{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:38:30Z","timestamp":1791959910802,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.carbpol.2022.120225","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T13:05:04Z","timestamp":1665752704000},"page":"120225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Laser thrombolysis and in vitro release kinetics of tPA encapsulated in chitosan polysulfate-coated nanoliposome"],"prefix":"10.1016","volume":"299","author":[{"given":"Parvin","family":"Ahmaditabar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Mahmoodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramezan Ali","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Asefnejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0005","doi-asserted-by":"crossref","first-page":"50","DOI":"10.15171\/jlms.2019.08","article-title":"Histopathological changes of the retina after nd: YAG laser thrombolysis in branch retinal vein occlusion: An experimental study","volume":"10","author":"Abdelkawi","year":"2019","journal-title":"Journal of Lasers in Medical Sciences"},{"issue":"12","key":"10.1016\/j.carbpol.2022.120225_bb0010","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1002\/jcb.26070","article-title":"Enhanced entrapment and improved in vitro controlled release of n-acetyl cysteine in hybrid PLGA\/lecithin nanoparticles prepared using a nanoprecipitation\/self-assembly method","volume":"118","author":"Ahmaditabar","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.carbpol.2022.120225_bb0015","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.foodhyd.2016.07.005","article-title":"Novel resveratrol delivery systems based on alginate-sucrose and alginate-chitosan microbeads containing liposomes","volume":"61","author":"Balan\u010d","year":"2016","journal-title":"Food Hydrocolloids"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-06383-w","article-title":"Molecular and physical mechanisms of fibrinolysis and thrombolysis from mathematical modeling and experiments","volume":"7","author":"Bannish","year":"2017","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.carbpol.2022.120225_bb0025","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11239-016-1470-0","article-title":"Development of a new catheter prototype for laser thrombolysis under guidance of optical coherence tomography (OCT): Validation of feasibility and efficacy in a preclinical model","volume":"43","author":"Berndt","year":"2017","journal-title":"Journal of Thrombosis and Thrombolysis"},{"issue":"2","key":"10.1016\/j.carbpol.2022.120225_bb0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00062-014-0347-x","article-title":"The impact of histological clot composition in embolic stroke","volume":"26","author":"Boeckh-Behrens","year":"2016","journal-title":"Clinical Neuroradiology"},{"issue":"2","key":"10.1016\/j.carbpol.2022.120225_bb0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.biomaterials.2007.09.027","article-title":"Accelerating thrombolysis with chitosan-coated plasminogen activators encapsulated in poly-(lactide-co-glycolide) (PLGA) nanoparticles","volume":"29","author":"Chung","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.carbpol.2022.120225_bb0040","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.carbpol.2018.09.011","article-title":"Sulfonated and sulfated chitosan derivatives for biomedical applications: A review","volume":"202","author":"Dimassi","year":"2018","journal-title":"Carbohydrate Polymers"},{"issue":"5","key":"10.1016\/j.carbpol.2022.120225_bb0045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0049-3848(01)00266-3","article-title":"Comparison of antithrombin activity of the polysulphate chitosan derivatives in in vivo and in vitro system","volume":"102","author":"Drozd","year":"2001","journal-title":"Thrombosis Research"},{"issue":"6","key":"10.1016\/j.carbpol.2022.120225_bb0050","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/CIRCULATIONAHA.107.759191","article-title":"Tumor necrosis factor-\u03b1 and mortality in heart failure: A community study","volume":"118","author":"Dunlay","year":"2008","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.carbpol.2022.120225_bb0055","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/13543776.2019.1679767","article-title":"An update on liposomes in drug delivery: A patent review (2014\u20132018)","volume":"29","author":"El-Hammadi","year":"2019","journal-title":"Expert Opinion on Therapeutic Patents"},{"issue":"47","key":"10.1016\/j.carbpol.2022.120225_bb0060","doi-asserted-by":"crossref","first-page":"10854","DOI":"10.1039\/D0TB02242J","article-title":"Human hair derived uPA loaded capsules with dual near-infrared (I and II biowindows) laser responsive capabilities for multi-effective thrombolysis therapy","volume":"8","author":"Fang","year":"2020","journal-title":"Journal of Materials Chemistry B"},{"key":"10.1016\/j.carbpol.2022.120225_bb0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.actbio.2021.03.052","article-title":"Blood clot fracture properties are dependent on red blood cell and fibrin content","volume":"127","author":"Fereidoonnezhad","year":"2021","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.carbpol.2022.120225_bb0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fchem.2021.643411","article-title":"Thrombolysis combined therapy using CuS@ SiO2-PEG\/uPA nanoparticles","volume":"9","author":"Fu","year":"2021","journal-title":"Frontiers in Chemistry"},{"issue":"02","key":"10.1016\/j.carbpol.2022.120225_bb0075","first-page":"1","article-title":"Application of mathematical models in drug release kinetics of carbidopa and levodopa ER tablets","volume":"6","author":"Gouda","year":"2017","journal-title":"Journal of Developing Drugs"},{"issue":"13","key":"10.1016\/j.carbpol.2022.120225_bb0080","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"The New England Journal of Medicine"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0085","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.apsb.2018.06.005","article-title":"Adapting liposomes for oral drug delivery","volume":"9","author":"He","year":"2019","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"3","key":"10.1016\/j.carbpol.2022.120225_bb0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ajps.2018.12.004","article-title":"Recent strategies on targeted delivery of thrombolytics","volume":"14","author":"Huang","year":"2019","journal-title":"Asian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.carbpol.2022.120225_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.02.033","article-title":"An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy","volume":"300","author":"Huang","year":"2019","journal-title":"Journal of Controlled Release"},{"issue":"2","key":"10.1016\/j.carbpol.2022.120225_bb0100","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/mp.14636","article-title":"Ultrasound-assisted laser thrombolysis with endovascular laser and high-intensity focused ultrasound","volume":"48","author":"Jo","year":"2021","journal-title":"Medical Physics"},{"issue":"3","key":"10.1016\/j.carbpol.2022.120225_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-017-0622-5","article-title":"IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation","volume":"112","author":"Jung","year":"2017","journal-title":"Basic Research in Cardiology"},{"issue":"4","key":"10.1016\/j.carbpol.2022.120225_bb0110","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable controlled-release polymers and polymeric nanoparticles: Mechanisms of controlling drug release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chemical Reviews"},{"key":"10.1016\/j.carbpol.2022.120225_bb0115","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphys.2015.00124","article-title":"Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10","volume":"6","author":"Kesherwani","year":"2015","journal-title":"Frontiers in Physiology"},{"issue":"3","key":"10.1016\/j.carbpol.2022.120225_bb0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4236\/anp.2018.73005","article-title":"Fabrication, visualization and analysis of fluorescein sodium encapsulated PLGA@ CS nanoparticles as model for photothermomechanical drug delivery using pulsed 532 nm laser","volume":"7","author":"Khosroshahi","year":"2018","journal-title":"Advances in Nanoparticles"},{"key":"10.1016\/j.carbpol.2022.120225_bb0125","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ijbiomac.2020.05.192","article-title":"A systematic study on chitosan-liposome based systems for biomedical applications","volume":"160","author":"Kumar","year":"2020","journal-title":"International Journal of Biological Macromolecules"},{"issue":"3","key":"10.1016\/j.carbpol.2022.120225_bb0130","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jbm.a.31999","article-title":"Anticoagulant surface modification of titanium via layer-by-layer assembly of collagen and sulfated chitosan multilayers","volume":"89","author":"Li","year":"2009","journal-title":"Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials"},{"issue":"2","key":"10.1016\/j.carbpol.2022.120225_bb0135","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0733-8635(05)70096-6","article-title":"Hair removal using an nd: YAG laser system","volume":"17","author":"Littler","year":"1999","journal-title":"Dermatologic Clinics"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0140","first-page":"1","article-title":"Nanobiotechnology approaches for cardiovascular diseases: Site-specific targeting of drugs and nanoparticles for atherothrombosis","volume":"20","author":"Liu","year":"2022","journal-title":"Journal of Nanobiotechnology"},{"issue":"2","key":"10.1016\/j.carbpol.2022.120225_bb0145","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/17425247.2018.1384464","article-title":"Tissue plasminogen activator-based nanothrombolysis for ischemic stroke","volume":"15","author":"Liu","year":"2018","journal-title":"Expert Opinion on Drug Delivery"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-022-01450-5","article-title":"Advances of nano drug delivery system for the theranostics of ischemic stroke","volume":"20","author":"Lv","year":"2022","journal-title":"Journal of Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000486042","article-title":"Erythrocyte-rich thrombus is associated with reduced number of maneuvers and procedure time in patients with acute ischemic stroke undergoing mechanical thrombectomy","volume":"8","author":"Maekawa","year":"2018","journal-title":"Cerebrovascular Diseases Extra"},{"issue":"3","key":"10.1016\/j.carbpol.2022.120225_bb0160","article-title":"Early experimental results of thrombolysis using controlled release of tissue plasminogen activator encapsulated by PLGA\/CS nanoparticles delivered bypulse532nmlaser","volume":"6","author":"Mahmoodi","year":"2011","journal-title":"Digest Journal of Nanomaterials & Biostructures (DJNB)"},{"key":"10.1016\/j.carbpol.2022.120225_bb0165","first-page":"1855","article-title":"Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer","volume":"9","author":"Matthaiou","year":"2014","journal-title":"International Journal of Nanomedicine"},{"issue":"3","key":"10.1016\/j.carbpol.2022.120225_bb0170","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/pharmaceutics11030140","article-title":"Mathematical modeling of release kinetics from supramolecular drug delivery systems","volume":"11","author":"Mircioiu","year":"2019","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0175","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1097\/01.RVI.0000112578.95689.66","article-title":"New and future endovascular treatment strategies for acute ischemic stroke","volume":"15","author":"Nesbit","year":"2004","journal-title":"Journal of Vascular and Interventional Radiology"},{"issue":"16","key":"10.1016\/j.carbpol.2022.120225_bb0180","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1016\/j.bmc.2018.08.006","article-title":"Dual-targeting for brain-specific liposomes drug delivery system: Synthesis and preliminary evaluation","volume":"26","author":"Peng","year":"2018","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/j.carbpol.2022.120225_bb0185","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3389\/fbioe.2020.00462","article-title":"Development of 3D-printed sulfated chitosan modified bioresorbable stents for coronary artery disease","volume":"8","author":"Qiu","year":"2020","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"10.1016\/j.carbpol.2022.120225_bb0190","series-title":"Laser thrombolysis: Basic ablation studies","author":"Sathyam","year":"1996"},{"issue":"10","key":"10.1016\/j.carbpol.2022.120225_bb0195","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.carres.2009.04.016","article-title":"Sulfonation of papain-treated chitosan and its mechanism for anticoagulant activity","volume":"344","author":"Suwan","year":"2009","journal-title":"Carbohydrate Research"},{"issue":"6","key":"10.1016\/j.carbpol.2022.120225_bb0200","first-page":"753","article-title":"The role of leukocytes in thrombosis","volume":"128","author":"Swystun","year":"2016","journal-title":"Blood, The Journal of the American Society of Hematology"},{"issue":"5","key":"10.1016\/j.carbpol.2022.120225_bb0205","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/(SICI)1096-9101(1999)25:5<379::AID-LSM3>3.0.CO;2-B","article-title":"Laser thrombolysis using long pulse frequency-doubled nd: YAG lasers","volume":"25","author":"Viator","year":"1999","journal-title":"Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery"},{"key":"10.1016\/j.carbpol.2022.120225_bb0210","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2306\/scienceasia1513-1874.2003.29.115","article-title":"Anticoagulant activities of the chitosan polysulfate synthesized from marine crab shell by semi-heterogeneous conditions","volume":"29","author":"Vongchan","year":"2003","journal-title":"Science Asia"},{"issue":"31","key":"10.1016\/j.carbpol.2022.120225_bb0215","doi-asserted-by":"crossref","first-page":"eaaz8204","DOI":"10.1126\/sciadv.aaz8204","article-title":"Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles","volume":"6","author":"Wang","year":"2020","journal-title":"Science Advances"},{"issue":"7","key":"10.1016\/j.carbpol.2022.120225_bb0220","first-page":"1663","article-title":"In vitro evaluation of polymeric micelles based on hydrophobically-modified sulfated chitosan as a carrier of doxorubicin","volume":"23","author":"Wang","year":"2012","journal-title":"Journal of Materials Science: Materials in Medicine"},{"issue":"2","key":"10.1016\/j.carbpol.2022.120225_bb0225","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jconrel.2008.01.017","article-title":"Controlled release of amoxicillin from hydroxyapatite-coated poly (lactic-co-glycolic acid) microspheres","volume":"127","author":"Xu","year":"2008","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.carbpol.2022.120225_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2019.101165","article-title":"Enhanced thrombolysis using tissue plasminogen activator (tPA)-loaded PEGylated PLGA nanoparticles for ischemic stroke","volume":"53","author":"Zamanlu","year":"2019","journal-title":"Journal of Drug Delivery Science and Technology"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-14-440","article-title":"MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer Ishikawa cells","volume":"14","author":"Zhang","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.carbpol.2022.120225_bb0240","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3389\/fphar.2020.00801","article-title":"Combined treatment with 2-(2-benzofu-ranyl)-2-imidazoline and recombinant tissue plasminogen activator protects blood-brain barrier integrity in a rat model of embolic middle cerebral artery occlusion","volume":"11","author":"Zhang","year":"2020","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/j.carbpol.2022.120225_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-01047-4","article-title":"An atherosclerotic plaque-targeted single-chain antibody for MR\/NIR-II imaging of atherosclerosis and anti-atherosclerosis therapy","volume":"19","author":"Zhang","year":"2021","journal-title":"Journal of Nanobiotechnology"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861722011304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861722011304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:39:40Z","timestamp":1758933580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861722011304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":49,"alternative-id":["S0144861722011304"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2022.120225","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Laser thrombolysis and in vitro release kinetics of tPA encapsulated in chitosan polysulfate-coated nanoliposome","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2022.120225","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120225"}}