{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:42:14Z","timestamp":1771472534033,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.cardfail.2016.07.440","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T11:05:26Z","timestamp":1469531126000},"page":"121-130","source":"Crossref","is-referenced-by-count":10,"title":["Worsening Renal Function during Management for Chronic Heart Failure with Reduced Ejection Fraction: Results From the Pro-BNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) Study"],"prefix":"10.1016","volume":"23","author":[{"given":"Nasrien E.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna K.","family":"Gaggin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin J.","family":"Rabideau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul U.","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"James L.","family":"Januzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2016.07.440_bib0010","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.jacc.2013.05.020","article-title":"2013 ACCF\/AHA Guideline for the Management of Heart Failure: Executive SummaryA Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0015","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/eurheartj\/eht386","article-title":"Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis","volume":"35","author":"Damman","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0020","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1161\/CIRCULATIONAHA.109.886473","article-title":"Cardiorenal syndrome: new perspectives","volume":"121","author":"Bock","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0025","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/hc4101.096153","article-title":"Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association","volume":"104","author":"Schoolwerth","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0030","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1056\/NEJMoa1210357","article-title":"Ultrafiltration in decompensated heart failure with cardiorenal syndrome","volume":"367","author":"Bart","year":"2012","journal-title":"NEJM"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0035","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1005419","article-title":"Diuretic strategies in patients with acute decompensated heart failure","volume":"364","author":"Felker","year":"2011","journal-title":"NEJM"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0040","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jchf.2015.05.009","article-title":"Competing risk of cardiac status and renal function during hospitalization for acute decompensated heart failure","volume":"3","author":"Salah","year":"2015","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0045","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.ahj.2010.01.005","article-title":"Design and methods of the Pro-B Type Natriuretic Peptide Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) study","volume":"159","author":"Bhardwaj","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0050","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.jacc.2011.03.072","article-title":"Use of amino-terminal Pro\u2013B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction","volume":"58","author":"Januzzi","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0055","article-title":"The importance of worsening heart failure in ambulatory patients definition, characteristics, and effects of amino-terminal Pro-B type natriuretic peptide guided therapy","author":"Mallick","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1114248","article-title":"Estimating glomeruler filtration rate from serum creatinine and cystatin C","volume":"367","author":"Inker","year":"2012","journal-title":"NEJM"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0065","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/eurjhf\/hfs180","article-title":"Improvement in structural and functional echocardiographic parameters during chronic heart failure therapy guided by natriuretic peptides: mechanistic insights from the ProBNP Outpatient Tailored Chronic Heart Failure (PROTECT) study","volume":"15","author":"Weiner","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112313","article-title":"Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS Study","volume":"9","author":"Legrand","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0075","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1097\/CCM.0000000000000404","article-title":"When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: the case of cardiorenal syndrome","volume":"42","author":"Legrand","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ejhf.13","article-title":"Worsening renal function during renin\u2013angiotensin\u2013aldosterone system inhibitor initiation and long-term outcomes in patients with left ventricular systolic dysfunction","volume":"16","author":"Clark","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ejhf.210","article-title":"Impact of worsening renal function related to medication in heart failure","volume":"17","author":"Brunner-La Rocca","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0090","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/CIRCULATIONAHA.112.120493","article-title":"Are serial BNP measurements useful in heart failure management? Serial natriuretic peptide measurements are not useful in heart failure management: the art of medicine remains long","volume":"127","author":"Desai","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0095","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/CIRCULATIONAHA.112.120485","article-title":"Are serial BNP measurements useful in heart failure management? Serial natriuretic peptide measurements are useful in heart failure management","volume":"127","author":"Januzzi","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cardfail.2014.10.008","article-title":"Characterization and prediction of adverse events from intensive chronic heart failure management and effect on quality of life: results from the Pro-B-Type Natriuretic Peptide Outpatient-Tailored Chronic Heart Failure Therapy (PROTECT) Study","volume":"21","author":"Gandhi","year":"2014","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/jama.2009.2","article-title":"BNP-guided vs symptom-guided heart failure therapy: the trial of intensified vs standard medical therapy in elderly patients with congestive heart failure (TIME-CHF) randomized trial","volume":"301","author":"Pfisterer","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/chf.12016","volume":"19","author":"Gaggin","year":"2013","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0115","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jchf.2014.05.007","article-title":"Rationale and design of the GUIDE-IT studyguiding evidence based therapy using biomarker intensified treatment in heart failure","volume":"2","author":"Felker","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.cardfail.2013.05.011","article-title":"Comparison of risk prediction with the CKD-EPI and MDRD equations in acute decompensated heart failure","volume":"19","author":"Manzano-Fern\u00e1ndez","year":"2013","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2016.07.440_bib0125","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/clc.22362","article-title":"Cystatin C\u2013based CKD-EPI equations and N-Terminal Pro-B-type natriuretic peptide for predicting outcomes in acutely decompensated heart failure","volume":"38","author":"Flores-Blanco","year":"2015","journal-title":"Clin Cardiol"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916416310569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916416310569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T07:51:20Z","timestamp":1536565880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916416310569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1071916416310569"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2016.07.440","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}