{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:14:21Z","timestamp":1790198061329,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.cardfail.2014.11.006","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T23:02:25Z","timestamp":1416524545000},"page":"91-96","source":"Crossref","is-referenced-by-count":307,"title":["Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":false,"given":"W.H. Wilson","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeneng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen G.","family":"Borowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-1876","authenticated-orcid":false,"given":"Yuping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Troughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan L.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley L.","family":"Hazen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2014.11.006_bib1","doi-asserted-by":"crossref","first-page":"12511","DOI":"10.1073\/pnas.0601056103","article-title":"Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice","volume":"103","author":"Dumas","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cardfail.2014.11.006_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cardfail.2014.11.006_bib3","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk","volume":"368","author":"Tang","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2014.11.006_bib4","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.cardfail.2014.11.006_bib5","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/eurheartj\/ehu002","article-title":"Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide","volume":"35","author":"Wang","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2014.11.006_bib6","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.jacc.2014.02.617","article-title":"Prognostic value of elevated levels of intestinal microbe-generated metabolite, trimethylamine-N-oxide (TMAO), in patients with heart failure: refining the gut hypothesis","volume":"64","author":"Tang","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2014.11.006_bib7","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1093\/eurheartj\/ehn360","article-title":"Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure","volume":"29","author":"Tang","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2014.11.006_bib8","first-page":"35","article-title":"Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry","volume":"455C","author":"Wang","year":"2014","journal-title":"Anal Biochem"},{"key":"10.1016\/j.cardfail.2014.11.006_bib9","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jacc.2011.12.022","article-title":"Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1","volume":"59","author":"Shao","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2014.11.006_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1751-7133.2011.00221.x","article-title":"Integrating plasma high-sensitivity C-reactive protein and myeloperoxidase for risk prediction in chronic systolic heart failure","volume":"17","author":"Tang","year":"2011","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.cardfail.2014.11.006_bib11","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/j.jacc.2007.02.053","article-title":"Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure","volume":"49","author":"Tang","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2014.11.006_bib12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.amjcard.2007.08.038","article-title":"Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure","volume":"101","author":"Tang","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2014.11.006_bib13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cardfail.2008.01.006","article-title":"Impact of myocardial function on cystatin C measurements in chronic systolic heart failure","volume":"14","author":"Tang","year":"2008","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2014.11.006_bib14","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1093\/eurheartj\/ehi389","article-title":"The importance of the gastrointestinal system in the pathogenesis of heart failure","volume":"26","author":"Krack","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2014.11.006_bib15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/eurheartj\/eht271","article-title":"The heart and the gut","volume":"35","author":"Rogler","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2014.11.006_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/CIRCHEARTFAILURE.113.000978","article-title":"Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat","volume":"7","author":"Gan","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2014.11.006_bib17","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.jacc.2007.07.016","article-title":"Altered intestinal function in patients with chronic heart failure","volume":"50","author":"Sandek","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2014.11.006_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijcard.2010.12.016","article-title":"Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure","volume":"157","author":"Sandek","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cardfail.2014.11.006_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/SHK.0b013e318279265f","article-title":"Temporal variations of the ileal microbiota in intestinal ischemia and reperfusion","volume":"39","author":"Wang","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.cardfail.2014.11.006_bib20","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.4049\/jimmunol.173.6.4137","article-title":"The essential role of the intestinal microbiota in facilitating acute inflammatory responses","volume":"173","author":"Souza","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cardfail.2014.11.006_bib21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/MCO.0b013e32830a4c6e","article-title":"The emerging role of the gut in chronic heart failure","volume":"11","author":"Sandek","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916414013050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916414013050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:09:53Z","timestamp":1650672593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916414013050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1071916414013050"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2014.11.006","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}