{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:05:13Z","timestamp":1785434713634,"version":"3.56.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["LCZ696BUSNC03T"],"award-info":[{"award-number":["LCZ696BUSNC03T"]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of Research and Development of the Department of Veterans Affairs 1 IK CX","award":["001043-01A2"],"award-info":[{"award-number":["001043-01A2"]}]},{"name":"Sumitomo Life Welfare and Culture Foundation and Fukuoka University, School of Medicine Alumni, Eboshikai"},{"name":"International Postdoctoral Exchange Fellowship Program","award":["20150050"],"award-info":[{"award-number":["20150050"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VA ORD"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.cardfail.2017.12.010","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T18:09:34Z","timestamp":1515434974000},"page":"266-275","source":"Crossref","is-referenced-by-count":86,"title":["LCZ696 (Sacubitril\/Valsartan), an Angiotensin-Receptor Neprilysin Inhibitor, Attenuates Cardiac Hypertrophy, Fibrosis, and Vasculopathy in a Rat Model of Chronic Kidney Disease"],"prefix":"10.1016","volume":"24","author":[{"given":"Yasunori","family":"Suematsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanghui","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moti L.","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahyar","family":"Khazaeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosratola D.","family":"Vaziri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2017.12.010_bib0010","author":"US Renal Data System"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0015","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(12)60033-6","article-title":"Prevalence of chronic kidney disease in China: a cross-sectional survey","volume":"379","author":"Zhang","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0020","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","article-title":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis","volume":"375","author":"Matsushita","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","article-title":"Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention","volume":"382","author":"Gansevoort","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0030","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0140-6736(96)07424-7","article-title":"The natriuretic-peptide family","volume":"349","author":"Wilkins","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0035","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/01.CIR.0000029801.86489.50","article-title":"Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE)","volume":"106","author":"Packer","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0040","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ejhf.474","article-title":"LCZ696, an angiotensin receptor\u2013neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice","volume":"18","author":"Suematsu","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCHEARTFAILURE.114.001785","article-title":"Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy","volume":"8","author":"von Lueder","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0050","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0055","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/hy0102.100540","article-title":"Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency","volume":"39","author":"Vaziri","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0060","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/CIRCULATIONAHA.114.011079","article-title":"NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt\/mTOR and NF\u03baB signaling pathways","volume":"131","author":"Zhao","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0065","doi-asserted-by":"crossref","first-page":"e0127110","DOI":"10.1371\/journal.pone.0127110","article-title":"Correction: angiotensin II\u2013induced arterial thickening, fibrosis and stiffening involves elevated arginase function","volume":"10","author":"Bhatta","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0070","doi-asserted-by":"crossref","first-page":"F662","DOI":"10.1152\/ajprenal.00421.2009","article-title":"Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure","volume":"298","author":"Kim","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0075","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.redox.2013.10.007","article-title":"The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease","volume":"1","author":"Aminzadeh","year":"2013","journal-title":"Redox Biol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0080","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s40620-014-0162-0","article-title":"Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2","volume":"28","author":"Pedruzzi","year":"2015","journal-title":"J Nephrol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0085","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000435838","article-title":"Left ventricular hypertrophy in chronic kidney disease patients: from pathophysiology to treatment","volume":"5","author":"Di Lullo","year":"2015","journal-title":"Cardiorenal Med"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0090","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1681\/ASN.2015060670","article-title":"IkappaB kinase inhibitor attenuates sepsis-induced cardiac dysfunction in CKD","volume":"28","author":"Chen","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10557-015-6581-x","article-title":"Cardioprotection by curcumin post-treatment in rats with established chronic kidney disease","volume":"29","author":"Hernandez-Resendiz","year":"2015","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0100","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000156715","article-title":"Effect of exercise on cardiac tissue oxidative and inflammatory mediators in chronic kidney disease","volume":"29","author":"Bai","year":"2009","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0105","first-page":"532","article-title":"Skeletal muscle mitochondrial depletion and dysfunction in chronic kidney disease","volume":"6","author":"Yazdi","year":"2013","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0110","doi-asserted-by":"crossref","first-page":"F579","DOI":"10.1152\/ajprenal.00442.2014","article-title":"Mitochondrial dysfunction in uremic cardiomyopathy","volume":"308","author":"Taylor","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0115","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.112.278457","article-title":"Cardiorenal syndrome: the emerging role of protein-bound uremic toxins","volume":"111","author":"Lekawanvijit","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0120","doi-asserted-by":"crossref","first-page":"e41281","DOI":"10.1371\/journal.pone.0041281","article-title":"Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate","volume":"7","author":"Lekawanvijit","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0125","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/jcmm.12813","article-title":"Renalase attenuates hypertension, renal injury and cardiac remodelling in rats with subtotal nephrectomy","volume":"20","author":"Yin","year":"2016","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0130","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1681\/ASN.2014050465","article-title":"Klotho and phosphate are modulators of pathologic uremic cardiac remodeling","volume":"26","author":"Hu","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0135","doi-asserted-by":"crossref","first-page":"30A","DOI":"10.1016\/j.amjcard.2009.10.009","article-title":"Renin-angiotensin system blockade and cardiovascular and renal protection","volume":"105","author":"Hoogwerf","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccl.2013.09.002","article-title":"The renin-angiotensin-aldosterone system and heart failure","volume":"32","author":"Sayer","year":"2014","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0145","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ki.2013.355","article-title":"Aggressive blood pressure reduction and renin-angiotensin system blockade in chronic kidney disease: time for re-evaluation?","volume":"85","author":"Sarafidis","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0150","doi-asserted-by":"crossref","first-page":"e002423","DOI":"10.1161\/JAHA.115.002423","article-title":"Natriuretic peptides in the regulation of cardiovascular physiology and metabolic events","volume":"4","author":"Kerkela","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0155","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00380-012-0311-0","article-title":"Atrial natriuretic peptide exerts protective action against angiotensin II-induced cardiac remodeling by attenuating inflammation via endothelin-1\/endothelin receptor A cascade","volume":"28","author":"Fujita","year":"2013","journal-title":"Heart Vessels"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0160","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/10715762.2015.1006216","article-title":"Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: benefits of atrial natriuretic peptide, losartan, and tempol","volume":"49","author":"Della Penna","year":"2015","journal-title":"Free Radic Res"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0165","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.RES.0000117070.86556.9F","article-title":"B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation","volume":"94","author":"Kapoun","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0170","doi-asserted-by":"crossref","first-page":"e0169743","DOI":"10.1371\/journal.pone.0169743","article-title":"Combined inhibition of the renin-angiotensin system and neprilysin positively influences complex mitochondrial adaptations in progressive experimental heart failure","volume":"12","author":"Grois","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0175","doi-asserted-by":"crossref","first-page":"e0163250","DOI":"10.1371\/journal.pone.0163250","article-title":"Recombinant atrial natriuretic peptide prevents aberrant Ca2+ leakage through the ryanodine receptor by suppressing mitochondrial reactive oxygen species production induced by isoproterenol in failing cardiomyocytes","volume":"11","author":"Murakami","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cardfail.2017.12.010_bib0180","first-page":"2043","article-title":"Randomized multicentre pilot study of sacubitril\/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)\u2013III\u2014rationale, trial design and baseline data","volume":"32","year":"2017","journal-title":"Nephrol Dial Transplant"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916418300022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916418300022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T20:55:38Z","timestamp":1535144138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916418300022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S1071916418300022"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2017.12.010","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}