{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:44:47Z","timestamp":1784011487256,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["302218\/2014-9"],"award-info":[{"award-number":["302218\/2014-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["459334\/2014-0"],"award-info":[{"award-number":["459334\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.carbpol.2016.05.031","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T22:03:44Z","timestamp":1463177024000},"page":"392-399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Structural characteristics are crucial to the benefits of guar gum in experimental osteoarthritis"],"prefix":"10.1016","volume":"150","author":[{"given":"Rondinelle R.","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Maria M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo M.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablyana L.R.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina Celia M.","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith P.A.","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virg\u00ednia C.C.","family":"Gir\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida M.L.","family":"Pompeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Alberto D.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco A.C.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carbpol.2016.05.031_bib0005","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0142-9418(01)00123-4","article-title":"Testing procedures for galactomannan purification","volume":"21","author":"Azero","year":"2002","journal-title":"Polymer Testing"},{"issue":"1","key":"10.1016\/j.carbpol.2016.05.031_bib0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7326\/M14-1231","article-title":"Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis","volume":"162","author":"Bannuru","year":"2015","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","article-title":"Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis)","volume":"21","author":"Berenbaum","year":"2013","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/sj.bjp.0705600","article-title":"Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis","volume":"141","author":"Bezerra","year":"2004","journal-title":"British Journal of Pharmacology"},{"issue":"3","key":"10.1016\/j.carbpol.2016.05.031_bib0025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.semarthrit.2014.05.014","article-title":"An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"44","author":"Bruy\u00e8re","year":"2014","journal-title":"Seminars in Arthritis Rheumatism"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0030","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.joca.2006.01.013","article-title":"A quantitative approach to measure joint pain in experimental osteoarthritis-evidence of a role for nitric oxide","volume":"14","author":"Castro","year":"2006","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijbiomac.2005.09.001","article-title":"Low viscosity hydrogel of guar gum: preparation and physicochemical characterization","volume":"37","author":"Cunha","year":"2005","journal-title":"International Journal of Biological Macromolecules"},{"issue":"1","key":"10.1016\/j.carbpol.2016.05.031_bib0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/S0103-50532007000100009","article-title":"Oxidation of cashew tree gum exudate polysaccharide with TEMPO reagent","volume":"18","author":"Cunha","year":"2007","journal-title":"Journal of the Brazilian Chemical Society"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0003-2697(72)90413-7","article-title":"Simple micro method for identification of heparin and other acidific mucopolysaccharides from mammalian tissues","volume":"46","author":"Dietrich","year":"1972","journal-title":"Analytical Biochemistry"},{"issue":"1","key":"10.1016\/j.carbpol.2016.05.031_bib0050","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.joca.2013.10.005","article-title":"Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model","volume":"22","author":"Elmorsy","year":"2014","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0055","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/acr.21596","article-title":"American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip and knee","volume":"64","author":"Hochberg","year":"2012","journal-title":"Arthritis Care Research"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0060","first-page":"14","article-title":"Cartilage collagen damage in hip osteoarthritis similar to that seen in knee osteoarthritis; a case-control study of relationship between collagen, glycosaminoglycan and cartilage swelling","volume":"9","author":"Hosseininia","year":"2013","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0065","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1056\/NEJMct1215534","article-title":"Viscosupplementation for osteoarthritis of the knee","volume":"372","author":"Hunter","year":"2015","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0968-0160(01)00075-8","article-title":"Is there a place for intra-articular hyaluronate in osteoarthritis of the knee?","volume":"8","author":"Kirwan","year":"2001","journal-title":"Knee"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0080","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0144-8617(02)00006-1","article-title":"Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea","volume":"49","author":"Melo","year":"2002","journal-title":"Carbohydrate Polymers"},{"issue":"10","key":"10.1016\/j.carbpol.2016.05.031_bib0085","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1590\/S0103-50532011001000017","article-title":"Preparation and characterization of a chemically sulfated cashew gum polysaccharide","volume":"22","author":"Moura Neto","year":"2011","journal-title":"Journal of the Brazilian Chemical Society"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0090","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.carbpol.2013.10.026","article-title":"Chemically sulfated galactomannan from Dimorphandra gardneriana seed: characterization and toxicity evaluation","volume":"101","author":"Moura Neto","year":"2014","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0095","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/rheumatology\/40.2.158","article-title":"Morphologycal analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan) and methylprednisolone acetate (Depomedrol) in osteoarthritis","volume":"40","author":"Pasquali Ronchetti","year":"2001","journal-title":"Rheumatology"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1016\/j.carbpol.2016.05.031_bib0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0144-8617(99)00137-X","article-title":"Specific modifications of galactomannans","volume":"42","author":"Sierakowski","year":"2000","journal-title":"Carbohydrate Polymers"},{"issue":"2","key":"10.1016\/j.carbpol.2016.05.031_bib0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10067-008-0988-8","article-title":"Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model","volume":"28","author":"Silva","year":"2009","journal-title":"Clinical Rheumatology"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861716305537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861716305537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T10:03:00Z","timestamp":1620986580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861716305537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":22,"alternative-id":["S0144861716305537"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2016.05.031","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural characteristics are crucial to the benefits of guar gum in experimental osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2016.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}