{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:25:47Z","timestamp":1777739147731,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21476052"],"award-info":[{"award-number":["21476052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51573071"],"award-info":[{"award-number":["51573071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Natural \"thirteenth five-year\" Infectious Disease Science and Technology Foundation of China","award":["2018zx10103001"],"award-info":[{"award-number":["2018zx10103001"]}]},{"name":"Major Natural \"thirteenth five-year\" Infectious Disease Science and Technology Foundation of China","award":["2017ZX10201302"],"award-info":[{"award-number":["2017ZX10201302"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313864"],"award-info":[{"award-number":["2015A030313864"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A020216021"],"award-info":[{"award-number":["2016A020216021"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Foundation of Guangdong Province","award":["A2015414"],"award-info":[{"award-number":["A2015414"]}]},{"name":"GDHVPS (2017)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.carbpol.2018.06.034","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T16:30:03Z","timestamp":1528389003000},"page":"403-413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Genipin-crosslinked carboxymethyl chitosan nanogel for lung-targeted delivery of isoniazid and rifampin"],"prefix":"10.1016","volume":"197","author":[{"given":"Ting","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-7348","authenticated-orcid":false,"given":"Dong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiye","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.carbpol.2018.06.034_bib0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.lfs.2014.06.019","article-title":"Development of alginate-reinforced chitosan nanoparticles utilizing w\/o nanoemulsification\/internal crosslinking technique for transdermal delivery of rabeprazole","volume":"110","author":"Ahmed","year":"2014","journal-title":"Life Sciences"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0010","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1021\/la201499s","article-title":"Synergistic antibacterial brilliant blue\/reduced graphene oxide\/quaternary phosphonium salt composite with excellent water solubility and specific targeting capability","volume":"27","author":"Cai","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0015","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.carres.2010.02.008","article-title":"Evaluation of amylose used as a drug delivery carrier","volume":"345","author":"Cai","year":"2010","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0020","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1016\/j.biortech.2009.04.005","article-title":"Synthesis and anaerobic biodegradation of indomethacin-conjugated cellulose ethers used for colon-specific drug delivery","volume":"100","author":"Cai","year":"2009","journal-title":"Bioresource Technology"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0025","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1021\/la400824f","article-title":"Bacteria-adsorbed palygorskite stabilizes the quaternary phosphonium salt with specific-targeting capability, long-term antibacterial activity, and lower cytotoxicity","volume":"29","author":"Cai","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0030","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.carbon.2012.02.002","article-title":"The use of polyethyleneimine-modified reduced graphene oxide as a substrate for silver nanoparticles to produce a material with lower cytotoxicity and long-term antibacterial activity","volume":"50","author":"Cai","year":"2012","journal-title":"Carbon"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0035","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/asia.201200045","article-title":"Sodium 1\u2010naphthalenesulfonate\u2010functionalized reduced graphene oxide stabilizes silver nanoparticles with lower cytotoxicity and long\u2010term antibacterial activity","volume":"7","author":"Cai","year":"2012","journal-title":"Chemistry\u2013An Asian Journal"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0040","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.msec.2015.08.055","article-title":"Lower cytotoxicity, high stability, and long-term antibacterial activity of a poly (methacrylic acid)\/isoniazid\/rifampin nanogel against multidrug-resistant intestinal Mycobacterium tuberculosis","volume":"58","author":"Chen","year":"2016","journal-title":"Materials Science and Engineering: C"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jconrel.2012.09.011","article-title":"Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol)(PEG) nanogel aggregates","volume":"164","author":"Deshmukh","year":"2012","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0050","first-page":"1487","article-title":"Development and validation of RP-HPLC method for simultaneous determination of pyridoxine hydrochloride, isoniazid, pyrazinamide and rifampicin in pharmaceutical formulation","volume":"54","author":"Dhal","year":"2009","journal-title":"Chemia Analityczna"},{"issue":"4","key":"10.1016\/j.carbpol.2018.06.034_bib0055","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.nano.2013.11.012","article-title":"Multimodal nanoparticles that provide immunomodulation and intracellular drug delivery for infectious diseases","volume":"10","author":"Dube","year":"2014","journal-title":"Nanomedicine Nanotechnology Biology & Medicine"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0060","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1517\/17425240903241788","article-title":"Preclinical models for pulmonary drug delivery","volume":"6","author":"Fernandes","year":"2009","journal-title":"Expert Opinion on Drug Delivery"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0065","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2013007259","article-title":"Stimuli-sensitive hydrogels: An excellent carrier for drug and cell delivery","volume":"30","author":"Garg","year":"2013","journal-title":"Critical Reviews\u2122 in Therapeutic Drug Carrier Systems"},{"issue":"3","key":"10.1016\/j.carbpol.2018.06.034_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/21691401.2015.1008508","article-title":"Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis","volume":"44","author":"Garg","year":"2015","journal-title":"Artificial Cells Nanomedicine & Biotechnology"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0075","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s11095-016-1926-0","article-title":"Preparation and preclinical evaluation of inhalable particles containing rapamycin and anti-tuberculosis agents for induction of autophagy","volume":"33","author":"Gupta","year":"2016","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.msec.2016.05.003","article-title":"Degradable UV-crosslinked hydrogel for the controlled release of triclosan with reduced cytotoxicity","volume":"67","author":"Hu","year":"2016","journal-title":"Materials Science and Engineering: C"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00006565-200202000-00008","article-title":"Suicidal psychosis secondary to isoniazid","volume":"18","author":"Iannaccone","year":"2002","journal-title":"Pediatric Emergency Care"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0090","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/21691401.2014.930747","article-title":"Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs","volume":"44","author":"Kaur","year":"2016","journal-title":"Artificial Cells, Nanomedicine, and Biotechnology"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0095","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3109\/10717544.2014.920428","article-title":"Development and characterization of spray-dried porous nanoaggregates for pulmonary delivery of anti-tubercular drugs","volume":"23","author":"Kaur","year":"2016","journal-title":"Drug Delivery"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0100","first-page":"88","article-title":"Isoniazid loaded chitosan microspheres for pulmonary delivery: Preparation and characterization","volume":"2","author":"Kundawala","year":"2011","journal-title":"Der Pharmacia Sinica"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0105","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1039\/C5TB01964H","article-title":"Folate-targeting redox hyperbranched poly (amido amine) s delivering MMP-9 siRNA for cancer therapy","volume":"4","author":"Li","year":"2016","journal-title":"Journal of Materials Chemistry B"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0110","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.msec.2014.07.067","article-title":"The use of poly(methacrylic acid) nanogel to control the release of amoxycillin with lower cytotoxicity","volume":"43","author":"Liu","year":"2014","journal-title":"Materials Science and Engineering: C"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0115","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1016\/j.biomaterials.2014.01.040","article-title":"Star-shaped cyclodextrin-poly (l-lysine) derivative co-delivering docetaxel and MMP-9 siRNA plasmid in cancer therapy","volume":"35","author":"Liu","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0120","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1016\/j.biomaterials.2014.01.070","article-title":"A star-shaped porphyrin-arginine functionalized poly(l-lysine) copolymer for photo-enhanced drug and gene co-delivery","volume":"35","author":"Ma","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0125","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1021\/bm100676a","article-title":"Bioactive supramolecular hydrogel with controlled dual drug release characteristics","volume":"11","author":"Ma","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0130","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/app.39293","article-title":"Alginate hydrogel sphere improves the alkali and heat resistances of isothiazolinones with long\u2010term antibacterial activity","volume":"130","author":"Ma","year":"2013","journal-title":"Journal of Applied Polymer Science"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0135","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/marc.201200742","article-title":"Star\u2010shaped polymer consisting of a porphyrin core and poly(L\u2010lysine) dendron arms: Synthesis, drug delivery, and in vitro chemo\/photodynamic therapy","volume":"34","author":"Ma","year":"2013","journal-title":"Macromolecular Rapid Communications"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0140","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1166\/sam.2013.1602","article-title":"Supramolecular hydrogels sustained release triclosan with controlled antibacterial activity and limited cytotoxicity","volume":"5","author":"Ma","year":"2013","journal-title":"Science of Advanced Materials"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/jamp.2014.1187","article-title":"Development and evaluation of chitosan microparticles based dry powder inhalation formulations of rifampicin and rifabutin","volume":"29","author":"Pai","year":"2016","journal-title":"Journal of Aerosol Medicine and Pulmonary Drug Delivery"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0150","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3109\/02652048.2011.599437","article-title":"Preparation and characterization of spray dried inhalable powders containing chitosan nanoparticles for pulmonary delivery of isoniazid","volume":"28","author":"Pourshahab","year":"2011","journal-title":"Journal of Microencapsulation"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0155","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.carbpol.2013.01.082","article-title":"Biodegradable chitosan nanogels crosslinked with genipin","volume":"94","author":"Pujana","year":"2013","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0160","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.carbpol.2013.09.014","article-title":"Water soluble folate-chitosan nanogels crosslinked by genipin","volume":"101","author":"Pujana","year":"2014","journal-title":"Carbohydrate Polymers"},{"issue":"8","key":"10.1016\/j.carbpol.2018.06.034_bib0165","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1080\/17425247.2016.1178232","article-title":"Chitosan nanoparticles in drug therapy of infectious and inflammatory diseases","volume":"13","author":"Rajitha","year":"2016","journal-title":"Expert Opinion on Drug Delivery"},{"issue":"3","key":"10.1016\/j.carbpol.2018.06.034_bib0170","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/jfb3030615","article-title":"Biocompatibility of chitosan carriers with application in drug delivery","volume":"3","author":"Rodrigues","year":"2012","journal-title":"Journal of Functional Biomaterials"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/21691401.2014.885442","article-title":"Transmucosal delivery of docetaxel by mucoadhesive polymeric nanofibers","volume":"43","author":"Singh","year":"2015","journal-title":"Artificial Cells, Nanomedicine, and Biotechnology"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0180","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.3109\/10717544.2015.1074765","article-title":"Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis\u2014A critical review","volume":"23","author":"Singh","year":"2016","journal-title":"Drug Delivery"},{"issue":"8","key":"10.1016\/j.carbpol.2018.06.034_bib0185","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/jbt.21502","article-title":"Synthesis and characterization of chitosan tripolyphosphate nanoparticles and its encapsulation efficiency containing russell\u2019s viper snake venom","volume":"27","author":"Venkatesan","year":"2013","journal-title":"Journal of Biochemical & Molecular Toxicology"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0190","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/ppul.22652","article-title":"Oral, inhaled, and intravenous antibiotic choice for treating pulmonary exacerbations in cystic fibrosis","volume":"48","author":"Wagener","year":"2013","journal-title":"Pediatric Pulmonology"},{"key":"10.1016\/j.carbpol.2018.06.034_bib0195","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.colsurfb.2011.04.009","article-title":"Antimicrobial effects of quaternary phosphonium salt intercalated clay minerals on Escherichia coli and Staphylococci aureus","volume":"86","author":"Wu","year":"2011","journal-title":"Colloids and Surfaces B: Biointerfaces"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861718306891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861718306891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T06:22:26Z","timestamp":1604384546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861718306891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":39,"alternative-id":["S0144861718306891"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2018.06.034","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genipin-crosslinked carboxymethyl chitosan nanogel for lung-targeted delivery of isoniazid and rifampin","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2018.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}