{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:56:42Z","timestamp":1787579802118,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.cardfail.2009.01.014","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T06:14:32Z","timestamp":1237356872000},"page":"565-571","source":"Crossref","is-referenced-by-count":187,"title":["Soluble Angiotensin-Converting Enzyme 2 in Human Heart Failure: Relation With Myocardial Function and Clinical Outcomes"],"prefix":"10.1016","volume":"15","author":[{"given":"Slava","family":"Epelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Troughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subha","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan L.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.H.","family":"Wilson Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2009.01.014_bib1","doi-asserted-by":"crossref","first-page":"27S","DOI":"10.1016\/S0002-9343(98)00208-3","article-title":"Evolution of angiotensin-converting enzyme inhibition in hypertension, heart failure, and vascular protection","volume":"105","author":"Parmley","year":"1998","journal-title":"Am J Med"},{"key":"10.1016\/j.cardfail.2009.01.014_bib2","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1161\/01.CIR.100.23.2312","article-title":"Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. ATLAS Study Group","volume":"100","author":"Packer","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2009.01.014_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pbiomolbio.2005.05.011","article-title":"ACE2: a novel therapeutic target for cardiovascular diseases","volume":"91","author":"Der Sarkissian","year":"2006","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib4","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system","volume":"292","author":"Mehta","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/BJ20040634","article-title":"Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism","volume":"383","author":"Rice","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.cardfail.2009.01.014_bib6","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cardfail.2009.01.014_bib7","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cardfail.2009.01.014_bib8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1152\/ajpheart.00937.2006","article-title":"Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7)","volume":"292","author":"Grobe","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib9","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/01.CIR.0000013847.07035.B9","article-title":"Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats","volume":"105","author":"Loot","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2009.01.014_bib10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jacc.2008.04.059","article-title":"An ACE in the hole alternative pathways of the renin angiotensin system and their potential role in cardiac remodeling","volume":"52","author":"Greenberg","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib11","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/ajpheart.00828.2006","article-title":"The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE 0991 attenuates heart failure induced by myocardial infarction","volume":"292","author":"Ferreira","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib12","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jacc.2008.02.088","article-title":"Detection of soluble angiotensin converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system","volume":"52","author":"Epelman","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.amjcard.2005.03.055","article-title":"Usefulness of tissue Doppler and color M-mode indexes of left ventricular diastolic function in predicting outcomes in systolic left ventricular heart failure (from the ADEPT study)","volume":"96","author":"Troughton","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.amjcard.2007.08.038","article-title":"Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure","volume":"101","author":"Tang","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib15","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/j.jacc.2007.02.053","article-title":"Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure","volume":"49","author":"Tang","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.HYP.0000244543.91937.79","article-title":"Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study","volume":"48","author":"Rice","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.cardfail.2009.01.014_bib17","doi-asserted-by":"crossref","first-page":"15532","DOI":"10.1074\/jbc.M212934200","article-title":"Novel peptide inhibitors of angiotensin-converting enzyme 2","volume":"278","author":"Huang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cardfail.2009.01.014_bib18","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/01.CIR.0000094734.67990.99","article-title":"Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2","volume":"108","author":"Zisman","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2009.01.014_bib19","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nature00786","article-title":"Angiotensin-converting enzyme 2 is an essential regulator of heart function","volume":"417","author":"Crackower","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cardfail.2009.01.014_bib20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/eurheartj\/ehi043","article-title":"ACE and ACE2: a tale of two enzymes","volume":"26","author":"Zisman","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2009.01.014_bib21","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1378\/chest.119.6.1761","article-title":"Impaired left ventricular filling due to right ventricular pressure overload in primary pulmonary hypertension: noninvasive monitoring using MRI","volume":"119","author":"Marcus","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.cardfail.2009.01.014_bib22","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.HYP.0000205833.89478.5b","article-title":"Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II","volume":"47","author":"Yamamoto","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.cardfail.2009.01.014_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00109-005-0718-5","article-title":"Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men Results of the MONICA Augsburg echocardiographic substudy","volume":"84","author":"Lieb","year":"2006","journal-title":"J Mol Med"},{"key":"10.1016\/j.cardfail.2009.01.014_bib24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/expphysiol.2005.031096","article-title":"Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats","volume":"90","author":"Huentelman","year":"2005","journal-title":"Exp Physiol"},{"key":"10.1016\/j.cardfail.2009.01.014_bib25","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.HYP.0000215289.51180.5c","article-title":"Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor MAS knockout mice","volume":"47","author":"Santos","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.cardfail.2009.01.014_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1741-7015-2-19","article-title":"ACE2 gene expression is up-regulated in the human failing heart","volume":"2","author":"Goulter","year":"2004","journal-title":"BMC Med"},{"key":"10.1016\/j.cardfail.2009.01.014_bib27","doi-asserted-by":"crossref","first-page":"30113","DOI":"10.1074\/jbc.M505111200","article-title":"Tumor necrosis factor-{alpha} convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)","volume":"280","author":"Lambert","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cardfail.2009.01.014_bib28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/CIRCULATIONAHA.105.571414","article-title":"Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy","volume":"113","author":"Fedak","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2009.01.014_bib29","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cardiores.2005.12.009","article-title":"Myocardial proteases and matrix remodeling in inflammatory heart disease","volume":"69","author":"Rutschow","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cardfail.2009.01.014_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cardiores.2007.04.007","article-title":"Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice","volume":"75","author":"Oudit","year":"2007","journal-title":"Cardiovasc Res"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916409000360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916409000360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T21:20:15Z","timestamp":1545340815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916409000360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S1071916409000360"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2009.01.014","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}