{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:34:53Z","timestamp":1774611293064,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.canrad.2009.04.003","type":"journal-article","created":{"date-parts":[[2009,6,13]],"date-time":"2009-06-13T05:04:59Z","timestamp":1244869499000},"page":"259-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Int\u00e9r\u00eat des applications cutan\u00e9es en cours de radioth\u00e9rapie pour la pr\u00e9vention et le traitement des \u00e9pith\u00e9liites radio-induites"],"prefix":"10.1016","volume":"13","author":[{"given":"C.","family":"Chargari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Fromantin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.M.","family":"Kirova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2009.04.003_bib1","first-page":"9","article-title":"Histochemical and biochemical modifications induced by experimental irradiation of human skin maintained in survival conditions and modulation by application of an emulsion containing trolamine","volume":"25","author":"Boisnic","year":"2003","journal-title":"Int J Tissue React"},{"key":"10.1016\/j.canrad.2009.04.003_bib2","first-page":"802","article-title":"The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline","volume":"14","author":"Bolderston","year":"2006","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.canrad.2009.04.003_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-8140(01)00327-9","article-title":"Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study","volume":"59","author":"Bostr\u00f6m","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.7547\/87507315-77-4-165","article-title":"Aloe vera and wound healing","volume":"77","author":"Davis","year":"1987","journal-title":"J Am Podiatr Med Assoc"},{"key":"10.1016\/j.canrad.2009.04.003_bib5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.7547\/87507315-79-11-559","article-title":"Wound healing: Oral and topical activity of aloe vera","volume":"79","author":"Davis","year":"1989","journal-title":"J Am Podiatr Med Assoc"},{"key":"10.1016\/j.canrad.2009.04.003_bib6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1440-1673.1997.tb00672.x","article-title":"Sucralfate cream in the management of moist desquamation during radiotherapy","volume":"41","author":"Delaney","year":"1997","journal-title":"Australas Radiol"},{"key":"10.1016\/j.canrad.2009.04.003_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/09553000500103033","article-title":"Effects of dexpanthenol with or without aloe vera extract on radiation-induced oral mucositis: preclinical studies","volume":"81","author":"D\u00f6rr","year":"2005","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.canrad.2009.04.003_bib8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S1278-3218(97)82951-4","article-title":"Late effects of mammary radiotherapy on skin and subcutaneous tissues","volume":"1","author":"Dubray","year":"1997","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2009.04.003_bib9","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1200\/JCO.2005.04.9148","article-title":"Phase III Trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99-13","volume":"24","author":"Elliott","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib10","first-page":"305","article-title":"Topical Biafine and Lipiderm for the prevention of radiation dermatitis: a randomized prospective trial","volume":"8","author":"Fenig","year":"2001","journal-title":"Oncol Rep"},{"key":"10.1016\/j.canrad.2009.04.003_bib11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","article-title":"Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13","volume":"48","author":"Fisher","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2009.04.003_bib12","first-page":"30397","article-title":"Effectiveness of topical steroids in the control of radiation dermatitis: a randomised trial using 1% hydrocortisone cream and 0,05% clobetasone butyrate (Eumovate)","author":"Glees","year":"1979","journal-title":"Clin Radiol"},{"key":"10.1016\/j.canrad.2009.04.003_bib13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00002820-200212000-00007","article-title":"A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue","volume":"25","author":"Heggie","year":"2002","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.canrad.2009.04.003_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/01.CCM.0000232625.63460.D4","article-title":"Advances in burn critical care","volume":"34","author":"Ipaktchi","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.canrad.2009.04.003_bib15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2407-6-119","article-title":"A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation","volume":"6","author":"Jim\u00e9nez-Medina","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canrad.2009.04.003_bib16","first-page":"317","article-title":"A double-blind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the effects of radiation on the skin: interim analysis","volume":"18","author":"Leonardi","year":"2008","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.canrad.2009.04.003_bib17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0167-8140(96)01882-8","article-title":"Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy","volume":"42","author":"Liguori","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib18","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3109\/02841869609100721","article-title":"Skin treatment with bepanthen cream versus no cream during radiotherapy - a randomized controlled trial","volume":"35","author":"Lokkevik","year":"1996","journal-title":"Acta Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1278-3218(01)80017-2","article-title":"Radiation-induced skin toxicities: prevention, treatment","volume":"5","author":"Lorette","year":"2001","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2009.04.003_bib20","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.ijrobp.2006.12.049","article-title":"Randomized comparison of dry dressings versus hydrogel in management of radiation-induced moist desquamation","volume":"68","author":"Macmillan","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2009.04.003_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1748-717X-2-45","article-title":"A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients","volume":"2","author":"Merchant","year":"2007","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib22","first-page":"543","article-title":"The effect of aloe vera gel\/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy","volume":"28","author":"Olsen","year":"2001","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.canrad.2009.04.003_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0378-6323.32755","article-title":"Topical betamethasone for prevention of radiation dermatitis","volume":"73","author":"Omidvari","year":"2007","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.canrad.2009.04.003_bib24","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1200\/JCO.2004.07.063","article-title":"Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer","volume":"22","author":"Pommier","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1148\/radiology.143.3.7079509","article-title":"Prophylaxis of radiation dermatitis with a topical cortisone cream","volume":"143","author":"Potera","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.canrad.2009.04.003_bib26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/15569520600860009","article-title":"A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis","volume":"25","author":"Primavera","year":"2006","journal-title":"Cutan Ocul Toxicol"},{"key":"10.1016\/j.canrad.2009.04.003_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000114871","article-title":"Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test","volume":"21","author":"Reuter","year":"2008","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.canrad.2009.04.003_bib28","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.clon.2005.04.013","article-title":"Aloe vera for preventing radiation-induced skin reactions: a systematic literature review","volume":"17","author":"Richardson","year":"2005","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.canrad.2009.04.003_bib29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00066-004-1174-9","article-title":"Th\u00eata-Cream versus Bepanthol lotion in breast cancer patients under radiotherapy. A new prophylactic agent in skin care?","volume":"180","author":"R\u00f6per","year":"2004","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.canrad.2009.04.003_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0167-8140(00)00322-4","article-title":"The impact of skin washing with water and soap during breast irradiation: a randomized study","volume":"58","author":"Roy","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib31","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1365-2133.2002.04751.x","article-title":"Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study","volume":"146","author":"Schmuth","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.canrad.2009.04.003_bib32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/0019-509X.29424","article-title":"Prophylactic beclomethasone spray to the skin during postoperative radiotherapy of carcinoma breast: a prospective randomized study","volume":"43","author":"Shukla","year":"2006","journal-title":"Indian J Cancer"},{"key":"10.1016\/j.canrad.2009.04.003_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-8140(97)00115-1","article-title":"Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans?","volume":"46","author":"Simonen","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijrobp.2004.02.012","article-title":"Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms","volume":"60","author":"Su","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2009.04.003_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0360-3016(01)01576-0","article-title":"Phase II study assessing the effectiveness of Biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy","volume":"51","author":"Szumacher","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2009.04.003_bib36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.canrad.2006.09.047","article-title":"Does concurrent radiochemotherapy affect cosmetic results in the adjuvant setting after breast-conserving surgery? Results of the ARCOSEIN multicenter. Phase III study: patients\u2019 and doctors\u2019 views","volume":"10","author":"Toledano","year":"2006","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2009.04.003_bib37","first-page":"124","article-title":"Phase 2 study of silver leaf dressing for treatment of radiation-induced dermatitis in patients receiving radiotherapy to the head and neck","volume":"37","author":"Vavassis","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.canrad.2009.04.003_bib38","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ijrobp.2003.11.031","article-title":"Silver Leaf Nylon Dressing to prevent radiation prevent radiation dermatitis in patients undergoing chemotherapy and external beam radiotherapy to the perineum","volume":"59","author":"Vuong","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2009.04.003_bib39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2004.07.032","article-title":"Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial","volume":"73","author":"Wells","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2009.04.003_bib40","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1188\/04.ONF.237-247","article-title":"Prevention and treatment of acute radiation dermatitis","volume":"31","author":"Wickline","year":"2004","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.canrad.2009.04.003_bib41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0360-3016(96)00320-3","article-title":"Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity","volume":"36","author":"Williams","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S127832180900050X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S127832180900050X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:15:15Z","timestamp":1761135315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S127832180900050X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S127832180900050X"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2009.04.003","relation":{},"ISSN":["1278-3218"],"issn-type":[{"value":"1278-3218","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Int\u00e9r\u00eat des applications cutan\u00e9es en cours de radioth\u00e9rapie pour la pr\u00e9vention et le traitement des \u00e9pith\u00e9liites radio-induites","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2009.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO). Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}