{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:48:28Z","timestamp":1772941708011,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007682","name":"Medicinski Fakultet, Sveu\u010dili\u0161te u Zagrebu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007682","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejcf.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.cardfail.2025.07.015","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T06:57:50Z","timestamp":1755241070000},"page":"406-418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rationale, design, and baseline characteristics of the multicENter, randomized, open-label, parallel group, study to evaluate the use of sacubitril\/valsartan in HeartMate 3 left ventricular assist device recipients (ENVAD-HF)"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-5549","authenticated-orcid":false,"given":"Maja","family":"Cikes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-6704","authenticated-orcid":false,"given":"Ivo","family":"Planinc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper J","family":"Brugts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich P.","family":"Jorde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davor","family":"Milicic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Uriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Jakus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Loncaric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Puskaric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Rubis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda W.","family":"van Laake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Rudez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marketa","family":"Hegarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandeep","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2025.07.015_bib0001","first-page":"1","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"00","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0002","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jacc.2022.01.017","article-title":"Trends and outcomes of left ventricular assist device therapy","volume":"79","author":"Varshney","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0003","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.2022.16197","article-title":"Five-year outcomes in patients with fully magnetically levitated vs axial-flow left ventricular assist devices in the MOMENTUM 3 randomized trial","volume":"328","author":"Mehra","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0004","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jacc.2023.05.066","article-title":"Predictors of 5-year mortality in patients managed with a magnetically levitated left ventricular assist device","volume":"82","author":"Nayak","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0005","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.cardfail.2022.09.007","article-title":"Hemodynamic aberrancies in left ventricular assist device-associated heart failure syndromes","volume":"28","author":"Boulet","year":"2022","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0006","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.healun.2020.08.017","article-title":"Use of sacubitril-valsartan in blood pressure control with left ventricular assist devices","volume":"39","author":"Dobarro","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0007","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/0391398821989066","article-title":"Angiotensin receptor neprilysin inhibitor use in patients with left ventricular assist devices: a single-center experience","volume":"45","author":"Alishetti","year":"2022","journal-title":"Int J Artif Organs"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0008","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.cardfail.2021.06.007","article-title":"Safety of contemporary heart failure therapy in patients with continuous-flow left ventricular assist devices","volume":"27","author":"Schnettler","year":"2021","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0009","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/jamacardio.2019.4965","article-title":"Neurohormonal blockade and clinical outcomes in patients with heart failure supported by left ventricular assist devices","volume":"5","author":"McCullough","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0010","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.3390\/jcm13247789","article-title":"A systematic review and meta-analysis of an angiotensin receptor-neprilysin inhibitor in patients using a durable left ventricular assist device","volume":"13","author":"Hasabo","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0011","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.healun.2022.12.004","article-title":"The 2023 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: a 10-year update","volume":"42","author":"Saeed","year":"2023","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0012","unstructured":"Estep J. Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT). Available at: ClinicalTrials.gov: https:\/\/clinicaltrials.gov\/study\/NCT04191681?term=LVAD%20SEAL-IT&rank=1."},{"key":"10.1016\/j.cardfail.2025.07.015_bib0013","doi-asserted-by":"crossref","DOI":"10.11589\/vad\/e2021712","article-title":"Guideline-directed heart failure therapy in patients after left ventricular assist device implantation","volume":"7","author":"Colvin","year":"2021","journal-title":"VAD J"},{"issue":"Suppl_1","key":"10.1016\/j.cardfail.2025.07.015_bib0014","doi-asserted-by":"crossref","DOI":"10.1161\/circ.148.suppl_1.12373","article-title":"Abstract 12373: Clinical outcomes in patients with left ventricular assist device on guideline directed medical therapy: a propensity score matched analysis","volume":"148","author":"Rawlley","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0015","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1001\/jama.2023.23204","article-title":"Aspirin and hemocompatibility events with a left ventricular assist device in advanced heart failure: the ARIES-HM3 randomized clinical trial","volume":"330","author":"Mehra","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0016","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/CIRCULATIONAHA.124.069726","article-title":"A prospective randomized trial of direct oral anticoagulant therapy with a fully magnetically levitated LVAD: the DOT-HM3 study","volume":"150","author":"Netuka","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0017","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.jchf.2024.04.013","article-title":"Evaluation of the hemocompatibility of the direct oral anticoagulant apixaban in left ventricular assist devices: the DOAC LVAD study","volume":"12","author":"Shah","year":"2024","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0018","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.healun.2025.04.012","article-title":"Low dose apixaban in HeartMate 3 LVAD patients, interim analysis of the ApixiVAD trial, a randomized controlled study","volume":"44","author":"Schnegg","year":"2025","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0019","article-title":"Increased thromboembolic events with dabigatran compared with vitamin K antagonism in left ventricular assist device patients: a randomized controlled pilot trial","volume":"10","author":"Andreas","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0020","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/ejhf.1773","article-title":"Randomized trial of a left ventricular assist device as destination therapy versus guideline-directed medical therapy in patients with advanced heart failure. Rationale and design of the SWEdish evaluation of left Ventricular Assist Device (SweVAD) trial","volume":"22","author":"Karason","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0021","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1161\/CIRCULATIONAHA.120.046415","article-title":"Prospective multicenter study of myocardial recovery using left ventricular assist devices (RESTAGE-HF [Remission from Stage D Heart Failure]): medium-term and primary end point results","volume":"142","author":"Birks","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0022","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0023","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/ejhf.1873","article-title":"Sacubitril\/valsartan in patients post-left ventricular assist device implant: a single-centre case series","volume":"22","author":"Randhawa","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0024","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1097\/MAT.0000000000001435","article-title":"Angiotensin receptor-neprilysin inhibition improves blood pressure and heart failure control in left ventricular assist device patients","volume":"67","author":"Goldberg","year":"2021","journal-title":"ASAIO J"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0025","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1002\/ehf2.13590","article-title":"HFA of the ESC position paper on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider part 3: at the hospital and discharge","volume":"8","author":"Gustafsson","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0026","doi-asserted-by":"crossref","DOI":"10.1161\/HHF.0000000000000074","article-title":"Management of hypertension in patients with ventricular assist devices: a scientific statement from the American Heart Association","volume":"15","author":"Eisen","year":"2022","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0027","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cardfail.2023.01.009","article-title":"HFSA expert consensus statement on the medical management of patients on durable mechanical circulatory support","volume":"29","author":"Trachtenberg","year":"2023","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0028","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/MAT.0000000000000805","article-title":"Noninvasive measures of pulsatility and blood pressure during continuous-flow left ventricular assist device support","volume":"65","author":"Rangasamy","year":"2019","journal-title":"ASAIO J"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0029","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ehf2.12456","article-title":"Accuracy of Doppler blood pressure measurement in continuous-flow left ventricular assist device patients","volume":"6","author":"Li","year":"2019","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0030","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jchf.2019.07.001","article-title":"Design of a \"lean\" case report form for heart failure therapeutic development","volume":"7","author":"Psotka","year":"2019","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0031","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research elec-tronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0032","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cardfail.2024.07.024","article-title":"Antithrombotic strategies with left ventricular assist devices","volume":"30","author":"Cikes","year":"2024","journal-title":"J Card Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0033","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1056\/NEJMoa1900486","article-title":"A fully magnetically levitated left ventricular assist device\u2014final report","volume":"380","author":"Mehra","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0034","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.healun.2019.11.016","article-title":"Outcomes based on blood pressure in patients on continuous flow left ventricular assist device support: an Interagency Registry for Mechanically Assisted Circulatory Support analysis","volume":"39","author":"Cowger","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0035","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.healun.2021.08.015","article-title":"Impact of renin-angiotensin-aldosterone system inhibition on morbidity and mortality during long-term continuous-flow left ventricular assist device support: an IMACS report","volume":"40","author":"Brinkley","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0036","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(09)61966-8","article-title":"Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study","volume":"375","author":"Ruilope","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0037","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/eurheartj\/ehw570","article-title":"Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril\/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF","volume":"38","author":"B\u00f6hm","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0038","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jchf.2019.09.011","article-title":"Mineralocorticoid receptor antagonists, blood pressure, and outcomes in heart failure with reduced ejection fraction","volume":"8","author":"Serenelli","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0039","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/ehf2.14261","article-title":"Sex-related differences in left ventricular assist device utilization and outcomes: results from the PCHF-VAD registry","volume":"10","author":"Radhoe","year":"2023","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0040","doi-asserted-by":"crossref","first-page":"ezaf016","DOI":"10.1093\/ejcts\/ezaf016","article-title":"The fourth report of the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) of the European Association for Cardiothoracic Surgery: focus on standardized outcome ratios","volume":"67","author":"Veen","year":"2025","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cardfail.2025.07.015_bib0041","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/MAT.0000000000000960","article-title":"Impact and measurement of blood pressure during continuous flow left ventricular assist device support: the pressure is on!","volume":"65","author":"Saeed","year":"2019","journal-title":"ASAIO J"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916425003367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916425003367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:13:53Z","timestamp":1772882033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916425003367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1071916425003367"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2025.07.015","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale, design, and baseline characteristics of the multicENter, randomized, open-label, parallel group, study to evaluate the use of sacubitril\/valsartan in HeartMate 3 left ventricular assist device recipients (ENVAD-HF)","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiac Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cardfail.2025.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}