{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:08:29Z","timestamp":1791317309328,"version":"4.3.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province of China","doi-asserted-by":"crossref","award":["ZD2015002"],"award-info":[{"award-number":["ZD2015002"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovative Research Team for Agricultural Microbiology Fermentation Technology at Heilongjiang Provincial University","award":["2012td009"],"award-info":[{"award-number":["2012td009"]}]},{"name":"Changjiang Scholar Candidates Program for Provincial Universities in Heilongjiang","award":["2014CJHB005"],"award-info":[{"award-number":["2014CJHB005"]}]},{"name":"Scientific and Technological Key Project of Heilongjiang Province","award":["GC13B403"],"award-info":[{"award-number":["GC13B403"]}]},{"name":"Early Research and Development Cultivation Project of Scientific and Technological Achievements Industrialization for Provincial Universities in Heilongjiang","award":["1253CGZH10"],"award-info":[{"award-number":["1253CGZH10"]}]},{"name":"Technological Innovation Talent Foundation of Harbin","award":["2013RFQXJ030"],"award-info":[{"award-number":["2013RFQXJ030"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.carbpol.2015.05.008","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T22:17:25Z","timestamp":1431814645000},"page":"280-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["O-2\u2032-Hydroxypropyltrimethyl ammonium chloride chitosan nanoparticles for the delivery of live Newcastle disease vaccine"],"prefix":"10.1016","volume":"130","author":[{"given":"Chunxiao","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guogang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.carbpol.2015.05.008_bib0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ejps.2011.10.003","article-title":"Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: Adjuvant-and site-dependent immunogenicity in mice","volume":"45","author":"Bal","year":"2012","journal-title":"European Journal of Pharmaceutical Sciences"},{"issue":"2","key":"10.1016\/j.carbpol.2015.05.008_bib0010","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.2042-7158.2010.01214.x","article-title":"Design and development of gliclazide-loaded chitosan microparticles for oral sustained drug delivery: In-vitro\/in-vivo evaluation","volume":"63","author":"Barakat","year":"2011","journal-title":"Journal of Pharmacy and Pharmacology"},{"issue":"3","key":"10.1016\/j.carbpol.2015.05.008_bib0015","first-page":"864","article-title":"Biocompatibility testing of chitosan hydrogels","volume":"115","author":"Cheburu","year":"2011","journal-title":"Revista Medico-chirurgical\u0103\u0306 a Societ\u0103\u0306\u0163\u031cii de Medici \u015f\u0327i Naturali\u015f\u0327ti Din Ia\u015f\u0327i"},{"issue":"1\u20132","key":"10.1016\/j.carbpol.2015.05.008_bib0020","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ijpharm.2009.12.033","article-title":"Gene-carried chitosan-linked-PEI induced high gene transfection efficiency with low toxicity and significant tumor-suppressive activity","volume":"387","author":"Gao","year":"2010","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.carbpol.2015.05.008_bib0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.carbpol.2014.09.056","article-title":"Characterization and antioxidant activity \u03b2-carotene loaded chitosan-graft-poly(lactide) nanomicelles","volume":"117","author":"Gea","year":"2015","journal-title":"Carbohydrate Polymers"},{"issue":"48","key":"10.1016\/j.carbpol.2015.05.008_bib0030","doi-asserted-by":"crossref","first-page":"9026","DOI":"10.1016\/j.vaccine.2011.09.033","article-title":"Development and characterization of chitosan coated poly-(\u025b-caprolactone) nanoparticulate system for effective immunization against influenza","volume":"29","author":"Gupta","year":"2012","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.carbpol.2015.05.008_bib0035","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jconrel.2009.08.018","article-title":"Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine","volume":"140","author":"Hagenaars","year":"2009","journal-title":"Journal of Controlled Release"},{"issue":"8","key":"10.1016\/j.carbpol.2015.05.008_bib0040","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1021\/bc300121y","article-title":"Use of biotinylated chitosan for substrate-mediated gene delivery","volume":"23","author":"Hu","year":"2012","journal-title":"Bioconjugate Chemistry"},{"issue":"1","key":"10.1016\/j.carbpol.2015.05.008_bib0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0169-409X(00)00123-X","article-title":"Polysaccharide colloidal particles as delivery systems for macromolecules","volume":"47","author":"Janes","year":"2001","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.carbpol.2015.05.008_bib0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cej.2013.02.011","article-title":"Antimicrobial activity and cytotoxicity of N-2-HACC and characterization of nanoparticles with N-2-HACC and CMC as a vaccine carrier","volume":"221","author":"Jin","year":"2013","journal-title":"Chemical Engineering Journal"},{"issue":"10","key":"10.1016\/j.carbpol.2015.05.008_bib0055","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.3390\/ijms11104140","article-title":"In vivo biocompatibility study of electrospun chitosan microfiber for tissue engineering","volume":"11","author":"Kang","year":"2010","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"10.1016\/j.carbpol.2015.05.008_bib0060","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.dci.2013.04.012","article-title":"Immune responses of poultry to Newcastle disease virus","volume":"41","author":"Kapczynski","year":"2013","journal-title":"Developmental and Comparative Immunology"},{"issue":"26","key":"10.1016\/j.carbpol.2015.05.008_bib0065","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1016\/j.vaccine.2005.01.140","volume":"23","author":"Kapezynsk","year":"2005","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.carbpol.2015.05.008_bib0070","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10611860410001693733","article-title":"Immunological implications of the use of plant lectins for drug and vaccine targeting to the gastrointestinal tract","volume":"12","author":"Lavelle","year":"2004","journal-title":"Journal of Drug Targeting"},{"key":"10.1016\/j.carbpol.2015.05.008_bib0075","first-page":"10","article-title":"The study of O-carboxymethyl chitosan antimicrobial properties","volume":"3","author":"Li","year":"2000","journal-title":"China Surfactant Detergent & Cosmetics"},{"issue":"2","key":"10.1016\/j.carbpol.2015.05.008_bib0080","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1166\/jnn.2011.3843","article-title":"Chitosan as a bioadhesive agent between porphyrins and phospholipids in a biomembrane model","volume":"11","author":"Luz","year":"2011","journal-title":"Journal of Nanoscience and Nanotechnology"},{"issue":"3","key":"10.1016\/j.carbpol.2015.05.008_bib0085","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bbamem.2011.12.004","article-title":"Cholesterol dependence of Newcastle disease virus entry","volume":"1818","author":"Mart\u00edn","year":"2012","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.carbpol.2015.05.008_bib0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.carbpol.2014.09.058","article-title":"Plasticized chitosan\/polyole\ufb01n \ufb01lms produced by extrusion","volume":"117","author":"Matet","year":"2015","journal-title":"Carbohydrate Polymers"},{"issue":"6","key":"10.1016\/j.carbpol.2015.05.008_bib0095","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1021\/bc800076n","article-title":"Oral delivery of peptide drugs using nanoparticles self-assembled by poly(\u03b3-glutamic acid) and a chitosan derivative functionalized by trimethylation","volume":"19","author":"Mi","year":"2008","journal-title":"Bioconjugate Chemistry"},{"issue":"3\u20134","key":"10.1016\/j.carbpol.2015.05.008_bib0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vetimm.2009.10.028","article-title":"The positive adjuvant effect of chitosan on antigen-specific cell-mediated immunity after chickens vaccination with live Newcastle disease vaccine","volume":"134","author":"Rauw","year":"2010","journal-title":"Veterinary Immunology and Immunopathology"},{"issue":"27","key":"10.1016\/j.carbpol.2015.05.008_bib0105","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.vaccine.2009.03.068","article-title":"Humoral, cell-mediated and mucosal immunity induced by oculo-nasal vaccination of one-day-old SPF and conventional layer chicks with two different live Newcastle disease vaccines","volume":"27","author":"Rauw","year":"2009","journal-title":"Vaccine"},{"issue":"3\u20134","key":"10.1016\/j.carbpol.2015.05.008_bib0110","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.prevetmed.2011.12.018","article-title":"Prevalence and incidence of Newcastle disease and prevalence of Avian Influenza infection of scavenging village chickens in Timor-Lest\u00e9","volume":"104","author":"Serr\u00e3o","year":"2012","journal-title":"Preventive Veterinary Medicine"},{"issue":"1\u20132","key":"10.1016\/j.carbpol.2015.05.008_bib0115","first-page":"1","article-title":"Chitosan microspheres as a potential carrier for drugs","volume":"274","author":"Sinha","year":"2004","journal-title":"International Journal of Pharmaceutics"},{"issue":"3","key":"10.1016\/j.carbpol.2015.05.008_bib0120","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1517\/17425247.4.3.263","article-title":"The promise of chitosan nanoparticles in drug delivery systems","volume":"4","author":"Varshosaz","year":"2007","journal-title":"Expert Opinion on Drug Delivery"},{"key":"10.1016\/j.carbpol.2015.05.008_bib0125","first-page":"765","article-title":"Recent advances of chitosan nanoparticles as drug carriers","volume":"6","author":"Wang","year":"2011","journal-title":"International Journal of Nanomedicine"},{"issue":"12","key":"10.1016\/j.carbpol.2015.05.008_bib0130","doi-asserted-by":"crossref","first-page":"e53314","DOI":"10.1371\/journal.pone.0053314","article-title":"Preparation and efficacy of a live Newcastle disease virus vaccine encapsulated in chitosan nanoparticles","volume":"7","author":"Zhao","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.carbpol.2015.05.008_bib0135","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2147\/IJN.S54226","article-title":"Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles","volume":"9","author":"Zhao","year":"2014","journal-title":"International Journal of Nanomedicine"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861715004063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861715004063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T23:37:50Z","timestamp":1656200270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861715004063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":27,"alternative-id":["S0144861715004063"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2015.05.008","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"O-2\u2032-Hydroxypropyltrimethyl ammonium chloride chitosan nanoparticles for the delivery of live Newcastle disease vaccine","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2015.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}