{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:12:51Z","timestamp":1790730771403,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006072","name":"General Commission for Investment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020994","name":"Toulouse Space Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020994","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.canrad.2024.05.002","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T15:51:47Z","timestamp":1726933907000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prediction of radiotherapy toxicity: 20 years of COPERNIC radiosensitivity diagnosis procedure"],"prefix":"10.1016","volume":"28","author":[{"given":"Laur\u00e8ne","family":"Sonzogni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Granzotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eymeric","family":"Le Reun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Al-Choboq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Bourguignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-1303","authenticated-orcid":false,"given":"Nicolas","family":"Foray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Bodgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2024.05.002_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.icrp.2008.07.001","article-title":"Radiation protection in medicine. Publication 105","volume":"37","year":"2007","journal-title":"Ann ICRP"},{"key":"10.1016\/j.canrad.2024.05.002_bib0145","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.mrrev.2016.09.001","article-title":"Individual response to ionizing radiation","volume":"770","author":"Foray","year":"2016","journal-title":"Mutat Res Rev"},{"key":"10.1016\/j.canrad.2024.05.002_bib0150","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/09553002.2019.1704908","article-title":"Establishing mechanisms affecting the individual response to ionizing radiation","volume":"96","author":"Averbeck","year":"2020","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0155","series-title":"Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. May 28, 2009 (v4.03: June 14, 2010)","author":"National Institutes of Health","year":"2010"},{"key":"10.1016\/j.canrad.2024.05.002_bib0160","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Biol Phys"},{"key":"10.1016\/j.canrad.2024.05.002_bib0165","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0360-3016(95)02029-2","article-title":"A review of human cell radiosensitivity in vitro","volume":"34","author":"Deschavanne","year":"1996","journal-title":"Int J Radiat Biol Phys"},{"key":"10.1016\/j.canrad.2024.05.002_bib0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0360-3016(81)90377-1","article-title":"Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy","volume":"7","author":"Fertil","year":"1981","journal-title":"Int J Radiat Biol Phys"},{"key":"10.1016\/j.canrad.2024.05.002_bib0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810434","article-title":"Quantitative correlations between radiosensitivity biomarkers show that the ATM protein kinase is strongly involved in the radiotoxicities observed after radiotherapy","volume":"23","author":"Le Reun","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.canrad.2024.05.002_bib0180","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.ebiom.2015.10.024","article-title":"Radiation-induced CD8 T-lymphocyte apoptosis as a predictor of breast fibrosis after radiotherapy: results of the prospective multicenter French trial","volume":"2","author":"Azria","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.canrad.2024.05.002_bib0185","doi-asserted-by":"crossref","first-page":"21416","DOI":"10.18632\/oncotarget.7893","article-title":"TNFSF10\/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis","volume":"7","author":"Baijer","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canrad.2024.05.002_bib0190","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/3576926","article-title":"A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts","volume":"111","author":"Cornforth","year":"1987","journal-title":"Radiat Res"},{"key":"10.1016\/j.canrad.2024.05.002_bib0195","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0027-5107(00)00065-8","article-title":"The in vitro micronucleus technique","volume":"455","author":"Fenech","year":"2000","journal-title":"Mutat Res"},{"key":"10.1016\/j.canrad.2024.05.002_bib0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0027-5107(98)00095-5","article-title":"Kinetics of the formation of chromosome aberrations in X-irradiated human lymphocytes, using PCC and FISH","volume":"404","author":"Darroudi","year":"1998","journal-title":"Mutat Res"},{"key":"10.1016\/j.canrad.2024.05.002_bib0205","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1038\/sj.onc.1210868","article-title":"DNA double-strand breaks: their cellular and clinical impact?","volume":"26","author":"Jeggo","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.canrad.2024.05.002_bib0210","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.3390\/ijms20215339","article-title":"What does the history of research on the repair of DNA double strand breaks tell us? \u2013 A comprehensive review of human radiosensitivity","volume":"20","author":"Berthel","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.canrad.2024.05.002_bib0215","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ijrobp.2015.11.013","article-title":"Influence of nucleoshuttling of the ATM protein in the healthy tissues response to radiation therapy: toward a molecular classification of human radiosensitivity","volume":"94","author":"Granzotto","year":"2016","journal-title":"Int J Radiat Biol Phys"},{"key":"10.1016\/j.canrad.2024.05.002_bib0220","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1470-2045(11)70302-3","article-title":"Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study","volume":"13","author":"Barnett","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0225","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.radonc.2014.02.012","article-title":"A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity","volume":"111","author":"Barnett","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0230","series-title":"Abujamra A.L. Brain, tumors\/books","article-title":"DNA double-strand breaks repair and signaling of human gliomas and normal brain cells in response to radiation: potential impact of the ATM- and BRCA1-dependent pathways. Chapter 1","author":"Granzotto","year":"2011"},{"key":"10.1016\/j.canrad.2024.05.002_bib0235","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/cancers11070905","article-title":"The nucleoshuttling of the ATM Protein: a unified model to describe the individual response to high- and low-dose of radiation?","volume":"11","author":"Berthel","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.canrad.2024.05.002_bib0240","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/09553002.2016.1135260","article-title":"The nucleo-shuttling of the ATM protein as a basis for a novel theory of radiation response: resolution of the linear-quadratic model","volume":"92","author":"Bodgi","year":"2016","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0245","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jtbi.2016.01.018","article-title":"Mathematical models of radiation action on living cells: From the target theory to the modern approaches. A historical and critical review","volume":"394","author":"Bodgi","year":"2016","journal-title":"J Theor Biol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0250","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/095530097143266","article-title":"Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks","volume":"72","author":"Foray","year":"1997","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0255","first-page":"1","article-title":"Some mutations in the xeroderma pigmentosum D gene may lead to moderate but significant radiosensitivity associated with a delayed radiation-induced ATM nuclear localization","author":"Ferlazzo","year":"2019","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0260","first-page":"395","article-title":"Observations of radiation-induced chromosome fragment loss in live mammalian cells in culture, and its effect on colony-forming ability","volume":"39","author":"Grote","year":"1981","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.canrad.2024.05.002_bib0265","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1073\/pnas.0830918100","article-title":"Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses","volume":"100","author":"Rothkamm","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.canrad.2024.05.002_bib0270","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.3390\/ijms22137158","article-title":"Human radiosensitivity and radiosusceptibility: what are the differences?","volume":"22","author":"El-Nachef","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321824001215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321824001215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T18:02:16Z","timestamp":1729188136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1278321824001215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1278321824001215"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2024.05.002","relation":{},"ISSN":["1278-3218"],"issn-type":[{"value":"1278-3218","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of radiotherapy toxicity: 20 years of COPERNIC radiosensitivity diagnosis procedure","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2024.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO).","name":"copyright","label":"Copyright"}]}}