{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:46:43Z","timestamp":1789444003224,"version":"build-2803163510"},"reference-count":99,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.canrad.2011.01.008","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T21:17:36Z","timestamp":1306099056000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Modulation pharmacologique des effets tardifs de l\u2019irradiation"],"prefix":"10.1016","volume":"15","author":[{"given":"C.","family":"Bourgier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Monceau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bourhis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9.","family":"Deutsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-C.","family":"Vozenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2011.01.008_bib0005","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.2307\/3579813","article-title":"How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues","volume":"150","author":"Barcellos-Hoff","year":"1998","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0010","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.semradonc.2006.11.005","article-title":"Responses of normal cells to ionizing radiation","volume":"17","author":"Rodemann","year":"2007","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0167-8140(02)00060-9","article-title":"The radiotherapeutic injury: a complex \u2018wound\u2019","volume":"63","author":"Denham","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0020","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0360-3016(00)00744-6","article-title":"Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy","volume":"48","author":"Hovdenak","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0025","first-page":"254","article-title":"Erfahrungen \u00fcber die vertr\u00e4glichkeitsgrenze f\u00fcr r\u00f6ntgenstrahlen und deren nutzanwendung zur verh\u00fctung von sch\u00e4den","volume":"57","author":"Holthusen","year":"1936","journal-title":"Strahlentherapie"},{"key":"10.1016\/j.canrad.2011.01.008_bib0030","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.canrad.2010.04.004","article-title":"Effets secondaires des rayonnements sur les tissus sains et organes \u00e0 risque","volume":"14","author":"Cosset","year":"2010","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2011.01.008_bib0035","series-title":"Clinical radiation pathology","author":"Rubin","year":"1968"},{"key":"10.1016\/j.canrad.2011.01.008_bib0040","series-title":"Radiation biology in cancer research","author":"Withers","year":"1980"},{"key":"10.1016\/j.canrad.2011.01.008_bib0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0167-8140(01)00429-7","article-title":"Consequential late effects in normal tissues","volume":"61","author":"Dorr","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1053-4296(05)80034-7","article-title":"Patient-to-patient variability in the expression of radiation-induced normal tissue injury","volume":"4","author":"Bentzen","year":"1994","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0167-8140(96)01806-3","article-title":"The p53\u00a0gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy","volume":"40","author":"Bristow","year":"1996","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0060","first-page":"557","article-title":"Radiation reaction in ataxia telangiectasia","volume":"116","author":"Morgan","year":"1968","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.canrad.2011.01.008_bib0065","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/02841860152619115","article-title":"The inherited basis of human radiosensitivity","volume":"40","author":"Gatti","year":"2001","journal-title":"Acta Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0070","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.canrad.2011.01.008_bib0075","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0360-3016(03)00523-6","article-title":"Relative roles of ICAM-1\u00a0and VCAM-1\u00a0in the pathogenesis of experimental radiation-induced intestinal inflammation","volume":"57","author":"Molla","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0080","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.3748\/wjg.v13.i22.3043","article-title":"Radiation-induced intestinal inflammation","volume":"13","author":"Molla","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0085","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0360-3016(99)00286-2","article-title":"Influence of dose-rate on inflammatory damage and adhesion molecule expression after abdominal radiation in the rat","volume":"45","author":"Molla","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0090","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2\u00a0paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0095","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0100","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF02147594","article-title":"Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction","volume":"27","author":"Gabbiani","year":"1971","journal-title":"Experientia"},{"key":"10.1016\/j.canrad.2011.01.008_bib0105","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast. One function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0115","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/clim.2001.5008","article-title":"Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment","volume":"99","author":"Sime","year":"2001","journal-title":"Clin Immunol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0120","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1513\/pats.200601-004TK","article-title":"Epithelial origin of myofibroblasts during fibrosis in the lung","volume":"3","author":"Willis","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.canrad.2011.01.008_bib0125","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nri954","article-title":"The lineage decisions of helper T cells","volume":"2","author":"Murphy","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0130","series-title":"The radiation biology of the vascular endothelium","first-page":"1","article-title":"The endothelial cell is a unique target of radiation: an overview","author":"Fajardo","year":"1998"},{"key":"10.1016\/j.canrad.2011.01.008_bib0135","first-page":"9","article-title":"Radiation-induced vascular injury and its relation to late effects in normal tissues","author":"Law","year":"1981","journal-title":"Adv Radiat Biol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0140","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1006\/bbrc.1995.2841","article-title":"E-selectin gene induction by ionizing radiation is independent of cytokine induction","volume":"217","author":"Hallahan","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.canrad.2011.01.008_bib0145","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1182\/blood.V88.10.3801.bloodjournal88103801","article-title":"Ionizing irradiation increases transcription of the von Willebrand factor gene in endothelial cells","volume":"88","author":"Jahroudi","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.canrad.2011.01.008_bib0150","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1152\/jappl.1985.58.2.592","article-title":"Prostacyclin synthesis in irradiated endothelial cells cultured from bovine aorta","volume":"58","author":"Rubin","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0155","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1055\/s-0038-1653889","article-title":"The effect of ionizing radiation on endothelial tissue factor activity and its cellular localization","volume":"73","author":"Verheij","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.canrad.2011.01.008_bib0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0360-3016(88)90357-4","article-title":"Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme","volume":"15","author":"Ward","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0165","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2307\/3578417","article-title":"Thrombomodulin as a marker of radiation-induced endothelial cell injury","volume":"131","author":"Zhou","year":"1992","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0170","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/sj.bjc.6603637","article-title":"The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes","volume":"96","author":"Giotopoulos","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.canrad.2011.01.008_bib0175","first-page":"1135","article-title":"Terminal differentiation of human fibroblasts is induced by radiation","volume":"5","author":"Rodemann","year":"1991","journal-title":"Scanning Microsc"},{"key":"10.1016\/j.canrad.2011.01.008_bib0180","first-page":"35","article-title":"Radiation-induced alterations of the proliferation dynamics of human skin fibroblasts after repeated irradiation in the subtherapeutic dose range","volume":"171","author":"Bumann","year":"1995","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0185","first-page":"1077","article-title":"Redox-mediated activation of latent transforming growth factor-beta 1","volume":"10","author":"Barcellos-Hoff","year":"1996","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0190","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1667\/RR0695.1","article-title":"Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species","volume":"166","author":"Jobling","year":"2006","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0195","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1053\/gast.2000.19282","article-title":"Recombinant soluble transforming growth factor beta type II receptor ameliorates radiation enteropathy in mice","volume":"119","author":"Zheng","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canrad.2011.01.008_bib0200","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ijrobp.2008.02.046","article-title":"Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury","volume":"71","author":"Anscher","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0205","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1667\/RR3128","article-title":"Gene expression profile in human late radiation enteritis obtained by high-density cDNA array hybridization","volume":"161","author":"Vozenin-Brotons","year":"2004","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0210","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1164\/ajrccm.163.1.2001089","article-title":"Contribution of small GTPase Rho and its target protein rock in a murine model of lung fibrosis","volume":"163","author":"Shimizu","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.canrad.2011.01.008_bib0215","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1681\/ASN.V1291853","article-title":"Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP","volume":"12","author":"Heusinger-Ribeiro","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0220","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1046\/j.1523-1755.2002.00328.x","article-title":"Y-27632\u00a0prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction","volume":"61","author":"Nagatoya","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.canrad.2011.01.008_bib0225","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/sj.bjp.0704173","article-title":"Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)","volume":"133","author":"Eberlein","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0230","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0168-8278(01)00169-6","article-title":"Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells","volume":"35","author":"Murata","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0235","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/gut.2004.051169","article-title":"Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression","volume":"54","author":"Bourgier","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.canrad.2011.01.008_bib0240","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1158\/1078-0432.CCR-07-0625","article-title":"Pravastatin Inhibits the Rho\/CCN2\/extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats","volume":"13","author":"Haydont","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0245","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1259\/bjr\/58514380","article-title":"Rho\/ROCK pathway as a molecular target for modulation of intestinal radiation-induced toxicity","volume":"80","author":"Haydont","year":"2007","journal-title":"Br J Radiol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0250","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.ijrobp.2007.03.044","article-title":"Successful mitigation of delayed intestinal radiation injury using pravastatin is not associated with acute injury improvement or tumor protection","volume":"68","author":"Haydont","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0255","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.radonc.2005.06.029","article-title":"Induction of CTGF by TGF-beta1\u00a0in normal and radiation enteritis human smooth muscle cells: Smad\/Rho balance and therapeutic perspectives","volume":"76","author":"Haydont","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0260","doi-asserted-by":"crossref","first-page":"L510","DOI":"10.1152\/ajplung.00144.2002","article-title":"Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process?","volume":"283","author":"Demayo","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0265","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1165\/ajrcmb.16.3.9070613","article-title":"Alveolar macrophages stimulated with titanium dioxide, chrysotile asbestos, and residual oil fly ash upregulate the PDGF receptor-alpha on lung fibroblasts through an IL-1beta-dependent mechanism","volume":"16","author":"Lindroos","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0270","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.RES.81.3.320","article-title":"Platelet-derived growth factor ligand and receptor expression in response to altered blood flow in vivo","volume":"81","author":"Mondy","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0275","first-page":"395","article-title":"Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma","volume":"79","author":"Zhang","year":"1999","journal-title":"Lab Invest"},{"key":"10.1016\/j.canrad.2011.01.008_bib0280","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/35074588","article-title":"PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor","volume":"3","author":"Bergsten","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0285","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/35010579","article-title":"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor","volume":"2","author":"Li","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0290","doi-asserted-by":"crossref","first-page":"L182","DOI":"10.1152\/ajplung.00083.2003","article-title":"Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis","volume":"286","author":"Zhuo","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0295","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0167-8140(94)90446-4","article-title":"Expression of fibrogenic cytokines in rat small intestine after fractionated irradiation","volume":"32","author":"Langberg","year":"1994","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0300","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-3083.1988.tb02349.x","article-title":"Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation","volume":"27","author":"Rubin","year":"1988","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0305","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1667\/0033-7587(2003)159[0805:IBACCO]2.0.CO;2","article-title":"Increased binding and chemotactic capacities of PDGF-BB on fibroblasts in radiation pneumonitis","volume":"159","author":"Tada","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0310","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cytogfr.2004.03.006","article-title":"Regulation of PDGF and its receptors in fibrotic diseases","volume":"15","author":"Bonner","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.canrad.2011.01.008_bib0315","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2174\/156652406777435426","article-title":"EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases","volume":"6","author":"Ingram","year":"2006","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.canrad.2011.01.008_bib0320","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1084\/jem.20041393","article-title":"Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis","volume":"201","author":"Abdollahi","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.canrad.2011.01.008_bib0325","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev"},{"key":"10.1016\/j.canrad.2011.01.008_bib0330","first-page":"1","article-title":"IGF-I mediated survival pathways in normal and malignant cells","volume":"1766","author":"Kurmasheva","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.canrad.2011.01.008_bib0335","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(03)00159-9","article-title":"The insulin-like growth factor system and cancer","volume":"195","author":"LeRoith","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canrad.2011.01.008_bib0340","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1164\/rccm.200802-228OC","article-title":"Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury","volume":"179","author":"Choi","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.canrad.2011.01.008_bib0345","doi-asserted-by":"crossref","unstructured":"Ai W, Zhang Y, Tang QZ, Bian ZY, Liu C, Huang H, et al. Silibinin attenuates cardiac hypertrophy and fibrosis through blocking EGFR-dependent signaling. J Cell Biochem 2010;110:1111\u201322.","DOI":"10.1002\/jcb.22623"},{"key":"10.1016\/j.canrad.2011.01.008_bib0350","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/10715768609051643","article-title":"Treatment of radiofibrosis with liposomal superoxide dismutase. Preliminary results of 50\u00a0cases","volume":"1","author":"Baillet","year":"1986","journal-title":"Free Radic Res Commun"},{"key":"10.1016\/j.canrad.2011.01.008_bib0355","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0167-8140(94)90444-8","article-title":"Successful treatment of radiation-induced fibrosis using liposomal Cu\/Zn superoxide dismutase: clinical trial","volume":"32","author":"Delanian","year":"1994","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0360","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/1523-1747.ep12612819","article-title":"Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1\u00a0down-regulation","volume":"104","author":"Duncan","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0365","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.radonc.2004.08.021","article-title":"The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway","volume":"73","author":"Delanian","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0370","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1200\/JCO.2003.06.064","article-title":"Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis","volume":"21","author":"Delanian","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0375","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1200\/JCO.2005.02.4729","article-title":"Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis","volume":"23","author":"Delanian","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0380","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1278-3218(00)00010-X","article-title":"Radiation-induced superficial fibrosis and TGF-alpha 1","volume":"4","author":"Martin","year":"2000","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2011.01.008_bib0385","article-title":"Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a Phase II trial","author":"Delanian","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0390","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jns.2008.08.004","article-title":"Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo)","volume":"275","author":"Delanian","year":"2008","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.canrad.2011.01.008_bib0395","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1200\/JCO.2004.09.101","article-title":"Pentoxifylline in the treatment of radiation-induced fibrosis","volume":"22","author":"Okunieff","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0400","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.radonc.2005.02.002","article-title":"Phase II study of vitamin E and pentoxifylline in patients with late side effects of pelvic radiotherapy","volume":"75","author":"Gothard","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0405","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.radonc.2004.09.013","article-title":"Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer","volume":"73","author":"Gothard","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0410","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1667\/RR3383","article-title":"Modulation of DNA damage by pentoxifylline and alpha-tocopherol in skin fibroblasts exposed to Gamma rays","volume":"164","author":"Laurent","year":"2005","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0415","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/09553000600733150","article-title":"DNA damage in cultured skin microvascular endothelial cells exposed to gamma rays and treated by the combination pentoxifylline and alpha-tocopherol","volume":"82","author":"Laurent","year":"2006","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0420","first-page":"202","article-title":"La fibrose iatrog\u00e9nique en canc\u00e9rologie (2e partie)\u00a0: principales \u00e9tiologies et possibilit\u00e9s th\u00e9rapeutiques","volume":"80","author":"Delanian","year":"1993","journal-title":"Bull Cancer"},{"key":"10.1016\/j.canrad.2011.01.008_bib0425","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2307\/3578505","article-title":"Amelioration of radiation nephropathy in rats by dexamethasone treatment after irradiation","volume":"134","author":"Geraci","year":"1993","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0430","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2307\/3577947","article-title":"Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis","volume":"127","author":"Gross","year":"1991","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0435","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/02841869409098397","article-title":"On radiation damage to normal tissues and its treatment. II. Anti-inflammatory drugs","volume":"33","author":"Michalowski","year":"1994","journal-title":"Acta Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0440","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-8140(01)00430-3","article-title":"Hyperbaric oxygen: an effective tool to treat radiation morbidity in prostate cancer","volume":"61","author":"Mayer","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0445","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2004.04.005","article-title":"Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review","volume":"72","author":"Pasquier","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0450","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.ijrobp.2010.07.129","article-title":"Attenuation and reversal of radiation-induced pulmonary fibrosis in a murine model by an Anti-CTGF monoclonal antibody","volume":"78","author":"Bickelhaupt","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0455","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2174\/156652409787847164","article-title":"Molecular aspects of intestinal radiation-induced fibrosis","volume":"9","author":"Gervaz","year":"2009","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.canrad.2011.01.008_bib0460","doi-asserted-by":"crossref","unstructured":"Monceau V, Pasinetti N, Schupp C, Pouzoulet F, Opolon P, Vozenin MC. Modulation of the Rho\/ROCK Pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity. Curr Drug Targets 2010;11:1395\u2013404.","DOI":"10.2174\/1389450111009011395"},{"key":"10.1016\/j.canrad.2011.01.008_bib0465","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1667\/RR3302","article-title":"Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses","volume":"163","author":"Gaugler","year":"2005","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0470","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/jid.2008.360","article-title":"Pravastatin limits radiation-induced vascular dysfunction in the skin","volume":"129","author":"Holler","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0475","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00001721-200309000-00010","article-title":"Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation","volume":"14","author":"Shi","year":"2003","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.canrad.2011.01.008_bib0480","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3748\/wjg.v13.i22.3047","article-title":"Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy","volume":"13","author":"Wang","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.canrad.2011.01.008_bib0485","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.ijrobp.2007.03.036","article-title":"Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism","volume":"68","author":"Wang","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2011.01.008_bib0490","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1667\/RR3168","article-title":"Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model","volume":"161","author":"Williams","year":"2004","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2011.01.008_bib0495","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.canrad.2006.03.001","article-title":"La chimioth\u00e9rapie concomitante de la radioth\u00e9rapie augmente la toxicit\u00e9 tardive apr\u00e8s chirurgie conservatrice du cancer du sein","volume":"10","author":"Toledano","year":"2006","journal-title":"Cancer Radiother"}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321811000606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321811000606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:18:25Z","timestamp":1761135505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1278321811000606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":99,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S1278321811000606"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2011.01.008","relation":{},"ISSN":["1278-3218"],"issn-type":[{"value":"1278-3218","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation pharmacologique des effets tardifs de l\u2019irradiation","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2011.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO). Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}