{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:48:13Z","timestamp":1791913693345,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer\/Radioth\u00e9rapie"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.canrad.2026.104875","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:41:08Z","timestamp":1790199668000},"page":"104875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of cervical cancer with lymph nodes involvement in a large tertiary centre: Results from the preimmunotherapy era"],"prefix":"10.1016","volume":"30","author":[{"given":"Gr\u00e9goire","family":"Laurent Delanghe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Escande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Risbourg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Sayadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Noeuv\u00e9glise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00efcha","family":"Ben Miled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Pasquesoone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortense","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Martinez-Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Bresson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Cayez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-C\u00e9cile","family":"Le Deley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Narducci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric F.","family":"Lartigau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Cordoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canrad.2026.104875_bib0140","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.radonc.2016.05.014","article-title":"Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer","volume":"120","author":"Tanderup","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0145","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ygyno.2012.01.034","article-title":"Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma in locally advanced cervical cancer","volume":"125","author":"Katanyoo","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4103\/ijmr.IJMR_4183_20","article-title":"Para-aortic lymph node involvement in cervical cancer: implications for staging, outcome and treatment","volume":"154","author":"Shylasree","year":"2021","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.canrad.2026.104875_bib0155","first-page":"48","article-title":"The EMBRACE II study: The outcome and prospect of two decades of evolution within the Gec-ESTRO GYN working group and the EMBRACE studies","volume":"9","author":"P\u00f6tter","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0160","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.radonc.2016.03.011","article-title":"Image guided brachytherapy in locally advanced cervical cancer: improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study","volume":"120","author":"Sturdza","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0165","doi-asserted-by":"crossref","first-page":"102747","DOI":"10.1016\/j.ijgc.2025.102747","article-title":"European Society of Gynaecological Oncology resource-stratified guidelines for the management of patients with cervical cancer","volume":"36","author":"Cibula","year":"2026","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.canrad.2026.104875_bib0170","doi-asserted-by":"crossref","first-page":"104753","DOI":"10.1016\/j.canrad.2025.104753","article-title":"Radiotherapy and brachytherapy for cervical cancer: recommendations of the Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique","volume":"29","author":"Chargari","year":"2025","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.canrad.2026.104875_bib0175","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0140-6736(24)01808-7","volume":"404","author":"Lorusso","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2026.104875_bib0180","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/ijgc-2022-004223","article-title":"PARa-aOrtic LymphAdenectomy in locally advanced cervical cancer (PAROLA trial): a GINECO, ENGOT, and GCIG study","volume":"33","author":"Martinez","year":"2023","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.canrad.2026.104875_bib0185","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S1470-2045(20)30753-1","article-title":"MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study","volume":"22","author":"P\u00f6tter","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0190","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.radonc.2021.08.020","article-title":"Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: an EMBRACE analysis","volume":"163","author":"Peters","year":"2021","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.canrad.2026.104875_bib0195","first-page":"CD008285","article-title":"Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis","volume":"2010","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.canrad.2026.104875_bib0200","doi-asserted-by":"crossref","first-page":"1347727","DOI":"10.3389\/fonc.2024.1347727","article-title":"Interstitial needles versus intracavitary applicators only for locally advanced cervical cancer: results from real-life dosimetric comparisons","volume":"14","author":"Cordoba","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0205","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2005.11.014","article-title":"Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy\u20143D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology","volume":"78","author":"P\u00f6tter","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0210","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.radonc.2021.05.010","article-title":"IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer","volume":"160","author":"Mahantshetty","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0215","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.radonc.2011.12.024","article-title":"Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy","volume":"103","author":"Dimopoulos","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0220","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5114\/jcb.2022.118674","article-title":"Prognostic factors for IB2-IIIB cervical cancer patients treated by radiation therapy with high-dose-rate brachytherapy in a single-institution study","volume":"14","author":"Xiu","year":"2022","journal-title":"J Contemp Brachyther"},{"key":"10.1016\/j.canrad.2026.104875_bib0225","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1002\/cncr.23400","article-title":"Surgical versus radiographic determination of para-aortic lymph node metastases before chemoradiation for locally advanced cervical carcinoma: a Gynecol Oncol Group study","volume":"112","author":"Gold","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.canrad.2026.104875_bib0230","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1136\/ijgc-2020-001973","article-title":"Surgical versus clinical staging prior to primary chemoradiation in patients with cervical cancer FIGO stages IIB\u2013IVA: oncologic results of a prospective randomized international multicenter (Uterus-11) intergroup study","volume":"30","author":"Marnitz","year":"2020","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.canrad.2026.104875_bib0235","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12885-021-07821-9","article-title":"False negative rate at 18F-FDG PET\/CT in para-aortic lymphnode involvement in patients with locally advanced cervical cancer: impact of PET technology","volume":"21","author":"Gouy","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canrad.2026.104875_bib0240","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.3802\/jgo.2023.34.e55","article-title":"Efficacy of lymph node dissection on stage IIICr of cervical cancer before CCRT: study protocol for a phase III, randomized controlled clinical trial (CQGOG0103)","volume":"34","author":"He","year":"2023","journal-title":"J Gynecol Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0245","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(24)01438-7","article-title":"Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial","volume":"404","author":"McCormack","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.canrad.2026.104875_bib0250","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.3802\/jgo.2024.35.e10","article-title":"Improving the efficacy and safety of concurrent chemoradiotherapy by neoadjuvant chemotherapy: a randomized controlled study of locally advanced cervical cancer with a large tumor","volume":"35","author":"Li","year":"2024","journal-title":"J Gynecol Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0255","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1200\/JCO.2009.25.9663","article-title":"Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix","volume":"29","author":"Due\u00f1as-Gonz\u00e1lez","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0260","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S1470-2045(23)00147-X","article-title":"Adjuvant chemotherapy following chemoradiotherapy as primary treatment for locally advanced cervical cancer versus chemoradiotherapy alone (OUTBACK): an international, open-label, randomised, phase 3 trial","volume":"24","author":"Mileshkin","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0265","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/S1470-2045(23)00479-5","article-title":"Durvalumab versus placebo with chemoradiotherapy for locally advanced cervical cancer (CALLA): a randomised, double-blind, phase 3 trial","volume":"24","author":"Monk","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.canrad.2026.104875_bib0270","unstructured":"Trial Assessing the Inhibitor of Programmed Cell Death Ligand 1 (PD-L1) Immune Checkpoint Atezolizumab (ATEZOLACC). Available from: https:\/\/clinicaltrials.gov\/study\/NCT03612791 (access on 2 March 2026)."}],"container-title":["Cancer\/Radioth\u00e9rapie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321826000788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1278321826000788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:03:50Z","timestamp":1791911030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1278321826000788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1278321826000788"],"URL":"https:\/\/doi.org\/10.1016\/j.canrad.2026.104875","relation":{},"ISSN":["1278-3218"],"issn-type":[{"value":"1278-3218","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of cervical cancer with lymph nodes involvement in a large tertiary centre: Results from the preimmunotherapy era","name":"articletitle","label":"Article Title"},{"value":"Cancer\/Radioth\u00e9rapie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canrad.2026.104875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104875"}}