{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:58:28Z","timestamp":1758405508360},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.cardfail.2006.08.212","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T07:27:38Z","timestamp":1166167658000},"page":"752-758","source":"Crossref","is-referenced-by-count":5,"title":["Direct Effects of 3 Combinations of Enalapril, Metoprolol, and Spironolactone on Cardiac Remodeling in Dilated Cardiomyopathic Hamsters"],"prefix":"10.1016","volume":"12","author":[{"given":"Bruno","family":"Laviolle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Pape","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Turlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bellissant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 7A","key":"10.1016\/j.cardfail.2006.08.212_bib1","doi-asserted-by":"crossref","first-page":"37S","DOI":"10.1016\/S0002-9343(98)00385-4","article-title":"Pathophysiology of chronic heart failure","volume":"110","author":"Francis","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.cardfail.2006.08.212_bib2","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2006.08.212_bib3","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM198706043162301","article-title":"Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group","volume":"316","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2006.08.212_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators","volume":"325","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2006.08.212_bib5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199605233342101","article-title":"The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group","volume":"334","author":"Packer","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2006.08.212_bib6","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","article-title":"Effect of metoprolol CR\/XL in chronic heart failure: Metoprolol CR\/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2006.08.212_bib7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2006.08.212_bib8","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(00)02213-3","article-title":"Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial\u2014the Losartan Heart Failure Survival Study ELITE II","volume":"355","author":"Pitt","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2006.08.212_bib9","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/01.CIR.0000125741.88712.77","article-title":"Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of angiotensin-converting enzyme inhibitor","volume":"109","author":"Sakata","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2006.08.212_bib10","first-page":"1389","article-title":"Abnormality in plasma catecholamines and myocardial adrenoceptors in cardiomyopathic BIO 53.58 Syrian hamsters and improvement by metoprolol treatment","volume":"283","author":"Yamada","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.cardfail.2006.08.212_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1253\/jcj.59.213","article-title":"Effects of angiotensin-converting enzyme inhibitor and aldosterone antagonist on myocardial collagen in cardiomyopathic hamsters","volume":"59","author":"Araki","year":"1995","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.cardfail.2006.08.212_bib12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00005344-200210000-00007","article-title":"Combined effects of metoprolol and spironolactone in dilated cardiomyopathic hamsters","volume":"40","author":"Goineau","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00005344-200301000-00007","article-title":"Combined effects of enalapril and spironolactone in hamsters with dilated cardiomyopathy","volume":"41","author":"Goineau","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1440-1681.1996.tb03060.x","article-title":"Effects of ACE inhibition and beta-blockade on collagen remodelling in the heart of Bio 14.6 hamsters","volume":"23","author":"Mansoor","year":"1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1139\/y01-003","article-title":"Hemodynamic and histomorphometric characteristics of dilated cardiomyopathy of Syrian hamsters (Bio TO-2 strain)","volume":"79","author":"Goineau","year":"2001","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1023\/A:1027351808326","article-title":"Pharmacological modulation of cardiovascular remodeling: a guide to heart failure therapy","volume":"17","author":"Remme","year":"2003","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.cardfail.2006.08.212_bib17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0022-2828(95)90000-4","article-title":"Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure","volume":"27","author":"Gerdes","year":"1995","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-2828(08)80028-4","article-title":"The cellular basis of dilated cardiomyopathy in humans","volume":"27","author":"Beltrami","year":"1995","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib19","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1161\/01.CIR.96.11.4065","article-title":"Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation","volume":"96","author":"Weber","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2006.08.212_bib20","doi-asserted-by":"crossref","first-page":"15L","DOI":"10.1016\/S0002-9149(97)00845-X","article-title":"Molecular and cellular mechanisms of myocardial failure","volume":"80","author":"Colucci","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib21","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.RES.73.3.413","article-title":"Molecular characterization of angiotensin II\u2014induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype","volume":"73","author":"Sadoshima","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.cardfail.2006.08.212_bib22","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1006\/jmcc.1994.1098","article-title":"Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone","volume":"26","author":"Brilla","year":"1994","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib23","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S1071-9164(96)80054-6","article-title":"Altered signal transduction system in hypertrophied myocardium: angiotensin II stimulates collagen synthesis in hypertrophied hearts","volume":"2","author":"Kawaguchi","year":"1996","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2006.08.212_bib24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/01.CIR.102.2.253","article-title":"Reverse remodeling of cardiac myocyte hypertrophy in hypertension and failure by targeting of the renin-angiotensin system","volume":"102","author":"Tamura","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2006.08.212_bib25","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.HYP.28.4.627","article-title":"Role of angiotensin-converting enzyme, adrenergic receptors, and blood pressure in cardiac gene expression of spontaneously hypertensive rats during development","volume":"28","author":"Ohta","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.cardfail.2006.08.212_bib26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/01.HYP.28.2.269","article-title":"Advanced hypertensive heart disease in spontaneously hypertensive rats. Lisinopril-mediated regression of myocardial fibrosis","volume":"28","author":"Brilla","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.cardfail.2006.08.212_bib27","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1111\/j.1476-5381.1995.tb17230.x","article-title":"Reduction by oral propranolol treatment of left ventricular hypertrophy secondary to pressure-overload in the rat","volume":"116","author":"Ostman-Smith","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1006\/jmcc.2000.1332","article-title":"Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart","volume":"33","author":"Morisco","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1161\/01.CIR.102.3.344","article-title":"Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes","volume":"102","author":"Zaugg","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2006.08.212_bib30","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1172\/JCI119883","article-title":"Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts","volume":"101","author":"Calderone","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cardfail.2006.08.212_bib31","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0002-9149(99)00059-4","article-title":"Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure","volume":"83","author":"Lowes","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib32","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0735-1097(00)01006-8","article-title":"Antiremodeling effects on the left ventricle during beta-blockade with metoprolol in the treatment of chronic heart failure","volume":"36","author":"Groenning","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.CIR.78.2.369","article-title":"Long-term propranolol administration alters myocyte and ventricular geometry in rat hearts with and without infarction","volume":"78","author":"Fishbein","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2006.08.212_bib34","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1006\/jmcc.2000.1129","article-title":"Induction of cardiac fibrosis by aldosterone","volume":"32","author":"Lijnen","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1365-2796.1999.00458.x","article-title":"The circulating renin-angiotensin system during treatment with metoprolol or captopril in patients with heart failure due to non-ischaemic dilated cardiomyopathy","volume":"245","author":"Jansson","year":"1999","journal-title":"J Intern Med"},{"key":"10.1016\/j.cardfail.2006.08.212_bib36","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1253\/circj.68.376","article-title":"Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats with myocardial infarction","volume":"68","author":"Matsumoto","year":"2004","journal-title":"Circ J"},{"key":"10.1016\/j.cardfail.2006.08.212_bib37","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1161\/01.CIR.102.22.2700","article-title":"Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators","volume":"102","author":"Zannad","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2006.08.212_bib38","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2005.08.022","article-title":"ACC\/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure)","volume":"46","author":"Hunt","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2006.08.212_bib39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0008-6363(03)00251-7","article-title":"Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure","volume":"58","author":"Cittadini","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cardfail.2006.08.212_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1071-9164(03)00578-5","article-title":"Role of a selective aldosterone blocker in mice with chronic heart failure","volume":"10","author":"Wang","year":"2004","journal-title":"J Card Fail"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916406011109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916406011109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T15:58:38Z","timestamp":1547135918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916406011109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S1071916406011109"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2006.08.212","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}