{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:50:56Z","timestamp":1791496256556,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012309","name":"Royal Golden Jubilee (RGJ) Ph.D. Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.carbpol.2019.115049","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T14:16:02Z","timestamp":1562076962000},"page":"115049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Dual pH\/thermal-dependent coloring polymeric dye through Mannich reaction of chitosan: Synthesis and characterization"],"prefix":"10.1016","volume":"223","author":[{"given":"Jongjit","family":"Chalitangkoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathavuth","family":"Monvisade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.carbpol.2019.115049_bib0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF03002523","article-title":"Phenolphthalein today: A critical review","volume":"17","author":"Abramowitz","year":"1950","journal-title":"The American Journal of Digestive Diseases"},{"issue":"3","key":"10.1016\/j.carbpol.2019.115049_bib0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1134\/S1063774518030033","article-title":"Polymorphic modifications of chitosan","volume":"63","author":"Baklagina","year":"2018","journal-title":"Crystallography Reports"},{"issue":"1\u20133","key":"10.1016\/j.carbpol.2019.115049_bib0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0925-4005(03)00045-5","article-title":"Temperature sensing using reversible thermochromic polymeric films","volume":"90","author":"Baron","year":"2003","journal-title":"Sensors and Actuators B, Chemical"},{"issue":"7","key":"10.1016\/j.carbpol.2019.115049_bib0020","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1007\/s11172-014-0645-0","article-title":"Tetrazole derivatives of chitosan: Synthetic approaches and evaluation of toxicity","volume":"63","author":"Berezin","year":"2014","journal-title":"Russian Chemical Bulletin"},{"issue":"2","key":"10.1016\/j.carbpol.2019.115049_bib0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1023\/A:1016681502731","article-title":"Fluorescein and phenolphthalein\u2014Correlation of fluorescence and photoelectric properties","volume":"11","author":"Boguta","year":"2001","journal-title":"Journal of Fluorescence"},{"issue":"9","key":"10.1016\/j.carbpol.2019.115049_bib0030","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/j.cemconres.2004.07.025","article-title":"The experimental investigation of concrete carbonation depth","volume":"36","author":"Chang","year":"2006","journal-title":"Cement and Concrete Research"},{"issue":"21","key":"10.1016\/j.carbpol.2019.115049_bib0035","first-page":"4922","article-title":"Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems","volume":"56","author":"Dunnick","year":"1996","journal-title":"Cancer Research"},{"issue":"7","key":"10.1016\/j.carbpol.2019.115049_bib0040","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.carres.2009.03.002","article-title":"Chitosan-LiOH-urea aqueous solution--a novel water-based system for chitosan processing","volume":"344","author":"Fan","year":"2009","journal-title":"Carbohydrate Research"},{"issue":"13","key":"10.1016\/j.carbpol.2019.115049_bib0045","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1021\/ma300670x","article-title":"Extended applicability of classical phenolphthalein: Color changing polymeric materials derived from pH-Sensitive acrylated phenolphthalein derivatives","volume":"45","author":"Fleischmann","year":"2012","journal-title":"Macromolecules"},{"key":"10.1016\/j.carbpol.2019.115049_bib0050","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cej.2018.02.061","article-title":"Improving the functionality and performance of AA2024 corrosion sensing coatings with nanocontainers","volume":"341","author":"Galv\u00e3o","year":"2018","journal-title":"Chemical Engineering Journal"},{"key":"10.1016\/j.carbpol.2019.115049_bib0055","first-page":"349074","article-title":"PCT Int. Appl. WO 2005027901, 2005","volume":"142","author":"Gazit","year":"2005","journal-title":"Chemical Abstracts"},{"issue":"3406","key":"10.1016\/j.carbpol.2019.115049_bib0060","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1136\/bmj.1.3406.650","article-title":"The kastle-meyer test for the detection of blood: Considered from the medico-legal aspect","volume":"1","author":"Glaister","year":"1926","journal-title":"British Medical Journal"},{"issue":"1A","key":"10.1016\/j.carbpol.2019.115049_bib0065","first-page":"94","article-title":"Synthesis of Phenolphthalein-formaldehyde resin and study of it\u2019s antibacterial activity","volume":"36","author":"Hamad","year":"2010","journal-title":"Journal of Basrah Researches (Sciences)"},{"key":"10.1016\/j.carbpol.2019.115049_bib0070","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ijbiomac.2016.02.077","article-title":"Aqueous Co(II) adsorption using 8-hydroxyquinoline anchored \u03b3-Fe2O3@chitosan with Co(II) as imprinted ions","volume":"87","author":"Hossein Beyki","year":"2016","journal-title":"International Journal of Biological Macromolecules"},{"issue":"2","key":"10.1016\/j.carbpol.2019.115049_bib0075","doi-asserted-by":"crossref","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2013005678","article-title":"A new horizon in modifications of chitosan: Syntheses and applications","volume":"30","author":"Jain","year":"2013","journal-title":"Critical Reviews in Therapeutic Drug Carrier Systems"},{"issue":"2","key":"10.1016\/j.carbpol.2019.115049_bib0080","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1021\/acsabm.8b00148","article-title":"Phenolphthalein-conjugated hydrogel formation under visible-light irradiation for reducing variability of colorimetric biodetection","volume":"1","author":"Kim","year":"2018","journal-title":"ACS Applied Bio Materials"},{"issue":"2","key":"10.1016\/j.carbpol.2019.115049_bib0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1386-1425(00)00371-1","article-title":"Molecular structure and vibrational spectra of phenolphthalein and its dianion","volume":"57","author":"Kunimoto","year":"2001","journal-title":"Spectrochimica Acta Part A, Molecular and Biomolecular Spectroscopy"},{"issue":"16","key":"10.1016\/j.carbpol.2019.115049_bib0090","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/macp.200350053","article-title":"Chemically amplified photolithography of a copolymer containing phenolphthalein","volume":"204","author":"Lee","year":"2003","journal-title":"Macromolecular Chemistry and Physics"},{"issue":"1","key":"10.1016\/j.carbpol.2019.115049_bib0095","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jpowsour.2006.06.010","article-title":"Proton conducting composite membranes from sulfonated polyethersulfone Cardo and phosphotungstic acid for fuel cell application","volume":"162","author":"Li","year":"2006","journal-title":"Journal of Power Sources"},{"key":"10.1016\/j.carbpol.2019.115049_bib0100","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.polymer.2018.03.012","article-title":"Unique gelation of chitosan in an alkali\/urea aqueous solution","volume":"141","author":"Liu","year":"2018","journal-title":"Polymer"},{"issue":"2","key":"10.1016\/j.carbpol.2019.115049_bib0105","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.aca.2004.01.019","article-title":"Phenolphthalein immobilized membrane for an optical pH sensor","volume":"510","author":"Liu","year":"2004","journal-title":"Analytica Chimica Acta"},{"issue":"53","key":"10.1016\/j.carbpol.2019.115049_bib0110","doi-asserted-by":"crossref","first-page":"33494","DOI":"10.1039\/C7RA04024E","article-title":"Synthesis and color properties of novel polymeric dyes based on grafting of anthraquinone derivatives onto O-carboxymethyl chitosan","volume":"7","author":"Lv","year":"2017","journal-title":"RSC Advances"},{"key":"10.1016\/j.carbpol.2019.115049_bib0115","first-page":"459","article-title":"Antibacterial drug","volume":"4","author":"Mchugh","year":"1984","journal-title":"US Patent"},{"issue":"10","key":"10.1016\/j.carbpol.2019.115049_bib0120","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/(SICI)1097-4628(19980906)69:10<1923::AID-APP5>3.0.CO;2-G","article-title":"Blends of phenolphthalein poly(ether ether ketone) and a thermotropic liquid crystalline copolyester","volume":"69","author":"Mi","year":"1998","journal-title":"Journal of Applied Polymer Science"},{"issue":"5","key":"10.1016\/j.carbpol.2019.115049_bib0125","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1039\/a900531e","article-title":"Development of novel thermochromic plastic films for optical temperature sensing","volume":"124","author":"Mills","year":"1999","journal-title":"The Analyst"},{"issue":"3","key":"10.1016\/j.carbpol.2019.115049_bib0130","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.carbpol.2012.06.067","article-title":"Synthesis of organosoluble chitosan derivatives with polyphenolic side chains","volume":"90","author":"Morimoto","year":"2012","journal-title":"Carbohydrate Polymers"},{"issue":"4","key":"10.1016\/j.carbpol.2019.115049_bib0135","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1109\/JSEN.2015.2495338","article-title":"Halochromic chemosensor from poly(acrylonitrile)\/Phenolphthalein nanofibers as pH sensor","volume":"16","author":"Noshirvani Sharifabad","year":"2016","journal-title":"IEEE Sensors Journal"},{"issue":"1","key":"10.1016\/j.carbpol.2019.115049_bib0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0300-483X(02)00586-3","article-title":"Lack of susceptibility of heterozygous p53-knockout CBA and CIEA mice to phenolphthalein in a 6-month carcinogenicity study","volume":"185","author":"Okamura","year":"2003","journal-title":"Toxicology"},{"issue":"41","key":"10.1016\/j.carbpol.2019.115049_bib0145","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1016\/S0040-4039(01)01491-5","article-title":"Regioselective Mannich reaction of phenolic compounds and its application to the synthesis of new chitosan derivatives","volume":"42","author":"Omura","year":"2001","journal-title":"Tetrahedron Letters"},{"key":"10.1016\/j.carbpol.2019.115049_bib0150","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijbiomac.2014.01.050","article-title":"Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives","volume":"65","author":"Prichystalova","year":"2014","journal-title":"International Journal of Biological Macromolecules"},{"issue":"7","key":"10.1016\/j.carbpol.2019.115049_bib0155","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.progpolymsci.2006.06.001","article-title":"Chitin and chitosan: Properties and applications","volume":"31","author":"Rinaudo","year":"2006","journal-title":"Progress in Polymer Science"},{"issue":"7","key":"10.1016\/j.carbpol.2019.115049_bib0160","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/pol.1981.180190706","article-title":"Solid state characterization of the structure of chitosan films","volume":"19","author":"Samuels","year":"1981","journal-title":"Journal of Polymer Science Polymer Physics Edition"},{"issue":"26","key":"10.1016\/j.carbpol.2019.115049_bib0165","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1039\/C6TB00639F","article-title":"Blend electrospinning of dye-functionalized chitosan and poly(\u03b5-caprolactone): Towards biocompatible pH-sensors","volume":"4","author":"Schoolaert","year":"2016","journal-title":"Journal of Materials Chemistry B"},{"issue":"Suppl 1","key":"10.1016\/j.carbpol.2019.115049_bib0170","first-page":"S208","article-title":"Detection and quantitation of trace phenolphthalein (in pharmaceutical preparations and in forensic exhibits) by liquid chromatography-tandem mass spectrometry, a sensitive and accurate method","volume":"58","author":"Sharma","year":"2013","journal-title":"Journal of Forensic Sciences"},{"issue":"3","key":"10.1016\/j.carbpol.2019.115049_bib0175","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF02706490","article-title":"External stimuli response on a novel chitosan hydrogel crosslinked with formaldehyde","volume":"29","author":"Singh","year":"2006","journal-title":"Bulletin of Materials Science"},{"key":"10.1016\/j.carbpol.2019.115049_bib0180","first-page":"303","article-title":"Recent research in the applications of chitin","author":"Sudha","year":"2015","journal-title":"Chitosan and Oligosaccharides."},{"issue":"8","key":"10.1016\/j.carbpol.2019.115049_bib0185","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1246\/cl.130266","article-title":"High-strength chitosan hydrogels prepared from LiOH\/Urea solvent system","volume":"42","author":"Sun","year":"2013","journal-title":"Chemistry Letters"},{"issue":"6","key":"10.1016\/j.carbpol.2019.115049_bib0190","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2116\/analsci.12.927","article-title":"Spectrophotometric analysis of the relationship between dissociation and coloration, and of the structural formulas of phenolphthalein in aqueous solution","volume":"12","author":"Tamura","year":"1996","journal-title":"Analytical Sciences"},{"key":"10.1016\/j.carbpol.2019.115049_bib0195","doi-asserted-by":"crossref","first-page":"12033","DOI":"10.1038\/ncomms12033","article-title":"Gelation process visualized by aggregation-induced emission fluorogens","volume":"7","author":"Wang","year":"2016","journal-title":"Nature Communications"},{"issue":"88","key":"10.1016\/j.carbpol.2019.115049_bib0200","doi-asserted-by":"crossref","first-page":"71824","DOI":"10.1039\/C5RA12453K","article-title":"Color changing Pickering emulsions stabilized by polysiloxane microspheres bearing phenolphthalein groups","volume":"5","author":"Wei","year":"2015","journal-title":"RSC Advances"},{"issue":"2","key":"10.1016\/j.carbpol.2019.115049_bib0205","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.carbpol.2013.04.006","article-title":"Preparation, characterization and antioxidant property of water-soluble ferulic acid grafted chitosan","volume":"96","author":"Woranuch","year":"2013","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2019.115049_bib0210","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijbiomac.2018.07.060","article-title":"Novel chitosan hydrogels reinforced by silver nanoparticles with ultrahigh mechanical and high antibacterial properties for accelerating wound healing","volume":"119","author":"Xie","year":"2018","journal-title":"International Journal of Biological Macromolecules"},{"issue":"6","key":"10.1016\/j.carbpol.2019.115049_bib0215","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s10965-011-9578-6","article-title":"Synthesis and curing behavior of a benzoxazine based on phenolphthalein and its high performance polymer","volume":"18","author":"Yang","year":"2011","journal-title":"Journal of Polymer Research"},{"issue":"6","key":"10.1016\/j.carbpol.2019.115049_bib0220","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1002\/app.26947","article-title":"Synthesis and characterization of carboxymethyl chitosan containing functional ultraviolet absorber substituent","volume":"106","author":"Yu","year":"2007","journal-title":"Journal of Applied Polymer Science"},{"issue":"4","key":"10.1016\/j.carbpol.2019.115049_bib0225","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.reactfunctpolym.2009.01.001","article-title":"Synthesis and characterization of novel phenolphthalein immobilized halochromic fiber","volume":"69","author":"Zhang","year":"2009","journal-title":"Reactive & Functional Polymers"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861719307167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861719307167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T23:49:09Z","timestamp":1758930549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861719307167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":45,"alternative-id":["S0144861719307167"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2019.115049","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual pH\/thermal-dependent coloring polymeric dye through Mannich reaction of chitosan: Synthesis and characterization","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2019.115049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115049"}}