{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:00:04Z","timestamp":1780920004425,"version":"3.54.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.cardfail.2003.10.012","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T10:34:16Z","timestamp":1092220456000},"page":"297-303","source":"Crossref","is-referenced-by-count":97,"title":["How prevalent is hyperkalemia and renal dysfunction during treatment with spironolactone in patients with congestive heart failure?"],"prefix":"10.1016","volume":"10","author":[{"given":"Morten","family":"Svensson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00d8ren","family":"Galatius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per R","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Atar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2003.10.012_BIB1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators","volume":"325","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB2","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.283.10.1295","article-title":"Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR\/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group","volume":"283","author":"Hjalmarson","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.cardfail.2003.10.012_BIB4","first-page":"59","article-title":"Treatment of heart failure: state of the art and prospectives","volume":"38","author":"Greenberg","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1388-9842(01)00231-8","article-title":"Comprehensive guidelines for the diagnosis and treatment of chronic heart failure. Task force for the diagnosis and treatment of chronic heart failure of the European Society of Cardiology","volume":"4","author":"Remme","year":"2002","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB6","first-page":"510","article-title":"Kalemia during combined therapy with an angiotensin converting enzyme inhibitor and a potassium-sparing diuretic","volume":"3","author":"Mooser","year":"1987","journal-title":"J Clin Hypertens"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB7","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1067\/mhj.2002.123841","article-title":"An integrated approach to diagnosis and therapeutic management of patients with systolic heart failure in the Copenhagen metropolitan area","volume":"144","author":"Galatius","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB8","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0002-9149(96)00465-1","article-title":"Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure. The Randomized Aldactone Evaluation Study (RALES)","volume":"78","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB9","first-page":"315","article-title":"Elderly heart failure patients with drug-induced serious hyperkalemia","volume":"12","author":"Vanpee","year":"2000","journal-title":"Aging"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB10","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1136\/heart.85.4.e8","article-title":"Serious adverse effects experienced by patients with chronic heart failure taking spironolactone","volume":"85","author":"Berry","year":"2001","journal-title":"Heart"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0002-9343(01)00642-8","article-title":"Life-threatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: an analysis of 25 cases","volume":"110","author":"Schepkens","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB12","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"EPHESUS (Eplerenone Post-AMI Heart Failure Efficacy and Survival Study): a double-blind, randomized, placebo-controlled trial evaluating the safety and efficacy of eplerenone in patients with heart failure following acute myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0002-9149(92)91194-9","article-title":"Renal function in severe congestive heart failure during treatment with enalapril (the Cooperative North Scandinavian Enalapril Survival Study [CONSENSUS] Trial)","volume":"70","author":"Ljungman","year":"1992","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB14","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1161\/hy1101.099484","article-title":"Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship","volume":"38","author":"Zannad","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB15","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0002-9149(02)02580-8","article-title":"Estimation of glomerular filtration rate to prevent life-threatening hyperkalemia due to combined therapy with spironolactone and angiotensin-converting enzyme inhibition or angiotensin receptor blockade","volume":"90","author":"Blaustein","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2003.10.012_BIB16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916403007978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916403007978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T19:22:54Z","timestamp":1549308174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916403007978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S1071916403007978"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2003.10.012","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}