{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:02:46Z","timestamp":1788022966440,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinejcf.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.cardfail.2024.02.022","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T19:45:02Z","timestamp":1711050302000},"page":"1111-1119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of Temporary Warfarin Reversal in Patients With Left Ventricular Assist Devices: the KVAD Study*"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-2354","authenticated-orcid":false,"given":"KATELYN W.","family":"SYLVESTER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JESSICA","family":"GRANDONI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEGAN","family":"RHOTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LARA","family":"COAKLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERIN","family":"LYONS-MATIELLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATIE","family":"FRANKEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BROOKE","family":"FORTIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATE","family":"JOLLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAE SOO","family":"PARK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REVITAL Y.","family":"FREEDMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MANDEEP R.","family":"MEHRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL M.","family":"GIVERTZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-582X","authenticated-orcid":false,"given":"JEAN M.","family":"CONNORS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2024.02.022_bib0001","doi-asserted-by":"crossref","first-page":"e1145","DOI":"10.1161\/CIR.0000000000000507","article-title":"Recommendations for the Use of Mechanical Circulatory Support: Ambulatory and Community Patient Care: A Scientific Statement From the American Heart Association","volume":"135","author":"Cook","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0002","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.healun.2020.01.1329","article-title":"American Association for Thoracic Surgery\/International Society for Heart and Lung Transplantation guidelines on selected topics in mechanical circulatory support","volume":"39","author":"Kirklin","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0003","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.athoracsur.2022.11.023","article-title":"The Society of Thoracic Surgeons Intermacs 2022 Annual Report: focus on the 2018 heart transplant allocation system","volume":"115","author":"Yuzefpolskaya","year":"2023","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0004","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jchf.2023.05.013","article-title":"Life-prolonging benefits of LVAD therapy in advanced heart failure: a clinician's action and communication aid","volume":"11","author":"Mehra","year":"2023","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0005","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.2022.16197","article-title":"Five-year outcomes in patients with fully magnetically levitated vs axial-flow left ventricular assist devices in the MOMENTUM 3 randomized trial","volume":"328","author":"Mehra","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0006","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/eurheartj\/ehx036","article-title":"The burden of haemocompatibility with left ventricular assist systems: a complex weave","volume":"40","author":"Mehra","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0007","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1056\/NEJMoa1900486","article-title":"MOMENTUM 3 Investigators. A fully magnetically levitated left ventricular assist device: final report","volume":"380","author":"Mehra","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0008","series-title":"Management of Bleeding Patients","first-page":"321","article-title":"Management of Bleeding Patients: Chapter 33: Management of Bleeding Associated with Durable Mechanical Circulatory Support","author":"Collins","year":"2021"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0009","doi-asserted-by":"crossref","first-page":"E123","DOI":"10.1111\/aor.13848","article-title":"The use of direct oral anticoagulants in patients with ventricular assist devices: Is there hope for Factor Xa inhibition?","volume":"45","author":"Meredith","year":"2021","journal-title":"Artif Organs"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0010","article-title":"Increased thromboembolic events with dabigatran compared with vitamin K antagonism in left ventricular assist device patients: a randomized controlled pilot trial","volume":"10","author":"Andreas","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14312\/2397-8694.2016-1","article-title":"Lowering using four factor prothrombin complex concentrate for procedures in patients with ventricular assist devices: a case series","volume":"1","author":"Nashett","year":"2016","journal-title":"J Hematol Ther"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0012","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s11239-018-1680-8","article-title":"Four-factor prothrombin complex concentrate for warfarin reversal in patients with left ventricular assist devices","volume":"46","author":"Rimsans","year":"2018","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0013","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/MAT.0000000000001021","article-title":"Prothrombin Complex concentrate for warfarin reversal in patients with continuous-flow left ventricular assist devices: a narrative review","volume":"66","author":"Jennings","year":"2020","journal-title":"ASAIO J"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0014","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1097\/MAT.0000000000000783","article-title":"Low-dose prothrombin complex concentrate in patients with left ventricular assist devices","volume":"65","author":"Brown","year":"2019","journal-title":"ASAIO J"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0015","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/jth.13140","article-title":"Subcommittee on Control of Anticoagulation. Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH","volume":"13","author":"Kaatz","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0016","doi-asserted-by":"crossref","first-page":"45S","DOI":"10.1111\/j.1537-2995.2012.03690.x","article-title":"Reversal of drug-induced anticoagulation: old solutions and new problems","volume":"52","author":"Dzik","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0017","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1538-7933.2003.00617.x","article-title":"Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system","volume":"2","author":"Allen","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0018","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1538-7836.2007.02824.x","article-title":"Coagulation factors and the protein C system as determinants of thrombin generation in a normal population","volume":"6","author":"Dielis","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0019","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10557-021-07192-0","article-title":"Efficacy and safety of the fixed-dose versus variable-dose of 4-PCC for vitamin K antagonist reversal: a comprehensive systematic review and meta-analysis","volume":"36","author":"Mohammadi","year":"2022","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0020","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1182\/bloodadvances.2018024893","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy","volume":"2","author":"Witt","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0021","article-title":"Perioperative management of antithrombotic therapy: an American College of Chest Physicians Clinical Practice Guideline","volume":"S0012","author":"Douketis","year":"2022","journal-title":"Chest"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0022","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1056\/NEJMoa1501035","article-title":"Perioperative bridging anticoagulation in patients with atrial fibrillation","volume":"373","author":"Douketis","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0023","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/clc.23336","article-title":"Thromboembolic and bleeding risk of periprocedural bridging anticoagulation: a systematic review and meta-analysis","volume":"43","author":"Kuo","year":"2020","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0024","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.thromres.2022.08.022","article-title":"A systematic review and meta-analysis of periprocedural bridging for patients with mechanical heart valves undergoing non-cardiac interventions","volume":"218","author":"Bontinis","year":"2022","journal-title":"Thromb Res"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0025","unstructured":"AmerisourceBergen Wholesale Acquisition Cost. https:\/\/www.amerisourcebergen.com\/. Accessed July 2023."},{"key":"10.1016\/j.cardfail.2024.02.022_bib0026","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1001\/jama.2023.23204","article-title":"ARIES-HM3 Investigators. Aspirin and hemocompatibility events with a left ventricular assist device in advanced heart failure: the ARIES-HM3 randomized clinical trial","volume":"330","author":"Mehra","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0027","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1182\/bloodadvances.2022009015","article-title":"INR and vitamin K-dependent factor levels after vitamin K antagonist reversal with 4F-PCC or plasma","volume":"7","author":"Hood","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.cardfail.2024.02.022_bib0028","series-title":"Kcentra (prothrombin complex concentrate human) [prescribing information]","year":"2018"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916424000873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916424000873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T17:31:22Z","timestamp":1726594282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916424000873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1071916424000873"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2024.02.022","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of Temporary Warfarin Reversal in Patients With Left Ventricular Assist Devices: the KVAD Study*","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiac Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cardfail.2024.02.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}