{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:54:32Z","timestamp":1786985672858,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302688"],"award-info":[{"award-number":["81302688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.carbpol.2017.06.061","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:16:22Z","timestamp":1497917782000},"page":"182-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["A cell-penetrating peptide mediated chitosan nanocarriers for improving intestinal insulin delivery"],"prefix":"10.1016","volume":"174","author":[{"given":"Lei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaoqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liefeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carbpol.2017.06.061_bib0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.addr.2009.11.009","article-title":"Chitosan-based delivery systems for protein therapeutics and antigens","volume":"62","author":"Amidi","year":"2010","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/adc.2010.183731","article-title":"Lipoatrophy with insulin analogues in type I diabetes","volume":"96","author":"Babiker","year":"2011","journal-title":"Archives of Disease in Childhood"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0015","first-page":"50","article-title":"In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides","volume":"22","author":"Bolhassani","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0020","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijpharm.2007.07.035","article-title":"In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery","volume":"349","author":"Chen","year":"2008","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jddst.2016.10.010","article-title":"Nanoencapsulated chitosan nanoparticles in emulsion-based oral delivery system: In vitro and in vivo evaluation of insulin loaded formulation","volume":"36","author":"Erel","year":"2016","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0030","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2013.07.079","article-title":"Chitosan\/o-carboxymethyl chitosan nanoparticles for efficient and safe oralanticancer drug delivery: In vitro and in vivo evaluation","volume":"457","author":"Feng","year":"2013","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0035","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.biomaterials.2011.10.075","article-title":"Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport","volume":"33","author":"Jin","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jconrel.2009.02.015","article-title":"Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide\/protein absorption using cell-penetrating peptides","volume":"136","author":"Kamei","year":"2009","journal-title":"Journal Controlled Release"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jconrel.2008.09.076","article-title":"Effect of cell-penetrating peptides on the nasal absorption of insulin","volume":"133","author":"Khafagy","year":"2009","journal-title":"Journal Controlled Release"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1081\/DDC-120018199","article-title":"New developments in insulin delivery","volume":"29","author":"Khan","year":"2003","journal-title":"Drug Development and Industrial Pharmacy"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0055","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/bc100093v","article-title":"A novel approach to oral delivery of insulin by conjugating with low molecular weight chitosan","volume":"21","author":"Lee","year":"2010","journal-title":"Bioconjugate Chemistry"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0060","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.msec.2016.08.083","article-title":"Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin","volume":"70","author":"Li","year":"2017","journal-title":"Materials Science and Engineering C"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0065","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/bm0607776","article-title":"Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery","volume":"8","author":"Lin","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijpharm.2013.03.033","article-title":"Oligoarginine-modified biodegradable nanoparticles improve the intestinal absorption of insulin","volume":"448","author":"Liu","year":"2013","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejps.2010.12.007","article-title":"Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery","volume":"42","author":"Makhlofa","year":"2011","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jconrel.2006.12.022","article-title":"A novel approach using functional peptides for efficient intestinal absorption of insulin","volume":"118","author":"Morishita","year":"2007","journal-title":"Journal Controlled Release"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0085","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ijbiomac.2014.08.040","article-title":"pH-sensitive chitosan\/alginate core? Shell nanoparticles for efficient and safe oral insulin delivery","volume":"72","author":"Mukhopadhyay","year":"2015","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0090","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0955-0674(00)00108-3","article-title":"Messenger proteins: Homeoproteins, TAT and others","volume":"12","author":"Prochiantz","year":"2000","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0095","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1039\/c3bm60064e","article-title":"Competingproperties of mucoadhesive films designed for localized delivery of imiquimod","volume":"1","author":"Ramineni","year":"2013","journal-title":"Biomaterials Science"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0100","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1023\/A:1015893832222","article-title":"Degradation of insulin by trypsin and alphachymotrypsin","volume":"8","author":"Schilling","year":"1991","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0105","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1016\/j.biomaterials.2014.04.104","article-title":"Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers","volume":"35","author":"Shrestha","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0110","first-page":"30236","article-title":"Functional peptides for siRNA delivery","volume":"13","author":"Tai","year":"2016","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0115","first-page":"31256","article-title":"Intelligent substance delivery into cells using cell-penetrating peptides","volume":"30","author":"Tashima","year":"2016","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0120","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1073\/pnas.151247498","article-title":"TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors","volume":"98","author":"Torchilin","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0125","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.carbpol.2015.09.103","article-title":"Positive\/negative surface charge of chitosan based nanogels and its potential influence on oral insulin delivery","volume":"136","author":"Wang","year":"2016","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0130","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/jphp.12607","article-title":"Oral delivery of insulin for treatment of diabetes: Status quo, challenges and opportunities","volume":"68","author":"Wong","year":"2016","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0135","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.carbpol.2011.10.002","article-title":"Improving intestinal insulin absorption efficiency through coadministration of cell-penetrating peptide and hydroxypropyl-\u00df-cyclodextrin","volume":"87","author":"Zhang","year":"2012","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0140","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ijbiomac.2013.08.034","article-title":"Synthesis and evaluation of a novel \u03b2-cyclodextrin derivative for oral insulin delivery and absorption","volume":"61","author":"Zhang","year":"2013","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.carbpol.2017.06.061_bib0145","doi-asserted-by":"crossref","first-page":"21569","DOI":"10.3390\/molecules201219771","article-title":"Amphiphilic lipopeptide-mediated transport of insulin and cell membrane penetration mechanism","volume":"20","author":"Zhang","year":"2015","journal-title":"Molecules"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861717306987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861717306987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T14:02:53Z","timestamp":1575640973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861717306987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":29,"alternative-id":["S0144861717306987"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2017.06.061","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A cell-penetrating peptide mediated chitosan nanocarriers for improving intestinal insulin delivery","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2017.06.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}