{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T19:08:08Z","timestamp":1794251288253,"version":"4.9.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202507293"],"award-info":[{"award-number":["tsqn202507293"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017669","name":"Basic Scientific Fund for National Public Research Institutes of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470132"],"award-info":[{"award-number":["32470132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42176130"],"award-info":[{"award-number":["42176130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Polymers"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.carbpol.2026.125403","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:40:21Z","timestamp":1777941621000},"page":"125403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Double-network PVA\/\u03b3-PGA\/fucoidan hydrogels with favourable biocompatibility and anti-inflammatory activity for wound healing"],"prefix":"10.1016","volume":"385","author":[{"given":"Aoyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfeng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlai","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.carbpol.2026.125403_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/md19120702","article-title":"Anti-inflammatory activity of fucoidan extracts in vitro","volume":"19","author":"Ahmad","year":"2021","journal-title":"Marine Drugs"},{"issue":"10","key":"10.1016\/j.carbpol.2026.125403_bb0010","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0006-2952(03)00579-3","article-title":"Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2","volume":"66","author":"Angulo","year":"2003","journal-title":"Biochemical Pharmacology"},{"issue":"11","key":"10.1016\/j.carbpol.2026.125403_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/md20110714","article-title":"Structural characterization and in vivo anti-inflammatory activity of Fucoidan from Cystoseira crinita (Desf.) Borry","volume":"20","author":"Apostolova","year":"2022","journal-title":"Marine Drugs"},{"key":"10.1016\/j.carbpol.2026.125403_bb0020","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad081","article-title":"Double-crosslinked PNIPAM-based hydrogel dressings with adjustable adhesion and contractility","volume":"10","author":"Cao","year":"2023","journal-title":"Regenerative Biomaterials"},{"key":"10.1016\/j.carbpol.2026.125403_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejbt.2023.09.001","article-title":"Alginate and c -polyglutamic acid hydrogels: Microbial production strategies and biomedical applications","volume":"66","author":"Castillo","year":"2023","journal-title":"Electronic Journal of Biotechnology"},{"key":"10.1016\/j.carbpol.2026.125403_bb9000","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177134","article-title":"Low molecular weight fucoidan induces M2 macrophage polarization to attenuate inflammation through activation of the AMPK\/mTOR autophagy pathway","volume":"986","author":"Chen","year":"2025","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"10.1016\/j.carbpol.2026.125403_bb0030","doi-asserted-by":"crossref","DOI":"10.26599\/NR.2026.94908545","article-title":"Defect engineering of zinc-based metal organic framework with enhanced ROS generation for antibacterial and wound healing applications","volume":"19","author":"Cheng","year":"2026","journal-title":"Nano Research"},{"key":"10.1016\/j.carbpol.2026.125403_bb8000","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ijbiomac.2021.10.188","article-title":"Low molecular weight fucoidan LF2 improves metabolic syndrome via up-regulating PI3K-AKT-mTOR axis and increasing the abundance of Akkermansia muciniphila in the gut microbiota","volume":"193","author":"Deng","year":"2021","journal-title":"International Journal of Biological Macromolecules"},{"issue":"399","key":"10.1016\/j.carbpol.2026.125403_bb0035","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ijbiomac.2022.01.057","article-title":"Bio-based poly (\u03b3 -glutamic acid) -gelatin double-network hydrogel with high strength for wound healing","volume":"202","author":"Dou","year":"2022","journal-title":"International Journal of Biological Macromolecules"},{"issue":"12","key":"10.1016\/j.carbpol.2026.125403_bb0040","first-page":"41","article-title":"How hyperarousal and sleep reactivity are represented in different adult age groups: Results from a large cohort study on insomnia","volume":"7","author":"Ellemarije","year":"2017","journal-title":"Brain Ences"},{"issue":"5","key":"10.1016\/j.carbpol.2026.125403_bb0045","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1080\/14786419.2024.2358387","article-title":"From seaweed to healing: The potential of fucoidan in wound therapy","volume":"39","author":"Ghahtan","year":"2025","journal-title":"Natural Product Research"},{"issue":"5","key":"10.1016\/j.carbpol.2026.125403_bb0050","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1080\/14786419.2024.2358387","article-title":"From seaweed to healing: The potential of fucoidan in wound therapy","volume":"39","author":"Ghahtan","year":"2025","journal-title":"Natural Product Research"},{"issue":"43","key":"10.1016\/j.carbpol.2026.125403_bb0055","article-title":"Hydrogels and wound healing: Current and future prospects","volume":"10","author":"Gounden","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.carbpol.2026.125403_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124751","article-title":"Dynamic boronate ester crosslinked hyaluronic acid hydrogel patch enabling fast dissolution and rapid oral mucosal delivery of amorphous sumatriptan","volume":"375","author":"Gu","year":"2026","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2026.125403_bb0065","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.ijbiomac.2021.05.190","article-title":"Marine polysaccharide-based composite hydrogels containing fucoidan: Preparation, physicochemical characterization, and biocompatible evaluation","volume":"183","author":"Hao","year":"2021","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.carbpol.2026.125403_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121193","article-title":"Double-network cellulose-based hybrid hydrogels with favourable biocompatibility and antibacterial activity for wound healing","volume":"319","author":"Hu","year":"2023","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2026.125403_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138254","article-title":"Wound healing effect of fucoidan-loaded gelatin\/oxidized carboxymethyl cellulose hydrogel","volume":"286","author":"Jeong","year":"2025","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.carbpol.2026.125403_bb0080","doi-asserted-by":"crossref","first-page":"8662","DOI":"10.1021\/acsnano.2c00662","article-title":"Infant skin friendly adhesive hydrogel patch activated at body temperature for bioelectronics securing and diabetic wound healing","volume":"16","author":"Jiang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.carbpol.2026.125403_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127449","article-title":"Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom","volume":"253","author":"Li","year":"2023","journal-title":"International Journal of Biological Macromolecules"},{"issue":"8","key":"10.1016\/j.carbpol.2026.125403_bb0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/acs.biomac.4c00403","article-title":"Preparation of multifunctional hydrogels with in situ dual network structure and promotion of wound healing","volume":"25","author":"Lu","year":"2024","journal-title":"Biomacromolecules"},{"issue":"9","key":"10.1016\/j.carbpol.2026.125403_bb7000","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/md17090487","article-title":"Therapeutic effects of fucoidan: A review on recent studies","volume":"17","author":"Luthuli","year":"2019","journal-title":"Marine Drugs"},{"key":"10.1016\/j.carbpol.2026.125403_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145214","article-title":"The genome sequence of Mesua ferrea and comparative demographic histories of forest trees","volume":"769","author":"Patil","year":"2021","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.carbpol.2026.125403_bb0100","doi-asserted-by":"crossref","first-page":"45e","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Research"},{"issue":"23","key":"10.1016\/j.carbpol.2026.125403_bb0105","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1039\/D5BM00676G","article-title":"Fucoidan based hydrogel biomaterials for tissue engineering","volume":"13","author":"Prova","year":"2025","journal-title":"Biomaterials Science"},{"key":"10.1016\/j.carbpol.2026.125403_bb0110","first-page":"1","article-title":"An Antioxidative and active shrinkage hydrogel Integratedly promotes re-epithelization and skin constriction for enhancing wound closure","volume":"36","author":"Sun","year":"2024","journal-title":"Advanced Materials"},{"key":"10.1016\/j.carbpol.2026.125403_bb0115","article-title":"Engineered heterojunction microneedles initiate ROS-mediated \u201ctwo-hit\u201d mechanism for accelerating impaired wound healing in diabetes","author":"Wang","year":"2025","journal-title":"Cell Biomaterials"},{"issue":"31","key":"10.1016\/j.carbpol.2026.125403_bb0120","doi-asserted-by":"crossref","first-page":"2304738","DOI":"10.1002\/adma.202304738","article-title":"Emerging bioprinting for wound healing","volume":"37","author":"Wang","year":"2025","journal-title":"Advanced Materials"},{"key":"10.1016\/j.carbpol.2026.125403_bb0125","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1111\/iwj.14239","article-title":"Fucoidan promotes angiogenesis and accelerates wound healing through AKT\/ Nrf2\/ HIF-1 \u03b1 signalling pathway","volume":"20","author":"Wen","year":"2023","journal-title":"International Wound Journal"},{"key":"10.1016\/j.carbpol.2026.125403_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118567","article-title":"Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition","volume":"273","author":"Wu","year":"2021","journal-title":"Carbohydrate Polymers"},{"issue":"13\u201314","key":"10.1016\/j.carbpol.2026.125403_bb0135","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.intimp.2008.08.007","article-title":"Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells","volume":"8","author":"Yang","year":"2008","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.carbpol.2026.125403_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.131005","article-title":"A shape memory and antibacterial cryogel with rapid hemostasis for noncompressible hemorrhage and wound healing","volume":"428","author":"Yao","year":"2022","journal-title":"Chemical Engineering Journal"},{"issue":"120011","key":"10.1016\/j.carbpol.2026.125403_bb0145","first-page":"1","article-title":"Fucoidan functionalization on poly (vinyl alcohol) hydrogels for improved endothelialization and hemocompatibility","volume":"249","author":"Yao","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.carbpol.2026.125403_bb0150","article-title":"Injectable ROS\/pH-responsive hydrogel for synergistic chemo-photodynamic tumor therapy and enhanced wound healing","volume":"15","author":"Yi","year":"2025","journal-title":"Advanced Healthcare Materials"},{"key":"10.1016\/j.carbpol.2026.125403_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118493","article-title":"Preparation of triamcinolone acetonide-loaded chitosan\/fucoidan hydrogel and its potential application as an oral mucosa patch","volume":"272","author":"Zheng","year":"2021","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/j.carbpol.2026.125403_bb0160","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.carbpol.2018.08.124","article-title":"Cytocompatible chitosan based multi-network hydrogels with antimicrobial, cell anti-adhesive and mechanical properties","volume":"202","author":"Zou","year":"2018","journal-title":"Carbohydrate Polymers"}],"container-title":["Carbohydrate Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861726005205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0144861726005205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T22:22:41Z","timestamp":1783203761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0144861726005205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"alternative-id":["S0144861726005205"],"URL":"https:\/\/doi.org\/10.1016\/j.carbpol.2026.125403","relation":{},"ISSN":["0144-8617"],"issn-type":[{"value":"0144-8617","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Double-network PVA\/\u03b3-PGA\/fucoidan hydrogels with favourable biocompatibility and anti-inflammatory activity for wound healing","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Polymers","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carbpol.2026.125403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125403"}}