{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:44:53Z","timestamp":1777477493436,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe chest radiographic findings in patients with isolated and complicated acute novel influenza A (H1N1) virus infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective study of 147 patients (64 men, mean age 41) with reverse-transcriptase polymerase chain reaction confirmed acute influenza A (H1N1) infection, who also had a chest radiograph &lt;72 hours of viral specimen collection. Radiographs were analysed for acute findings. A correlation with bacterial cultures results was performed. The unpaired 2-sample equal-variance Student t test was applied to continuous variables and the Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test of association to discrete variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 71% of cases, chest radiograph was normal. The presence of acute imaging findings was associated with older age ( P &lt; .05), increased number of comorbidities (most commonly, chronic obstructive pulmonary disease, diabetes, asthma) ( P &lt; .05), higher rate of hospitalization ( P &lt; .05) and intensive care unit admission, and increased mortality. Predominant acute radiographic finding in isolated influenza A (H1N1) was alveolar opacity (88%), either unifocal or multifocal, most often in the lower lobes. In the subgroup of patients with positive imaging findings and for whom nonviral microbiologic data was available, 62% had superimposed bacterial or fungal infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the majority of patients with acute influenza A (H1N1) infection, the chest radiograph is normal. Acute imaging findings are associated with older age, an increased number of comorbidities, and a higher rate of complications and mortality. The predominant radiographic finding of isolated primary influenza A (H1N1) infection is alveolar opacity. Superimposed bacterial infection is frequent and must be excluded in patients with abnormal imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.carj.2010.03.008","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T09:56:27Z","timestamp":1274954187000},"page":"233-240","source":"Crossref","is-referenced-by-count":6,"title":["Pandemic Influenza A (H1N1) 2009: Chest Radiographic Findings from 147 Proven Cases in the Montreal Area"],"prefix":"10.1177","volume":"61","author":[{"given":"Alexandre","family":"Semionov","sequence":"first","affiliation":[{"name":"Radiology Department, University of Montreal Medical Center (CHUM), Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Microbiology Department, University of Montreal Medical Center, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Samson","sequence":"additional","affiliation":[{"name":"Radiology Department, University of Montreal Medical Center (CHUM), Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Chandonnet","sequence":"additional","affiliation":[{"name":"Radiology Department, University of Montreal Medical Center (CHUM), Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Chalaoui","sequence":"additional","affiliation":[{"name":"Radiology Department, University of Montreal Medical Center (CHUM), Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Chartrand-Lefebvre","sequence":"additional","affiliation":[{"name":"Radiology Department, University of Montreal Medical Center (CHUM), Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"bibr1-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904252"},{"key":"bibr2-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906695"},{"key":"bibr3-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904023"},{"key":"bibr4-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1496"},{"key":"bibr5-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3599"},{"key":"bibr6-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.11.005"},{"key":"bibr7-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3625"},{"key":"bibr8-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09092083"},{"key":"bibr9-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903810"},{"key":"bibr10-j.carj.2010.03.008","unstructured":"WrightP.F. WebsterR.G. Orthomyxoviruses KnipeD.M. HowleyP.M. GriffinD.E.  Fields' virology, vol. 1 4th ed. 2001 Lippincott Williams & Wilkins: Philadelphia 1533\u20131579"},{"key":"bibr11-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1353\/bhm.2002.0022"},{"key":"bibr12-j.carj.2010.03.008","unstructured":"Centers for Disease Control and Prevention Influenza AtkinsonW. WolfeS. HamborskyJ. McIntyreL. Epidemiology and Prevention of Vaccine-Preventable Diseases11th ed. 2009 Public Health Foundation: Washington DC 138\u2013139"},{"key":"bibr13-j.carj.2010.03.008","first-page":"497","volume":"58","author":"Centers for Disease Control and Prevention (CDC)","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr14-j.carj.2010.03.008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1583"},{"key":"bibr15-j.carj.2010.03.008","unstructured":"World Health Organization (WHO), 2010. Pandemic (H1N1) 2009: update 83. 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