{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:11:34Z","timestamp":1791223894415,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"6-7","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.canrad.2015.05.018","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T09:39:52Z","timestamp":1439804392000},"page":"515-518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Radioth\u00e9rapie et immunomodulation\u00a0: mise au point sur les donn\u00e9es exp\u00e9rimentales"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8223-3697","authenticated-orcid":false,"given":"\u00c9.","family":"Deutsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-3429","authenticated-orcid":false,"given":"A.","family":"L\u00e9vy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chargari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2015.05.018_bib0230","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/1097-0142(197603)37:3<1417::AID-CNCR2820370324>3.0.CO;2-N","article-title":"The effect of radiation therapy on lymphocyte subpopulations in cancer patients","volume":"37","author":"Raben","year":"1976","journal-title":"Cancer"},{"key":"10.1016\/j.canrad.2015.05.018_bib0235","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.immuni.2004.07.017","article-title":"The immunobiology of cancer immunosurveillance and immunoediting","volume":"21","author":"Dunn","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.canrad.2015.05.018_bib0240","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrc3246","article-title":"The determinants of tumour immunogenicity","volume":"12","author":"Blankenstein","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.canrad.2015.05.018_bib0245","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S1470-2045(09)70082-8","article-title":"Systemic effects of local radiotherapy","volume":"10","author":"Formenti","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0250","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ijrobp.2005.06.032","article-title":"Combining radiotherapy and immunotherapy: a revived partnership","volume":"63","author":"Demaria","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2015.05.018_bib0255","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.immunol.22.012703.104803","article-title":"The three Es of cancer immunoediting","volume":"22","author":"Dunn","year":"2004","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0260","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1600-065X.2006.00442.x","article-title":"Immune resistance orchestrated by the tumor microenvironment","volume":"213","author":"Gajewski","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1016\/j.canrad.2015.05.018_bib0265","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.coi.2010.11.013","article-title":"Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment","volume":"23","author":"Gajewski","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0270","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0065-2776(08)60911-6","article-title":"Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance","volume":"74","author":"Marincola","year":"2000","journal-title":"Adv Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0275","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1200\/JCO.2009.27.6360","article-title":"Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape","volume":"28","author":"Ferris","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0280","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00262-007-0441-x","article-title":"The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients","volume":"57","author":"Osada","year":"2008","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.canrad.2015.05.018_bib0285","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.cell.2010.02.015","article-title":"Decoding cell death signals in inflammation and immunity","volume":"140","author":"Zitvogel","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.canrad.2015.05.018_bib0290","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0295","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1034\/j.1600-065X.2002.18806.x","article-title":"Tumor-specific shared antigenic peptides recognized by human T cells","volume":"188","author":"Van Der Bruggen","year":"2002","journal-title":"Immunol Rev"},{"key":"10.1016\/j.canrad.2015.05.018_bib0300","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/7403","article-title":"Dendritic cells directly trigger NK cell functions: crosstalk relevant in innate anti-tumor immune responses in vivo","volume":"5","author":"Fernandez","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.canrad.2015.05.018_bib0305","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.immunol.24.021605.090733","article-title":"Human T cell responses against melanoma","volume":"24","author":"Boon","year":"2006","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0310","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nm1622","article-title":"Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy","volume":"13","author":"Apetoh","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.canrad.2015.05.018_bib0315","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/nm.2028","article-title":"Activation of the NLRP3\u00a0inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors","volume":"15","author":"Ghiringhelli","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.canrad.2015.05.018_bib0320","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin exposure dictates the immunogenicity of cancer cell death","volume":"13","author":"Obeid","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.canrad.2015.05.018_bib0325","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4161\/onci.18852","article-title":"Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer","volume":"1","author":"Pere","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.canrad.2015.05.018_bib0330","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1200\/JCO.2008.18.7229","article-title":"Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer","volume":"27","author":"Salama","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0335","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.critrevonc.2010.02.004","article-title":"Targeting immune suppressing myeloid-derived suppressor cells in oncology","volume":"77","author":"Kao","year":"2011","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1667\/RR3196","article-title":"A sense of danger from radiation","volume":"162","author":"McBride","year":"2004","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2015.05.018_bib0345","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1259\/0007-1285-26-305-234","article-title":"Whole body irradiation; radiobiology or medicine?","volume":"26","author":"Mole","year":"1953","journal-title":"Br J Radiol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0350","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.canrad.2014.08.004","article-title":"Effets non cibl\u00e9s (bystander, abscopal) de la radioth\u00e9rapie externe\u00a0: potentielles implications pour le clinicien\u00a0?","volume":"18","author":"Sun","year":"2014","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2015.05.018_bib0355","first-page":"4311","article-title":"Tumor necrosis factor alpha (TNF_lpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature","volume":"56","author":"Mauceri","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.canrad.2015.05.018_bib0360","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1200\/JCO.2004.01.227","article-title":"TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors","volume":"22","author":"Senzer","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0365","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1158\/1078-0432.CCR-04-0296","article-title":"A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities","volume":"10","author":"Mundt","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.canrad.2015.05.018_bib0370","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0375","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.4049\/jimmunol.181.5.3099","article-title":"Radiation-induced CXCL16\u00a0release by breast cancer cells attracts effector T cells","volume":"181","author":"Matsumura","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0380","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-065X.2011.01006.x","article-title":"Armed response: how dying cells influence T-cell functions","volume":"241","author":"Ferguson","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.canrad.2015.05.018_bib0385","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1084\/jem.20052494","article-title":"Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy","volume":"203","author":"Reits","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.canrad.2015.05.018_bib0390","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1182\/blood-2009-02-206870","article-title":"Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment","volume":"114","author":"Lee","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.canrad.2015.05.018_bib0395","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.drup.2013.01.001","article-title":"Understanding the functions of tumor stroma in resistance to ionizing radiation: emerging targets for pharmacological modulation","volume":"16","author":"Chargari","year":"2013","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.canrad.2015.05.018_bib0400","first-page":"5150","article-title":"Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium","volume":"56","author":"Hallahan","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.canrad.2015.05.018_bib0405","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1158\/1078-0432.361.11.1","article-title":"Targeting toll-like receptor\u00a09\u00a0with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy","volume":"11","author":"Mason","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.canrad.2015.05.018_bib0410","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.critrevonc.2012.09.001","article-title":"Radiation therapy and immunotherapy: implications for a combined cancer treatment","volume":"85","author":"L\u00e9vy","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0415","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1084\/jem.171.1.249","article-title":"Synergistic antitumor activity of tumor-infiltrating lymphocytes, interleukin 2, and local tumor irradiation. Studies on the mechanism of action","volume":"171","author":"Cameron","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.canrad.2015.05.018_bib0420","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archotol.131.12.1079","article-title":"Combination nonviral murine interleukin\u00a02\u00a0and interleukin 12\u00a0gene therapy and radiotherapy for head and neck squamous cell carcinoma","volume":"131","author":"Xian","year":"2005","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.canrad.2015.05.018_bib0425","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/CJI.0b013e3181a95165","article-title":"Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer","volume":"32","author":"Teitz-Tennenbaum","year":"2009","journal-title":"J Immunother"},{"key":"10.1016\/j.canrad.2015.05.018_bib0430","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/CJI.0b013e3181880f1e","article-title":"Intratumoral dendritic cells and chemoradiation for the treatment of murine squamous cell carcinoma","volume":"31","author":"Moyer","year":"2008","journal-title":"J Immunother"},{"key":"10.1016\/j.canrad.2015.05.018_bib0435","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1158\/1078-0432.728.11.2","article-title":"Immune-mediated inhibition of metastases following treatment with local radiation and CTLA-4\u00a0blockade in a mouse model of breast cancer","volume":"11","author":"Demaria","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.canrad.2015.05.018_bib0440","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1158\/1535-7163.MCT-14-1015","article-title":"Synergy of radiotherapy and a cancer vaccine for the treatment of HPV-associated head and neck cancer","volume":"14","author":"Mondini","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.canrad.2015.05.018_bib0445","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/ni0702-611","article-title":"CTLA-4: new insights into its biological function and use in tumor immunotherapy","volume":"3","author":"Egen","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.canrad.2015.05.018_bib0225","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature14292","article-title":"Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer","volume":"520","author":"Twyman-Saint Victor","year":"2015","journal-title":"Nature"}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321815001353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321815001353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:26:18Z","timestamp":1761135978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1278321815001353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":45,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1278321815001353"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2015.05.018","relation":{},"ISSN":["1278-3218"],"issn-type":[{"value":"1278-3218","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radioth\u00e9rapie et immunomodulation\u00a0: mise au point sur les donn\u00e9es exp\u00e9rimentales","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2015.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}