{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:33:50Z","timestamp":1790735630302,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.canrad.2021.11.013","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T09:46:36Z","timestamp":1640252796000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Radiotherapy of breast cancer"],"prefix":"10.1016","volume":"26","author":[{"given":"C.","family":"Hennequin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Belkac\u00e9mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bourgier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cutuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fourquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Hannoun-L\u00e9vi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Racadot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2021.11.013_bib0155","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1200\/JCO.2012.45.2615","article-title":"Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343","volume":"31","author":"Hughes","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0160","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1470-2045(14)71221-5","article-title":"Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial","volume":"16","author":"Kunkler","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0165","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials","volume":"378","author":"Early Breast Cancer Trialists\u2019 Collaborative G","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2021.11.013_bib0170","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1200\/JCO.20.00070","article-title":"Accelerated partial breast irradiation and intraoperative partial breast irradiation: reducing the burden of effective breast conservation","volume":"38","author":"White","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0175","doi-asserted-by":"crossref","first-page":"m2836","DOI":"10.1136\/bmj.m2836","article-title":"Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial","volume":"370","author":"Vaidya","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.canrad.2021.11.013_bib0180","doi-asserted-by":"crossref","first-page":"e200249","DOI":"10.1001\/jamaoncol.2020.0249","article-title":"Effect of delayed targeted intraoperative radiotherapy vs whole-breast radiotherapy on local recurrence and survival: long-term results from the TARGIT-A randomized clinical trial in early breast cancer","volume":"16","author":"Vaidya","year":"2020","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0185","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/S0140-6736(19)32514-0","article-title":"Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial","volume":"394","author":"Vicini","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2021.11.013_bib0190","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/S0140-6736(19)32515-2","article-title":"External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial","volume":"394","author":"Whelan","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2021.11.013_bib0195","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(17)31145-5","article-title":"Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial","volume":"390","author":"Coles","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2021.11.013_bib0200","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(14)60488-8","article-title":"Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials","volume":"383","author":"Early Breast Cancer Trialists\u2019 Collaborative EBCTCGG","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2021.11.013_bib0205","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1200\/JCO.19.02850","article-title":"Integration of breast reconstruction and postmastectomy radiotherapy","volume":"38","author":"Shumway","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0210","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1200\/JCO.19.02888","article-title":"De-escalation of locoregional therapy in low-risk disease for DCIS and early-stage invasive cancer","volume":"38","author":"Hwang","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0215","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1200\/JCO.2014.57.9029","article-title":"RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation","volume":"33","author":"McCormick","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0220","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.canrad.2018.06.012","article-title":"The sentinel lymph node of breast cancer and the radiation oncologist","volume":"22","author":"Hennequin","year":"2018","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2021.11.013_bib0225","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/annonc\/mdt151","article-title":"The standard tangential fields used for breast irradiation do not allow optimal coverage and dose distribution in axillary levels I-II and the sentinel node area","volume":"24","author":"Belkac\u00e9mi","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0230","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10549-017-4118-7","article-title":"Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials","volume":"162","author":"Valle","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canrad.2021.11.013_bib0235","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial","volume":"395","author":"Murray Brunt","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2021.11.013_bib0240","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.radonc.2018.04.009","article-title":"ESTRO-ACROP guideline: Interstitial multi-catheter breast brachytherapy as Accelerated Partial Breast Irradiation alone or as boost - GEC-ESTRO Breast Cancer Worki*up practical recommendations","volume":"128","author":"Strnad","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0245","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1470-2045(18)30813-1","article-title":"Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non-inferiority, open-label, phase 3 trial","volume":"20","author":"Wang","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0250","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.radonc.2015.12.027","article-title":"ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer, version 1.1","volume":"118","author":"Offersen","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0255","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ijrobp.2020.04.012","article-title":"Comparison of nodal target volume definition in breast cancer radiation therapy according to RTOG versus ESTRO atlases: a practical review from the TransAtlantic Radiation Oncology Network (TRONE)","volume":"107","author":"Loganadane","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2021.11.013_bib0260","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.radonc.2006.05.014","article-title":"CT-scan based localization of the internal mammary chain and supra clavicular nodes for breast cancer radiation therapy planning","volume":"79","author":"Kirova","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0265","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijrobp.2009.10.058","article-title":"Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer","volume":"79","author":"Feng","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2021.11.013_bib0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13014-019-1242-z","article-title":"The relationship between radiation doses to coronary arteries and location of coronary stenosis requiring intervention in breast cancer survivors","volume":"14","author":"Wennstig","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.canrad.2021.11.013_bib0275","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.canrad.2021.11.013_bib0280","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1684\/bdc.2013.1855","article-title":"[The issue of low doses in radiation therapy and impact on radiation-induced secondary malignancies]","volume":"100","author":"Chargari","year":"2013","journal-title":"Bull Cancer"},{"key":"10.1016\/j.canrad.2021.11.013_bib0285","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3109\/07357907.2012.657818","article-title":"Contribution of respiratory gating techniques for optimization of breast cancer radiotherapy","volume":"30","author":"Giraud","year":"2012","journal-title":"Cancer Invest"},{"key":"10.1016\/j.canrad.2021.11.013_bib0290","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.ijrobp.2004.08.051","article-title":"Breast radiotherapy in the lateral decubitus position: a technique to prevent lung and heart irradiation","volume":"61","author":"Campana","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2021.11.013_bib0295","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.ijrobp.2007.05.007","article-title":"Postmastectomy electron beam chest wall irradiation in women with breast cancer: a clinical step toward conformal electron therapy","volume":"69","author":"Kirova","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.canrad.2021.11.013_bib0300","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S1470-2045(10)70013-9","article-title":"Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): a phase 2 randomised trial","volume":"11","author":"Azria","year":"2010","journal-title":"Lancet Oncol"}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321821003036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321821003036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:37:10Z","timestamp":1761136630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1278321821003036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":30,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S1278321821003036"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2021.11.013","relation":{},"ISSN":["1278-3218"],"issn-type":[{"value":"1278-3218","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiotherapy of breast cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2021.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}