{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:58:52Z","timestamp":1790981932599,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.cardfail.2005.03.009","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T08:01:32Z","timestamp":1115280092000},"page":"260-269","source":"Crossref","is-referenced-by-count":146,"title":["Rationale and Design of the Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST)"],"prefix":"10.1016","volume":"11","author":[{"given":"Mihai","family":"Gheorghiade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John C.","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"DeMets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Grinfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Maggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Swedberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Udelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin A.","family":"Konstam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2005.03.009_bib1","series-title":"2001 National Hospital Discharge Survey. Advance data from vital and health statistics","author":"Hall","year":"2003"},{"key":"10.1016\/j.cardfail.2005.03.009_bib2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1388-9842(02)00116-2","article-title":"Annual rates of admission and seasonal variations in hospitalizations for heart failure","volume":"4","author":"Martinez-Selles","year":"2002","journal-title":"Eur J Heart Fail"},{"issue":"Suppl 7","key":"10.1016\/j.cardfail.2005.03.009_bib3","first-page":"S21","article-title":"ADHERE Scientific Advisory Committee. The Acute Decompensated Heart Failure National Registry (ADHERE): opportunities to improve care of patients hospitalized with acute decompensated heart failure","volume":"4","author":"Fonarow","year":"2003","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.cardfail.2005.03.009_bib4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1067\/mhj.2000.110933","article-title":"Freedom from congestion predicts good survival despite previous class IV symptoms of heart failure","volume":"140","author":"Lucas","year":"2000","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2005.03.009_bib5","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.jacc.2003.12.040","article-title":"Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial","volume":"43","author":"Gattis","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib6","first-page":"860","article-title":"OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats","volume":"287","author":"Yamamura","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.cardfail.2005.03.009_bib7","first-page":"288","article-title":"Effects of the V2-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats","volume":"292","author":"Hirano","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.cardfail.2005.03.009_bib8","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/01.CIR.0000070422.41439.04","article-title":"Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial","volume":"107","author":"Gheorghiade","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2005.03.009_bib9","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1067\/mhj.2003.154","article-title":"Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Congestive Heart Failure Investigators. Rationale and study design of a multicenter, randomized, double-blind, placebo-controlled study of the effect of tolvaptan on acute and chronic outcomes of patients hospitalized with worsening congestive heart failure","volume":"145","author":"Gheorghiade","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2005.03.009_bib10","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1001\/jama.291.16.1963","article-title":"Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Congestive Heart Failure (ACTIV in CHF) Investigators. Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled study","volume":"291","author":"Gheorghiade","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2005.03.009_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2307\/2344317","article-title":"Asymptomatically efficient rank invariant test procedures","volume":"135","author":"Peto","year":"1972","journal-title":"J R Stat Soc A"},{"key":"10.1016\/j.cardfail.2005.03.009_bib12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1259\/0007-1285-44-526-793","article-title":"Repeated assessment of results in clinical trials of cancer treatment","volume":"44","author":"Haybittle","year":"1971","journal-title":"Br J Radiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib13","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2307\/2336502","article-title":"Discrete sequential boundaries for clinical trials","volume":"70","author":"Lan","year":"1983","journal-title":"Biometrika"},{"key":"10.1016\/j.cardfail.2005.03.009_bib14","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2307\/2531870","article-title":"The B-value: a tool for monitoring data","volume":"44","author":"Lan","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.cardfail.2005.03.009_bib15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1056\/NEJMoa010641","article-title":"Prognostic importance of elevated jugular venous pressure and a third heart sound in patients with heart failure","volume":"345","author":"Drazner","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2005.03.009_bib16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0735-1097(02)02896-6","article-title":"Ongoing right ventricular hemodynamics in heart failure: clinical value of measurements derived from an implantable monitoring system","volume":"41","author":"Adamson","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0002-9149(99)80111-8","article-title":"Relation of left ventricular chamber shape in patients with low (< or=40%) ejection fraction to severity of functional mitral regurgitation","volume":"76","author":"Nass","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib18","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1161\/01.CIR.88.6.2953","article-title":"Sudden death prevention in patients with advanced ventricular dysfunction","volume":"88","author":"Stevenson","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2005.03.009_bib19","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1001\/jama.287.12.1531","article-title":"Intravenous nesiritide versus nitroglycerin for the treatment of decompensated congestive heart failure. A randomized trial","volume":"287","author":"Publication Committee for the VMAC Investigators (Vasodilatation in the Management of Acute CHF)","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2005.03.009_bib20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1053\/hj.1999.v137.95495","article-title":"Hospitalization of patients with heart failure: National Hospital Discharge Survey, 1985\u20131995","volume":"137","author":"Haldeman","year":"1999","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2005.03.009_bib21","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.amjcard.2004.01.070","article-title":"Relation of unrecognized hypervolemia in chronic heart failure to clinical status, hemodynamics, and patient outcome","volume":"93","author":"Androne","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib22","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1161\/hc4901.102568","article-title":"American College of Cardiology\/American Heart Association Guidelines for the Evaluation and Management of Heart Failure in the adult: executive summary: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure)","volume":"104","author":"Hunt","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2005.03.009_bib23","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/euhj.2001.2783","article-title":"Guidelines for the diagnosis and treatment of chronic heart failure","volume":"22","author":"Remme","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2005.03.009_bib24","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0002-9149(89)90912-0","article-title":"Radiographic pulmonary congestion in end-stage congestive heart failure","volume":"63","author":"Mahdyoon","year":"1989","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0002-9343(91)80016-F","article-title":"Clinical, radiographic, and hemodynamic correlations in chronic congestive heart failure: conflicting results may lead to inappropriate care","volume":"90","author":"Chakko","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/j.cardfail.2005.03.009_bib26","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0002-8703(92)90960-4","article-title":"Estimating severity of chronic congestive heart failure: a clinical challenge for the 1990s","volume":"124","author":"Chakko","year":"1992","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2005.03.009_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM198107303050506","article-title":"Radioimmunoassay of plasma arginine vasopressin in hyponatremic patients with congestive heart failure","volume":"305","author":"Szatalowicz","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2005.03.009_bib28","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0735-1097(83)80040-0","article-title":"Increased plasma arginine vasopressin levels in patients with congestive heart failure","volume":"1","author":"Goldsmith","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib29","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1161\/01.CIR.82.5.1724","article-title":"Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure: a substudy of the Studies of Left Ventricular Dysfunction (SOLVD)","volume":"82","author":"Francis","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2005.03.009_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0002-9149(86)90065-2","article-title":"Arginine vasopressin and the renal response to water loading in congestive heart failure","volume":"58","author":"Goldsmith","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-8703(02)94708-3","article-title":"Vasopressin: a new target for the treatment of heart failure","volume":"146","author":"Lee","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2005.03.009_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1071-9164(03)00234-3","article-title":"Tolvaptan (OPC-41061), a V2 vasopressin receptor antagonist, protects against the decline in renal function observed with loop diuretic therapy","volume":"9","author":"Burnett","year":"2003","journal-title":"J Card Fail"},{"issue":"Suppl A","key":"10.1016\/j.cardfail.2005.03.009_bib33","first-page":"810","article-title":"Vasopressin receptor blockade in patients with congestive heart failure: results from a placebo-controlled, randomized study comparing the effects of tolvaptan, furosemide, and their combination","volume":"39","author":"Udelson","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 2","key":"10.1016\/j.cardfail.2005.03.009_bib34","first-page":"438","article-title":"Vasopressin V2 receptor blockade versus fluid restriction in the treatment of hyponatremia: results from a multicenter randomized controlled trial","volume":"104","author":"Gheorghiade","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2005.03.009_bib35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/cs0590443","article-title":"Hemodynamic and hormone response to acute and chronic furosemide therapy in congestive heart failure","volume":"59","author":"Ikram","year":"1980","journal-title":"Clin Sci"},{"key":"10.1016\/j.cardfail.2005.03.009_bib36","doi-asserted-by":"crossref","first-page":"18F","DOI":"10.1016\/S0002-9149(02)03336-2","article-title":"Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations","volume":"91","author":"Klein","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib37","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1056\/NEJM199908193410806","article-title":"Hormones and hemodynamics in heart failure","volume":"341","author":"Schrier","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2005.03.009_bib38","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1161\/01.CIR.100.12.1311","article-title":"Diuretics and risk of arrhythmic death in patients with left ventricular dysfunction","volume":"100","author":"Cooper","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2005.03.009_bib39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0735-1097(03)00765-4","article-title":"Studies of left ventricular dysfunction. Diuretic use, progressive heart failure and death in patients in the Studies Of Left Ventricular Dysfunction (SOLVD)","volume":"42","author":"Domanski","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2005.03.009_bib40","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1067\/mhj.2003.166","article-title":"Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus in refractory congestive heart failure: long-term effects","volume":"145","author":"Licata","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2005.03.009_bib41","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1001\/jama.290.19.2581","article-title":"Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model","volume":"290","author":"Lee","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2005.03.009_bib42","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1001\/jama.287.12.1541","article-title":"Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Investigators. Effects of short-term, intravenous milrinone on acute exacerbation of chronic heart failure","volume":"287","author":"Cuffe","year":"2002","journal-title":"JAMA"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916405001363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916405001363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T13:58:51Z","timestamp":1548511131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916405001363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S1071916405001363"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2005.03.009","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}