{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:13:05Z","timestamp":1779909185280,"version":"3.53.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"6-7","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.canrad.2016.07.079","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T08:31:02Z","timestamp":1473409862000},"page":"467-474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Radioth\u00e9rapie conformationnelle avec modulation d\u2019intensit\u00e9 des cancers des voies a\u00e9rodigestives sup\u00e9rieures\u00a0: dose de tol\u00e9rance de l\u2019\u0153il et des voies optiques"],"prefix":"10.1016","volume":"20","author":[{"given":"J.","family":"Thariat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Racadot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Pointreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Boisselier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-D.","family":"Grange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Graff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2016.07.079_bib0005","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.canrad.2015.04.008","article-title":"Tumeurs malignes ophtalmologiques\u00a0: indications de la radioth\u00e9rapie et techniques","volume":"19","author":"Jardel","year":"2015","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2016.07.079_bib0010","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/1097-0142(19910315)67:6<1539::AID-CNCR2820670613>3.0.CO;2-Q","article-title":"Radiation apoptosis of serous acinar cells of salivary and lacrimal glands","volume":"67","author":"Stephens","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.canrad.2016.07.079_bib0015","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0360-3016(92)90716-U","article-title":"The relationship between apoptosis and atrophy in the irradiated lacrimal gland","volume":"24","author":"Gazda","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0020","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/bjo.54.11.705","article-title":"A fluorescence fundus angiographic study","volume":"54","author":"Hayreh","year":"1970","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.canrad.2016.07.079_bib0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijrobp.2011.06.1957","article-title":"Radiogenic side effects after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212\u00a0patients treated between 1997\u00a0and 2007","volume":"83","author":"Dunavoelgyi","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0030","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ijrobp.2010.09.056","article-title":"Ocular risks from orbital and periorbital radiation therapy: a critical review","volume":"79","author":"Jeganathan","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0035","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/1097-0142(19830315)51:6<980::AID-CNCR2820510603>3.0.CO;2-Y","article-title":"Ocular and orbital complications following radiation therapy of paranasal sinus malignancies and review of literature","volume":"51","author":"Nakissa","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.canrad.2016.07.079_bib0040","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bjo.75.10.629","article-title":"Synergism between diabetic and radiation retinopathy: case report and review","volume":"75","author":"Viebahn","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.canrad.2016.07.079_bib0045","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0360-3016(94)90347-6","article-title":"Radiation retinopathy after external-beam irradiation: analysis of time-dose factors","volume":"30","author":"Parsons","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0050","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0360-3016(99)00057-7","article-title":"Late retinal complications of radiation therapy for nasal and paranasal malignancies: relationship between irradiated-dose area and severity","volume":"44","author":"Takeda","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0060","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.ijrobp.2004.07.664","article-title":"Preventing radiation retinopathy with hyperfractionation","volume":"61","author":"Monroe","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0065","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0360-3016(94)90346-8","article-title":"Radiation optic neuropathy after megavoltage external-beam irradiation: analysis of time-dose factors","volume":"30","author":"Parsons","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0070","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0360-3016(94)90348-4","article-title":"Severe dry-eye syndrome following external beam irradiation","volume":"30","author":"Parsons","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0075","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.ijrobp.2011.05.026","article-title":"Severe dry eye syndrome after radiotherapy for head-and-neck tumors","volume":"82","author":"Bhandare","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0080","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ijrobp.2008.08.010","article-title":"Lacrimal gland radiosensitivity in uveal melanoma patients","volume":"74","author":"Muller","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0085","first-page":"145","article-title":"Prevention of radiation-induced stenosis of the nasolacrimal duct","volume":"25","author":"de Smet","year":"1990","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.canrad.2016.07.079_bib0090","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.ijrobp.2003.08.014","article-title":"Evaluation of the effects of radiotherapy to the chiasm and optic nerve by visual psychophysical and electrophysiologic tests in nasopharyngeal carcinoma","volume":"58","author":"Esassolak","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.radonc.2006.09.009","article-title":"Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons\/protons","volume":"81","author":"Weber","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2016.07.079_bib0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ijrobp.2015.12.011","article-title":"Visual outcomes of parapapillary uveal melanomas following proton beam therapy","volume":"95","author":"Thariat","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2016.07.079_bib0105","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.ijrobp.2004.12.009","article-title":"Does altered fractionation influence the risk of radiation-induced optic neuropathy?","volume":"62","author":"Bhandare","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. 3","key":"10.1016\/j.canrad.2016.07.079_bib0110","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.ijrobp.2009.07.1753","article-title":"Radiation dose\u2013volume effects of optic nerves and chiasm","volume":"76","author":"Mayo","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321816303560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321816303560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:25:45Z","timestamp":1761135945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1278321816303560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":22,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1278321816303560"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2016.07.079","relation":{},"ISSN":["1278-3218"],"issn-type":[{"value":"1278-3218","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radioth\u00e9rapie conformationnelle avec modulation d\u2019intensit\u00e9 des cancers des voies a\u00e9rodigestives sup\u00e9rieures\u00a0: dose de tol\u00e9rance de l\u2019\u0153il et des voies optiques","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2016.07.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}