{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T12:59:24Z","timestamp":1794056364911,"version":"4.8.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technology Program of Shandong Province (the Key Technology)","award":["2015ZDJS04002"],"award-info":[{"award-number":["2015ZDJS04002"]}]},{"name":"Major State Basic Research Development Program of China (973 Program)","award":["2012CB822102"],"award-info":[{"award-number":["2012CB822102"]}]},{"name":"High Technology Research and Development Program of China (863 Program)","award":["2012AA021501"],"award-info":[{"award-number":["2012AA021501"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81702581"],"award-info":[{"award-number":["81702581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific and Technological Innovation Commission of Shenzhen","award":["JCYJ20170306091400043"],"award-info":[{"award-number":["JCYJ20170306091400043"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.carbpol.2018.06.076","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T22:56:38Z","timestamp":1529362598000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice"],"prefix":"10.1016","volume":"198","author":[{"given":"Zhihong","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-5465","authenticated-orcid":false,"given":"Kaoshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carbpol.2018.06.076_bib0005","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1189\/jlb.0713360","article-title":"A novel immunomodulatory function of PHLPP1: Inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages","volume":"95","author":"Alamuru","year":"2014","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0010","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/35092620","article-title":"Immune recognition \u2013 A new receptor for beta-glucans","volume":"413","author":"Brown","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0020","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.carbpol.2013.05.068","article-title":"Polysaccharides from Rhizopus nigricans mycelia induced apoptosis and G2\/M arrest in BGC-823 cells","volume":"97","author":"Chen","year":"2013","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0025","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/aps.2009.93","article-title":"Macrophage receptors of polysaccharide isolated from a marine filamentous fungus Phoma herbarum YS4108","volume":"30","author":"Chen","year":"2009","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2017.02.029","article-title":"Salvia miltiorrhiza polysaccharide activates T lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-kappa B signaling pathways","volume":"200","author":"Chen","year":"2017","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0008-6215(84)85242-8","article-title":"A simple and rapid method for the permethylation of carbohydrates","volume":"131","author":"Ciucanu","year":"1984","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0040","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1126\/science.342.6165.1432","article-title":"Cancer immunotherapy","volume":"342","author":"Couzin-Frankel","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0045","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ijbiomac.2011.05.016","article-title":"Size, structure and scaling relationships in glycogen from various sources investigated with asymmetrical flow field-flow fractionation and H-1 NMR","volume":"49","author":"Fernandez","year":"2011","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0050","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2","volume":"197","author":"Gantner","year":"2003","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses","volume":"16","author":"Ghosh","year":"1998","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0060","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes & Development"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0065","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2174\/1871520611313050002","article-title":"The use of lentinan for treating gastric cancer","volume":"13","author":"Ina","year":"2013","journal-title":"Anti-Cancer Agents in Medicinal Chemistry"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0070","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0075","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/j.carres.2007.07.024","article-title":"Relationship between structure and immuno stimulating activity of enzymatically synthesized glycogen","volume":"342","author":"Kakutani","year":"2007","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0080","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.intimp.2011.10.017","article-title":"The effect of orally administered glycogen on anti-tumor activity and natural killer cell activity in mice","volume":"12","author":"Kakutani","year":"2012","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0085","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: The control of NF-kappaB activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.carbpol.2014.11.059","article-title":"Mechanism of macrophage activation induced by polysaccharide from Cordyceps militaris culture broth","volume":"120","author":"Lee","year":"2015","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0095","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/1541-4337.12161","article-title":"Molecular modification of polysaccharides and resulting bioactivities","volume":"15","author":"Li","year":"2016","journal-title":"Comprehensive Reviews in Food Science and Food Safety"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0100","doi-asserted-by":"crossref","first-page":"e26860","DOI":"10.4161\/onci.26860","article-title":"Harnessing the antitumor potential of macrophages for cancer immunotherapy","volume":"2","author":"Long","year":"2013","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0105","doi-asserted-by":"crossref","first-page":"e0173621","DOI":"10.1371\/journal.pone.0173621","article-title":"Antitumor activity of orally administered maitake alpha-glucan by stimulating antitumor immune response in murine tumor","volume":"12","author":"Masuda","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0110","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ejso.2015.02.012","article-title":"Clinical efficacy of protein-bound polysaccharide K in patients with gastric cancer undergoing chemotherapy with an oral fluoropyrimidine (S-1)","volume":"41","author":"Namikawa","year":"2015","journal-title":"European Journal of Surgical Oncology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0115","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.foodhyd.2015.05.023","article-title":"Biological effects of chitosan and its derivatives","volume":"51","author":"Ngo","year":"2015","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0120","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.biochi.2009.11.003","article-title":"Enzymatic degradation products from a marine polysaccharide YCP with different immunological activity and binding affinity to macrophages, hydrolyzed by alpha-amylases from different origins","volume":"92","author":"Ren","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0125","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1271\/bbb.68.2332","article-title":"Anti-tumor activity of an enzymatically synthesized alpha-1,6 branched alpha-1,4-glucan, glycogen","volume":"68","author":"Ryoyama","year":"2004","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0130","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.87.2257.304","article-title":"The presence of a type-and species-specific conjugated polysaccharide in type I Pneumococcus","volume":"87","author":"Sevag","year":"1938","journal-title":"Science"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0135","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijbiomac.2015.11.001","article-title":"An exopolysaccharide isolated from a coral-associated fungus and its sulfated derivative activates macrophages","volume":"82","author":"Sun","year":"2016","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0140","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.carbpol.2012.09.077","article-title":"Structural diversity of fungal glucans","volume":"92","author":"Synytsya","year":"2013","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0145","first-page":"208","article-title":"Antitumor glycogen from scallops and the interrelationship of structure and antitumor activity","volume":"6","author":"Takaya","year":"1998","journal-title":"Journal of Marine Biotechnology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0150","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4049\/jimmunol.156.3.1235","article-title":"Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b\/CD18)","volume":"156","author":"Thornton","year":"1996","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.foodhyd.2017.01.010","article-title":"Structural characterization and immunostimulatory activity of a glucan from natural Cordyceps sinensis","volume":"67","author":"Wang","year":"2017","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0160","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1039\/C4FO00202D","article-title":"Antitumor efficacy in H22 tumor bearing mice and immunoregulatory activity on RAW 264.7 macrophages of polysaccharides from Talinum triangulare","volume":"5","author":"Wang","year":"2014","journal-title":"Food & Function"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-2670(93)80373-S","article-title":"Light-scattering and the absolute characterization of macromolecules","volume":"272","author":"Wyatt","year":"1993","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/IntJMedMushr.v12.i1.10","article-title":"Medicinal mushroom science: History, current status, future trends, and unsolved problems","volume":"12","author":"Wasser","year":"2010","journal-title":"International Journal of Medicinal Mushrooms"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0175","doi-asserted-by":"crossref","first-page":"31194","DOI":"10.1074\/jbc.M111.246470","article-title":"Immunomodulatory beta-glucan from Lentinus edodes activates mitogen-activated protein kinases and nuclear factor-kappaB in murine RAW 264.7 macrophages","volume":"286","author":"Xu","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0180","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.biochi.2005.03.004","article-title":"Purification, characterization and enzymatic degradation of YCP, a polysaccharide from marine filamentous fungus Phoma herbarum YS4108","volume":"87","author":"Yang","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.carbpol.2017.12.009","article-title":"Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review","volume":"183","author":"Yu","year":"2018","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0190","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.carres.2005.02.032","article-title":"Correlation between antitumor activity, molecular weight, and conformation of lentinan","volume":"340","author":"Zhang","year":"2005","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.carbpol.2018.06.076_bib0195","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.carbpol.2014.04.106","article-title":"Preparation and immunomodulating activities of a library of low-molecular-weight alpha-glucans","volume":"111","author":"Zhu","year":"2014","journal-title":"Carbohydrate Polymers"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861718307306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861718307306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:05:33Z","timestamp":1693724733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861718307306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":39,"alternative-id":["S0144861718307306"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2018.06.076","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2018.06.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}