{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:46:28Z","timestamp":1791751588504,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejcf.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Failure"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cardfail.2026.07.029","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:10:22Z","timestamp":1786633822000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beta\u2010Blocker Discontinuation in Heart Failure With Preserved or Improved Ejection Fraction: A Systematic Review"],"prefix":"10.1016","author":[{"given":"Wade","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Alaeiilkhchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raha","family":"Eskandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong Maggie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"Salzwedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cardfail.2026.07.029_bib0001","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/jama.287.7.883","article-title":"\u03b2-Blocker therapy in heart failure","volume":"287","author":"Foody","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0002","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.29519","article-title":"\u03b2-Blocker use and health status among patients with heart failure with preserved ejection fraction","volume":"8","author":"Abdel Jawad","year":"2025","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0003","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.29524","article-title":"Uncertainties about use of \u03b2-blockers in heart failure with preserved ejection fraction","volume":"8","author":"Reddy","year":"2025","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2024.102376","article-title":"Beta-blocker therapy in heart failure with preserved ejection fraction (B-HFpEF): A systematic review and meta-analysis","volume":"49","author":"Kaddoura","year":"2024","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0005","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0006","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jchf.2025.02.007","article-title":"Management of heart failure with improved ejection fraction","volume":"13","author":"Kodur","year":"2025","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0007","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jacc.2022.08.754","article-title":"2022 ACC expert consensus decision pathway for integrating atherosclerotic cardiovascular disease and multimorbidity treatment: A framework for pragmatic, patient-centered care","volume":"81","author":"Birtcher","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0008","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0009","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0010","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0011","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.jacc.2021.08.073","article-title":"Effect of \u03b2-blocker withdrawal on functional capacity in heart failure and preserved ejection fraction","volume":"78","author":"Palau","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0012","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.jacc.2020.01.040","article-title":"Withdrawal of neurohumoral blockade after cardiac resynchronization therapy","volume":"75","author":"Nijst","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0013","article-title":"Characteristics, outcomes and the necessity of continued guideline-directed medical therapy in patients with heart failure with improved ejection fraction","volume":"57","author":"Chen","year":"2025","journal-title":"Ann Med"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0014","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1161\/CIRCULATIONAHA.124.072855","article-title":"Withdrawal of guideline-directed medical therapy in patients with heart failure and improved ejection fraction","volume":"151","author":"Basile","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/bcp.16223","article-title":"The effect of down-titration and discontinuation of heart failure pharmacotherapy in older people: A systematic review and meta-analysis","volume":"91","author":"Duong","year":"2025","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0016","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)32484-X","article-title":"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): An open-label, pilot, randomised trial","volume":"393","author":"Halliday","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0017","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ejhf.3383","article-title":"Beta-blocker use and outcomes in patients with heart failure and mildly reduced and preserved ejection fraction","volume":"27","author":"Matsumoto","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0018","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jchf.2023.03.017","article-title":"Beta-blocker use and heart failure outcomes in mildly reduced and preserved ejection fraction","volume":"11","author":"Arnold","year":"2023","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0019","unstructured":"Goyal P. DEPRESCRIBE-HFPEF 2024. Accessed 10 December 2025. https:\/\/reporter.nih.gov\/search\/PBq_kmaVYkSw1rP1ys7_iw\/project-details\/11027886"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0020","unstructured":"Hulot JS. Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction (BONFIRE) 2024. Accessed 10 December 2025. https:\/\/clinicaltrials.gov\/study\/NCT06518694"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0021","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1111\/bcp.15442","article-title":"N-of-1 trials to facilitate evidence-based deprescribing: Rationale and case study","volume":"88","author":"Goyal","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0022","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1001\/jama.2022.21383","article-title":"Target trial emulation","volume":"328","author":"Hern\u00e1n","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0023","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.amjcard.2023.01.050","article-title":"Physician perspectives on the use of beta blockers in heart failure with preserved ejection fraction","volume":"193","author":"Musse","year":"2023","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0024","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1001\/jamainternmed.2016.7701","article-title":"Association of \u03b2-blockers with functional outcomes, death, and rehospitalization in older nursing home residents after acute myocardial infarction","volume":"177","author":"Steinman","year":"2017","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.cardfail.2026.07.029_bib0025","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1080\/14740338.2018.1546841","article-title":"An update on the clinical consequences of polypharmacy in older adults: A narrative review","volume":"17","author":"Wastesson","year":"2018","journal-title":"Expert Opin Drug Saf"}],"container-title":["Journal of Cardiac Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916426004495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071916426004495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:03:21Z","timestamp":1791749001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071916426004495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":25,"alternative-id":["S1071916426004495"],"URL":"https:\/\/doi.org\/10.1016\/j.cardfail.2026.07.029","relation":{},"ISSN":["1071-9164"],"issn-type":[{"value":"1071-9164","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beta\u2010Blocker Discontinuation in Heart Failure With Preserved or Improved Ejection Fraction: A Systematic Review","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiac Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cardfail.2026.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}