title":"H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients","volume":"11","author":"Schleich","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218913_bib30","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41586-019-1016-7","article-title":"Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally","volume":"567","author":"Huang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218913_bib31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nature25784","article-title":"The SMAD2\/3 interactome reveals that TGF\u03b2 controls m(6)A mRNA methylation in pluripotency","volume":"555","author":"Bertero","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218913_bib32","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1158\/1078-0432.CCR-14-2588","article-title":"The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma","volume":"21","author":"Pokorny","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218913_bib33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41419-022-04590-6","article-title":"Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218913_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.835273","article-title":"Cellular heterogeneity and cooperativity in glioma persister cells under temozolomide treatment","volume":"10","author":"Rab\u00e9","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2026.218913_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2010.02.027","article-title":"A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations","volume":"141","author":"Sharma","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218913_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-026-10791-2","article-title":"Mitochondrial metabolism and epigenetic crosstalk drive SASP","author":"Martini","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218913_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41420-023-01327-y","article-title":"METTL3 knockdown promotes temozolomide sensitivity of glioma stem cells via decreasing MGMT and APNG mRNA stability","volume":"9","author":"Shi","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.canlet.2026.218913_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003769","article-title":"c-Myc is required for maintenance of glioma cancer stem cells","volume":"3","author":"Wang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218913_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2026.218418","article-title":"WEE1 stabilizes MYC to promote therapeutic resistance in esophageal adenocarcinoma","volume":"646","author":"Thangaretnam","year":"2026","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218913_bib40","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1093\/nar\/gkv722","article-title":"SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells","volume":"43","author":"Alagoz","year":"2015","journal-title":"Nucleic Acids Res."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526006774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:36:13Z","timestamp":1793324173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526006774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S0304383526006774"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218913","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early WEE1 inhibition prevents senescence-like epigenetic reprogramming of pioneer TMZ-resistant cells and synergizes with temozolomide in MYC-high glioblastoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218913"}}