{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:26:53Z","timestamp":1787678813136,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006593","name":"BRNS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"DAE"},{"name":"Government of India"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.carbpol.2013.10.015","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T11:16:08Z","timestamp":1381576568000},"page":"760-768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"C","title":["Synthesis and characterization of dextran stabilized superparamagnetic iron oxide nanoparticles for in vivo MR imaging of liver fibrosis"],"prefix":"10.1016","volume":"101","author":[{"given":"Ariya","family":"Saraswathy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaiju. S.","family":"Nazeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Nimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabareeswaran","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin. J.","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramapurath. S.","family":"Jayasree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.carbpol.2013.10.015_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annual Review of Biomedical Engineering"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jmmm.2005.01.038","article-title":"Surface characterisation of dextran-coated iron oxide nanoparticles prepared by laser pyrolysis and coprecipitation","volume":"293","author":"Bautista","year":"2005","journal-title":"Journal of Magnetism and Magnetic Materials"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10973-009-0593-3","article-title":"Thermal analysis of two types of dextran-coated magnetite","volume":"101","author":"Carp","year":"2010","journal-title":"Journal of Thermal Analysis and Calorimetry"},{"issue":"4","key":"10.1016\/j.carbpol.2013.10.015_bib0020","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.carbpol.2012.07.058","article-title":"Design of deformable chitosan microspheres loaded with superparamagnetic iron oxide nanoparticles for embolotherapy detectable by magnetic resonance imaging","volume":"90","author":"Chung","year":"2012","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2013.10.015_bib0025","first-page":"237","article-title":"Modeling liver fibrosis in rodents","volume":"117","author":"Constandinou","year":"2005","journal-title":"Methods in Molecular Medicine"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0030","doi-asserted-by":"crossref","DOI":"10.1148\/rg.e38","article-title":"The hypointense liver lesion on T2-weighted MR images and what it means","volume":"30","author":"Curvo-Semedo","year":"2010","journal-title":"Radiographics"},{"issue":"6047","key":"10.1016\/j.carbpol.2013.10.015_bib0035","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/bmj.2.6047.1300","article-title":"Low molecular weight dextran: A continuing cause of acute renal failure","volume":"2","author":"Feest","year":"1976","journal-title":"British Medical Journal"},{"issue":"5","key":"10.1016\/j.carbpol.2013.10.015_bib0040","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/cmmi.391","article-title":"Cytotoxicity of iron oxide nanoparticles made from the thermal decomposition of organometallics and aqueous phase transfer with Pluronic F127","volume":"5","author":"Gonzales","year":"2010","journal-title":"Contrast Media & Molecular Imaging"},{"issue":"3","key":"10.1016\/j.carbpol.2013.10.015_bib0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/wnan.36","article-title":"Magnetic resonance relaxation properties of superparamagnetic particles","volume":"1","author":"Gossuin","year":"2009","journal-title":"Wiley Interdisciplinary Reviews \u2013 Nanomedicine and Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1109\/TNB.2003.820277","article-title":"Surface-modified superparamagnetic nanoparticles for drug delivery: Preparation, characterization, and cytotoxicity studies","volume":"3","author":"Gupta","year":"2004","journal-title":"IEEE Transactions on Nanobioscience"},{"issue":"1-2","key":"10.1016\/j.carbpol.2013.10.015_bib0055","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cpart.2007.01.003","article-title":"Dextran-modified iron oxide nanoparticles","volume":"5","author":"Hradil","year":"2007","journal-title":"China Particuology"},{"issue":"3","key":"10.1016\/j.carbpol.2013.10.015_bib0060","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejpb.2011.03.016","article-title":"A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer), a new intravenous iron preparation and its clinical implications","volume":"78","author":"Jahn","year":"2011","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"issue":"2","key":"10.1016\/j.carbpol.2013.10.015_bib0065","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"23","key":"10.1016\/j.carbpol.2013.10.015_bib0070","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1021\/cm031104m","article-title":"Starch-coated superparamagnetic nanoparticles as MR contrast agents","volume":"15","author":"Kim","year":"2003","journal-title":"Chemistry of Materials"},{"issue":"46","key":"10.1016\/j.carbpol.2013.10.015_bib0075","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.3748\/wjg.v12.i46.7413","article-title":"Role of Kupffer cells in the pathogenesis of liver disease","volume":"12","author":"Kolios","year":"2006","journal-title":"World Journal of Gastroenterology"},{"issue":"23","key":"10.1016\/j.carbpol.2013.10.015_bib0080","doi-asserted-by":"crossref","first-page":"10260","DOI":"10.1021\/ac302072t","article-title":"In situ chemical composition analysis of cirrhosis by combining synchrotron Fourier transform infrared and synchrotron X-ray fluorescence microspectroscopies on the same tissue section","volume":"84","author":"Le Naour","year":"2012","journal-title":"Analytical Chemistry"},{"issue":"39","key":"10.1016\/j.carbpol.2013.10.015_bib0085","doi-asserted-by":"crossref","first-page":"15708","DOI":"10.1039\/c1jm12528a","article-title":"Targeted coadministration of sparingly soluble paclitaxel and curcumin into cancer cells by surface engineered magnetic nanoparticles","volume":"21","author":"Manju","year":"2011","journal-title":"Journal of Materials Chemistry"},{"issue":"3","key":"10.1016\/j.carbpol.2013.10.015_bib0090","first-page":"209","article-title":"The epidemiology of alcoholic liver disease","volume":"27","author":"Mann","year":"2003","journal-title":"Alcohol Research & Health"},{"issue":"9","key":"10.1016\/j.carbpol.2013.10.015_bib0095","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1681\/ASN.2006060601","article-title":"Nephrogenic systemic fibrosis: Suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging","volume":"17","author":"Marckmann","year":"2006","journal-title":"Journal of the American Society of Nephrology"},{"issue":"3","key":"10.1016\/j.carbpol.2013.10.015_bib0100","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0022-1759(82)90007-2","article-title":"Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells","volume":"52","author":"Molday","year":"1982","journal-title":"Journal of Immunological Methods"},{"issue":"5516","key":"10.1016\/j.carbpol.2013.10.015_bib0105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/bmj.2.5516.737","article-title":"Renal failure associated with low-molecular-weight dextran infusion","volume":"2","author":"Morgan","year":"1966","journal-title":"British Medical Journal"},{"issue":"19","key":"10.1016\/j.carbpol.2013.10.015_bib0110","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1039\/c3ra23232h","article-title":"Flower shaped assembly of cobalt ferrite nanoparticles: Application as T2 contrast agent in MRI","volume":"3","author":"Nidhin","year":"2013","journal-title":"RSC Advances"},{"issue":"5","key":"10.1016\/j.carbpol.2013.10.015_bib0115","first-page":"447","article-title":"Classification and diagnosis of iron overload","volume":"83","author":"Piperno","year":"1998","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.carbpol.2013.10.015_bib0120","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1007\/s00330-002-1721-7","article-title":"Ferucarbotran (Resovist): A new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: Properties, clinical development, and applications","volume":"13","author":"Reimer","year":"2003","journal-title":"European Radiology"},{"issue":"3","key":"10.1016\/j.carbpol.2013.10.015_bib0125","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1148\/radiology.178.3.1994416","article-title":"Asialoglycoprotein receptor function in benign liver disease: Evaluation with MR imaging","volume":"178","author":"Reimer","year":"1991","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.carbpol.2013.10.015_bib0130","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.carbpol.2010.02.034","article-title":"Synthesis and characterization of superparamagnetic chitosan-dextran sulfate hydrogels as nano carriers for colon-specific drug delivery","volume":"81","author":"Saboktakin","year":"2010","journal-title":"Carbohydrate Polymers"},{"issue":"3","key":"10.1016\/j.carbpol.2013.10.015_bib0135","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.carbpol.2009.11.051","article-title":"A synthetic macromolecule as MRI detectable drug carriers: Aminodextran-coated iron oxide nanoparticles","volume":"80","author":"Saboktakin","year":"2010","journal-title":"Carbohydrate Polymers"},{"issue":"23-24","key":"10.1016\/j.carbpol.2013.10.015_bib0140","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1016\/j.biomaterials.2009.03.056","article-title":"Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance","volume":"30","author":"Simberg","year":"2009","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.carbpol.2013.10.015_bib0145","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2217\/17435889.4.2.177","article-title":"Magnetoliposomes: Versatile innovative nanocolloids for use in biotechnology and biomedicine","volume":"4","author":"Soenen","year":"2009","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0150","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s13361-010-0010-y","article-title":"Epitope structure of the carbohydrate recognition domain of asialoglycoprotein receptor to a monoclonal antibody revealed by high-resolution proteolytic excision mass spectrometry","volume":"22","author":"Stefanescu","year":"2011","journal-title":"Journal of the American Society for Mass Spectrometry"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0155","first-page":"87","article-title":"Focus on: Alcohol and the liver","volume":"33","author":"Szabo","year":"2010","journal-title":"Alcohol Research & Health"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0160","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/hep.21972","article-title":"Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications","volume":"47","author":"Talwalkar","year":"2008","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0165","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.colsurfb.2010.07.015","article-title":"Dextran-protamine polycation: An efficient nonviral and haemocompatible gene delivery system","volume":"81","author":"Thomas","year":"2010","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1021\/mp200485b","article-title":"Unraveling the intracellular efficacy of dextran\u2013histidine polycation as an efficient nonviral gene delivery system","volume":"9","author":"Thomas","year":"2012","journal-title":"Molecular Pharmaceutics"},{"issue":"11","key":"10.1016\/j.carbpol.2013.10.015_bib0175","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.3390\/md10112403","article-title":"Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential magnetic resonance imaging (MRI) T2 contrast agent","volume":"10","author":"Tsai","year":"2012","journal-title":"Marine Drugs"},{"issue":"4","key":"10.1016\/j.carbpol.2013.10.015_bib0180","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tiv.2006.12.009","article-title":"Liver fibrosis in vitro: Cell culture models and precision-cut liver slices","volume":"21","author":"Van de Bovenkamp","year":"2007","journal-title":"Toxicology In Vitro"},{"issue":"11","key":"10.1016\/j.carbpol.2013.10.015_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027210","article-title":"A secreted form of the asialoglycoprotein receptor, sH2a, as a novel potential noninvasive marker for liver fibrosis","volume":"6","author":"Veselkin","year":"2011","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.carbpol.2013.10.015_bib0190","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.carbpol.2012.01.067","article-title":"Carboxylic mannan-coated iron oxide nanoparticles targeted to immune cells for lymph node-specific MRI in vivo","volume":"88","author":"Vu-Quang","year":"2012","journal-title":"Carbohydrate Polymers"},{"issue":"2","key":"10.1016\/j.carbpol.2013.10.015_bib0195","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.carbpol.2011.08.091","article-title":"Immune cell-specific delivery of beta-glucan-coated iron oxide nanoparticles for diagnosing liver metastasis by MR imaging","volume":"87","author":"Vu-Quang","year":"2012","journal-title":"Carbohydrate Polymers"},{"issue":"27","key":"10.1016\/j.carbpol.2013.10.015_bib0200","doi-asserted-by":"crossref","first-page":"13500","DOI":"10.1039\/c2jm30684k","article-title":"Facile synthesis of zinc ferrite nanoparticles as non-lanthanide T-1 MRI contrast agents","volume":"22","author":"Wan","year":"2012","journal-title":"Journal of Materials Chemistry"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0205","first-page":"35","article-title":"Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application","volume":"1","author":"Wang","year":"2011","journal-title":"Quantitative Imaging in Medicine and Surgery"},{"issue":"11","key":"10.1016\/j.carbpol.2013.10.015_bib0210","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s003300100908","article-title":"Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in MR imaging","volume":"11","author":"Wang","year":"2001","journal-title":"European Radiology"},{"issue":"5","key":"10.1016\/j.carbpol.2013.10.015_bib0215","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.3390\/ijms14059111","article-title":"Tumour cell labelling by magnetic nanoparticles with determination of intracellular iron content and spatial distribution of the intracellular iron","volume":"14","author":"Wang","year":"2013","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/j.carbpol.2013.10.015_bib0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/jcbfm.2009.192","article-title":"Superparamagnetic iron oxide nanoparticles: Diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review","volume":"30","author":"Weinstein","year":"2010","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"2","key":"10.1016\/j.carbpol.2013.10.015_bib0225","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2215\/CJN.03250906","article-title":"Nephrogenic systemic fibrosis: A mysterious disease in patients with renal failure-role of gadolinium-based contrast media in causation and the beneficial effect of intravenous sodium thiosulfate","volume":"2","author":"Yerram","year":"2007","journal-title":"Clinical Journal of the American Society of Nephrology"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861713010266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861713010266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T23:36:12Z","timestamp":1758929772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861713010266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":45,"alternative-id":["S0144861713010266"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2013.10.015","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and characterization of dextran stabilized superparamagnetic iron oxide nanoparticles for in vivo MR imaging of liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2013.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}