{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:28:39Z","timestamp":1760549319357},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute of Health, U.S. Department of Health and Human Services","award":["HHSN266200500045C","HHSN272201000030C"],"award-info":[{"award-number":["HHSN266200500045C","HHSN272201000030C"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.carbpol.2012.11.071","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T05:01:14Z","timestamp":1354251674000},"page":"1915-1920","source":"Crossref","is-referenced-by-count":11,"title":["Preparation of alginate beads containing a prodrug of diethylenetriaminepentaacetic acid"],"prefix":"10.1016","volume":"92","author":[{"given":"Yu-Tsai","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Di Pasqua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiling","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuimin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Sueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Jay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.carbpol.2012.11.071_bib0005","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1126\/science.183.4126.715","article-title":"Plutonium: Biomedical research","volume":"183","author":"Bair","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0010","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1667\/RR1485.1","article-title":"Medical countermeasures against nuclear threats: Radionuclide decorporation agents","volume":"170","author":"Cassatt","year":"2008","journal-title":"Radiation Research"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0015","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/10717540701604769","article-title":"Preparation and characterisation of phenytoin-loaded alginate and alginate\u2013chitosan microparticles","volume":"14","author":"Cekic","year":"2007","journal-title":"Drug Delivery"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0020","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.carbpol.2011.01.015","article-title":"Preparation of Ca\u2013alginate beads containing high oil content: Influence of process variables on encapsulation efficiency and bead properties","volume":"84","author":"Chana","year":"2011","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/02652040309178063","article-title":"Alginate-diltiazem hydrochloride beads: Optimization of formulation factors, in vitro and in vivo availability","volume":"20","author":"El-Kamel","year":"2003","journal-title":"Journal of Microencapsulation"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0030","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1021\/jf703739k","article-title":"Alginate and chitosan functionalization for micronutrient encapsulation","volume":"56","author":"Han","year":"2008","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/02652049609026019","article-title":"Chitosan\/calcium alginate microcapsules for intestinal delivery of nitrofurantoin","volume":"13","author":"Hari","year":"1996","journal-title":"Journal of Microencapsulation"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.colsurfb.2011.02.020","article-title":"Preparation and characterization of zein\/chitosan complex for encapsulation of alpha-tocopherol, and its in vitro controlled release study","volume":"85","author":"Luo","year":"2011","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0045","first-page":"109","article-title":"Calcium alginate cross-linked polymeric microbeads for oral sustained drug delivery in arthritis","volume":"4","author":"Manjanna","year":"2010","journal-title":"Drug Discoveries & Therapeutics"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0050","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0378-5173(94)90350-6","article-title":"Calcium alginate matrices for oral multiple unit administration. III. Influence of calcium concentration, amount of drug added and alginate charateristics on drug release","volume":"111","author":"\u00d8stberg","year":"1994","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.carbpol.2010.02.038","article-title":"Enhanced entrapment efficiency and modulated drug release of alginate beads loaded with drug\u2013clay intercalated complexes as microreservoirs","volume":"81","author":"Pongjanyakul","year":"2010","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0060","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/026520400405660","article-title":"Lipoinsulin encapsulated alginate\u2013chitosan capsules: Intestinal delivery in diabetic rats","volume":"17","author":"Ramadas","year":"2000","journal-title":"Journal of Microencapsulation"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0065","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0168-3659(87)90035-6","article-title":"A simple equation for description of solute release II. Fickian and anomalous release from swellable devices","volume":"5","author":"Ritger","year":"1987","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0032-3861(96)00458-2","article-title":"Determination of the cation content of alginate thin films by FTIR spectroscopy","volume":"38","author":"Sartori","year":"1997","journal-title":"Polymer"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0075","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0169-409X(01)00112-0","article-title":"Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)","volume":"48","author":"Siepmann","year":"2001","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0080","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1002\/jps.23218","article-title":"Physicochemical characterization of a prodrug of a radionuclide decorporation agent for oral delivery","volume":"101","author":"Sueda","year":"2012","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0928-0987(97)10005-7","article-title":"Formulation and investigation of nicardipine HCl\u2013alginate gel beads with factorial design-based studies","volume":"6","author":"Takka","year":"1998","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0090","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/02652049209021245","article-title":"Drug encapsulation in alginate microspheres by emulsification","volume":"9","author":"Wan","year":"1992","journal-title":"Journal of Microencapsulation"},{"key":"10.1016\/j.carbpol.2012.11.071_bib0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1081\/PDT-120003494","article-title":"Hydrolysis in pharmaceutical formulations","volume":"7","author":"Waterman","year":"2002","journal-title":"Pharmaceutical Development and Technology"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861712011873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861712011873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T22:25:30Z","timestamp":1540074330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861712011873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0144861712011873"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2012.11.071","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}