{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:19:30Z","timestamp":1777475970177,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the detection of parathyroid adenoma and hyperplasia in the setting of primary hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Records of 48 patients with biochemically confirmed primary hyperparathyroidism, who underwent preoperative imaging with 16- or 64-slice contrast-enhanced MDCT and subsequent successful parathyroidectomy over a 3-year period, were reviewed. Two radiologists, blinded to the operative and histologic findings, independently evaluated multiplanar computed tomographic images for all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On pathologic examination, 63 abnormal glands were confirmed in 41 female and 7 male patients (mean age, 63 years). Of the 63 abnormal glands, 40 were adenomatous and 23 were hyperplastic. MDCT demonstrated an 88% (95% confidence interval [CI], 77%\u201399%) positive predictive value for localizing abnormal hyperfunctioning parathyroid glands. The sensitivity of MDCT in detecting single-gland disease was 80% (95% CI, 68%\u201392%); whereas the specificity for ruling out hyperfunctioning parathyroid tissue, either adenomatous or hyperplastic, was 75% (95% CI, 51%\u201399%). The sensitivity for exclusively localizing parathyroid hyperplasia was 17% (95% CI, 2%\u201333%). The parathyroid adenomas were substantially larger and heavier than their hyperplastic counterparts, with an average weight of 1.51 g (range, 0.08\u20136.00 g) and 0.42 g (range, 0.02\u20132.0 g) for adenoma and hyperplasia, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Contrast-enhanced MDCT demonstrated an 88% positive predictive value for localizing adenomatous and hyperplastic parathyroid glands. The poor sensitivity for detection of multigland disease was likely a result of the smaller size and weight of the abnormal hyperplastic glands.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.carj.2010.12.002","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T21:31:35Z","timestamp":1317245495000},"page":"100-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Utility of Multidetector Computed Tomography for Detection of Parathyroid Disease in the Setting of Primary Hyperparathyroidism"],"prefix":"10.1177","volume":"63","author":[{"given":"Dorota D.","family":"Linda","sequence":"first","affiliation":[{"name":"Department of Radiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Radiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Rebello","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, St Joseph's Healthcare and Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasan","family":"Harish","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, St Joseph's Healthcare and Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Ioannidis","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.M.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Joseph's Healthcare and Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"bibr1-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2008.03.006"},{"key":"bibr2-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0938"},{"key":"bibr3-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/44399050"},{"key":"bibr4-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.029"},{"key":"bibr5-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2004.04.005"},{"key":"bibr6-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2203000998"},{"key":"bibr7-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2003.00564.x"},{"key":"bibr8-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-007-0179-8"},{"key":"bibr9-j.carj.2010.12.002","first-page":"213","volume":"29","author":"Younes N.A.","year":"2008","journal-title":"Saudi Med J"},{"key":"bibr10-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.028"},{"key":"bibr11-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.2098"},{"key":"bibr12-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2282011860"},{"key":"bibr13-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.12.044"},{"key":"bibr14-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318177098c"},{"key":"bibr15-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200402000-00010"},{"key":"bibr16-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.062"},{"key":"bibr17-j.carj.2010.12.002","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2481071066"}],"container-title":["Canadian Association of Radiologists Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0846537110002366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0846537110002366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.carj.2010.12.002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1016\/j.carj.2010.12.002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.carj.2010.12.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:54:38Z","timestamp":1777384478000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1016\/j.carj.2010.12.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1016\/j.carj.2010.12.002"],"URL":"https:\/\/doi.org\/10.1016\/j.carj.2010.12.002","relation":{},"ISSN":["0846-5371","1488-2361"],"issn-type":[{"value":"0846-5371","type":"print"},{"value":"1488-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}