{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T04:00:25Z","timestamp":1772337625249,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.carbpol.2020.117335","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T23:46:44Z","timestamp":1604274404000},"page":"117335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Adsorptivity of cationic cellulose nanocrystals for phosphate and its application in hyperphosphatemia therapy"],"prefix":"10.1016","volume":"255","author":[{"given":"Qimeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haotian","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congshuang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruitao","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.carbpol.2020.117335_bib0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/jcis.2001.7773","article-title":"ATR-FTIR spectroscopic investigation on phosphate adsorption mechanisms at the ferrihydrite-water interface","volume":"241","author":"Arai","year":"2001","journal-title":"Journal of Colloid and Interface Science"},{"issue":"4","key":"10.1016\/j.carbpol.2020.117335_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/01.mnh.0000133973.86816.e9","article-title":"Lanthanum carbonate: A new phosphate binder","volume":"13","author":"Behets","year":"2004","journal-title":"Current Opinion in Nephrology and Hypertension"},{"issue":"4","key":"10.1016\/j.carbpol.2020.117335_bib0015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000331988","article-title":"Effectiveness and cost-efficacy of phosphate binders in hemodialysis","volume":"58","author":"Brunner-Ziegler","year":"2011","journal-title":"Annals of Nutrition & Metabolism"},{"issue":"2","key":"10.1016\/j.carbpol.2020.117335_bib0020","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.carbpol.2012.01.026","article-title":"Preparation and characterization of thermal\/pH-sensitive hydrogel from carboxylated nanocrystalline cellulose","volume":"88","author":"Cha","year":"2012","journal-title":"Carbohydrate Polymers"},{"issue":"1","key":"10.1016\/j.carbpol.2020.117335_bib0025","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/hdi.12334","article-title":"Risk of major depression in patients with chronic renal failure on different treatment modalities: A matched-cohort and population-based study in Taiwan","volume":"20","author":"Chen","year":"2016","journal-title":"Hemodialysis International"},{"issue":"3","key":"10.1016\/j.carbpol.2020.117335_bib0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.21037\/atm.2018.06.50","article-title":"Hyperphosphatemia: A novel risk factor for mortality in chronic kidney disease","volume":"7","author":"Cozzolino","year":"2019","journal-title":"Annals of Translational Medicine"},{"issue":"11","key":"10.1016\/j.carbpol.2020.117335_bib0035","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1093\/ndt\/gfq292","article-title":"Evaluation of calcium acetate\/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: A controlled randomized study (CALMAG study) assessing efficacy and tolerability","volume":"25","author":"de Francisco","year":"2010","journal-title":"Nephrology Dialysis Transplantation"},{"key":"10.1016\/j.carbpol.2020.117335_bib0040","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.carbpol.2019.01.020","article-title":"Cellulose nanocrystals and cellulose nanofibrils based hydrogels for biomedical applications","volume":"209","author":"Du","year":"2019","journal-title":"Carbohydrate Polymers"},{"issue":"11","key":"10.1016\/j.carbpol.2020.117335_bib0045","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/jn\/116.11.2219","article-title":"Contrasting effects of the stomach and small-intestine of rats on copper absorption","volume":"116","author":"Fields","year":"1986","journal-title":"The Journal of Nutrition"},{"issue":"8","key":"10.1016\/j.carbpol.2020.117335_bib0050","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1039\/C6CS00895J","article-title":"Current characterization methods for cellulose nanomaterials","volume":"47","author":"Foster","year":"2018","journal-title":"Chemical Society Reviews"},{"issue":"4","key":"10.1016\/j.carbpol.2020.117335_bib0055","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.jrn.2016.01.009","article-title":"An update on phosphate binders: A dietitian\u2019s perspective","volume":"26","author":"Gutekunst","year":"2016","journal-title":"Journal of Renal Nutrition"},{"issue":"4","key":"10.1016\/j.carbpol.2020.117335_bib0060","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s10924-017-1075-5","article-title":"Hemicellulose-based films reinforced with unmodified and cationically modified nanocrystalline cellulose","volume":"26","author":"Huang","year":"2018","journal-title":"Journal of Polymers and the Environment"},{"key":"10.1016\/j.carbpol.2020.117335_bib0065","first-page":"360","article-title":"The clinical significance of serum and urinary neopterin levels in several renal diseases","volume":"21","author":"Kim","year":"2006","journal-title":"Nephrology Dialysis Transplantation"},{"key":"10.1016\/j.carbpol.2020.117335_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119474","article-title":"Nanomaterials for the theranostics of obesity","volume":"223","author":"Li","year":"2019","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.carbpol.2020.117335_bib0075","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800334","article-title":"Nanocellulose-based antibacterial materials","volume":"7","author":"Li","year":"2018","journal-title":"Advanced Healthcare Materials"},{"issue":"40","key":"10.1016\/j.carbpol.2020.117335_bib0080","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1039\/C8TB01657G","article-title":"Iron oxide nanoparticles for targeted imaging of liver tumors with ultralow hepatotoxicity","volume":"6","author":"Li","year":"2018","journal-title":"Journal of Materials Chemistry B"},{"key":"10.1016\/j.carbpol.2020.117335_bib0085","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1021\/acssuschemeng.8b04786","article-title":"Modified Fenton oxidation of cellulose fibers for cellulose nanofibrils preparation","volume":"7","author":"Li","year":"2018","journal-title":"ACS Sustainable Chemistry & Engineering"},{"issue":"3","key":"10.1016\/j.carbpol.2020.117335_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.26599\/PBM.2019.9260024","article-title":"Application of cellulose and cellulose nanofibers in oil exploration","author":"Liu","year":"2019","journal-title":"Paper and Biomaterials"},{"key":"10.1016\/j.carbpol.2020.117335_bib0095","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.powtec.2015.02.055","article-title":"Removal of phosphate anions using the modified chitosan beads: Adsorption kinetic, isotherm and mechanism studies","volume":"277","author":"Liu","year":"2015","journal-title":"Powder Technology"},{"key":"10.1016\/j.carbpol.2020.117335_bib0100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.carbpol.2016.04.064","article-title":"Development of nanocellulose scaffolds with tunable structures to support 3D cell culture","volume":"148","author":"Liu","year":"2016","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2020.117335_bib0105","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.carbpol.2016.06.025","article-title":"Properties of nanocellulose isolated from corncob residue using sulfuric acid, formic acid, oxidative and mechanical methods","volume":"151","author":"Liu","year":"2016","journal-title":"Carbohydrate Polymers"},{"issue":"1","key":"10.1016\/j.carbpol.2020.117335_bib0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/089686080802800115","article-title":"Efficacy and side effects of Sevelamer hydrochloride as sole phosphate binder in peritoneal dialysis patients with severe hyperphosphatemia","volume":"28","author":"Lo","year":"2008","journal-title":"Peritoneal Dialysis International"},{"issue":"8","key":"10.1016\/j.carbpol.2020.117335_bib0115","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3390\/molecules24081491","article-title":"Renoprotective effect of Laminaria japonica polysaccharide in adenine-induced chronic renal failure","volume":"24","author":"Long","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.carbpol.2020.117335_bib0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12882-017-0560-3","article-title":"Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study","volume":"18","author":"Neradova","year":"2017","journal-title":"BMC Nephrology"},{"issue":"2","key":"10.1016\/j.carbpol.2020.117335_bib0125","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2215\/CJN.06800615","article-title":"Sevelamer versus calcium-based binders for treatment of hyperphosphatemia in CKD: A meta-analysis of randomized controlled trials","volume":"11","author":"Patel","year":"2016","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"10.1016\/j.carbpol.2020.117335_bib0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2369-12-55","article-title":"Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?","volume":"12","author":"Pepper","year":"2011","journal-title":"BMC Nephrology"},{"issue":"4","key":"10.1016\/j.carbpol.2020.117335_bib0135","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jsps.2015.01.009","article-title":"Hyperphosphatemia management in patients with chronic kidney disease","volume":"24","author":"Shaman","year":"2016","journal-title":"Journal of the Saudi Pharmaceutical Society"},{"issue":"12","key":"10.1016\/j.carbpol.2020.117335_bib0140","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1185\/030079907X242719","article-title":"A comparative review of the efficacy and safety of established phosphate binders: Calcium, sevelamer, and lanthanum carbonate","volume":"23","author":"Sprague","year":"2007","journal-title":"Current Medical Research and Opinion"},{"issue":"6","key":"10.1016\/j.carbpol.2020.117335_bib0145","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1440-1797.2004.00338.x","article-title":"Efficacy and side-effect profile of sevelamer hydrochloride used in combination with conventional phosphate binders","volume":"9","author":"Sturtevant","year":"2004","journal-title":"Nephrology"},{"key":"10.1016\/j.carbpol.2020.117335_bib0150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.carbpol.2018.05.073","article-title":"Preparation and properties of chitosan\/guar gum\/nanocrystalline cellulose nanocomposite films","volume":"197","author":"Tang","year":"2018","journal-title":"Carbohydrate Polymers"},{"issue":"1","key":"10.1016\/j.carbpol.2020.117335_bib0155","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF02783848","article-title":"High accumulation of calcium and phosphorus in human iliac arteries","volume":"70","author":"Tohno","year":"1999","journal-title":"Biological Trace Element Research"},{"issue":"3","key":"10.1016\/j.carbpol.2020.117335_bib0160","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/ndt\/gfq520","article-title":"Does the choice of phosphate binder affect trace element levels in chronic kidney disease patients treated by regular haemodialysis?","volume":"26","author":"Veighey","year":"2011","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"7805","key":"10.1016\/j.carbpol.2020.117335_bib0165","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0140-6736(73)91512-2","article-title":"Chronic renal-failure or simple starvation","volume":"1","author":"Walser","year":"1973","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.carbpol.2020.117335_bib0170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.26599\/PBM.2019.9260016","article-title":"Industrialization progress of nanocellulose in China","volume":"4","author":"Wang","year":"2019","journal-title":"Paper and Biomaterials"},{"key":"10.1016\/j.carbpol.2020.117335_bib0175","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s10570-012-9765-6","article-title":"Approaching zero cellulose loss in cellulose nanocrystal (CNC) production: Recovery and characterization of cellulosic solid residues (CSR) and CNC","volume":"19","author":"Wang","year":"2012","journal-title":"Cellulose"},{"key":"10.1016\/j.carbpol.2020.117335_bib0180","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.carbpol.2019.03.097","article-title":"Preparation of cellulose-base amphoteric flocculant and its application in the treatment of wastewater","volume":"215","author":"Wang","year":"2019","journal-title":"Carbohydrate Polymers"},{"issue":"43","key":"10.1016\/j.carbpol.2020.117335_bib0185","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1039\/C8TB01757C","article-title":"3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application","volume":"6","author":"Xu","year":"2018","journal-title":"Journal of Materials Chemistry B"},{"issue":"7","key":"10.1016\/j.carbpol.2020.117335_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180430","article-title":"PA21, a novel phosphate binder, improves renal osteodystrophy in rats with chronic renal failure","volume":"12","author":"Yaguchi","year":"2017","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.carbpol.2020.117335_bib0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.carbpol.2012.02.066","article-title":"Synthesis and characterization of cationically modified nanocrystalline cellulose","volume":"89","author":"Zaman","year":"2012","journal-title":"Carbohydrate Polymers"},{"issue":"51","key":"10.1016\/j.carbpol.2020.117335_bib0200","doi-asserted-by":"crossref","first-page":"40785","DOI":"10.1039\/C5RA02035B","article-title":"Synthesis and characterization of ferric tannate as a novel porous adsorptive-catalyst for nitrogen removal from wastewater","author":"Zhang","year":"2015","journal-title":"RSC Advances"},{"issue":"6","key":"10.1016\/j.carbpol.2020.117335_bib0205","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1007\/s10570-018-1815-2","article-title":"Design and preparation of a cellulose-based adsorbent modified by imidazolium ionic liquid functional groups and their studies on anionic dye adsorption","volume":"25","author":"Zhang","year":"2018","journal-title":"Cellulose"},{"key":"10.1016\/j.carbpol.2020.117335_bib0210","doi-asserted-by":"crossref","first-page":"22151","DOI":"10.1038\/srep22151","article-title":"An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure","volume":"6","author":"Zhang","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1016\/j.carbpol.2020.117335_bib0215","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.carbpol.2015.09.060","article-title":"Study on the sorption process of triclosan on cationic microfibrillated cellulose and its antibacterial activity","volume":"136","author":"Zhang","year":"2016","journal-title":"Carbohydrate Polymers"},{"issue":"3","key":"10.1016\/j.carbpol.2020.117335_bib0220","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4314\/ahs.v18i3.27","article-title":"A meta-analysis of phosphate binders lanthanum carbonate versus sevelamer hydrochloride in patients with end-stage renal disease undergoing hemodialysis","volume":"18","author":"Zhou","year":"2018","journal-title":"African Health Sciences"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861720315083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861720315083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:10:26Z","timestamp":1758931826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861720315083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":44,"alternative-id":["S0144861720315083"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2020.117335","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adsorptivity of cationic cellulose nanocrystals for phosphate and its application in hyperphosphatemia therapy","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2020.117335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117335"}}