{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:09:44Z","timestamp":1788322184816,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.cardfail.2012.04.003","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T08:17:30Z","timestamp":1337933850000},"page":"493-501","source":"Crossref","is-referenced-by-count":65,"title":["Markers of Oxidative Damage and Antioxidant Enzyme Activities as Predictors of Morbidity and Mortality in Patients With Chronic Heart Failure"],"prefix":"10.1016","volume":"18","author":[{"given":"Slavica","family":"Radovanovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Savic-Radojevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Pljesa-Ercegovac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Djukic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Suvakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Krotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan V.","family":"Simic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Matic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Radojicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Pekmezovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Simic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2012.04.003_bib1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/hrt.2005.068270","article-title":"Oxidative stress and redox signalling in cardiac hypertrophy and heart failure","volume":"93","author":"Seddon","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.cardfail.2012.04.003_bib2","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.jacc.2004.01.036","article-title":"Hydroxyl radical generation, levels of tumor necrosis factor-alpha, and progression to heart failure after acute myocardial infarction","volume":"43","author":"Valgimigli","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI200524408","article-title":"Oxygen, oxidative stress, hypoxia and heart failure","volume":"115","author":"Giordano","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.cardfail.2012.04.003_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1586\/14779072.3.4.717","article-title":"Prevention of remodeling in congestive heart failure due to myocardial infarction by blockade of the renin-angiotensin system","volume":"3","author":"Guo","year":"2005","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.cardfail.2012.04.003_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1939-1676.2005.tb02724.x","article-title":"Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failure","volume":"19","author":"Freeman","year":"2005","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cardfail.2012.04.003_bib6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/eurjhf\/hfp042","article-title":"Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure","volume":"11","author":"Bergamini","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2012.04.003_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yjmcc.2004.04.001","article-title":"Mitochondrial Ca2+ flux and respiratory enzyme activity decline are early events in cardiomyocyte response to H2O2","volume":"37","author":"Long","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/heart.89.8.871","article-title":"Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stress","volume":"89","author":"Nonaka-Sarukawa","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.cardfail.2012.04.003_bib9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0002-8703(96)90063-0","article-title":"Increased malondialdehide in peripheral blood of patients with congestive heart failure","volume":"131","author":"Diaz-Velez","year":"1996","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2012.04.003_bib10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1179\/135100008X259204","article-title":"Markers of oxidative damage in chronic heart failure: Role in disease progression","volume":"13","author":"Radovanovic","year":"2008","journal-title":"Redox Rep"},{"key":"10.1016\/j.cardfail.2012.04.003_bib11","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0735-1097(02)01721-7","article-title":"Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure","volume":"39","author":"Tsutsui","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cardfail.2009.05.009","article-title":"Antibodies to oxidized LDL as predictors of morbidity and mortality in patients with chronic heart failure","volume":"15","author":"Charach","year":"2009","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2012.04.003_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3240001","article-title":"Biochemistry and pathology of radical-mediated protein oxidation","volume":"324","author":"Dean","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.cardfail.2012.04.003_bib14","series-title":"Free Radicals in Biology and Medicine","first-page":"268","article-title":"Measurement of reactive species","author":"Halliwell","year":"2007"},{"key":"10.1016\/j.cardfail.2012.04.003_bib15","first-page":"1","article-title":"Oxidative modification of plasma proteins in different stages of chronic renal failure","volume":"8","author":"Mimic-Oka","year":"2001","journal-title":"Facta Universitatis"},{"key":"10.1016\/j.cardfail.2012.04.003_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.jhh.1001945","article-title":"Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension","volume":"20","author":"Simic","year":"2006","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.cardfail.2012.04.003_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/hrt.65.5.245","article-title":"Oxygen free radicals and congestive heart failure","volume":"65","author":"Belch","year":"1991","journal-title":"Br Heart J"},{"key":"10.1016\/j.cardfail.2012.04.003_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.cardfail.2012.04.003_bib19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","article-title":"Carbonyl assays for determination of oxidatively modified proteins","volume":"233","author":"Levine","year":"1994","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0076-6879(87)43013-9","article-title":"Spectrophotometric assay of thiols","volume":"143","author":"Jocelyn","year":"1987","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cardfail.2012.04.003_bib22","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cardfail.2012.04.003_bib23","first-page":"444","article-title":"An improved coupled test procedure for glutathione peroxidase in blood","volume":"12","author":"Gunzler","year":"1974","journal-title":"Z Klin Chem Klin Biochem"},{"key":"10.1016\/j.cardfail.2012.04.003_bib24","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.2741\/3375","article-title":"Role of oxidative and nitrosative stress biomarkers in chronic heart failure","volume":"14","author":"Eleuteri","year":"2009","journal-title":"Front Biosci"},{"key":"10.1016\/j.cardfail.2012.04.003_bib25","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1046\/j.1523-1755.1999.00613.x","article-title":"Serum malondialdehyde and prevalent cardiovascular disease in hemodialysis","volume":"56","author":"Boaz","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.cardfail.2012.04.003_bib26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/ndt\/gfg020","article-title":"Cardiac troponin T and malondialdehyde modified plasma lipids in haemodialysis patients","volume":"18","author":"Scott","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cardfail.2012.04.003_bib27","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1001\/jama.281.18.1718","article-title":"Malondialdehyde-modified LDL as a marker of acute coronary syndromes","volume":"281","author":"Holvoet","year":"1999","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.cardfail.2012.04.003_bib28","doi-asserted-by":"crossref","first-page":"18473","DOI":"10.1074\/jbc.M110.118182","article-title":"Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway","volume":"285","author":"Shao","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cardfail.2012.04.003_bib29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/00365510260390019","article-title":"Evidence of increased oxidative stress by simple measurements in patients with dilated cardiomyopathy","volume":"62","author":"Yucel","year":"2002","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.cardfail.2012.04.003_bib30","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/S0021-9258(17)41960-0","article-title":"Identification of oxidized histidine generated at the active site of Cu, Zn-superoxide dismutase exposed to H2O2. Selective generation of 2-oxo-histidine at the histidine 118","volume":"269","author":"Uchida","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cardfail.2012.04.003_bib31","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1161\/01.CIR.0000041431.57222.AF","article-title":"Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase","volume":"106","author":"Landmesser","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2012.04.003_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10741-006-9188-2","article-title":"Selenium and antioxidant defenses as major mediators in the development of chronic heart failure","volume":"11","author":"de Lorgeril","year":"2006","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.cardfail.2012.04.003_bib33","doi-asserted-by":"crossref","first-page":"e4871","DOI":"10.1371\/journal.pone.0004871","article-title":"Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities","volume":"4","author":"Damy","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.cardfail.2012.04.003_bib34","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1210\/me.2008-0023","article-title":"Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress","volume":"22","author":"Lee","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib35","doi-asserted-by":"crossref","first-page":"A31","DOI":"10.1253\/circj.CJ-08-0014","article-title":"Oxidative stress and mitochondrial DNA damage in heart failure","volume":"72","author":"Tsutsui","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.cardfail.2012.04.003_bib36","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1253\/circj.CJ-08-0072","article-title":"Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase","volume":"72","author":"Masano","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.cardfail.2012.04.003_bib37","doi-asserted-by":"crossref","first-page":"R284","DOI":"10.1152\/ajpregu.00880.2006","article-title":"Development of contractile dysfunction in rat heart failure; hierarchy of cellular events","volume":"293","author":"Daniels","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1440-1681.2008.04923.x","article-title":"Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodeling induced by chronic volume overload in rats","volume":"35","author":"Ding","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.cardfail.2012.04.003_bib39","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/CIRCHEARTFAILURE.109.864785","article-title":"Cardiac-specific overexpression of catalase identifies hydrogen peroxide-dependent and -independent phases of myocardial remodeling and prevents the progression to overt heart failure in G(alpha)q-overexpressing transgenic mice","volume":"3","author":"Qin","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2012.04.003_bib40","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1172\/JCI119076","article-title":"Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in\u00a0vitro. Implications for atherosclerotic plaque stability","volume":"98","author":"Rajagopalan","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cardfail.2012.04.003_bib41","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/01.RES.0000033523.08033.16","article-title":"Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators","volume":"91","author":"Seshiah","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.cardfail.2012.04.003_bib42","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.2003.055913","article-title":"Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications","volume":"555","author":"Berry","year":"2004","journal-title":"J\u00a0Physiol"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916412001182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916412001182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T07:06:56Z","timestamp":1642316816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916412001182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1071916412001182"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2012.04.003","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}