{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:07:20Z","timestamp":1758892040374,"version":"3.40.5"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005942","name":"Butantan Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005942","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BNDES","award":["11.2.0322.1\/2012"],"award-info":[{"award-number":["11.2.0322.1\/2012"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.carbpol.2014.04.004","type":"journal-article","created":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T11:02:16Z","timestamp":1397386936000},"page":"167-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Study of the chemical stability of the capsular polysaccharide produced by Haemophilus influenzae type b"],"prefix":"10.1016","volume":"116","author":[{"given":"Felipe de Oliveira","family":"Cintra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-4070","authenticated-orcid":false,"given":"Mickie","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.carbpol.2014.04.004_bib0005","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1007\/s12010-012-9750-4","article-title":"Improvement in the purification process of the capsular polysaccharide from Haemophilus influenzae type b by using tangential ultrafiltration and diafiltration","volume":"167","author":"Albani","year":"2012","journal-title":"Applied Biochemistry and Biotechnology"},{"issue":"2","key":"10.1016\/j.carbpol.2014.04.004_bib0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3201\/eid0402.980210","article-title":"Haemophilus influenzae invasive disease in the United States, 1994\u20131995: Near disappearance of a vaccine-preventable childhood disease","volume":"4","author":"Bisgard","year":"1998","journal-title":"Emerging Infectious Diseases"},{"issue":"4","key":"10.1016\/j.carbpol.2014.04.004_bib0015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0144-8617(88)90044-6","article-title":"The determination of the kinetics of polysaccharide thermal degradation using high temperature viscosity measurements","volume":"9","author":"Bradley","year":"1988","journal-title":"Carbohydrate Polymers"},{"issue":"10","key":"10.1016\/j.carbpol.2014.04.004_bib0020","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1021\/ja00374a033","article-title":"Structural studies and chemistry of bacterial capsular polysaccharides. Investigations of phosphodiester-linked capsular polysaccharides isolated from Haemophilus influenzae types a, b, c, and f: NMR spectroscopic identification and chemical modification","volume":"104","author":"Egan","year":"1982","journal-title":"Journal of the American Chemical Society"},{"year":"2013","series-title":"Hib vaccine","author":"GAVI","key":"10.1016\/j.carbpol.2014.04.004_bib0025"},{"issue":"23","key":"10.1016\/j.carbpol.2014.04.004_bib0030","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1021\/ja990592p","article-title":"Kinetics of RNA degradation by specific base catalysis of transesterification involving the 2\u2032-hydroxyl group","volume":"121","author":"Li","year":"1999","journal-title":"Journal of the American Chemical Society"},{"issue":"2-3","key":"10.1016\/j.carbpol.2014.04.004_bib0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0168-1656(00)00320-5","article-title":"Development and scale-up of a fed-batch process for the production of capsular polysaccharide from Haemophilus influenzae","volume":"81","author":"Merritt","year":"2000","journal-title":"Journal of Biotechnology"},{"key":"10.1016\/j.carbpol.2014.04.004_bib0040","series-title":"Handbook of instrumental techniques for analytical chemistry","first-page":"853","article-title":"Molecular weight determinations","author":"Meunier","year":"1997"},{"issue":"2","key":"10.1016\/j.carbpol.2014.04.004_bib0045","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1351\/PAC-REC-08-05-02","article-title":"Dispersity in polymer science (IUPAC recommendations 2009)","volume":"81","author":"Stepto","year":"2009","journal-title":"Pure and Applied Chemistry"},{"issue":"9\u201310","key":"10.1016\/j.carbpol.2014.04.004_bib0050","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0264-410X(98)00337-5","article-title":"Haemophilus influenzae type b conjugate vaccine stability: Catalytic depolymerization of PRP in the presence of aluminum hydroxide","volume":"17","author":"Sturgess","year":"1999","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.carbpol.2014.04.004_bib0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jctb.1377","article-title":"Improved cultivation conditions for polysaccharide production by H. influenzae type b","volume":"81","author":"Takagi","year":"2006","journal-title":"Journal of Chemical Technology & Biotechnology"},{"issue":"11","key":"10.1016\/j.carbpol.2014.04.004_bib0060","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s10295-008-0428-4","article-title":"Purification of capsular polysaccharide produced by Haemophilus influenzae type b through a simple, efficient and suitable method for scale-up","volume":"35","author":"Takagi","year":"2008","journal-title":"Journal of Industrial Microbiology & Biotechnology"},{"year":"2013","series-title":"Vaccine Price Data","author":"UNICEF","key":"10.1016\/j.carbpol.2014.04.004_bib0065"},{"year":"2013","series-title":"Immunization surveillance, assessment and monitoring","author":"WHO","key":"10.1016\/j.carbpol.2014.04.004_bib0070"},{"issue":"4 Pt 2","key":"10.1016\/j.carbpol.2014.04.004_bib0075","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1542\/peds.85.4.631","article-title":"Epidemiology of Haemophilus influenzae type b infections","volume":"85","author":"Wilfert","year":"1990","journal-title":"Pediatrics"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861714003543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861714003543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T14:56:14Z","timestamp":1648824974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861714003543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":15,"alternative-id":["S0144861714003543"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2014.04.004","relation":{},"ISSN":["0144-8617"],"issn-type":[{"type":"print","value":"0144-8617"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study of the chemical stability of the capsular polysaccharide produced by Haemophilus influenzae type b","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2014.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}