{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:02:25Z","timestamp":1788393745084,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejcf.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cardfail.2023.03.029","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T02:04:57Z","timestamp":1682733897000},"page":"1121-1131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-1099","authenticated-orcid":false,"given":"YU","family":"HORIUCHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NICHOLAS","family":"WETTERSTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIRK J.","family":"VANVELDHUISEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTIAN","family":"MUELLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD","family":"NOWAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER","family":"HOGAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL C.","family":"KONTOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHAD M.","family":"CANNON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT","family":"BIRKHAHN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GARY M.","family":"VILKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NIALL","family":"MAHON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JULIO","family":"NU\u00d1EZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARLO","family":"BRIGUORI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN","family":"DUFF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICK T.","family":"MURRAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALAN","family":"MAISEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2023.03.029_bib0001","first-page":"347","article-title":"Natriuretic peptides as inclusion criteria in clinical trials","volume":"8","author":"Ibrahim","year":"2020","journal-title":"JACC: Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0002","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijcard.2017.01.130","article-title":"BNP and obesity in acute decompensated heart failure with preserved vs. reduced ejection fraction: the Atherosclerosis Risk in Communities Surveillance Study","volume":"233","author":"Khalid","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0003","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1161\/CIRCULATIONAHA.116.024976","article-title":"Impact of body mass index on the accuracy of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide for predicting outcomes in patients with chronic heart failure and reduced ejection fraction","volume":"134","author":"Nadruz","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0004","doi-asserted-by":"crossref","first-page":"e006740","DOI":"10.1161\/JAHA.117.006740","volume":"7","author":"Bhatt","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0005","first-page":"653","article-title":"NT-proBNP for risk prediction in heart failure","volume":"9","author":"Vergaro","year":"2021","journal-title":"JACC: Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0006","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jacc.2005.08.050","article-title":"B-type natriuretic peptide levels in obese patients with advanced heart failure","volume":"47","author":"Horwich","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0007","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.CIR.0000112582.16683.EA","article-title":"Impact of obesity on plasma natriuretic peptide levels","volume":"109","author":"Wang","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0008","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1056\/NEJMoa020245","article-title":"Obesity and the risk of heart failure","volume":"347","author":"Kenchaiah","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0009","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/ejhf.2346","article-title":"Circulating heart failure biomarkers beyond natriuretic peptides: review from the Biomarker Study Group of the Heart Failure Association (HFA), European Society of Cardiology (ESC)","volume":"23","author":"Meijers","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0010","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000322822","article-title":"The role of overweight and obesity in the cardiorenal syndrome","volume":"1","author":"Sowers","year":"2011","journal-title":"Cardiorenal Med"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0011","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jchf.2014.05.017","article-title":"Obesity, subclinical myocardial injury, and incident heart failure","volume":"2","author":"Ndumele","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0012","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006414","article-title":"Obese-inflammatory phenotypes in heart failure with preserved ejection fraction","volume":"13","author":"Sabbah","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0013","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jacc.2016.06.055","article-title":"Neutrophil gelatinase-associated lipocalin for acute kidney injury during acute heart failure hospitalizations: the AKINESIS Study","volume":"68","author":"Maisel","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0014","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cardfail.2020.11.025","article-title":"Potential utility of cardiorenal biomarkers for prediction and prognostication of worsening renal function in acute heart failure","volume":"27","author":"Horiuchi","year":"2021","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0015","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.xkme.2021.02.013","article-title":"Urinary biomarkers and kidney outcomes: impact of indexing versus adjusting for urinary creatinine","volume":"3","author":"Wettersten","year":"2021","journal-title":"Kidney Med"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0016","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/eurheartj\/ehz390","article-title":"Weight and weight change and risk of atrial fibrillation: the HUNT study","volume":"40","author":"Feng","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0017","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1053\/j.ajkd.2005.08.015","article-title":"Association between body mass index and CKD in apparently healthy men","volume":"46","author":"Gelber","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0018","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/CIRCOUTCOMES.109.854877","article-title":"A validated risk score for in-hospital mortality in patients with heart failure from the American Heart Association get with the guidelines program","volume":"3","author":"Peterson","year":"2010","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0019","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/eurheartj\/ehs337","article-title":"Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies","volume":"34","author":"Pocock","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0020","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/CIRCHEARTFAILURE.111.962688","article-title":"Atrial fibrillation and mortality in heart failure: a community study","volume":"4","author":"Chamberlain","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0021","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1177\/2047487319852809","article-title":"Revisiting the obesity paradox in heart failure: percent body fat as predictor of biomarkers and outcome","volume":"26","author":"Aimo","year":"2019","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0022","first-page":"e003350","article-title":"Associations of body mass index with laboratory and biomarkers in patients with acute heart failure","volume":"10","author":"Streng","year":"2017","journal-title":"Circulation: Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0023","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1161\/01.CIR.0000144310.04433.BE","article-title":"N-terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients","volume":"110","author":"Bettencourt","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0024","first-page":"200124","article-title":"The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index","volume":"12","author":"Vavik","year":"2022","journal-title":"Int J Cardiol Cardiovasc Risk Prevent"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0025","first-page":"927","article-title":"The obesity paradox in heart failure","volume":"3","author":"Lavie","year":"2015","journal-title":"JACC: Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0026","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jacc.2013.09.072","article-title":"Body mass index and mortality in acutely decompensated heart failure across the world","volume":"63","author":"Shah","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0027","first-page":"1056","article-title":"Impact of age on comorbidities and outcomes in heart failure with reduced ejection fraction","volume":"7","author":"Regan","year":"2019","journal-title":"JACC: Heart Fail"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0028","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.jacc.2016.11.081","article-title":"Relationship between physical activity, body mass index, and risk of heart failure","volume":"69","author":"Pandey","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0029","doi-asserted-by":"crossref","first-page":"e010364","DOI":"10.1161\/JAHA.118.010364","article-title":"High-sensitivity troponin i in hospitalized and ambulatory patients with heart failure with preserved ejection fraction: insights from the Heart Failure Clinical Research Network","volume":"7","author":"Fudim","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0030","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.jacc.2017.08.074","article-title":"Heart failure with preserved, borderline, and reduced ejection fraction","volume":"70","author":"Shah","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0031","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1093\/eurheartj\/ehab579","article-title":"Novel biomarker-driven prognostic models to predict morbidity and mortality in chronic heart failure: the EMPEROR-Reduced trial","volume":"42","author":"Pocock","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0032","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.amjcard.2016.09.019","article-title":"Meta-analysis of the usefulness of plasma galectin-3 to predict the risk of mortality in patients with heart failure and in the general population","volume":"119","author":"Imran","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0033","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijcard.2014.12.137","article-title":"Prognostic value of serum galectin-3 in patients with heart failure: a meta-analysis","volume":"182","author":"Chen","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0034","doi-asserted-by":"crossref","first-page":"e011028","DOI":"10.1161\/JAHA.118.011028","article-title":"Association between plasma neutrophil gelatinase-associated lipocalin and cardiac disease hospitalizations and deaths in older women","volume":"8","author":"Chong","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cardfail.2023.03.029_bib0035","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3109\/1354750X.2015.1123354","article-title":"The potential of lipocalin-2\/NGAL as biomarker for inflammatory and metabolic diseases","volume":"20","author":"Abella","year":"2015","journal-title":"Biomarkers"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916423001501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916423001501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:50:57Z","timestamp":1761029457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916423001501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1071916423001501"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2023.03.029","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiac Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cardfail.2023.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}