{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:15:31Z","timestamp":1761178531710,"version":"build-2065373602"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.canrad.2019.11.005","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T09:11:55Z","timestamp":1588065115000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radioth\u00e9rapie avec modulation d\u2019intensit\u00e9 pr\u00e9op\u00e9ratoire des cancers rectaux\u00a0: int\u00e9r\u00eat et application"],"prefix":"10.1016","volume":"24","author":[{"given":"V.","family":"Randrian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Biau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Beno\u00eet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pezet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lapeyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2019.11.005_bib0330","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bulcan.2018.11.016","article-title":"\u00c9pid\u00e9miologie descriptive des cancers en France m\u00e9tropolitaine\u00a0: incidence, survie et pr\u00e9valence","volume":"106","author":"Cowppli-Bony","year":"2019","journal-title":"Bull Cancer"},{"key":"10.1016\/j.canrad.2019.11.005_bib0335","doi-asserted-by":"crossref","first-page":"874","DOI":"10.6004\/jnccn.2018.0061","article-title":"Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology","volume":"16","author":"Benson","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.canrad.2019.11.005_bib0340","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1200\/JCO.2006.06.7629","article-title":"Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4\u00a0rectal cancers: results of FFCD 9203","volume":"24","author":"G\u00e9rard","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0345","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJMoa060829","article-title":"Chemotherapy with preoperative radiotherapy in rectal cancer","volume":"355","author":"Bosset","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.canrad.2019.11.005_bib0350","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJMoa010580","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer","volume":"345","author":"Kapiteijn","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.canrad.2019.11.005_bib0355","first-page":"CD008368","article-title":"Pre-operative chemoradiation for non-metastatic locally advanced rectal cancer","volume":"12","author":"McCarthy","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.canrad.2019.11.005_bib0360","article-title":"Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer","volume":"2","author":"De Caluw\u00e9","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.canrad.2019.11.005_bib0365","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1200\/JCO.2009.22.0467","article-title":"Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03","volume":"27","author":"Roh","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0370","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1200\/JCO.2007.15.3858","article-title":"Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer","volume":"26","author":"Braendengen","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0375","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/j.canrad.2016.07.043","article-title":"Radioth\u00e9rapie des cancers du rectum","volume":"20Suppl","author":"Peiffert","year":"2016","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2019.11.005_bib0380","doi-asserted-by":"crossref","first-page":"vi81","DOI":"10.1093\/annonc\/mdt240","article-title":"ESMO Guidelines Working Group. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Glimelius","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0385","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0140-6736(09)60484-0","article-title":"Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07\u00a0and NCIC-CTG C016): a multicentre, randomised trial","volume":"373","author":"Sebag-Montefiore","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2019.11.005_bib0390","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1754-9485.2010.02212.x","article-title":"The utility of multimodality imaging with CT and MRI in defining rectal tumour volumes for radiotherapy treatment planning: a pilot study","volume":"54","author":"Tan","year":"2010","journal-title":"J Med Imaging Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0395","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1177\/000313481508101230","article-title":"Lymph node size alone is not an accurate predictor of metastases in rectal cancer: a node-for-node comparative study of specimens and histology","volume":"81","author":"Kono","year":"2015","journal-title":"Am Surg"},{"key":"10.1016\/j.canrad.2019.11.005_bib0400","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/DCR.0000000000000321","article-title":"Size and distribution of lymph nodes in rectal cancer resection specimens","volume":"58","author":"Langman","year":"2015","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.canrad.2019.11.005_bib0405","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1259\/bjr\/11855927","article-title":"An evaluation of four CT-MRI co-registration techniques for radiotherapy treatment planning of prone rectal cancer patients","volume":"85","author":"Dean","year":"2012","journal-title":"Br J Radiol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0410","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1259\/bjr\/60198873","article-title":"MR vs. CT imaging: low rectal cancer tumour delineation for three-dimensional conformal radiotherapy","volume":"82","author":"O\u2019Neill","year":"2009","journal-title":"Br J Radiol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0415","doi-asserted-by":"crossref","first-page":"20150097","DOI":"10.1259\/bjr.20150097","article-title":"MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer","volume":"88","author":"Seierstad","year":"2015","journal-title":"Br J Radiol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0420","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.radonc.2016.07.017","article-title":"International consensus guidelines on clinical target volume delineation in rectal cancer","volume":"120","author":"Valentini","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0425","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1748-717X-5-17","article-title":"Intensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications","volume":"5","author":"Arbea","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0430","doi-asserted-by":"crossref","first-page":"e431","DOI":"10.1016\/j.ijrobp.2011.04.060","article-title":"Quantification of organ motion during chemoradiotherapy of rectal cancer using cone-beam computed tomography","volume":"81","author":"Chong","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0435","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13014-014-0311-6","article-title":"Analysis of motion of the rectum during preoperative intensity modulated radiation therapy for rectal cancer using cone-beam computed tomography","volume":"10","author":"Yamashita","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0440","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.clon.2015.10.012","article-title":"Rectal radiotherapy--intensity-modulated radiotherapy delivery, delineation and doses","volume":"28","author":"Teoh","year":"2016","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.canrad.2019.11.005_bib0445","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.clon.2012.08.001","article-title":"Planning target volume margin evaluation and critical structure sparing for rectal cancer patients treated prone on a bellyboard","volume":"25","author":"Cranmer-Sargison","year":"2013","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.canrad.2019.11.005_bib0450","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijrobp.2010.01.046","article-title":"Three-dimensional analysis of recurrence patterns in rectal cancer: the cranial border in hypofractionated preoperative radiotherapy can be lowered","volume":"80","author":"Nijkamp","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0455","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1748-717X-6-63","article-title":"Intensity modulated radiation therapy (IMRT): differences in target volumes and improvement in clinically relevant doses to small bowel in rectal carcinoma","volume":"6","author":"Mok","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0460","first-page":"4935","article-title":"Dosimetric comparison between intensity modulated radiotherapy and 3\u00a0dimensional conformal radiotherapy in the treatment of rectal cancer","volume":"17","author":"Simson","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.canrad.2019.11.005_bib0465","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/1748-717X-8-181","article-title":"A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer","volume":"8","author":"Yu","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0470","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1748-717X-5-14","article-title":"Neoadjuvant chemoradiation of rectal cancer with volumetric modulated arc therapy: summary of technical and dosimetric features and early clinical experience","volume":"5","author":"Richetti","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0475","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijrobp.2007.06.066","article-title":"The dose-volume relationship of small bowel irradiation and acute grade 3\u00a0diarrhea during chemoradiotherapy for rectal cancer","volume":"70","author":"Robertson","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0480","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00066-005-1398-3","article-title":"Comparative analysis of the effects of belly board and bladder distension in postoperative radiotherapy of rectal cancer patients","volume":"181","author":"Kim","year":"2005","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0485","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.ijrobp.2012.09.036","article-title":"Small bowel dose parameters predicting grade\u22653\u00a0acute toxicity in rectal cancer patients treated with neoadjuvant chemoradiation: an independent validation study comparing peritoneal space versus small bowel loop contouring techniques","volume":"85","author":"Banerjee","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0490","first-page":"129","article-title":"Predictors of acute gastrointestinal toxicity during pelvic chemoradiotherapy in patients with rectal cancer","volume":"6","author":"Yang","year":"2013","journal-title":"Gastrointest Cancer Res"},{"key":"10.1016\/j.canrad.2019.11.005_bib0495","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/jrr\/rrw098","article-title":"A retrospective comparison of outcome and toxicity of preoperative image-guided intensity-modulated radiotherapy versus conventional pelvic radiotherapy for locally advanced rectal carcinoma","volume":"58","author":"Huang","year":"2017","journal-title":"J Radiat Res"},{"key":"10.1016\/j.canrad.2019.11.005_bib0500","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.radonc.2016.09.010","article-title":"Acute toxicity with intensity modulated radiotherapy versus 3-dimensional conformal radiotherapy during preoperative chemoradiation for locally advanced rectal cancer","volume":"121","author":"Ng","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0505","first-page":"137","article-title":"Acute gastrointestinal toxicity and tumor response with preoperative intensity modulated radiation therapy for rectal cancer","volume":"6","author":"Parekh","year":"2013","journal-title":"Gastrointest Cancer Res"},{"key":"10.1016\/j.canrad.2019.11.005_bib0510","first-page":"891067","article-title":"Intensity-modulated radiation therapy for rectal carcinoma can reduce treatment breaks and emergency department visits","volume":"2012","author":"Jabbour","year":"2012","journal-title":"Int J Surg Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0515","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1186\/s12885-015-1812-x","article-title":"Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy","volume":"15","author":"Dr\u00f6ge","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canrad.2019.11.005_bib0520","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.ijrobp.2011.01.051","article-title":"Reduced acute bowel toxicity in patients treated with intensity-modulated radiotherapy for rectal cancer","volume":"82","author":"Samuelian","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0525","doi-asserted-by":"crossref","first-page":"557","DOI":"10.7785\/tcrt.2012.500442","article-title":"A dosimetric analysis of preoperative intensity-modulated and image-guided radiation therapy with and without simultaneous integrated boost for locally advanced rectal cancer","volume":"14","author":"Yang","year":"2015","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.canrad.2019.11.005_bib0530","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13014-015-0454-0","article-title":"Can dosimetric parameters predict acute hematologic toxicity in rectal cancer patients treated with intensity-modulated pelvic radiotherapy?","volume":"10","author":"Wan","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0535","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.clon.2016.04.039","article-title":"Intensity-modulated radiotherapy and anal cancer: clinical outcome and late toxicity assessment","volume":"28","author":"De Francesco","year":"2016","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.canrad.2019.11.005_bib0540","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.clon.2012.08.008","article-title":"Organ-sparing Intensity-modulated radiotherapy for anal cancer using the ACTII schedule: a comparison of conventional and intensity-modulated radiotherapy plans","volume":"25","author":"Brooks","year":"2013","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.canrad.2019.11.005_bib0545","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijrobp.2005.02.030","article-title":"Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome","volume":"63","author":"Milano","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0550","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.canrad.2019.11.005_bib0555","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2011.07.030","article-title":"Preoperative concomitant boost intensity-modulated radiotherapy with oral capecitabine in locally advanced mid-low rectal cancer: A phase II trial","volume":"102","author":"Li","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0560","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.21873\/anticanres.13265","article-title":"Effectiveness of intensity-modulated radiotherapy for rectal cancer patients treated with neoadjuvant concurrent chemoradiotherapy: a population-based propensity score-matched analysis","volume":"39","author":"Li","year":"2019","journal-title":"Anticancer Res"},{"key":"10.1016\/j.canrad.2019.11.005_bib0565","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1259\/bjr\/86650067","article-title":"Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: analysis of phase II\/III trials","volume":"78","author":"Hartley","year":"2005","journal-title":"Br J Radiol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0570","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/COC.0b013e31826e0703","article-title":"A prospective pilot study of target-guided personalized chemotherapy with intensity-modulated radiotherapy in patients with early rectal cancer","volume":"37","author":"Cubillo","year":"2014","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0575","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.radonc.2013.10.026","article-title":"Preoperative intensity-modulated and image-guided radiotherapy with a simultaneous integrated boost in locally advanced rectal cancer: report on late toxicity and outcome","volume":"110","author":"Engels","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0580","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00066-014-0650-0","article-title":"Complete pathological responses in locally advanced rectal cancer after preoperative IMRT and integrated-boost chemoradiation","volume":"190","author":"Hernando-Requejo","year":"2014","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0585","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijrobp.2011.05.068","article-title":"Phase II study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer","volume":"83","author":"Engels","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0590","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1748-717X-9-70","article-title":"Concomitant boost IMRT-based neoadjuvant chemoradiotherapy for clinical stage II\/III rectal adenocarcinoma: results of a phase II study","volume":"9","author":"Zhu","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0595","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijrobp.2007.12.019","article-title":"Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566\u00a0ypCR patients","volume":"72","author":"Capirci","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0600","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.soc.2010.08.001","article-title":"Complete clinical response after neoadjuvant chemoradiation for distal rectal cancer","volume":"19","author":"Habr-Gama","year":"2010","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1016\/j.canrad.2019.11.005_bib0605","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/SLA.0000000000002447","article-title":"Organ preservation in cT2N0\u00a0rectal cancer after neoadjuvant chemoradiation therapy: the impact of radiation therapy dose-escalation and consolidation chemotherapy","volume":"269","author":"Habr-Gama","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.canrad.2019.11.005_bib0610","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2011.29.4_suppl.489","article-title":"Deferral of rectal surgery following a continued response to preoperative chemoradiotherapy (Watch and Wait) study: a phase II multicenter study in the United Kingdom","volume":"29","author":"Yu","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0615","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1463-1318.2011.02752.x","article-title":"A single-centre experience of chemoradiotherapy for rectal cancer: is there potential for nonoperative management?","volume":"14","author":"Dalton","year":"2012","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.canrad.2019.11.005_bib0620","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/bjs.8732","article-title":"Critical appraisal of the \u201cwait and see\u201d approach in rectal cancer for clinical complete responders after chemoradiation","volume":"99","author":"Glynne-Jones","year":"2012","journal-title":"Br J Surg"},{"key":"10.1016\/j.canrad.2019.11.005_bib0625","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.7150\/jca.21237","article-title":"A phase II trial of preoperative concurrent chemotherapy and dose escalated intensity modulated radiotherapy (IMRT) for locally advanced rectal cancer","volume":"8","author":"Tey","year":"2017","journal-title":"J Cancer"},{"key":"10.1016\/j.canrad.2019.11.005_bib0630","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.ijrobp.2016.08.031","article-title":"Acute toxicity and tumor response in locally advanced rectal cancer after preoperative chemoradiation therapy with shortening of the overall treatment time using intensity-modulated radiation therapy with simultaneous integrated boost: a phase 2\u00a0trial","volume":"96","author":"But-Hadzic","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2019.11.005_bib0635","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.canrad.2018.06.004","article-title":"La radioth\u00e9rapie des cancers du rectum: strat\u00e9gie th\u00e9rapeutique et perspective","volume":"22","author":"Vendrely","year":"2018","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2019.11.005_bib0640","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/COC.0b013e318161dbd3","article-title":"Preoperative capecitabine and accelerated intensity-modulated radiotherapy in locally advanced rectal cancer: a phase II trial","volume":"31","author":"Ballonoff","year":"2008","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.canrad.2019.11.005_bib0645","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s12029-012-9364-7","article-title":"Phase II trial of concomitant neoadjuvant chemotherapy with oxaliplatin and capecitabine and intensity-modulated radiotherapy (IMRT) in rectal cancer","volume":"43","author":"Gasent Blesa","year":"2012","journal-title":"J Gastrointest Cancer"},{"key":"10.1016\/j.canrad.2019.11.005_bib0325","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijrobp.2015.05.005","article-title":"NRG Oncology Radiation Therapy Oncology Group 0822: a phase 2\u00a0study of preoperative chemoradiation therapy using intensity modulated radiation therapy in combination with capecitabine and oxaliplatin for patients with locally advanced rectal cancer","volume":"93","author":"Hong","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321820300676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321820300676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:31:37Z","timestamp":1761136297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1278321820300676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1278321820300676"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2019.11.005","relation":{},"ISSN":["1278-3218"],"issn-type":[{"type":"print","value":"1278-3218"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radioth\u00e9rapie avec modulation d\u2019intensit\u00e9 pr\u00e9op\u00e9ratoire des cancers rectaux\u00a0: int\u00e9r\u00eat et application","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2019.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}