{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:52:09Z","timestamp":1791557529365,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejcf.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cardfail.2020.11.007","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T02:15:59Z","timestamp":1605924959000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Acute Unloading Effects of Sildenafil Enhance Right Ventricular\u2013Pulmonary Artery Coupling in Heart Failure"],"prefix":"10.1016","volume":"27","author":[{"given":"Luca","family":"Monzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Reichenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikmet","family":"Al-Hiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Havlenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevenka","family":"Solar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Tupy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Ters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojtech","family":"Melenovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2020.11.007_bib0001","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/CIRCULATIONAHA.117.030543","volume":"137","author":"Soliman","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2020.11.007_bib0002","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.healun.2017.03.014","article-title":"A new \"twist\" on right heart failure with left ventricular assist systems","volume":"36","author":"Houston","year":"2017","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"10.1016\/j.cardfail.2020.11.007_bib0003","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jchf.2013.05.001","article-title":"Clinical features, hemodynamics, and outcomes of pulmonary hypertension due to chronic heart failure with reduced ejection fraction: pulmonary hypertension and heart failure","volume":"1","author":"Miller","year":"2013","journal-title":"JACC Heart Fail"},{"issue":"6","key":"10.1016\/j.cardfail.2020.11.007_bib0004","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.ahj.2009.02.022","article-title":"Effect of pulmonary hypertension on clinical outcomes in advanced heart failure: analysis of the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) database","volume":"157","author":"Khush","year":"2009","journal-title":"Am Heart J"},{"issue":"1","key":"10.1016\/j.cardfail.2020.11.007_bib0005","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01897-2018","article-title":"Pulmonary hypertension due to left heart disease","volume":"53","author":"Vachiery","year":"2019","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.cardfail.2020.11.007_bib0006","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/CIRCHEARTFAILURE.108.796789","article-title":"PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support","volume":"1","author":"Tedford","year":"2008","journal-title":"Circ Heart Fail"},{"issue":"1","key":"10.1016\/j.cardfail.2020.11.007_bib0007","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.athoracsur.2006.08.051","article-title":"Effect of sildenafil on pulmonary artery pressure, systemic pressure, and nitric oxide utilization in patients with left ventricular assist devices","volume":"83","author":"Klodell","year":"2007","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"10.1016\/j.cardfail.2020.11.007_bib0008","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/MAT.0000000000000626","article-title":"Sildenafil in left ventricular assist device is safe and well-tolerated","volume":"64","author":"Ravichandran","year":"2018","journal-title":"ASAIO J"},{"issue":"6","key":"10.1016\/j.cardfail.2020.11.007_bib0009","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005537","article-title":"Preimplant phosphodiesterase-5 inhibitor use is associated with higher rates of severe early right heart failure after left ventricular assist device implantation","volume":"12","author":"Gulati","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"17","key":"10.1016\/j.cardfail.2020.11.007_bib0010","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/CIRCULATIONAHA.105.540500","article-title":"Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans","volume":"112","author":"Borlaug","year":"2005","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.cardfail.2020.11.007_bib0011","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCHEARTFAILURE.114.001915","article-title":"Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction","volume":"8","author":"Borlaug","year":"2015","journal-title":"Circ Heart Fail"},{"issue":"9","key":"10.1016\/j.cardfail.2020.11.007_bib0012","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006410","article-title":"Letter by Hutchings et al regarding article, \u201cpreimplant phosphodiesterase-5 inhibitor use is associated with higher rates of severe early right heart failure after left ventricular assist device implantation: an INTERMACS Analysis\u201d","volume":"12","author":"Hutchings","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1016\/j.cardfail.2020.11.007_bib0013","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/heartjnl-2011-300462","article-title":"Right ventriculo-arterial coupling in pulmonary hypertension: a magnetic resonance study","volume":"98","author":"Sanz","year":"2012","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.cardfail.2020.11.007_bib0014","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005512","article-title":"Reserve of right ventricular-arterial coupling in the setting of chronic overload","volume":"12","author":"Tello","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"6","key":"10.1016\/j.cardfail.2020.11.007_bib0015","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1183\/09031936.00156714","article-title":"Clinical relevance of right ventricular diastolic stiffness in pulmonary hypertension","volume":"45","author":"Trip","year":"2015","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.cardfail.2020.11.007_bib0016","doi-asserted-by":"crossref","first-page":"H1625","DOI":"10.1152\/ajpheart.01023.2002","article-title":"Single-beat estimation of right ventricular end-systolic pressure-volume relationship","volume":"284","author":"Brimioulle","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.cardfail.2020.11.007_bib0017","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cardfail.2015.10.019","article-title":"Pulmonary artery pulsatility index is associated with right ventricular failure after left ventricular assist device surgery","volume":"22","author":"Morine","year":"2016","journal-title":"J Card Fail"},{"issue":"3","key":"10.1016\/j.cardfail.2020.11.007_bib0018","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/01.CIR.73.3.428","article-title":"The relationship between pericardial pressure and right atrial pressure: an intraoperative study","volume":"73","author":"Tyberg","year":"1986","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.cardfail.2020.11.007_bib0019","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jchf.2019.03.021","article-title":"The role of the pericardium in heart failure: implications for pathophysiology and treatment","volume":"7","author":"Borlaug","year":"2019","journal-title":"JACC Heart Fail"},{"issue":"9067","key":"10.1016\/j.cardfail.2020.11.007_bib0020","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/S0140-6736(96)05109-4","article-title":"Diastolic ventricular interaction in chronic heart failure","volume":"349","author":"Atherton","year":"1997","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.cardfail.2020.11.007_bib0021","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jacc.2016.10.047","article-title":"The relationship between the right ventricle and its load in pulmonary hypertension","volume":"69","author":"Vonk Noordegraaf","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.cardfail.2020.11.007_bib0022","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jcmg.2015.02.009","article-title":"Right intraventricular dyssynchrony in idiopathic, heritable, and anorexigen-induced pulmonary arterial hypertension: clinical impact and reversibility","volume":"8","author":"Badagliacca","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.cardfail.2020.11.007_bib0023","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/eurjhf\/hfq161","article-title":"Relationship between right ventricular volumes measured by cardiac magnetic resonance imaging and prognosis in patients with chronic heart failure","volume":"13","author":"Bourantas","year":"2011","journal-title":"Eur J Heart Fail"},{"issue":"12","key":"10.1016\/j.cardfail.2020.11.007_bib0024","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jacc.2018.12.076","article-title":"Anatomy, function, and dysfunction of the right ventricle: JACC state-of-the-art review","volume":"73","author":"Sanz","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.cardfail.2020.11.007_bib0025","doi-asserted-by":"crossref","first-page":"737","DOI":"10.7326\/0003-4819-122-10-199505150-00001","article-title":"Contribution of external forces to left ventricular diastolic pressure. Implications for the clinical use of the Starling law","volume":"122","author":"Dauterman","year":"1995","journal-title":"Ann Intern Med"},{"issue":"25","key":"10.1016\/j.cardfail.2020.11.007_bib0026","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1161\/CIRCULATIONAHA.111.048520","article-title":"Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo","volume":"124","author":"Bishu","year":"2011","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.cardfail.2020.11.007_bib0027","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.113.001873","article-title":"Right ventricular diastolic impairment in patients with pulmonary arterial hypertension","volume":"128","author":"Rain","year":"2013","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.cardfail.2020.11.007_bib0028","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00764-2017","article-title":"How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension","volume":"50","author":"Vanderpool","year":"2017","journal-title":"Eur Respir J"},{"issue":"10","key":"10.1016\/j.cardfail.2020.11.007_bib0029","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/jamacardio.2018.2454","article-title":"Right ventricular function, right ventricular-pulmonary artery coupling, and heart failure risk in 4 US communities: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"3","author":"Nochioka","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"48","key":"10.1016\/j.cardfail.2020.11.007_bib0030","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1093\/eurheartj\/ehu193","article-title":"Right heart dysfunction in heart failure with preserved ejection fraction","volume":"35","author":"Melenovsky","year":"2014","journal-title":"Eur Heart J"},{"issue":"12","key":"10.1016\/j.cardfail.2020.11.007_bib0031","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/eurheartj\/ehv512","article-title":"Left ventricular heart failure and pulmonary hypertension","volume":"37","author":"Rosenkranz","year":"2016","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.cardfail.2020.11.007_bib0032","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jacc.2009.05.021","article-title":"Transpulmonary B-type natriuretic peptide uptake and cyclic guanosine monophosphate release in heart failure and pulmonary hypertension: the effects of sildenafil","volume":"54","author":"Melenovsky","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.cardfail.2020.11.007_bib0033","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/FJC.0000000000000749","article-title":"cGMP signaling and modulation in heart failure","volume":"75","author":"Blanton","year":"2020","journal-title":"J Cardiovasc Pharmacol"},{"issue":"4","key":"10.1016\/j.cardfail.2020.11.007_bib0034","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.transproceed.2009.03.042","article-title":"Role of oral sildenafil in the treatment of right ventricular dysfunction after heart transplantation","volume":"41","author":"Boffini","year":"2009","journal-title":"Transplant Proc"},{"issue":"1","key":"10.1016\/j.cardfail.2020.11.007_bib0035","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijcard.2012.09.074","article-title":"The effects of phosphodiesterase 5 inhibition on hemodynamics, functional status and survival in advanced heart failure and pulmonary hypertension: a case-control study","volume":"168","author":"Reichenbach","year":"2013","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.cardfail.2020.11.007_bib0036","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1053\/j.jvca.2017.10.032","article-title":"Vasoplegia after cardiovascular procedures-pathophysiology and targeted therapy","volume":"32","author":"Shaefi","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"5","key":"10.1016\/j.cardfail.2020.11.007_bib0037","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/MAT.0000000000000886","article-title":"Pharmacokinetics of sildenafil in patients with a left ventricular assist device: a word of caution","volume":"65","author":"Sabato","year":"2019","journal-title":"ASAIO J"},{"issue":"7","key":"10.1016\/j.cardfail.2020.11.007_bib0038","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/S0735-1097(02)02139-3","article-title":"The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia","volume":"40","author":"Halcox","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.cardfail.2020.11.007_bib0039","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/jama.2013.2024","article-title":"Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial","volume":"309","author":"Redfield","year":"2013","journal-title":"JAMA"},{"issue":"15","key":"10.1016\/j.cardfail.2020.11.007_bib0040","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/eurheartj\/ehx700","article-title":"Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial","volume":"39","author":"Bermejo","year":"2018","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.cardfail.2020.11.007_bib0041","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jacc.2011.09.062","article-title":"Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy","volume":"59","author":"Schwartzenberg","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.cardfail.2020.11.007_bib0042","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/CIRCULATIONAHA.111.076075","article-title":"Low myocardial protein kinase G activity in heart failure with preserved ejection fraction","volume":"126","author":"van Heerebeek","year":"2012","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.cardfail.2020.11.007_bib0043","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/CIRCULATIONAHA.106.655266","article-title":"Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility","volume":"116","author":"Nagendran","year":"2007","journal-title":"Circulation"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107191642031513X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107191642031513X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:44:48Z","timestamp":1761029088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107191642031513X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S107191642031513X"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2020.11.007","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Unloading Effects of Sildenafil Enhance Right Ventricular\u2013Pulmonary Artery Coupling in Heart Failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiac Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cardfail.2020.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}